CN1222522C - 二苯基氮杂环丁酮衍生物、它们的制备方法、含有这些化合物的药物和它们的用途 - Google Patents

二苯基氮杂环丁酮衍生物、它们的制备方法、含有这些化合物的药物和它们的用途 Download PDF

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Publication number
CN1222522C
CN1222522C CNB018210449A CN01821044A CN1222522C CN 1222522 C CN1222522 C CN 1222522C CN B018210449 A CNB018210449 A CN B018210449A CN 01821044 A CN01821044 A CN 01821044A CN 1222522 C CN1222522 C CN 1222522C
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CN
China
Prior art keywords
alkyl
ethoxy
phenyl
compound
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018210449A
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English (en)
Chinese (zh)
Other versions
CN1481381A (zh
Inventor
H·格隆比克
W·克拉默尔
S·弗洛尔
W·弗里克
H·霍伊尔
G·耶内
A·林登施密特
H-L·舍费尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10064402A external-priority patent/DE10064402A1/de
Priority claimed from DE2001154520 external-priority patent/DE10154520A1/de
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Publication of CN1481381A publication Critical patent/CN1481381A/zh
Application granted granted Critical
Publication of CN1222522C publication Critical patent/CN1222522C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB018210449A 2000-12-21 2001-12-11 二苯基氮杂环丁酮衍生物、它们的制备方法、含有这些化合物的药物和它们的用途 Expired - Fee Related CN1222522C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10064402A DE10064402A1 (de) 2000-12-21 2000-12-21 Diphenylazetidinonderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE10064402.3 2000-12-21
DE10154520.7 2001-11-07
DE2001154520 DE10154520A1 (de) 2001-11-07 2001-11-07 Diphenylazetidinonderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Publications (2)

Publication Number Publication Date
CN1481381A CN1481381A (zh) 2004-03-10
CN1222522C true CN1222522C (zh) 2005-10-12

Family

ID=26008045

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018210449A Expired - Fee Related CN1222522C (zh) 2000-12-21 2001-12-11 二苯基氮杂环丁酮衍生物、它们的制备方法、含有这些化合物的药物和它们的用途

Country Status (23)

Country Link
US (1) US6498156B2 (https=)
EP (1) EP1345932B1 (https=)
JP (1) JP2004516293A (https=)
KR (1) KR20030061462A (https=)
CN (1) CN1222522C (https=)
AR (1) AR034282A1 (https=)
AT (1) ATE342899T1 (https=)
AU (2) AU2002219173B2 (https=)
BR (1) BR0116482A (https=)
CA (1) CA2431985A1 (https=)
CZ (1) CZ20031731A3 (https=)
DE (1) DE50111293D1 (https=)
EE (1) EE200300237A (https=)
HR (1) HRP20030499A2 (https=)
HU (1) HUP0401067A2 (https=)
IL (1) IL156552A0 (https=)
MX (1) MXPA03005018A (https=)
NO (1) NO20032733L (https=)
NZ (1) NZ526592A (https=)
PL (1) PL362173A1 (https=)
SK (1) SK7812003A3 (https=)
WO (1) WO2002050068A1 (https=)
YU (1) YU46903A (https=)

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Publication number Publication date
AU2002219173B2 (en) 2006-06-22
DE50111293D1 (de) 2006-11-30
MXPA03005018A (es) 2003-09-25
WO2002050068A1 (de) 2002-06-27
PL362173A1 (en) 2004-10-18
EP1345932A1 (de) 2003-09-24
SK7812003A3 (en) 2004-01-08
CA2431985A1 (en) 2002-06-27
HUP0401067A2 (hu) 2004-09-28
EE200300237A (et) 2003-08-15
HRP20030499A2 (en) 2005-04-30
US20020128252A1 (en) 2002-09-12
YU46903A (sh) 2006-05-25
AU1917302A (en) 2002-07-01
HK1059936A1 (en) 2004-07-23
ATE342899T1 (de) 2006-11-15
US6498156B2 (en) 2002-12-24
NO20032733D0 (no) 2003-06-16
BR0116482A (pt) 2004-02-03
KR20030061462A (ko) 2003-07-18
CZ20031731A3 (cs) 2003-09-17
JP2004516293A (ja) 2004-06-03
CN1481381A (zh) 2004-03-10
EP1345932B1 (de) 2006-10-18
NO20032733L (no) 2003-08-14
IL156552A0 (en) 2004-01-04
AR034282A1 (es) 2004-02-18
NZ526592A (en) 2004-11-26

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