CN1237960A - N(－芳基/杂芳基乙酰基)氨基酸酯、包括这些酯的药用组合物以及用这些化合物抑制β淀粉样肽释放和/或合成的方法 - Google Patents

N(－芳基/杂芳基乙酰基)氨基酸酯、包括这些酯的药用组合物以及用这些化合物抑制β淀粉样肽释放和/或合成的方法 Download PDF

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CN1237960A
CN1237960A CN97199775A CN97199775A CN1237960A CN 1237960 A CN1237960 A CN 1237960A CN 97199775 A CN97199775 A CN 97199775A CN 97199775 A CN97199775 A CN 97199775A CN 1237960 A CN1237960 A CN 1237960A
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phenyl
different
butyl ester
ethanoyl
ala
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CN97199775A
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Chinese (zh)
Inventor
J·吴
E·D·托尔瑟特
J·S·尼森
T·E·马布赖
L·H·拉蒂默
V·约翰
L·Y·方
J·E·奥迪尔
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Elan Pharmaceuticals LLC
Eli Lilly and Co
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Elan Pharmaceuticals LLC
Eli Lilly and Co
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Publication of CN1237960A publication Critical patent/CN1237960A/zh
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    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/37—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
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    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/39—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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CN97199775A 1996-11-22 1997-11-20 N(－芳基/杂芳基乙酰基)氨基酸酯、包括这些酯的药用组合物以及用这些化合物抑制β淀粉样肽释放和/或合成的方法 Pending CN1237960A (zh)

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US75489596A 1996-11-22 1996-11-22
US08/754,895 1997-02-28

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WO1998022430A1 (en) 1998-05-28
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NO992463L (no) 1999-07-19
AU739035B2 (en) 2001-10-04
NZ334950A (en) 2001-03-30
ID21956A (id) 1999-08-19
HUP0000492A3 (en) 2000-06-28
BR9713404A (pt) 2000-01-25
AU5249898A (en) 1998-06-10
EP0951464A1 (en) 1999-10-27
IL129238A0 (en) 2000-02-17
JP2001505204A (ja) 2001-04-17
KR20000069074A (ko) 2000-11-25
DE69733272D1 (de) 2005-06-16
ATE295346T1 (de) 2005-05-15
HUP0000492A1 (hu) 2000-05-28
NO992463D0 (no) 1999-05-21
TR199901128T2 (xx) 1999-07-21

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