CN1247567A - 肿瘤坏死因子受体6α和6β - Google Patents

肿瘤坏死因子受体6α和6β Download PDF

Info

Publication number
CN1247567A
CN1247567A CN98801836A CN98801836A CN1247567A CN 1247567 A CN1247567 A CN 1247567A CN 98801836 A CN98801836 A CN 98801836A CN 98801836 A CN98801836 A CN 98801836A CN 1247567 A CN1247567 A CN 1247567A
Authority
CN
China
Prior art keywords
seq
tnfr
polypeptide
sequence
nucleotide sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98801836A
Other languages
English (en)
Chinese (zh)
Inventor
莱纳·L·根茨
倪健
莱因哈德·艾伯纳
余国良
斯蒂文·M·鲁宾
冯平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Human Genome Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21883066&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1247567(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Publication of CN1247567A publication Critical patent/CN1247567A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN98801836A 1997-01-14 1998-01-13 肿瘤坏死因子受体6α和6β Pending CN1247567A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3549697P 1997-01-14 1997-01-14
US60/035,496 1997-01-14

Publications (1)

Publication Number Publication Date
CN1247567A true CN1247567A (zh) 2000-03-15

Family

ID=21883066

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98801836A Pending CN1247567A (zh) 1997-01-14 1998-01-13 肿瘤坏死因子受体6α和6β

Country Status (12)

Country Link
US (2) US8003386B1 (enExample)
EP (1) EP1007659B1 (enExample)
JP (1) JP2001507937A (enExample)
KR (1) KR20000070174A (enExample)
CN (1) CN1247567A (enExample)
AT (1) ATE365796T1 (enExample)
AU (1) AU729062C (enExample)
BR (1) BR9806954A (enExample)
CA (1) CA2277925A1 (enExample)
DE (1) DE69837996T2 (enExample)
ES (1) ES2286843T3 (enExample)
WO (1) WO1998030694A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102421913A (zh) * 2009-03-13 2012-04-18 宾夕法尼亚大学董事会 Ox40/trail融合蛋白

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7597886B2 (en) 1994-11-07 2009-10-06 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US7429646B1 (en) 1995-06-05 2008-09-30 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor-like 2
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
US7357927B2 (en) 1996-03-12 2008-04-15 Human Genome Sciences, Inc. Death domain containing receptors
US6713061B1 (en) 1996-03-12 2004-03-30 Human Genome Sciences, Inc. Death domain containing receptors
WO1997033904A1 (en) 1996-03-12 1997-09-18 Human Genome Sciences, Inc. Death domain containing receptors
US6635743B1 (en) 1996-03-22 2003-10-21 Human Genome Sciences, Inc. Apoptosis inducing molecule II and methods of use
US7964190B2 (en) 1996-03-22 2011-06-21 Human Genome Sciences, Inc. Methods and compositions for decreasing T-cell activity
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
CA2277925A1 (en) 1997-01-14 1998-07-16 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6.alpha. and 6.beta.
AU9013998A (en) * 1997-07-21 1999-02-10 Zymogenetics Inc. Tumor necrosis factor receptor ztnfr-5
AU8767698A (en) * 1997-08-06 1999-03-01 Procter & Gamble Company, The Novel orphan receptor
AU9376498A (en) * 1997-09-05 1999-03-22 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
ATE393222T1 (de) * 1997-09-18 2008-05-15 Genentech Inc Dcr3 polypeptid, ein tnfr homolog
AU1535699A (en) * 1997-11-24 1999-06-15 Apotech S.A. Novel receptors opg-2
AU1541699A (en) * 1997-12-16 1999-07-05 Incyte Pharmaceuticals, Inc. Human tumor necrosis factor-r2-like proteins
DE19809978A1 (de) * 1998-03-09 1999-09-16 Basf Ag Neuer Rezeptor aus der menschlichen Lunge
CA2324517A1 (en) * 1998-03-30 1999-10-07 Eli Lilly And Company Therapeutic applications of mature flint (mflint) polypeptides or opg3, a member of the tnf receptor superfamily
US6916907B1 (en) * 1998-10-23 2005-07-12 Curagen Corporation Nucleic acids encoding osteoprotegern-like proteins and methods of using same
WO2000034782A1 (en) * 1998-12-09 2000-06-15 Eli Lilly And Company Flint compositions and uses thereof
CA2358508A1 (en) * 1998-12-22 2000-06-29 Eli Lilly And Company Therapeutic applications of flint polypeptides
WO2000046247A1 (en) * 1999-02-05 2000-08-10 Merck & Co., Inc. Methods of use for dna molecules encoding m68, a tnf receptor-related protein
JP2002537769A (ja) 1999-02-26 2002-11-12 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド ヒトエンドカインαおよび使用方法
MXPA01008936A (es) * 1999-03-04 2003-07-21 Human Genome Sciences Inc Receptores 6 alfa y 6 beta del factor de necrosis tumoral.
AU2495200A (en) * 1999-03-08 2000-09-28 Genentech Inc. Compositions and methods for the treatment of tumor
ATE371737T1 (de) * 1999-03-30 2007-09-15 Lilly Co Eli Proteaseresistente flint-analoge
US6835814B1 (en) 1999-03-30 2004-12-28 Eli Lilly And Company Protease resistant flint analogs
US6965012B1 (en) * 1999-03-30 2005-11-15 Eli Lilly And Company Flint polypeptide analogs
JP2002539828A (ja) * 1999-03-30 2002-11-26 イーライ・リリー・アンド・カンパニー Flintポリペプチドアナログ
US6627199B1 (en) 1999-07-09 2003-09-30 Amgen Inc Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family
AU6517800A (en) * 1999-08-04 2001-03-05 Amgen, Inc. Ntr3, a member of the tnf-receptor supergene family
JP2003506088A (ja) 1999-08-04 2003-02-18 アムジェン インコーポレーテッド TNFリガンドスーパー遺伝子ファミリーの新規のメンバーであるFhm
AU7053000A (en) * 1999-09-10 2001-04-10 Eli Lilly And Company Flint compounds and formulations thereof
EP1214411A2 (en) * 1999-09-10 2002-06-19 Eli Lilly And Company Flint analog compounds and formulations thereof
WO2001018055A1 (en) * 1999-09-10 2001-03-15 Eli Lilly And Company Flint analog compounds and formulations thereof
WO2001096528A2 (en) 2000-06-15 2001-12-20 Human Genome Sciences, Inc. Human tumor necrosis factor delta and epsilon
EP2275449B1 (en) 2000-06-16 2016-09-28 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to BLyS
CN1331125A (zh) * 2000-06-26 2002-01-16 上海博德基因开发有限公司 一种新的多肽——人含细胞色素c结构域的tnfr/ngfr蛋白9.02和编码这种多肽的多核苷酸
WO2002018622A2 (en) * 2000-08-25 2002-03-07 Human Genome Sciences, Inc. TUMOR NECROSIS FACTOR RECEPTORS 6α AND 6$g(b)
DK1572874T3 (da) 2001-05-25 2013-12-16 Human Genome Sciences Inc Antistoffer, der immunospecifikt binder til TRAIL receptorer
AU2002364586A1 (en) 2001-12-21 2003-07-30 Delta Biotechnology Limited Albumin fusion proteins
AU2003265994B2 (en) * 2002-09-11 2010-04-01 Genentech, Inc. Protein purification
EA015860B1 (ru) 2005-10-13 2011-12-30 Хьюман Дженом Сайенсиз, Инк. Способы лечения аутоиммунных заболеваний при использовании антагониста нейтрокина-альфа
WO2007076465A2 (en) * 2005-12-23 2007-07-05 Diadexus, Inc. Cln248 antibody compositions and methods of use
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
AR084141A1 (es) 2010-11-19 2013-04-24 Imai Toshio Anticuerpos neutralizadores anti-ccl20
EP3639841B1 (en) 2013-03-27 2023-09-06 Cedars-Sinai Medical Center Treating fibrosis by inhibiting tl1a
US20160115237A1 (en) 2013-05-24 2016-04-28 The University Of British Columbia Cell senescence markers as diagnostic and therapeutic targets
EP3022295A4 (en) 2013-07-19 2017-03-01 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
JP7082945B2 (ja) 2016-03-17 2022-06-09 シーダーズ―シナイ メディカル センター Rnaset2により炎症性腸疾患を診断する方法

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
DE69233441T2 (de) 1991-04-26 2005-10-13 Osaka Bioscience Institute, Suita Menschliches Zelloberflächen-Antigen codierende DNA
NZ275711A (en) 1993-10-14 1998-03-25 Immunex Corp Monoclonal antibodies and binding proteins which bind to human fas antigen (nerve growth factor/tumour necrosis factor receptor type)
US5830469A (en) 1993-10-14 1998-11-03 Immunex Corporation Fas antagonists and uses thereof
US5663070A (en) 1993-11-15 1997-09-02 Lxr Biotechnology Inc. Recombinant production of a soluble splice variant of the Fas (Apo-1) antigen, fas TM
US5741667A (en) 1994-05-27 1998-04-21 Genentech, Inc. Tumor necrosis factor receptor-associated factors
US5632994A (en) 1994-06-14 1997-05-27 La Jolla Cancer Research Foundation Fas associated proteins
JPH11507205A (ja) * 1995-04-27 1999-06-29 ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド ヒト腫瘍壊死因子受容体
US5985614A (en) * 1996-08-30 1999-11-16 Human Genome Sciences, Inc. Polynucleotides encoding interleukin-19
CA2277925A1 (en) 1997-01-14 1998-07-16 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6.alpha. and 6.beta.
US5885800A (en) 1997-02-04 1999-03-23 Smithkline Beecham Corporation DNA encoding tumor necrosis related receptor, TR4
WO1998056892A1 (en) 1997-06-11 1998-12-17 Human Genome Sciences, Inc. Human tumor necrosis factor receptor tr9
AU9013998A (en) 1997-07-21 1999-02-10 Zymogenetics Inc. Tumor necrosis factor receptor ztnfr-5
AU8767698A (en) 1997-08-06 1999-03-01 Procter & Gamble Company, The Novel orphan receptor
AU9376498A (en) 1997-09-05 1999-03-22 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
ATE393222T1 (de) 1997-09-18 2008-05-15 Genentech Inc Dcr3 polypeptid, ein tnfr homolog
AU1535699A (en) 1997-11-24 1999-06-15 Apotech S.A. Novel receptors opg-2
AU1541699A (en) 1997-12-16 1999-07-05 Incyte Pharmaceuticals, Inc. Human tumor necrosis factor-r2-like proteins
US6297367B1 (en) 1997-12-30 2001-10-02 Chiron Corporation Polynucleotide encoding TNFL1
AU2093499A (en) 1997-12-30 1999-07-19 Chiron Corporation Members of tnf and tnfr families
DE19809978A1 (de) 1998-03-09 1999-09-16 Basf Ag Neuer Rezeptor aus der menschlichen Lunge
CA2324517A1 (en) 1998-03-30 1999-10-07 Eli Lilly And Company Therapeutic applications of mature flint (mflint) polypeptides or opg3, a member of the tnf receptor superfamily
EP1093516A2 (en) 1998-07-06 2001-04-25 Schering Corporation Mammalian genes; dendritic cell prostaglandin-like transporter (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods
ATE458050T1 (de) 1998-12-01 2010-03-15 Genentech Inc Promotion oder inhibition von angiogenese und kardiovaskularisation
WO2000034782A1 (en) 1998-12-09 2000-06-15 Eli Lilly And Company Flint compositions and uses thereof
CA2358508A1 (en) 1998-12-22 2000-06-29 Eli Lilly And Company Therapeutic applications of flint polypeptides
WO2000046247A1 (en) 1999-02-05 2000-08-10 Merck & Co., Inc. Methods of use for dna molecules encoding m68, a tnf receptor-related protein
MXPA01008936A (es) 1999-03-04 2003-07-21 Human Genome Sciences Inc Receptores 6 alfa y 6 beta del factor de necrosis tumoral.
KR20010103046A (ko) 1999-03-08 2001-11-17 제넨테크, 인크. 면역 관련 질환 치료용 조성물 및 치료 방법
AU2495200A (en) 1999-03-08 2000-09-28 Genentech Inc. Compositions and methods for the treatment of tumor
JP2003528030A (ja) 1999-03-11 2003-09-24 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド アポトーシス誘導分子ii
JP2002539828A (ja) 1999-03-30 2002-11-26 イーライ・リリー・アンド・カンパニー Flintポリペプチドアナログ
ATE371737T1 (de) 1999-03-30 2007-09-15 Lilly Co Eli Proteaseresistente flint-analoge
AU7721500A (en) 1999-09-29 2001-04-30 Human Genome Sciences, Inc. Colon and colon cancer associated polynucleotides and polypeptides
WO2001028582A2 (en) 1999-10-20 2001-04-26 Eli Lilly And Company Therapeutic applications of flint polypeptides
WO2001042463A1 (en) 1999-12-07 2001-06-14 Eli Lilly And Company Improving stability of flint through o-linked glycosylation
WO2001042434A1 (en) 1999-12-09 2001-06-14 Merck & Co., Inc. Dna molecules encoding human nhl, a dna helicase
US20040029123A1 (en) 2000-03-15 2004-02-12 Alexander Olek Diagnosis of diseases associated with the cell cycle
WO2002000677A1 (en) 2000-06-07 2002-01-03 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
AU2001277521A1 (en) 2000-06-30 2002-01-14 Epigenomics Ag Diagnosis of diseases associated with cell signalling
WO2002009668A2 (en) 2000-08-02 2002-02-07 Eli Lilly And Company Pulmonary administration of flint
WO2002060317A2 (en) 2001-01-30 2002-08-08 Corixa Corporation Compositions and methods for the therapy and diagnosis of pancreatic cancer
EP1355945A2 (en) 2001-02-01 2003-10-29 Eli Lilly And Company Flint glycoforms
AU2002246967A1 (en) 2001-02-01 2002-08-12 Eli Lilly And Company Glycoforms a fas ligand inhibitory protein analog
US20040236091A1 (en) 2001-03-28 2004-11-25 Chicz Roman M. Translational profiling
FR2908832B1 (fr) 2006-11-20 2011-08-26 Valeo Systemes Thermiques Carter pour echangeur de chaleur

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102421913A (zh) * 2009-03-13 2012-04-18 宾夕法尼亚大学董事会 Ox40/trail融合蛋白

Also Published As

Publication number Publication date
DE69837996D1 (de) 2007-08-09
AU729062C (en) 2004-03-25
KR20000070174A (ko) 2000-11-25
AU5815798A (en) 1998-08-03
WO1998030694A2 (en) 1998-07-16
EP1007659B1 (en) 2007-06-27
BR9806954A (pt) 2000-03-21
ATE365796T1 (de) 2007-07-15
EP1007659A2 (en) 2000-06-14
WO1998030694A3 (en) 1998-11-12
US7186800B1 (en) 2007-03-06
DE69837996T2 (de) 2008-02-28
AU729062B2 (en) 2001-01-25
CA2277925A1 (en) 1998-07-16
ES2286843T3 (es) 2007-12-01
JP2001507937A (ja) 2001-06-19
US8003386B1 (en) 2011-08-23

Similar Documents

Publication Publication Date Title
CN1247567A (zh) 肿瘤坏死因子受体6α和6β
EP0990031B1 (en) Tumor necrosis factor receptor 5
JP4450870B2 (ja) 死ドメイン含有レセプター4(dr4:死レセプター4)、tnf−レセプタースーパーファミリーのメンバーおよびtrailへの結合
EP0970213B1 (en) Death domain containing receptor 5
CA2248868A1 (en) Apoptosis inducing molecule ii
WO1997033899A1 (en) Apoptosis inducing molecule i
CN1214050A (zh) 人肿瘤坏死因子δ和ε
AU763955B2 (en) Tumor necrosis factor receptors 6alpha and 6beta
HK1023790A (en) TUMOR NECROSIS FACTOR RECEPTORS 6α AND 6β
US20040048340A1 (en) Apoptosis inducing molecule I
MXPA99006586A (en) TUMOR NECROSIS FACTOR RECEPTORS 6&agr;AND 6&bgr;
AU734384B2 (en) Apoptosis inducing molecule II
AU771013B2 (en) Apoptosis inducing molecule II
AU2003259621A1 (en) Tumor Necrosis Factor Receptors 6alpha and 6beta
MXPA99008486A (en) Death domain containing receptor 5
HK1025352B (en) Death domain containing receptor 5

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1023790

Country of ref document: HK