CN1247567A - 肿瘤坏死因子受体6α和6β - Google Patents

肿瘤坏死因子受体6α和6β Download PDF

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Publication number
CN1247567A
CN1247567A CN98801836A CN98801836A CN1247567A CN 1247567 A CN1247567 A CN 1247567A CN 98801836 A CN98801836 A CN 98801836A CN 98801836 A CN98801836 A CN 98801836A CN 1247567 A CN1247567 A CN 1247567A
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China
Prior art keywords
seq
tnfr
polypeptide
sequence
nucleotide sequence
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN98801836A
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English (en)
Chinese (zh)
Inventor
莱纳·L·根茨
倪健
莱因哈德·艾伯纳
余国良
斯蒂文·M·鲁宾
冯平
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Human Genome Sciences Inc
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Human Genome Sciences Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21883066&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1247567(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Publication of CN1247567A publication Critical patent/CN1247567A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN98801836A 1997-01-14 1998-01-13 肿瘤坏死因子受体6α和6β Pending CN1247567A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3549697P 1997-01-14 1997-01-14
US60/035,496 1997-01-14

Publications (1)

Publication Number Publication Date
CN1247567A true CN1247567A (zh) 2000-03-15

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ID=21883066

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98801836A Pending CN1247567A (zh) 1997-01-14 1998-01-13 肿瘤坏死因子受体6α和6β

Country Status (12)

Country Link
US (2) US8003386B1 (enExample)
EP (1) EP1007659B1 (enExample)
JP (1) JP2001507937A (enExample)
KR (1) KR20000070174A (enExample)
CN (1) CN1247567A (enExample)
AT (1) ATE365796T1 (enExample)
AU (1) AU729062C (enExample)
BR (1) BR9806954A (enExample)
CA (1) CA2277925A1 (enExample)
DE (1) DE69837996T2 (enExample)
ES (1) ES2286843T3 (enExample)
WO (1) WO1998030694A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102421913A (zh) * 2009-03-13 2012-04-18 宾夕法尼亚大学董事会 Ox40/trail融合蛋白

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7597886B2 (en) 1994-11-07 2009-10-06 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US7429646B1 (en) 1995-06-05 2008-09-30 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor-like 2
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
WO1997033904A1 (en) 1996-03-12 1997-09-18 Human Genome Sciences, Inc. Death domain containing receptors
US7357927B2 (en) 1996-03-12 2008-04-15 Human Genome Sciences, Inc. Death domain containing receptors
US6713061B1 (en) 1996-03-12 2004-03-30 Human Genome Sciences, Inc. Death domain containing receptors
US7964190B2 (en) 1996-03-22 2011-06-21 Human Genome Sciences, Inc. Methods and compositions for decreasing T-cell activity
US6635743B1 (en) 1996-03-22 2003-10-21 Human Genome Sciences, Inc. Apoptosis inducing molecule II and methods of use
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
DE69837996T2 (de) 1997-01-14 2008-02-28 Human Genome Sciences, Inc. Tumornekrosefaktor-rezeptoren 6 alpha& 6 beta
WO1999004001A1 (en) * 1997-07-21 1999-01-28 Zymogenetics, Inc. Tumor necrosis factor receptor ztnfr-5
CA2299619A1 (en) * 1997-08-06 1999-02-18 Regeneron Pharmaceuticals, Inc. Human orphan receptor ntr-1
AU9376498A (en) * 1997-09-05 1999-03-22 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
WO1999014330A1 (en) * 1997-09-18 1999-03-25 Genentech, Inc. DcR3 POLYPEPTIDE, A TNFR HOMOLOG
WO1999026977A1 (en) * 1997-11-24 1999-06-03 Biogen, Inc. Novel receptors opg-2
EP1037908A2 (en) * 1997-12-16 2000-09-27 Incyte Pharmaceuticals, Inc. Human tumor necrosis factor-r2-like proteins
DE19809978A1 (de) * 1998-03-09 1999-09-16 Basf Ag Neuer Rezeptor aus der menschlichen Lunge
HUP0102067A2 (hu) * 1998-03-30 2001-10-28 Eli Lilly And Co. A TNF receptorcsaládba tartozó érett FLINT (mFLINT) polipeptid vagy más néven az OPG3 terápiás alkalmazásai
US6916907B1 (en) 1998-10-23 2005-07-12 Curagen Corporation Nucleic acids encoding osteoprotegern-like proteins and methods of using same
AU2164400A (en) * 1998-12-09 2000-06-26 Eli Lilly And Company Flint compositions and uses thereof
EP1140138A2 (en) * 1998-12-22 2001-10-10 Eli Lilly And Company Therapeutic applications of flint polypeptides
WO2000046247A1 (en) * 1999-02-05 2000-08-10 Merck & Co., Inc. Methods of use for dna molecules encoding m68, a tnf receptor-related protein
WO2000050620A2 (en) 1999-02-26 2000-08-31 Human Genome Sciences, Inc. Human endokine alpha and methods of use
CA2362929A1 (en) * 1999-03-04 2000-09-08 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6.alpha. and 6.beta.
AU2495200A (en) * 1999-03-08 2000-09-28 Genentech Inc. Compositions and methods for the treatment of tumor
US6965012B1 (en) * 1999-03-30 2005-11-15 Eli Lilly And Company Flint polypeptide analogs
CA2368760A1 (en) * 1999-03-30 2000-10-05 Eli Lilly And Company Flint polypeptide analogs
ES2291197T3 (es) * 1999-03-30 2008-03-01 Eli Lilly And Company Analogos de flint resistentes a proteasas.
US6835814B1 (en) 1999-03-30 2004-12-28 Eli Lilly And Company Protease resistant flint analogs
US6627199B1 (en) 1999-07-09 2003-09-30 Amgen Inc Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family
WO2001010908A1 (en) 1999-08-04 2001-02-15 Amgen Inc. Ntr3, a member of the tnf-receptor supergene family
MXPA02001264A (es) 1999-08-04 2002-07-22 Amgen Inc Fhm, nuevo miembro de la familia de supergenes de ligando de factor de necrosis tumoral.
EP1214411A2 (en) * 1999-09-10 2002-06-19 Eli Lilly And Company Flint analog compounds and formulations thereof
AU7053000A (en) * 1999-09-10 2001-04-10 Eli Lilly And Company Flint compounds and formulations thereof
AU6891800A (en) * 1999-09-10 2001-04-10 Eli Lilly And Company Flint analog compounds and formulations thereof
EP1294949A4 (en) 2000-06-15 2004-08-25 Human Genome Sciences Inc HUMAN TUMORNESCROSE FACTOR DELTA AND EPSILON
AU2001268427B2 (en) 2000-06-16 2007-03-29 Glaxosmithkline Intellectual Property Limited Antibodies that immunospecifically bind to blys
CN1331125A (zh) * 2000-06-26 2002-01-16 上海博德基因开发有限公司 一种新的多肽——人含细胞色素c结构域的tnfr/ngfr蛋白9.02和编码这种多肽的多核苷酸
EP1322667A4 (en) * 2000-08-25 2004-08-18 Human Genome Sciences Inc TUMOR NECROSE FACTOR RECEPTORS 6-ALPHA AND 6-BETA
MXPA03010747A (es) 2001-05-25 2004-03-02 Human Genome Sciences Inc Anticuerpos que se unen inmunoespecificamente a receptores de ligando inductor de apoptosis relacionado con factor de necrosis tumoral.
CA2841097A1 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin and g-csf fusion proteins
PT1543038T (pt) 2002-09-11 2017-07-07 Genentech Inc Purificação de proteína
KR20080074120A (ko) 2005-10-13 2008-08-12 휴먼 게놈 사이언시즈, 인코포레이티드 자가항체 양성 질환 환자의 치료에 유용한 방법 및 조성물
US20090269345A1 (en) * 2005-12-23 2009-10-29 Rong Fan CLN248 Antibody Compositions and Methods of Use
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
MX361929B (es) 2010-11-19 2018-12-19 Eisai R&D Man Co Ltd Star Anticuerpos anti-ligando de quimiocina cc 20 (ccl20) neutralizantes.
KR20240122922A (ko) 2013-03-27 2024-08-13 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
CA2922704A1 (en) 2013-05-24 2014-11-27 Neil R. Cashman Cell senescence markers as diagnostic and therapeutic targets
EP3022295A4 (en) 2013-07-19 2017-03-01 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
CN109462996A (zh) 2016-03-17 2019-03-12 西达-赛奈医疗中心 通过rnaset2诊断炎性肠病的方法

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
CA2067031C (en) 1991-04-26 2003-02-18 Shigekazu Nagata Dna coding for human cell surface antigen
NZ275711A (en) 1993-10-14 1998-03-25 Immunex Corp Monoclonal antibodies and binding proteins which bind to human fas antigen (nerve growth factor/tumour necrosis factor receptor type)
US5830469A (en) 1993-10-14 1998-11-03 Immunex Corporation Fas antagonists and uses thereof
US5663070A (en) 1993-11-15 1997-09-02 Lxr Biotechnology Inc. Recombinant production of a soluble splice variant of the Fas (Apo-1) antigen, fas TM
US5741667A (en) 1994-05-27 1998-04-21 Genentech, Inc. Tumor necrosis factor receptor-associated factors
US5632994A (en) 1994-06-14 1997-05-27 La Jolla Cancer Research Foundation Fas associated proteins
AU2363695A (en) 1995-04-27 1996-11-18 Human Genome Sciences, Inc. Human tumor necrosis factor receptors
US5985614A (en) * 1996-08-30 1999-11-16 Human Genome Sciences, Inc. Polynucleotides encoding interleukin-19
DE69837996T2 (de) 1997-01-14 2008-02-28 Human Genome Sciences, Inc. Tumornekrosefaktor-rezeptoren 6 alpha& 6 beta
US5885800A (en) 1997-02-04 1999-03-23 Smithkline Beecham Corporation DNA encoding tumor necrosis related receptor, TR4
CA2295991A1 (en) 1997-06-11 1998-12-17 Human Genome Sciences, Inc. Human tumor necrosis factor receptor tr9
WO1999004001A1 (en) 1997-07-21 1999-01-28 Zymogenetics, Inc. Tumor necrosis factor receptor ztnfr-5
CA2299619A1 (en) 1997-08-06 1999-02-18 Regeneron Pharmaceuticals, Inc. Human orphan receptor ntr-1
AU9376498A (en) 1997-09-05 1999-03-22 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
WO1999014330A1 (en) 1997-09-18 1999-03-25 Genentech, Inc. DcR3 POLYPEPTIDE, A TNFR HOMOLOG
WO1999026977A1 (en) 1997-11-24 1999-06-03 Biogen, Inc. Novel receptors opg-2
EP1037908A2 (en) 1997-12-16 2000-09-27 Incyte Pharmaceuticals, Inc. Human tumor necrosis factor-r2-like proteins
US6297367B1 (en) 1997-12-30 2001-10-02 Chiron Corporation Polynucleotide encoding TNFL1
AU2093499A (en) 1997-12-30 1999-07-19 Chiron Corporation Members of tnf and tnfr families
DE19809978A1 (de) 1998-03-09 1999-09-16 Basf Ag Neuer Rezeptor aus der menschlichen Lunge
HUP0102067A2 (hu) 1998-03-30 2001-10-28 Eli Lilly And Co. A TNF receptorcsaládba tartozó érett FLINT (mFLINT) polipeptid vagy más néven az OPG3 terápiás alkalmazásai
EP1093516A2 (en) 1998-07-06 2001-04-25 Schering Corporation Mammalian genes; dendritic cell prostaglandin-like transporter (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods
KR100529270B1 (ko) 1998-12-01 2005-11-21 제넨테크, 인크. 혈관신생 및 심혈관형성의 촉진 또는 억제
AU2164400A (en) 1998-12-09 2000-06-26 Eli Lilly And Company Flint compositions and uses thereof
EP1140138A2 (en) 1998-12-22 2001-10-10 Eli Lilly And Company Therapeutic applications of flint polypeptides
WO2000046247A1 (en) 1999-02-05 2000-08-10 Merck & Co., Inc. Methods of use for dna molecules encoding m68, a tnf receptor-related protein
CA2362929A1 (en) 1999-03-04 2000-09-08 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6.alpha. and 6.beta.
AU2495200A (en) 1999-03-08 2000-09-28 Genentech Inc. Compositions and methods for the treatment of tumor
KR20010103046A (ko) 1999-03-08 2001-11-17 제넨테크, 인크. 면역 관련 질환 치료용 조성물 및 치료 방법
CA2367315A1 (en) 1999-03-11 2000-09-14 Human Genome Sciences, Inc. Apoptosis inducing molecule ii and methods of use
ES2291197T3 (es) 1999-03-30 2008-03-01 Eli Lilly And Company Analogos de flint resistentes a proteasas.
CA2368760A1 (en) 1999-03-30 2000-10-05 Eli Lilly And Company Flint polypeptide analogs
CA2384713A1 (en) 1999-09-29 2001-04-05 Human Genome Sciences, Inc. Colon and colon cancer associated polynucleotides and polypeptides
AU1189101A (en) 1999-10-20 2001-04-30 Eli Lilly And Company Therapeutic applications of flint polypeptides
AU1915201A (en) 1999-12-07 2001-06-18 Eli Lilly And Company Improving stability of flint through o-linked glycosylation
WO2001042434A1 (en) 1999-12-09 2001-06-14 Merck & Co., Inc. Dna molecules encoding human nhl, a dna helicase
WO2001068912A2 (en) 2000-03-15 2001-09-20 Epigenomics Ag Diagnosis of diseases associated with tumor suppressor genes and oncogenes
AU2001266787A1 (en) 2000-06-07 2002-01-08 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
AU2001276371A1 (en) 2000-06-30 2002-01-14 Epigenomics Ag Method and nucleic acids for analysing the methylation of genes implicated pharmacogenomics
WO2002009668A2 (en) 2000-08-02 2002-02-07 Eli Lilly And Company Pulmonary administration of flint
WO2002060317A2 (en) 2001-01-30 2002-08-08 Corixa Corporation Compositions and methods for the therapy and diagnosis of pancreatic cancer
JP2005506282A (ja) 2001-02-01 2005-03-03 イーライ・リリー・アンド・カンパニー Ｆｌｉｎｔグリコフォーム
WO2002060947A2 (en) 2001-02-01 2002-08-08 Eli Lilly And Company Glycoforms a fas ligand inhibitory protein analog
US20040236091A1 (en) 2001-03-28 2004-11-25 Chicz Roman M. Translational profiling
FR2908832B1 (fr) 2006-11-20 2011-08-26 Valeo Systemes Thermiques Carter pour echangeur de chaleur

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102421913A (zh) * 2009-03-13 2012-04-18 宾夕法尼亚大学董事会 Ox40/trail融合蛋白

Also Published As

Publication number Publication date
ATE365796T1 (de) 2007-07-15
DE69837996T2 (de) 2008-02-28
BR9806954A (pt) 2000-03-21
EP1007659B1 (en) 2007-06-27
CA2277925A1 (en) 1998-07-16
KR20000070174A (ko) 2000-11-25
AU5815798A (en) 1998-08-03
AU729062C (en) 2004-03-25
JP2001507937A (ja) 2001-06-19
AU729062B2 (en) 2001-01-25
EP1007659A2 (en) 2000-06-14
WO1998030694A3 (en) 1998-11-12
DE69837996D1 (de) 2007-08-09
US7186800B1 (en) 2007-03-06
ES2286843T3 (es) 2007-12-01
US8003386B1 (en) 2011-08-23
WO1998030694A2 (en) 1998-07-16

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