CN1216046A - 3－[(1,2,3,4－四氢异喹啉－2－基)甲基]－8－氮杂双环[3.2.1]辛烷衍生物,其制备方法以及在疾病治疗中的应用 - Google Patents

3－[(1,2,3,4－四氢异喹啉－2－基)甲基]－8－氮杂双环[3.2.1]辛烷衍生物,其制备方法以及在疾病治疗中的应用 Download PDF

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Publication number
CN1216046A
CN1216046A CN97193750A CN97193750A CN1216046A CN 1216046 A CN1216046 A CN 1216046A CN 97193750 A CN97193750 A CN 97193750A CN 97193750 A CN97193750 A CN 97193750A CN 1216046 A CN1216046 A CN 1216046A
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CN
China
Prior art keywords
compound
och
general formula
azabicyclo
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN97193750A
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English (en)
Chinese (zh)
Inventor
M·瑟维林
B·马拉鲍特
P·乔治
J·P·梅尔莱
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SYNTHETIC LABORATORY CORP
Original Assignee
SYNTHETIC LABORATORY CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SYNTHETIC LABORATORY CORP filed Critical SYNTHETIC LABORATORY CORP
Publication of CN1216046A publication Critical patent/CN1216046A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN97193750A 1996-04-12 1997-04-10 3－[(1,2,3,4－四氢异喹啉－2－基)甲基]－8－氮杂双环[3.2.1]辛烷衍生物,其制备方法以及在疾病治疗中的应用 Pending CN1216046A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9604565A FR2747386B1 (fr) 1996-04-12 1996-04-12 Derives de 3-[(1,2,3,4-tetrahydroisoquinolein-2-yl)methyl] -8-azabicyclo [3.2.1] octane, leur preparation et leur application en therapeutique
FR96/04565 1996-04-12

Publications (1)

Publication Number Publication Date
CN1216046A true CN1216046A (zh) 1999-05-05

Family

ID=9491132

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97193750A Pending CN1216046A (zh) 1996-04-12 1997-04-10 3－[(1,2,3,4－四氢异喹啉－2－基)甲基]－8－氮杂双环[3.2.1]辛烷衍生物,其制备方法以及在疾病治疗中的应用

Country Status (22)

Country Link
EP (1) EP0892800A1 (enExample)
JP (1) JP2000512620A (enExample)
KR (1) KR20000005392A (enExample)
CN (1) CN1216046A (enExample)
AR (1) AR008587A1 (enExample)
AU (1) AU2640997A (enExample)
BG (1) BG102779A (enExample)
BR (1) BR9708654A (enExample)
CA (1) CA2251335A1 (enExample)
CO (1) CO4900067A1 (enExample)
CZ (1) CZ326898A3 (enExample)
EE (1) EE9800396A (enExample)
FR (1) FR2747386B1 (enExample)
IL (1) IL126473A0 (enExample)
NO (1) NO984736L (enExample)
NZ (1) NZ332257A (enExample)
PL (1) PL329243A1 (enExample)
SK (1) SK141598A3 (enExample)
TR (1) TR199801839T2 (enExample)
TW (1) TW407158B (enExample)
WO (1) WO1997038998A1 (enExample)
ZA (1) ZA973124B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009156458A1 (en) * 2008-06-27 2009-12-30 H. Lundbeck A/S Novel phenolic and catecholic amines and prodrugs thereof
WO2018021447A1 (ja) 2016-07-28 2018-02-01 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する含窒素縮環化合物
TW201938537A (zh) 2018-01-26 2019-10-01 日商鹽野義製藥股份有限公司 具有多巴胺ｄ３受體拮抗作用的稠環化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8701682A (nl) * 1986-07-30 1988-02-16 Sandoz Ag Werkwijze voor het therapeutisch toepassen van serotonine antagonisten, aktieve verbindingen en farmaceutische preparaten die deze verbindingen bevatten.
EP0306375A1 (fr) * 1987-08-07 1989-03-08 Synthelabo Dérivés de[(pipéridinyl-4)méthyl]-2 tétrahydro-1,2,3,4 isoquinoléine, leur préparation et leur application en thérapeutique
IL89156A (en) * 1988-07-12 1993-05-13 Synthelabo Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics
FR2661178B1 (fr) * 1990-04-24 1993-03-12 Synthelabo Derives de [(tetrahydro-1,2,3,4 isoquinoleinyl-2)methyl]-4 piperidinecarboxylates-1 d'alkyle, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
BR9708654A (pt) 1999-08-03
NO984736L (no) 1998-11-23
CO4900067A1 (es) 2000-03-27
TR199801839T2 (enExample) 1998-12-21
CA2251335A1 (en) 1997-10-23
TW407158B (en) 2000-10-01
FR2747386B1 (fr) 1998-05-15
SK141598A3 (en) 1999-03-12
NO984736D0 (no) 1998-10-09
EP0892800A1 (fr) 1999-01-27
IL126473A0 (en) 1999-08-17
ZA973124B (en) 1997-11-05
BG102779A (en) 1999-09-30
KR20000005392A (ko) 2000-01-25
FR2747386A1 (fr) 1997-10-17
WO1997038998A1 (fr) 1997-10-23
AU2640997A (en) 1997-11-07
AR008587A1 (es) 2000-02-09
PL329243A1 (en) 1999-03-15
EE9800396A (et) 1999-06-15
CZ326898A3 (cs) 1999-01-13
JP2000512620A (ja) 2000-09-26
NZ332257A (en) 1999-03-29

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