CN1216034C - 特比萘芬的苹果酸加成盐 - Google Patents

特比萘芬的苹果酸加成盐 Download PDF

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Publication number
CN1216034C
CN1216034C CN028046080A CN02804608A CN1216034C CN 1216034 C CN1216034 C CN 1216034C CN 028046080 A CN028046080 A CN 028046080A CN 02804608 A CN02804608 A CN 02804608A CN 1216034 C CN1216034 C CN 1216034C
Authority
CN
China
Prior art keywords
terbinafine
compound
oxysuccinic acid
malic acid
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN028046080A
Other languages
English (en)
Chinese (zh)
Other versions
CN1491206A (zh
Inventor
D·吉龙
J-L·雷伯
S·希尔施
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1491206A publication Critical patent/CN1491206A/zh
Application granted granted Critical
Publication of CN1216034C publication Critical patent/CN1216034C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
CN028046080A 2001-02-07 2002-02-06 特比萘芬的苹果酸加成盐 Expired - Fee Related CN1216034C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0103046.9A GB0103046D0 (en) 2001-02-07 2001-02-07 Organic Compounds
GB0103046.9 2001-02-07

Publications (2)

Publication Number Publication Date
CN1491206A CN1491206A (zh) 2004-04-21
CN1216034C true CN1216034C (zh) 2005-08-24

Family

ID=9908301

Family Applications (1)

Application Number Title Priority Date Filing Date
CN028046080A Expired - Fee Related CN1216034C (zh) 2001-02-07 2002-02-06 特比萘芬的苹果酸加成盐

Country Status (27)

Country Link
US (2) US20040147603A1 (enExample)
EP (1) EP1370513B1 (enExample)
JP (1) JP4078206B2 (enExample)
KR (2) KR20080041756A (enExample)
CN (1) CN1216034C (enExample)
AT (1) ATE294154T1 (enExample)
AU (1) AU2002238534C1 (enExample)
BR (1) BR0207077A (enExample)
CA (1) CA2437592A1 (enExample)
CZ (1) CZ20032132A3 (enExample)
DE (1) DE60203890T2 (enExample)
DK (1) DK1370513T3 (enExample)
EC (1) ECSP034713A (enExample)
ES (1) ES2240698T3 (enExample)
GB (1) GB0103046D0 (enExample)
HU (1) HUP0303174A3 (enExample)
IL (2) IL157241A0 (enExample)
MX (1) MXPA03007072A (enExample)
NO (1) NO20033473L (enExample)
NZ (1) NZ527300A (enExample)
PL (1) PL204812B1 (enExample)
PT (1) PT1370513E (enExample)
RU (1) RU2289570C2 (enExample)
SI (1) SI1370513T1 (enExample)
SK (1) SK9992003A3 (enExample)
WO (1) WO2002070455A1 (enExample)
ZA (1) ZA200306029B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050209339A1 (en) * 2002-07-02 2005-09-22 Ercem Atillasoy Methods for the treatment of sinusitis
GB0503942D0 (en) * 2005-02-25 2005-04-06 Novartis Ag Purification process
RU2286144C2 (ru) * 2004-12-02 2006-10-27 Государственное научное учреждение Институт экспериментальной ветеринарии Сибири и Дальнего Востока Сибирского отделения Россельхозакадемии (ГНУ ИЭВСиДВ СО РАСХН) Способ лечения микроспории кошек
WO2007104474A1 (en) * 2006-03-10 2007-09-20 Novartis Ag Antifungal compositions comprising (1) a salt of terbinafine with malic acid and (2) malic acid
EP2043604A2 (en) 2006-06-14 2009-04-08 Dr. Reddy's Laboratories Ltd. Topical compositions
RU2350343C1 (ru) * 2007-08-13 2009-03-27 Государственное научное учреждение Институт экспериментальной ветеринарии Сибири и Дальнего Востока Сибирского отделения Россельхозакадемии (ГНУ ИЭВС и ДВ СО Россельхозакадемии) Способ лечения микроспории кошек
KR101733773B1 (ko) 2009-01-16 2017-05-10 엑셀리시스, 인코포레이티드 Ｎ-（４-｛〔６，７-비스（메틸옥시）퀴놀린-4-일〕옥시｝페닐）-ｎ＇-（４-플루오로페닐）사이클로프로판-1,1-디카르복사미드의 말산염 및 그 결정형
CN106106449A (zh) * 2016-06-21 2016-11-16 广西中烟工业有限责任公司 特比萘芬制剂及其在提高烟叶角鲨烯含量中的应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507755A (en) * 1967-10-17 1970-04-21 Bayer Ag Process for the purification of acrylonitrile by distillation with side stream withdrawal and decantation
US4276125A (en) 1979-02-02 1981-06-30 Asahi Kasei Kogyo Kabushiki Kaisha Process for purification of crude olefinically unsaturated nitrile and condenser useful for same process
US4269667A (en) 1979-08-02 1981-05-26 Standard Oil Company Acrylonitrile purification by extractive distillation
ATE10272T1 (de) * 1979-08-22 1984-11-15 Sandoz Ag Propenylamine, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zusammensetzungen und ihre verwendung als arzneimittel.
KR850001603B1 (ko) 1980-12-03 1985-10-24 아사히 가세이 고오교오 가부시기가이샤 불포화 니트릴의 제조법
GB8608335D0 (en) 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
NZ227042A (en) * 1987-11-27 1991-05-28 Banyu Pharma Co Ltd Substituted alkylamine derivatives and pharmaceutical compositions
US6005001A (en) 1991-05-20 1999-12-21 Novartis Ag (Formerly Sandoz Ag) Pharmaceutical composition
HU223343B1 (hu) * 1991-05-20 2004-06-28 Novartis Ag. Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására
HU219480B (hu) 1991-05-23 2001-04-28 Novartis Ag. Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására
US5461068A (en) * 1993-09-29 1995-10-24 Corwood Laboratories, Inc. Imidazole derivative tincture and method of manufacture
DE4400770C1 (de) * 1994-01-13 1995-02-02 Lohmann Therapie Syst Lts Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung
NZ280065A (en) * 1995-09-20 1998-04-27 Apotex Inc Preparation of n-alkyl-n-(1-naphthylmethyl)alk-2-en-4-ynylamine derivatives
CA2285368A1 (en) * 1997-03-31 1998-10-08 Johnson & Johnson Consumer Companies Inc. Solvent system for enhanced penetration of pharmaceutical compounds
WO1999049895A2 (en) 1998-03-31 1999-10-07 Johnson And Johnson Consumer Companies, Inc. Method for increasing the permeability of horny human tissue
US6231875B1 (en) 1998-03-31 2001-05-15 Johnson & Johnson Consumer Companies, Inc. Acidified composition for topical treatment of nail and skin conditions
AU758679B2 (en) * 1998-07-24 2003-03-27 Seo Hong Yoo Preparation of aqueous clear solution dosage forms with bile acids
JP2000053681A (ja) 1998-08-10 2000-02-22 Sankyo Co Ltd 三環性複素環化合物を含有する抗菌剤
ATE245624T1 (de) 1999-10-22 2003-08-15 Richter Gedeon Vegyeszet Verfahren zur herstellung substituierter allylamin derivative und deren salze
GB0014448D0 (en) 2000-06-13 2000-08-09 Novartis Ag Organic compounds
JP4899139B2 (ja) 2000-08-10 2012-03-21 株式会社ポーラファルマ 抗真菌医薬組成物
JP4803511B2 (ja) 2000-08-25 2011-10-26 株式会社ポーラファルマ 抗真菌医薬組成物
JP2002068975A (ja) 2000-08-25 2002-03-08 Pola Chem Ind Inc 抗真菌医薬組成物

Also Published As

Publication number Publication date
NZ527300A (en) 2005-02-25
HK1060876A1 (en) 2004-08-27
ECSP034713A (es) 2003-09-24
IL157241A (en) 2009-06-15
DE60203890T2 (de) 2006-01-19
HUP0303174A3 (en) 2008-03-28
ES2240698T3 (es) 2005-10-16
US7488759B2 (en) 2009-02-10
PL362554A1 (en) 2004-11-02
JP2004523567A (ja) 2004-08-05
CN1491206A (zh) 2004-04-21
PT1370513E (pt) 2005-08-31
NO20033473L (no) 2003-09-17
AU2002238534B2 (en) 2005-09-29
DE60203890D1 (de) 2005-06-02
ZA200306029B (en) 2004-06-28
JP4078206B2 (ja) 2008-04-23
EP1370513A1 (en) 2003-12-17
PL204812B1 (pl) 2010-02-26
BR0207077A (pt) 2004-01-20
US20040147603A1 (en) 2004-07-29
KR100859609B1 (ko) 2008-09-23
CZ20032132A3 (cs) 2003-10-15
HUP0303174A2 (hu) 2003-12-29
KR20030077606A (ko) 2003-10-01
EP1370513B1 (en) 2005-04-27
CA2437592A1 (en) 2002-09-12
GB0103046D0 (en) 2001-03-21
RU2289570C2 (ru) 2006-12-20
DK1370513T3 (da) 2005-08-01
SK9992003A3 (en) 2004-01-08
ATE294154T1 (de) 2005-05-15
US20070088084A1 (en) 2007-04-19
MXPA03007072A (es) 2003-11-18
NO20033473D0 (no) 2003-08-05
SI1370513T1 (en) 2005-10-31
KR20080041756A (ko) 2008-05-13
RU2003126176A (ru) 2005-03-10
IL157241A0 (en) 2004-02-19
AU2002238534C1 (en) 2006-04-13
WO2002070455A1 (en) 2002-09-12

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050824

Termination date: 20110206