AU2002238534C1 - Malic acid addition salts of terbinafine - Google Patents

Malic acid addition salts of terbinafine Download PDF

Info

Publication number
AU2002238534C1
AU2002238534C1 AU2002238534A AU2002238534A AU2002238534C1 AU 2002238534 C1 AU2002238534 C1 AU 2002238534C1 AU 2002238534 A AU2002238534 A AU 2002238534A AU 2002238534 A AU2002238534 A AU 2002238534A AU 2002238534 C1 AU2002238534 C1 AU 2002238534C1
Authority
AU
Australia
Prior art keywords
compound
terbinafine
compound according
malic acid
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002238534A
Other languages
English (en)
Other versions
AU2002238534A1 (en
AU2002238534B2 (en
Inventor
Danielle Giron
Stefan Hirsch
Jean-Louis Reber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2002238534A1 publication Critical patent/AU2002238534A1/en
Application granted granted Critical
Publication of AU2002238534B2 publication Critical patent/AU2002238534B2/en
Publication of AU2002238534C1 publication Critical patent/AU2002238534C1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
AU2002238534A 2001-02-07 2002-02-06 Malic acid addition salts of terbinafine Ceased AU2002238534C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0103046.9 2001-02-07
GBGB0103046.9A GB0103046D0 (en) 2001-02-07 2001-02-07 Organic Compounds
PCT/EP2002/001249 WO2002070455A1 (en) 2001-02-07 2002-02-06 Malic acid addition salts of terbinafine

Publications (3)

Publication Number Publication Date
AU2002238534A1 AU2002238534A1 (en) 2003-03-13
AU2002238534B2 AU2002238534B2 (en) 2005-09-29
AU2002238534C1 true AU2002238534C1 (en) 2006-04-13

Family

ID=9908301

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002238534A Ceased AU2002238534C1 (en) 2001-02-07 2002-02-06 Malic acid addition salts of terbinafine

Country Status (27)

Country Link
US (2) US20040147603A1 (enExample)
EP (1) EP1370513B1 (enExample)
JP (1) JP4078206B2 (enExample)
KR (2) KR20080041756A (enExample)
CN (1) CN1216034C (enExample)
AT (1) ATE294154T1 (enExample)
AU (1) AU2002238534C1 (enExample)
BR (1) BR0207077A (enExample)
CA (1) CA2437592A1 (enExample)
CZ (1) CZ20032132A3 (enExample)
DE (1) DE60203890T2 (enExample)
DK (1) DK1370513T3 (enExample)
EC (1) ECSP034713A (enExample)
ES (1) ES2240698T3 (enExample)
GB (1) GB0103046D0 (enExample)
HU (1) HUP0303174A3 (enExample)
IL (2) IL157241A0 (enExample)
MX (1) MXPA03007072A (enExample)
NO (1) NO20033473L (enExample)
NZ (1) NZ527300A (enExample)
PL (1) PL204812B1 (enExample)
PT (1) PT1370513E (enExample)
RU (1) RU2289570C2 (enExample)
SI (1) SI1370513T1 (enExample)
SK (1) SK9992003A3 (enExample)
WO (1) WO2002070455A1 (enExample)
ZA (1) ZA200306029B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005538067A (ja) * 2002-07-02 2005-12-15 ノバルティス アクチエンゲゼルシャフト 副鼻腔炎の処置方法
GB0503942D0 (en) * 2005-02-25 2005-04-06 Novartis Ag Purification process
RU2286144C2 (ru) * 2004-12-02 2006-10-27 Государственное научное учреждение Институт экспериментальной ветеринарии Сибири и Дальнего Востока Сибирского отделения Россельхозакадемии (ГНУ ИЭВСиДВ СО РАСХН) Способ лечения микроспории кошек
WO2007104474A1 (en) * 2006-03-10 2007-09-20 Novartis Ag Antifungal compositions comprising (1) a salt of terbinafine with malic acid and (2) malic acid
US8431140B2 (en) 2006-06-14 2013-04-30 Dr. Reddy's Laboratories, Inc. Topical compositions
RU2350343C1 (ru) * 2007-08-13 2009-03-27 Государственное научное учреждение Институт экспериментальной ветеринарии Сибири и Дальнего Востока Сибирского отделения Россельхозакадемии (ГНУ ИЭВС и ДВ СО Россельхозакадемии) Способ лечения микроспории кошек
TWI511956B (zh) 2009-01-16 2015-12-11 Exelixis Inc 製備ｎ-（４-｛〔６，７-雙（甲氧基）喹啉-４-基〕氧基｝苯基）-ｎ’-（４-氟苯基）環丙烷-１，１-二甲醯胺之方法
CN106106449A (zh) * 2016-06-21 2016-11-16 广西中烟工业有限责任公司 特比萘芬制剂及其在提高烟叶角鲨烯含量中的应用

Family Cites Families (23)

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Publication number Priority date Publication date Assignee Title
US3507755A (en) * 1967-10-17 1970-04-21 Bayer Ag Process for the purification of acrylonitrile by distillation with side stream withdrawal and decantation
US4276125A (en) 1979-02-02 1981-06-30 Asahi Kasei Kogyo Kabushiki Kaisha Process for purification of crude olefinically unsaturated nitrile and condenser useful for same process
US4269667A (en) 1979-08-02 1981-05-26 Standard Oil Company Acrylonitrile purification by extractive distillation
ATE10272T1 (de) * 1979-08-22 1984-11-15 Sandoz Ag Propenylamine, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zusammensetzungen und ihre verwendung als arzneimittel.
KR850001603B1 (ko) 1980-12-03 1985-10-24 아사히 가세이 고오교오 가부시기가이샤 불포화 니트릴의 제조법
GB8608335D0 (en) 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
NZ227042A (en) * 1987-11-27 1991-05-28 Banyu Pharma Co Ltd Substituted alkylamine derivatives and pharmaceutical compositions
US6005001A (en) 1991-05-20 1999-12-21 Novartis Ag (Formerly Sandoz Ag) Pharmaceutical composition
HU223343B1 (hu) * 1991-05-20 2004-06-28 Novartis Ag. Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására
HU219480B (hu) 1991-05-23 2001-04-28 Novartis Ag. Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására
US5461068A (en) * 1993-09-29 1995-10-24 Corwood Laboratories, Inc. Imidazole derivative tincture and method of manufacture
DE4400770C1 (de) * 1994-01-13 1995-02-02 Lohmann Therapie Syst Lts Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung
NZ280065A (en) * 1995-09-20 1998-04-27 Apotex Inc Preparation of n-alkyl-n-(1-naphthylmethyl)alk-2-en-4-ynylamine derivatives
CN1252003A (zh) 1997-03-31 2000-05-03 强生消费者公司 增强药物化合物渗透作用的溶剂系统
US6231875B1 (en) 1998-03-31 2001-05-15 Johnson & Johnson Consumer Companies, Inc. Acidified composition for topical treatment of nail and skin conditions
AU3212099A (en) 1998-03-31 1999-10-18 Johnson & Johnson Consumer Companies, Inc. Method for increasing the permeability of horny human tissue
WO2000004875A2 (en) * 1998-07-24 2000-02-03 Seo Hong Yoo Preparation of aqueous clear solution dosage forms with bile acids
JP2000053681A (ja) 1998-08-10 2000-02-22 Sankyo Co Ltd 三環性複素環化合物を含有する抗菌剤
SI1222160T1 (en) * 1999-10-22 2003-12-31 Richter Gedeon Vegyeszeti Gyar R.T. Process for preparing a substituted allylamine derivative and the salts thereof
GB0014448D0 (en) 2000-06-13 2000-08-09 Novartis Ag Organic compounds
JP4899139B2 (ja) 2000-08-10 2012-03-21 株式会社ポーラファルマ 抗真菌医薬組成物
JP4803511B2 (ja) 2000-08-25 2011-10-26 株式会社ポーラファルマ 抗真菌医薬組成物
JP2002068975A (ja) 2000-08-25 2002-03-08 Pola Chem Ind Inc 抗真菌医薬組成物

Also Published As

Publication number Publication date
US20040147603A1 (en) 2004-07-29
ES2240698T3 (es) 2005-10-16
EP1370513A1 (en) 2003-12-17
GB0103046D0 (en) 2001-03-21
JP4078206B2 (ja) 2008-04-23
RU2003126176A (ru) 2005-03-10
NO20033473L (no) 2003-09-17
DK1370513T3 (da) 2005-08-01
HK1060876A1 (en) 2004-08-27
PT1370513E (pt) 2005-08-31
CN1491206A (zh) 2004-04-21
CZ20032132A3 (cs) 2003-10-15
CN1216034C (zh) 2005-08-24
JP2004523567A (ja) 2004-08-05
PL204812B1 (pl) 2010-02-26
RU2289570C2 (ru) 2006-12-20
SK9992003A3 (en) 2004-01-08
KR20030077606A (ko) 2003-10-01
DE60203890D1 (de) 2005-06-02
PL362554A1 (en) 2004-11-02
SI1370513T1 (en) 2005-10-31
KR20080041756A (ko) 2008-05-13
BR0207077A (pt) 2004-01-20
US20070088084A1 (en) 2007-04-19
NZ527300A (en) 2005-02-25
DE60203890T2 (de) 2006-01-19
US7488759B2 (en) 2009-02-10
KR100859609B1 (ko) 2008-09-23
ECSP034713A (es) 2003-09-24
HUP0303174A3 (en) 2008-03-28
IL157241A0 (en) 2004-02-19
IL157241A (en) 2009-06-15
CA2437592A1 (en) 2002-09-12
MXPA03007072A (es) 2003-11-18
NO20033473D0 (no) 2003-08-05
ATE294154T1 (de) 2005-05-15
HUP0303174A2 (hu) 2003-12-29
WO2002070455A1 (en) 2002-09-12
ZA200306029B (en) 2004-06-28
AU2002238534B2 (en) 2005-09-29
EP1370513B1 (en) 2005-04-27

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Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 25 OCT 2005.

FGA Letters patent sealed or granted (standard patent)
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 25 OCT 2005

MK14 Patent ceased section 143(a) (annual fees not paid) or expired