CN107915672A - 一种取代异吲哚啉化合物的制备方法 - Google Patents
一种取代异吲哚啉化合物的制备方法 Download PDFInfo
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- CN107915672A CN107915672A CN201610880079.0A CN201610880079A CN107915672A CN 107915672 A CN107915672 A CN 107915672A CN 201610880079 A CN201610880079 A CN 201610880079A CN 107915672 A CN107915672 A CN 107915672A
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- Prior art keywords
- compound
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- isoindoline
- reaction
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
Abstract
Description
Claims (10)
Priority Applications (1)
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CN201610880079.0A CN107915672A (zh) | 2016-10-09 | 2016-10-09 | 一种取代异吲哚啉化合物的制备方法 |
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CN201610880079.0A CN107915672A (zh) | 2016-10-09 | 2016-10-09 | 一种取代异吲哚啉化合物的制备方法 |
Publications (1)
Publication Number | Publication Date |
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CN107915672A true CN107915672A (zh) | 2018-04-17 |
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CN201610880079.0A Pending CN107915672A (zh) | 2016-10-09 | 2016-10-09 | 一种取代异吲哚啉化合物的制备方法 |
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CN (1) | CN107915672A (zh) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1894214A (zh) * | 2003-12-18 | 2007-01-10 | 阿斯利康(瑞典)有限公司 | 作为凝血酶抑制剂的新型5,6-二氢吡啶-2-酮化合物 |
CN101128439A (zh) * | 2004-12-23 | 2008-02-20 | 葛兰素集团有限公司 | 用于治疗预产期前分娩、痛经和子宫内膜异位症的作为催产素受体拮抗剂的1,6-取代的(3r,6r)-3-(2,3-二氢-1h-茚-2-基)-2,5-哌嗪二酮衍生物 |
CN101668538A (zh) * | 2007-01-08 | 2010-03-10 | 芬诺密克斯公司 | 大环类丙型肝炎蛋白酶抑制剂 |
WO2013014665A1 (en) * | 2011-07-28 | 2013-01-31 | Mapi Pharma Ltd. | Intermediate compounds and process for the preparation of lurasidone and salts thereof |
-
2016
- 2016-10-09 CN CN201610880079.0A patent/CN107915672A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1894214A (zh) * | 2003-12-18 | 2007-01-10 | 阿斯利康(瑞典)有限公司 | 作为凝血酶抑制剂的新型5,6-二氢吡啶-2-酮化合物 |
CN101128439A (zh) * | 2004-12-23 | 2008-02-20 | 葛兰素集团有限公司 | 用于治疗预产期前分娩、痛经和子宫内膜异位症的作为催产素受体拮抗剂的1,6-取代的(3r,6r)-3-(2,3-二氢-1h-茚-2-基)-2,5-哌嗪二酮衍生物 |
CN101668538A (zh) * | 2007-01-08 | 2010-03-10 | 芬诺密克斯公司 | 大环类丙型肝炎蛋白酶抑制剂 |
WO2013014665A1 (en) * | 2011-07-28 | 2013-01-31 | Mapi Pharma Ltd. | Intermediate compounds and process for the preparation of lurasidone and salts thereof |
Non-Patent Citations (2)
Title |
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FENG XU,等: "Chlorination/Cyclodehydration of Amino Alcohols with SOCl2: An Old Reaction Revisited", 《JOURNAL OF ORGANIC CHEMISTRY》 * |
SEBASTIAAN VAN GOETHEM,等: "Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitors", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
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PB01 | Publication | ||
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TA01 | Transfer of patent application right |
Effective date of registration: 20191126 Address after: 310016 2-4 / F, building 2, Heke technology center, No. 500, QiaoXin Road, Xiasha street, Jianggan economic and Technological Development Zone, Hangzhou City, Zhejiang Province Applicant after: Ruibo (Hangzhou) Pharmaceutical Technology Co.,Ltd. Address before: 5 Building 4, building 88, 310051 Jiangling Road, Binjiang District, Zhejiang, Hangzhou Applicant before: ZHEJIANG JIUZHOU PHARMA SCIENCE & TECHNOLOGY Co.,Ltd. |
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RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180417 |