CN121873082A - 具有二环性哌嗪环的苯并噁唑衍生物或其盐的制造方法以及其原料的制造方法 - Google Patents
具有二环性哌嗪环的苯并噁唑衍生物或其盐的制造方法以及其原料的制造方法Info
- Publication number
- CN121873082A CN121873082A CN202610020318.9A CN202610020318A CN121873082A CN 121873082 A CN121873082 A CN 121873082A CN 202610020318 A CN202610020318 A CN 202610020318A CN 121873082 A CN121873082 A CN 121873082A
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- acid
- reaction
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Health & Medical Sciences (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021-108230 | 2021-06-30 | ||
| JP2021108230 | 2021-06-30 | ||
| CN202280035356.1A CN117295744A (zh) | 2021-06-30 | 2022-06-30 | 具有二环性哌嗪环的苯并噁唑衍生物或其盐的制造方法以及其原料的制造方法 |
| PCT/JP2022/026168 WO2023277120A1 (ja) | 2021-06-30 | 2022-06-30 | 二環性ピペラジン環を有するベンゾオキサゾール誘導体又はその塩の製造方法、並びに、その原料の製造方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280035356.1A Division CN117295744A (zh) | 2021-06-30 | 2022-06-30 | 具有二环性哌嗪环的苯并噁唑衍生物或其盐的制造方法以及其原料的制造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN121873082A true CN121873082A (zh) | 2026-04-17 |
Family
ID=84691891
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280035356.1A Pending CN117295744A (zh) | 2021-06-30 | 2022-06-30 | 具有二环性哌嗪环的苯并噁唑衍生物或其盐的制造方法以及其原料的制造方法 |
| CN202610020318.9A Pending CN121873082A (zh) | 2021-06-30 | 2022-06-30 | 具有二环性哌嗪环的苯并噁唑衍生物或其盐的制造方法以及其原料的制造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280035356.1A Pending CN117295744A (zh) | 2021-06-30 | 2022-06-30 | 具有二环性哌嗪环的苯并噁唑衍生物或其盐的制造方法以及其原料的制造方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20240309010A1 (https=) |
| EP (1) | EP4365174A4 (https=) |
| JP (2) | JP7476431B2 (https=) |
| KR (1) | KR20240027603A (https=) |
| CN (2) | CN117295744A (https=) |
| AR (1) | AR126290A1 (https=) |
| AU (1) | AU2022300611A1 (https=) |
| BR (1) | BR112023025934A2 (https=) |
| CA (1) | CA3223354A1 (https=) |
| IL (1) | IL309736A (https=) |
| MX (1) | MX2023014123A (https=) |
| WO (1) | WO2023277120A1 (https=) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102214222B1 (ko) | 2013-07-10 | 2021-02-08 | 메이지 세이카 파루마 가부시키가이샤 | 신규 pde4 저해제 |
| TWI752141B (zh) | 2016-12-26 | 2022-01-11 | 日商明治製菓藥業股份有限公司 | 新穎化合物以及其藥理上所容許之鹽 |
| JP2021155336A (ja) * | 2018-06-27 | 2021-10-07 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | 新規ｐｄｅ４阻害剤 |
| JP6815566B2 (ja) * | 2018-06-27 | 2021-01-20 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | 炎症性疾患、自己免疫疾患、線維化疾患、及びがん疾患の治療剤 |
-
2022
- 2022-06-30 CN CN202280035356.1A patent/CN117295744A/zh active Pending
- 2022-06-30 EP EP22833266.4A patent/EP4365174A4/en active Pending
- 2022-06-30 WO PCT/JP2022/026168 patent/WO2023277120A1/ja not_active Ceased
- 2022-06-30 AU AU2022300611A patent/AU2022300611A1/en active Pending
- 2022-06-30 IL IL309736A patent/IL309736A/en unknown
- 2022-06-30 CA CA3223354A patent/CA3223354A1/en active Pending
- 2022-06-30 JP JP2023532045A patent/JP7476431B2/ja active Active
- 2022-06-30 MX MX2023014123A patent/MX2023014123A/es unknown
- 2022-06-30 BR BR112023025934A patent/BR112023025934A2/pt unknown
- 2022-06-30 US US18/575,158 patent/US20240309010A1/en active Pending
- 2022-06-30 AR ARP220101722A patent/AR126290A1/es unknown
- 2022-06-30 CN CN202610020318.9A patent/CN121873082A/zh active Pending
- 2022-06-30 KR KR1020237043708A patent/KR20240027603A/ko active Pending
-
2024
- 2024-04-17 JP JP2024067062A patent/JP7839217B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2023277120A1 (https=) | 2023-01-05 |
| IL309736A (en) | 2024-02-01 |
| WO2023277120A1 (ja) | 2023-01-05 |
| JP2024096941A (ja) | 2024-07-17 |
| AU2022300611A1 (en) | 2024-01-25 |
| MX2023014123A (es) | 2023-12-12 |
| JP7476431B2 (ja) | 2024-04-30 |
| CA3223354A1 (en) | 2023-01-05 |
| JP7839217B2 (ja) | 2026-04-01 |
| EP4365174A1 (en) | 2024-05-08 |
| CN117295744A (zh) | 2023-12-26 |
| TW202311242A (zh) | 2023-03-16 |
| AR126290A1 (es) | 2023-10-04 |
| EP4365174A4 (en) | 2025-07-02 |
| KR20240027603A (ko) | 2024-03-04 |
| US20240309010A1 (en) | 2024-09-19 |
| BR112023025934A2 (pt) | 2024-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination |