CN1233224A - 包含造影剂的容器 - Google Patents
包含造影剂的容器 Download PDFInfo
- Publication number
- CN1233224A CN1233224A CN97198709A CN97198709A CN1233224A CN 1233224 A CN1233224 A CN 1233224A CN 97198709 A CN97198709 A CN 97198709A CN 97198709 A CN97198709 A CN 97198709A CN 1233224 A CN1233224 A CN 1233224A
- Authority
- CN
- China
- Prior art keywords
- leakproof tank
- volatile matter
- plastic material
- tank according
- leakproof
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002872 contrast media Substances 0.000 title abstract description 10
- 239000000463 material Substances 0.000 claims abstract description 42
- 239000004033 plastic Substances 0.000 claims abstract description 37
- 229920003023 plastic Polymers 0.000 claims abstract description 37
- 239000002243 precursor Substances 0.000 claims abstract description 12
- 238000002360 preparation method Methods 0.000 claims description 29
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical class CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 15
- 238000007789 sealing Methods 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 13
- -1 aromatic halide Chemical class 0.000 claims description 11
- 238000004108 freeze drying Methods 0.000 claims description 10
- 239000011521 glass Substances 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 6
- 229960000909 sulfur hexafluoride Drugs 0.000 claims description 6
- 229910018503 SF6 Inorganic materials 0.000 claims description 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 5
- 239000005864 Sulphur Substances 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- SFZCNBIFKDRMGX-UHFFFAOYSA-N sulfur hexafluoride Chemical compound FS(F)(F)(F)(F)F SFZCNBIFKDRMGX-UHFFFAOYSA-N 0.000 claims description 5
- 230000004888 barrier function Effects 0.000 claims description 4
- 239000006185 dispersion Substances 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 230000026030 halogenation Effects 0.000 claims description 4
- 238000005658 halogenation reaction Methods 0.000 claims description 4
- 229960004692 perflenapent Drugs 0.000 claims description 4
- NJCBUSHGCBERSK-UHFFFAOYSA-N perfluoropentane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F NJCBUSHGCBERSK-UHFFFAOYSA-N 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 125000001931 aliphatic group Chemical group 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 claims description 3
- 229960004065 perflutren Drugs 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 230000000087 stabilizing effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 5
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 abstract description 2
- 150000008282 halocarbons Chemical class 0.000 abstract 1
- 239000007789 gas Substances 0.000 description 39
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 229930195733 hydrocarbon Natural products 0.000 description 8
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 241001411320 Eriogonum inflatum Species 0.000 description 5
- 239000003570 air Substances 0.000 description 5
- 150000001336 alkenes Chemical class 0.000 description 5
- 150000002430 hydrocarbons Chemical class 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 4
- 150000004820 halides Chemical class 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 239000004809 Teflon Substances 0.000 description 3
- 229920006362 Teflon® Polymers 0.000 description 3
- 150000001335 aliphatic alkanes Chemical class 0.000 description 3
- 230000031709 bromination Effects 0.000 description 3
- 238000005893 bromination reaction Methods 0.000 description 3
- 239000001273 butane Substances 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 239000002502 liposome Substances 0.000 description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000004411 aluminium Substances 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 238000005266 casting Methods 0.000 description 2
- 238000005660 chlorination reaction Methods 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 2
- CRSOQBOWXPBRES-UHFFFAOYSA-N neopentane Chemical compound CC(C)(C)C CRSOQBOWXPBRES-UHFFFAOYSA-N 0.000 description 2
- 150000002896 organic halogen compounds Chemical class 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 229920001084 poly(chloroprene) Polymers 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- PWMJXZJISGDARB-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,5,5-decafluorocyclopentane Chemical compound FC1(F)C(F)(F)C(F)(F)C(F)(F)C1(F)F PWMJXZJISGDARB-UHFFFAOYSA-N 0.000 description 1
- LGPPATCNSOSOQH-UHFFFAOYSA-N 1,1,2,3,4,4-hexafluorobuta-1,3-diene Chemical compound FC(F)=C(F)C(F)=C(F)F LGPPATCNSOSOQH-UHFFFAOYSA-N 0.000 description 1
- DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
- WXLJJIHGDBUBJM-UHFFFAOYSA-N 1,3,5-triiodobenzene Chemical compound IC1=CC(I)=CC(I)=C1 WXLJJIHGDBUBJM-UHFFFAOYSA-N 0.000 description 1
- RFCAUADVODFSLZ-UHFFFAOYSA-N 1-Chloro-1,1,2,2,2-pentafluoroethane Chemical compound FC(F)(F)C(F)(F)Cl RFCAUADVODFSLZ-UHFFFAOYSA-N 0.000 description 1
- DHIVLKMGKIZOHF-UHFFFAOYSA-N 1-fluorooctane Chemical class CCCCCCCCF DHIVLKMGKIZOHF-UHFFFAOYSA-N 0.000 description 1
- BKOOMYPCSUNDGP-UHFFFAOYSA-N 2-methylbut-2-ene Chemical group CC=C(C)C BKOOMYPCSUNDGP-UHFFFAOYSA-N 0.000 description 1
- MJBPUQUGJNAPAZ-UHFFFAOYSA-N Butine Natural products O1C2=CC(O)=CC=C2C(=O)CC1C1=CC=C(O)C(O)=C1 MJBPUQUGJNAPAZ-UHFFFAOYSA-N 0.000 description 1
- 239000004340 Chloropentafluoroethane Substances 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 229920013646 Hycar Polymers 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- FINLWPDMTDQXJR-UHFFFAOYSA-N S(F)F.[S] Chemical compound S(F)F.[S] FINLWPDMTDQXJR-UHFFFAOYSA-N 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000004964 aerogel Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 150000001345 alkine derivatives Chemical class 0.000 description 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 description 1
- 238000013155 cardiography Methods 0.000 description 1
- 235000019406 chloropentafluoroethane Nutrition 0.000 description 1
- AFYPFACVUDMOHA-UHFFFAOYSA-N chlorotrifluoromethane Chemical compound FC(F)(F)Cl AFYPFACVUDMOHA-UHFFFAOYSA-N 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- DPYMFVXJLLWWEU-UHFFFAOYSA-N desflurane Chemical compound FC(F)OC(F)C(F)(F)F DPYMFVXJLLWWEU-UHFFFAOYSA-N 0.000 description 1
- 229960003537 desflurane Drugs 0.000 description 1
- 229940087091 dichlorotetrafluoroethane Drugs 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000008393 encapsulating agent Substances 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- WMIYKQLTONQJES-UHFFFAOYSA-N hexafluoroethane Chemical compound FC(F)(F)C(F)(F)F WMIYKQLTONQJES-UHFFFAOYSA-N 0.000 description 1
- HCDGVLDPFQMKDK-UHFFFAOYSA-N hexafluoropropylene Chemical compound FC(F)=C(F)C(F)(F)F HCDGVLDPFQMKDK-UHFFFAOYSA-N 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 230000009191 jumping Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- VNXBKJFUJUWOCW-UHFFFAOYSA-N methylcyclopropane Chemical compound CC1CC1 VNXBKJFUJUWOCW-UHFFFAOYSA-N 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- MWWATHDPGQKSAR-UHFFFAOYSA-N propyne Chemical compound CC#C MWWATHDPGQKSAR-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- NXHILIPIEUBEPD-UHFFFAOYSA-H tungsten hexafluoride Chemical compound F[W](F)(F)(F)(F)F NXHILIPIEUBEPD-UHFFFAOYSA-H 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/007—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/005—Closures provided with linings or internal coatings so as to avoid contact of the closure with the contents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
- B65D51/28—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
- B65D51/30—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials for desiccators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
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- A—HUMAN NECESSITIES
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- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
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Abstract
本发明公开了一种含塑料材质的密闭容器(如,弹性体加塞小瓶),它可用于含有或适于含有挥发物(如,气态卤化烃,如全氟烃)的造影剂和其前体,其中所述塑料材质通过暴露于挥发物中而进行预处理。这种容器可提高造影剂或其前体的储存稳定性。
Description
本发明涉及用于造影剂、更具体地用于含有或适于含有挥发物的造影剂的储存装置。
人们熟知,例如在血管系统,特别是在心动描记法,以及组织微血管的研究中,超声成像法包括一种可能有价值的诊断工具。现已提出,使用各种造影剂来增强所得声像,其中包括固体颗粒的悬浮液、乳化液滴、气泡和密封气体或液体。一般认为,易压缩的低密度造影剂在其所产生的声能反向散射方面特别有效,因此,制备含气体系和气体生成体系,如含有或适于含有挥发物的造影剂已引起人们的极大关注。
人们非常关注对用于含气超声造影介质的气体的选择,这样可增强各种性能,如其稳定性和回声效应的持续时间。因此,例如,WO-A-9305819提出,使用系数Q大于5的气体的自由微泡,其中
Q=4.0×10-7×ρ/CsD
(ρ为气体密度,公斤/米3;Cs为气体的水溶解度,摩尔/升;D为气体在溶液中的扩散率,厘米3/秒)。现已详细列出了据说能满足这种要求的气体,其中包括各种烃类,如烷烃、烯烃等,和卤化物,如六氟化硫、十氟化二硫、六氟化钨,溴化和/氯化和/或氟化和/或碘化烃类,溴化醛类、氟化酮类、氟化胺类、氟化硫醇类、等。
EP-A-0554213提出,人们可通过向注气微囊中加入至少一种气体而赋予其以耐压破性,对于所述气体来说,除以其分子量平方根的其水溶解度、以标准条件下的气体升数/水升数表示、不超过0.003。据说,优选的这些气体包括,卤化物如六氟化硫、六氟化硒和各种Freons。
WO-A-9416739公开了包含液包液胶态分散液的超声造影剂,其中分散相为其沸点低于成像者体温的液体。因此,在投药给成像者之后,这种试剂可通过相变成为回声气泡。据说,合适的挥发性分散相液体的例子包括:脂族烃类,如丁烷和戊烷,和有机卤化物,特别是氟烃类,如全氟丁烷、全氟戊烷和全氟新戊烷。
WO-A-9503835提出,使用包含其组成基于微泡内外气体分压的气体混合物的微泡,这样需根据微泡尺寸来考虑渗透效应。有代表性的混合物包含,在血液或浆液中具有低气压和有限溶解度的气体(如,氟烃)、以及能够与正常血液或浆液中气体较快交换的另一种气体(如,氮气、氧气、二氧化碳或其混合物)。
WO-A-9516467提出,使用包含气体A和B的混合物的超声造影剂,其中气体B的量为0.5-41%v/v,分子量大于80道尔顿,且其在标准条件下的水溶解度低于0.0283ml/ml。有代表性的气体B包括:卤化气体,如硫氟化硫,和各种溴化和/或氯化和/或氟化烃类。作为混合物剩余部分的气体A,其代表例包括:空气、氧气、氮气、二氧化碳及其混合物。
WO-A-9608234所要求的容器包含脂悬浮水相和完全与脂相分离的气相,比如包含诸如烷烃或烯烃的烃类或,更优选氟化气体如全氟烃。据说,通过振荡这种容器的内容物可产生在,例如超声或磁谐振成像中用作造影剂的注气微脂粒组合物。
WO-A-9618420涉及包含气泡的产品,所述气泡固定在包含合适稳定助剂等的生理上可接受的冻结含水载体介质内;这种产品可融化生成可注射的超声造影剂。据说,有代表性的气体包括:含卤气体,如六氟化硫、全氟甲烷、全氟乙烷、全氟乙烯、全氟丙烷、全氟丙烯、全氟丁烷、全氟丁-2烯、全氟丁二烯、全氟环丁烷、全氟戊烷、全氟环戊烷及其混合物。
在具有给定气体含量的气氛下,通过包含合适的表面活性剂、助剂、稳定剂等,如上述EP-A-0554213、WO-A-9503835和WO-A-9516467中所公开的造影剂通常可用作干配方。通过在,例如静脉注射投药前含有加入载液,如无菌无热原水或盐水,可重新配制这种干配方。
WO-A-9416739和WO-A-9608234中所公开的造影剂可用作液体配方。WO-A-9608234中的那些造影剂特别要求,在脂水相上的液上空间存在气体。按照WO-A-9416739,造影剂储存态上的任何液上空间都可能包含某些蒸汽态的分散相物质,这归因于这种物质所固有的挥发性。
一般来说,造影剂及其前体,如干配方通常装在密闭容器,如用各种密闭装置如塞子或隔膜密封的小瓶或其它容器,或预注注射器中。有利的是,这种容器的内容物可构成或生成合适的单位剂量的造影剂。容器如小瓶通常可包含玻璃和/或塑料材质,且用包含塑料的密封装置,如弹性体进行密封。容器如注射器也可包含玻璃和/或塑料材质,且通常可包括塑料柱塞。
本发明部分基于以下发现,当包含挥发物的造影剂储存在密闭塑料容器中时,通过用所述挥发物预处理该塑料,该试剂的储存稳定性可显著增强,这种储存稳定性可例如由在标准条件下的储存时间长短来度量,其间该产品能够连续产生可再生回声性。还有,现已发现,这种预处理塑料材质也可用作挥发物,加入密闭容器中并由此加入其中所含的造影剂或其前体。
因此,按照本发明,提供了一种包含其中含有或适于含有挥发物的造影剂或其前体的密闭容器,所述容器至少部分包含一种塑料,其特征在于,在密封该容器之前,将其暴露于所述挥发物的样品中而预处理所述塑料。
可用于本发明的密闭容器的例子包括:小瓶,如玻璃瓶、塑料瓶或至少部分衬有塑料的玻璃瓶,这些小瓶例如通过可含有塑料和/或含有密封衬垫和/或该材质衬里的塞子、隔膜或螺帽进行密封;注射器,例如可以是单腔的、双腔的、多腔的,而且例如可包含玻璃、塑料或至少部分衬有塑料的玻璃,这种注射器例如包括含有和/或涂覆有塑料材质的柱塞;以及袋、盒和箱,例如包含和/或涂覆有基本上不可渗透的物质如金属箔,而且也可包括塑料,这些袋、盒和箱通常包含多个含造影剂的小瓶。如果需要,如上所述的容器可另外或可选地包括塑料材质衬垫,例如可以是杆、管、球、盘、片、海绵、泡沫、气凝胶、蜂窝格子、薄膜、等形状。在诸如注射器的容器中,柱塞可有效地构成一种密封装置;其上也可有其它密封装置,如预镶嵌针或针镶嵌配置。
受欢迎的是,按照本发明的容器只要含有一种以上塑料材质和/或塑料组分,就可用挥发物预处理任何或所有这些材质和/或组分。
可用于本发明的塑料材质包括范围广泛的各种天然和合成聚合物。特别是,当这些物质用作密闭或密封装置,如塞子、隔膜、螺帽、帽衬垫或注射器柱塞时,采用弹性聚合物可能是有利的,其例子包括,但不限于,聚乙烯、聚丙烯、聚异丁烯、聚苯乙烯、聚氯乙烯、聚丙烯腈、全氟化聚合物如Teflon、天然橡胶、丁基橡胶、合成橡胶如Hycars或氯丁橡胶、硅氧烷聚合物、Teflon-硅氧烷层压件、Teflon-橡胶层压件、和本领域已知用于密封小瓶如药物、诊断试剂等的容器的其它弹性体。
如果需要,用于本发明的塑料材质可含有吸收剂,如无机物如沸石或分子筛,这样可提高在预处理时对挥发物的吸收。
还有,比如,当塑料材质用作加入密闭容器的挥发物源时,根据例如,在预处理时挥发物的用量水平以及以后挥发物的释放速率,可以选择塑料材质如塞子和衬垫的尺寸和形状以产生合适的性能。为了提高所吸收和吸附的挥发物量,可增加这些尺寸如厚度。通过使用具有较高的表面积:体积比率的塑料材质,如多孔、纤维状(如,在纤维束中)或杆状材质或具有折边、凸纹、沟槽或糙化表面的材质,可提高预处理吸收速率以及以后的挥发物释放速率。
挥发物一般可包含一种或多种气体(该术语包括,基本上或完全为气态的包括混合物在内的任何物质,其中包括在常人体温37℃下形成的蒸汽)、挥发性液体(如,其沸点不超过60℃的)、固体(如,通过升华作用或由分解气体而产生明显蒸汽压的固体)、以及前述物质的任何混合物。挥发物的代表例包括,如含有最多10个碳原子的低分子量烃类,比如丁烷、戊烷、己烷、庚烷和相应的环烷烃、烯烃等。但挥发物更优选为含卤物质,如包含选自溴、氯、氟和碘中,优选自氯和/或氟中的至少一个卤原子的含卤物质;使用氟化,更尤其全氟化合物是特别有利的。因此,含卤化合物的代表例包括,卤化硫,如六卤化硫或十氟化二硫,有机卤化物,如包含多至20个碳原子的脂族(可以是直链或支链、饱和或不饱和的)、环脂族、芳脂族或芳族卤化物,比如:含氯烃,如氯仿、二氯甲烷或三氯甲烷;Freons,如三氯氟甲烷、二氯二氟甲烷、氯三氟甲烷、二氯四氟乙烷或氯五氟乙烷;氟溴烃,如溴十七氟辛烷;含碘烃,如1,3,5-三碘苯或1,3,5-三(三氟甲基)-2,4,6-三碘苯;卤化醚麻醉剂,如血清氟烃(seroflurane)或脱氟烃(desflurane);以及,包含多至8个碳原子的饱和或不饱和、脂族或环脂族氟烃,如烷烃如甲烷、乙烷、丙烷、丁烷、戊烷、己烷、庚烷或辛烷的氟化(优选全氟化)衍生物;烯烃,如乙烯、丙烯、丁烯、丁二烯或戊烯;炔烃,如乙炔、丙炔或丁炔;环烷烃,如环丙烷、甲基环丙烷、环丁烷、环戊烷或环己烷;以及芳烃,如苯。
优选使用气态含卤化合物,如全氟化气体如六氟化硫、全氟丙烷、全氟丁烷或全氟戊烷。如果需要,这些气体可与气体非卤化气体混合,比如空气、氧气、氮气、二氧化碳或其混合物。
存在于本发明容器中的造影剂可采用合适的形式,例如包括,适于盛装并稳定气体微泡的含水组合物,如美国专利4466442或WO-A-9115244中所描述的;气体微泡在合适载液中的分散液,它可选地密封在注气微气球中(如,其中气体包含在包络物质如聚合物、蛋白质或成膜表面活性剂中,比如在磷脂囊等中),挥发性液体或固体微颗粒;以及固体造影剂前体配方,它可与载液如无菌水或盐水重新配制用于注射。这些固体配方可以例如通过冻干进行制备,通常包含一种或多种表面活性剂,比如,成膜脂如磷脂、助剂如低温防护剂和/或毒性添加剂、稳定剂等。
对用在或用作本发明密闭容器的塑料材质来说,可在室温或高温和压力下,通过暴露于密封反应器如Parr弹状储气瓶(Parr bomb)中的物质来进行预处理;较为有利的条件应使得,该物质被所吸收或吸附的挥发物饱和。只要必要或需要,也可在密封前将挥发物气氛注入容器中。另外,可让挥发物由预处理塑料材质渗透到容器中,然后与造影剂或其前体相互作用。考虑到工艺成本,后一技术可能有利。因此,包括将挥发物加入容器如小瓶中的步骤的方法,可能会浪费容器腔中的残余挥发物,其中挥发物是这样加入的:在作为冻干法一部分的低压冻干器的腔中,抽空一个或多个小瓶成真空腔,然后向腔中加入挥发物。另一方面,对塑料材质的压力处理可更有效地利用剩余挥发物,因为它在处理完成时易回到挥发物源。
在用密封装置如塞子、隔膜、螺帽等密闭容器如小瓶之后,进一步密封该密封装置的外表面可能是有利的,例如,使用金属箔或金属卷帽,或使用基本上不渗透挥发物的一层物质,如合适的天然和合成蜡或硅氧烷密封剂、或作为挥发物非溶剂的亲水物质如甘油或低分子量聚乙二醇。另外,可以采用例如,在其外表面或表面上含有这种不渗透物质作为涂层或固有组件的预成形密闭装置。
以下非限定性实施例用于说明本发明。
实施例1
将瓶塞置于保持在0℃的无菌Parr弹状储气瓶中。加入全氟丁烷,然后密封该弹状储气瓶,然后加热至50℃ 24小时。冷却弹状储气瓶至20℃,然后透气,释放出气态全氟丁烷。去除塞子,用其密封小瓶,其中含有冻干磷脂微脂粒造影剂配方和在液上空间中的空气与全氟丁烷的混合物;然后用铝卷帽包覆塞子。相对其中塞子未经过全氟丁烷预处理的对比小瓶来说,全氟丁烷在该小瓶中的浓度和造影剂组合物的适用期都得到了提高。
实施例2
如实施例1所述,用全氟丁烷处理瓶塞,然后用其密封小瓶,其中含有冻干磷脂微脂粒造影剂配方和在液上空间中的空气;然后用铝卷帽包覆塞子。在用水重新配制以进行注射时,该组合物可不断产生含全氟丁烷的微泡分散液。
实施例3
洗涤瓶塞,高压灭菌,然后热处理(121℃,15小时)以去除在高压灭菌时所吸收的水分。将热瓶塞暴露于气态全氟丁烷中,然后在该气体下冷却至室温。
实施例4
在配有手套箱的冻干腔中,冻干包含造影剂前体的未加塞小瓶。冻干之后,向装置中加入全氟丁烷。通过使用手套箱,手工将实施例3中制备的预处理瓶塞应用到小瓶中。
实施例5
用实施例3中制备并在冻干腔中冻干的预处理塞子,轻轻地塞住包含造影剂前体的小瓶,然后将塞子压到密封部位上。向腔中加入氮气以解除真空,然后打开密封小瓶。结果发现,全氟丁烷逐渐由塞子释放到小瓶的液上空间。
Claims (17)
1.一种包含其中含有或适于含有挥发物的造影剂或其前体的密闭容器,所述容器至少部分包含一种塑料材质,其特征在于,在密封所述容器之前,将其暴露于所述挥发物的样品中而预处理所述塑料材质。
2.根据权利要求1所述的密闭容器,其形式为小瓶、柱塞、袋、盒和箱。
3.根据权利要求1或2所述的密闭容器,其中所述塑料材质是一种密闭/密封装置、衬里材料或衬垫。
4.根据权利要求3所述的密闭容器,其中所述密闭/密封装置包括塞子、隔膜、螺帽、帽衬垫或注射器柱塞。
5.根据前述权利要求中任何一项所述的密闭容器,其中所述塑料材质包括弹性聚合物。
6.根据权利要求1所述的密闭容器,包括用弹性聚合物塞子密封的一种玻璃瓶。
7.根据权利要求6所述的密闭容器,其中所述塞子还含有基本上不渗透挥发物的一种物质作为涂层或作为整体组件。
8.根据前述权利要求中任何一项所整体的密闭容器,其中所述挥发物包括卤化硫或包含多至20个碳原子的脂族、环脂族、芳脂族或芳族卤化物。
9.根据权利要求8所述的密闭容器,其中所述挥发物包括六氟化硫或包含多至8个碳原子的全氟烃。
10.根据权利要求9所述的密闭容器,其中所述全氟烃选自全氟丙烷、全氟丁烷和全氟戊烷。
11.根据前述权利要求中任何一项所述的密闭容器,包含:一种适于盛装并稳定气体微泡的含水组合物,可选密封的气体微泡在载液中的一种分散液,或适于与载液重新配制的固体造影剂前体配方。
12.根据权利要求11所述的密闭容器,其中所述固体造影剂前体配方包含冻干磷脂。
13.根据前述权利要求中任何一项所述的密闭容器,其中所述塑料材质是一种密闭装置,其外表面具有其它密封装置。
14.根据权利要求13所述的密闭容器,其中所述其它密封装置包括金属箔或金属卷帽。
15.一种制造根据权利要求1所述的密闭容器的方法,其中包括:通过暴露于所述挥发物的样品来处理所述塑料材质,然后密闭所述容器。
16.根据权利要求15所述的方法,其中所述塑料材质是在高压和/或高温下暴露于所述挥发物的。
17.根据权利要求15或16所述的方法,其中所述塑料材质被所述挥发物所饱和。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9617811.6A GB9617811D0 (en) | 1996-08-27 | 1996-08-27 | Improvements in or relating to contrast agents |
GB9617811.6 | 1996-08-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1233224A true CN1233224A (zh) | 1999-10-27 |
Family
ID=10798944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN97198709A Pending CN1233224A (zh) | 1996-08-27 | 1997-08-27 | 包含造影剂的容器 |
Country Status (11)
Country | Link |
---|---|
US (1) | US6177160B1 (zh) |
EP (1) | EP0929465B1 (zh) |
JP (1) | JP2000517272A (zh) |
CN (1) | CN1233224A (zh) |
AT (1) | ATE208330T1 (zh) |
AU (1) | AU4026197A (zh) |
CA (1) | CA2264075A1 (zh) |
DE (1) | DE69708134T2 (zh) |
GB (1) | GB9617811D0 (zh) |
NO (1) | NO990866L (zh) |
WO (1) | WO1998008747A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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KR100874813B1 (ko) * | 2000-11-08 | 2008-12-19 | 다이킨 고교 가부시키가이샤 | 드라이 에칭 가스 및 드라이 에칭 방법 |
US7717945B2 (en) * | 2002-07-22 | 2010-05-18 | Acumed Llc | Orthopedic systems |
US7493743B2 (en) * | 2005-03-02 | 2009-02-24 | E.I. Du Pont De Nemours And Company | Packages for alkanes having ultra-high transparency at 193 nm |
EP2727584A1 (en) * | 2012-10-31 | 2014-05-07 | Takeda GmbH | Vent gases for use in drying, storing and/or reconstituting biomolecules |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2573637A (en) * | 1950-05-22 | 1951-10-30 | Lilly Co Eli | Treated stopper for and method of introducing antifoam agent into a liquid medicament or the like |
DE3141641A1 (de) | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Ultraschall-kontrastmittel und dessen herstellung |
CA1295195C (en) * | 1985-11-08 | 1992-02-04 | Shigeyoshi Maeda | Materials having a deoxidation function and a method of removing oxygen in sealed containers |
US5773024A (en) | 1989-12-22 | 1998-06-30 | Imarx Pharmaceutical Corp. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
IN172208B (zh) | 1990-04-02 | 1993-05-01 | Sint Sa | |
GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
US5874062A (en) * | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
US5205290A (en) * | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
MX9205298A (es) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
CZ191695A3 (en) * | 1993-01-25 | 1996-05-15 | Sonus Pharma Inc | Biologically compatible contrast agent, process of its preparation and representation method by ultrasound |
DK0711179T3 (da) | 1993-07-30 | 2005-02-14 | Imcor Pharmaceutical Co | Stabiliserede sammensætninger med mikrobobler til ultralyd |
JPH10508284A (ja) | 1993-12-15 | 1998-08-18 | ブラッコ リサーチ ソシエテ アノニム | 超音波造影媒体、この媒体を含む造影剤及び方法 |
US5641510A (en) * | 1994-07-01 | 1997-06-24 | Genentech, Inc. | Method for treating capsules used for drug storage |
IL116328A (en) | 1994-12-16 | 1999-09-22 | Bracco Research Sa | Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging |
-
1996
- 1996-08-27 GB GBGB9617811.6A patent/GB9617811D0/en active Pending
-
1997
- 1997-08-27 CN CN97198709A patent/CN1233224A/zh active Pending
- 1997-08-27 CA CA002264075A patent/CA2264075A1/en not_active Abandoned
- 1997-08-27 WO PCT/GB1997/002310 patent/WO1998008747A1/en active IP Right Grant
- 1997-08-27 AU AU40261/97A patent/AU4026197A/en not_active Abandoned
- 1997-08-27 EP EP97937731A patent/EP0929465B1/en not_active Expired - Lifetime
- 1997-08-27 JP JP10511387A patent/JP2000517272A/ja active Pending
- 1997-08-27 DE DE69708134T patent/DE69708134T2/de not_active Expired - Fee Related
- 1997-08-27 AT AT97937731T patent/ATE208330T1/de not_active IP Right Cessation
-
1999
- 1999-02-24 NO NO990866A patent/NO990866L/no not_active Application Discontinuation
- 1999-02-26 US US09/258,397 patent/US6177160B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO990866L (no) | 1999-04-19 |
EP0929465B1 (en) | 2001-11-07 |
WO1998008747A1 (en) | 1998-03-05 |
NO990866D0 (no) | 1999-02-24 |
ATE208330T1 (de) | 2001-11-15 |
US6177160B1 (en) | 2001-01-23 |
JP2000517272A (ja) | 2000-12-26 |
EP0929465A1 (en) | 1999-07-21 |
DE69708134D1 (de) | 2001-12-13 |
DE69708134T2 (de) | 2002-08-22 |
AU4026197A (en) | 1998-03-19 |
GB9617811D0 (en) | 1996-10-09 |
CA2264075A1 (en) | 1998-03-05 |
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