CN1229408A - 用作5－ht－2c受体拮抗剂的二氢吲哚类衍生物 - Google Patents
用作5－ht－2c受体拮抗剂的二氢吲哚类衍生物 Download PDFInfo
- Publication number
- CN1229408A CN1229408A CN97197311A CN97197311A CN1229408A CN 1229408 A CN1229408 A CN 1229408A CN 97197311 A CN97197311 A CN 97197311A CN 97197311 A CN97197311 A CN 97197311A CN 1229408 A CN1229408 A CN 1229408A
- Authority
- CN
- China
- Prior art keywords
- compound
- methyl
- trifluoromethyl
- solution
- picoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9612883.0A GB9612883D0 (en) | 1996-06-20 | 1996-06-20 | Novel compounds |
| GB9612883.0 | 1996-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1229408A true CN1229408A (zh) | 1999-09-22 |
Family
ID=10795575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97197311A Pending CN1229408A (zh) | 1996-06-20 | 1997-06-16 | 用作5－ht－2c受体拮抗剂的二氢吲哚类衍生物 |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US6369060B1 (https=) |
| EP (1) | EP0912554B1 (https=) |
| JP (1) | JP2000512306A (https=) |
| KR (1) | KR20000022045A (https=) |
| CN (1) | CN1229408A (https=) |
| AP (2) | AP9801410A0 (https=) |
| AR (1) | AR008243A1 (https=) |
| AT (1) | ATE228514T1 (https=) |
| AU (1) | AU718597B2 (https=) |
| BG (1) | BG103089A (https=) |
| BR (1) | BR9709911A (https=) |
| CA (1) | CA2258240A1 (https=) |
| CO (1) | CO4890847A1 (https=) |
| CZ (1) | CZ420598A3 (https=) |
| DE (1) | DE69717449T2 (https=) |
| DZ (1) | DZ2250A1 (https=) |
| EA (1) | EA001780B1 (https=) |
| ES (1) | ES2187783T3 (https=) |
| GB (1) | GB9612883D0 (https=) |
| HU (1) | HUP9903439A3 (https=) |
| ID (1) | ID19433A (https=) |
| IL (1) | IL127417A0 (https=) |
| MA (1) | MA24214A1 (https=) |
| NO (1) | NO985972D0 (https=) |
| NZ (1) | NZ333229A (https=) |
| OA (1) | OA10944A (https=) |
| PE (1) | PE86698A1 (https=) |
| PL (1) | PL330796A1 (https=) |
| SK (1) | SK282706B6 (https=) |
| TR (1) | TR199802661T2 (https=) |
| TW (1) | TW382015B (https=) |
| WO (1) | WO1997048699A1 (https=) |
| ZA (1) | ZA975415B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999043650A2 (en) * | 1998-02-25 | 1999-09-02 | Smithkline Beecham Plc | Process(es) for the preparation of 6-trifluoromethyl-indoline derivatives |
| GB0019950D0 (en) * | 2000-08-12 | 2000-09-27 | Smithkline Beecham Plc | Compounds |
| AU2002346507A1 (en) * | 2001-11-28 | 2003-06-10 | Pharmacia And Upjohn Company | Benzazepine derivatives and their use as 5-ht ligands |
| MXPA04008517A (es) * | 2002-03-04 | 2005-08-19 | Pharmacia & Upjohn Co Llc | Compuestos terapeuticos. |
| KR101062376B1 (ko) * | 2008-04-10 | 2011-09-06 | 한국화학연구원 | 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물 |
| AU2010204995A1 (en) | 2009-01-16 | 2011-08-18 | Massachusetts Institute Of Technology | Diagnosis and treatment of autism spectrum disorders |
| EP2651403B1 (en) | 2010-12-17 | 2020-12-02 | Glaxo Group Limited | Use of lp-pla2 inhibitors in the treatment and prevention of eye diseases |
| WO2014046544A1 (en) | 2012-09-21 | 2014-03-27 | Aapa B.V. | Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin ht2c receptor modulators |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989001333A1 (en) * | 1987-08-07 | 1989-02-23 | The Australian National University | IMIDAZO[1,2-b]PYRIDAZINES |
| AU4704693A (en) * | 1992-08-20 | 1994-03-15 | Smithkline Beecham Plc | Condensed indole derivatives as 5HT-2C and 5HT-2B antagonists |
| GB9313913D0 (en) * | 1993-07-06 | 1993-08-18 | Smithkline Beecham Plc | Novel compounds |
| RO115522B1 (ro) * | 1995-02-02 | 2000-03-30 | Smithkline Beecham P.L.C. | Derivaţi de indolină, procedee pentru prepararea acestora, compoziţii farmaceutice care îi conţin şi metodă de tratament |
| GB9607219D0 (en) * | 1996-04-04 | 1996-06-12 | Smithkline Beecham Plc | Novel compounds |
| GB9615767D0 (en) * | 1996-07-26 | 1996-09-04 | Smithkline Beecham Plc | Novel treatment |
-
1996
- 1996-06-20 GB GBGB9612883.0A patent/GB9612883D0/en active Pending
-
1997
- 1997-06-16 EP EP97928224A patent/EP0912554B1/en not_active Expired - Lifetime
- 1997-06-16 CA CA002258240A patent/CA2258240A1/en not_active Abandoned
- 1997-06-16 BR BR9709911A patent/BR9709911A/pt unknown
- 1997-06-16 EA EA199900043A patent/EA001780B1/ru not_active IP Right Cessation
- 1997-06-16 AP APAP/P/1998/001410A patent/AP9801410A0/en unknown
- 1997-06-16 AU AU32602/97A patent/AU718597B2/en not_active Ceased
- 1997-06-16 US US09/202,780 patent/US6369060B1/en not_active Expired - Fee Related
- 1997-06-16 CZ CZ984205A patent/CZ420598A3/cs unknown
- 1997-06-16 TR TR1998/02661T patent/TR199802661T2/xx unknown
- 1997-06-16 WO PCT/EP1997/003156 patent/WO1997048699A1/en not_active Ceased
- 1997-06-16 CN CN97197311A patent/CN1229408A/zh active Pending
- 1997-06-16 AT AT97928224T patent/ATE228514T1/de not_active IP Right Cessation
- 1997-06-16 DE DE69717449T patent/DE69717449T2/de not_active Expired - Fee Related
- 1997-06-16 HU HU9903439A patent/HUP9903439A3/hu unknown
- 1997-06-16 JP JP10502259A patent/JP2000512306A/ja active Pending
- 1997-06-16 ES ES97928224T patent/ES2187783T3/es not_active Expired - Lifetime
- 1997-06-16 KR KR1019980710443A patent/KR20000022045A/ko not_active Ceased
- 1997-06-16 PL PL97330796A patent/PL330796A1/xx unknown
- 1997-06-16 IL IL12741797A patent/IL127417A0/xx unknown
- 1997-06-16 SK SK1752-98A patent/SK282706B6/sk unknown
- 1997-06-16 NZ NZ333229A patent/NZ333229A/xx unknown
- 1997-06-18 AR ARP970102673A patent/AR008243A1/es unknown
- 1997-06-18 DZ DZ970100A patent/DZ2250A1/fr active
- 1997-06-18 AP APAP/P/1997/001037A patent/AP745A/en active
- 1997-06-18 MA MA24666A patent/MA24214A1/fr unknown
- 1997-06-18 PE PE1997000510A patent/PE86698A1/es not_active Application Discontinuation
- 1997-06-19 ZA ZA975415A patent/ZA975415B/xx unknown
- 1997-06-19 TW TW086108551A patent/TW382015B/zh not_active IP Right Cessation
- 1997-06-20 ID IDP972126A patent/ID19433A/id unknown
- 1997-06-20 CO CO97034431A patent/CO4890847A1/es unknown
-
1998
- 1998-12-18 NO NO985972A patent/NO985972D0/no unknown
- 1998-12-18 OA OA9800245A patent/OA10944A/en unknown
-
1999
- 1999-01-15 BG BG103089A patent/BG103089A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |