CN1209807A - 作为中枢神经系统药物的1－吡唑－3－基乙基－4－吲哚－3－基吡啶 - Google Patents

作为中枢神经系统药物的1－吡唑－3－基乙基－4－吲哚－3－基吡啶 Download PDF

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Publication number
CN1209807A
CN1209807A CN97191852A CN97191852A CN1209807A CN 1209807 A CN1209807 A CN 1209807A CN 97191852 A CN97191852 A CN 97191852A CN 97191852 A CN97191852 A CN 97191852A CN 1209807 A CN1209807 A CN 1209807A
Authority
CN
China
Prior art keywords
ethyl
methyl
pyrazolyl
indoles
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN97191852A
Other languages
English (en)
Chinese (zh)
Inventor
H·博特切尔
J·玛尔兹
G·巴尔托兹克
H·格瑞那
J·哈汀
C·希弗瑞德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CN1209807A publication Critical patent/CN1209807A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN97191852A 1996-01-25 1997-01-17 作为中枢神经系统药物的1－吡唑－3－基乙基－4－吲哚－3－基吡啶 Pending CN1209807A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602505.2 1996-01-25
DE19602505A DE19602505A1 (de) 1996-01-25 1996-01-25 1-(Pyrazol-4-Indol-3-yl)-Piperidine

Publications (1)

Publication Number Publication Date
CN1209807A true CN1209807A (zh) 1999-03-03

Family

ID=7783568

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97191852A Pending CN1209807A (zh) 1996-01-25 1997-01-17 作为中枢神经系统药物的1－吡唑－3－基乙基－4－吲哚－3－基吡啶

Country Status (16)

Country Link
EP (1) EP0879234A1 (es)
JP (1) JP2000503972A (es)
KR (1) KR19990081970A (es)
CN (1) CN1209807A (es)
AR (1) AR005549A1 (es)
AU (1) AU715785B2 (es)
BR (1) BR9707467A (es)
CA (1) CA2244136A1 (es)
CZ (1) CZ231898A3 (es)
DE (1) DE19602505A1 (es)
HU (1) HUP9900980A2 (es)
NO (1) NO983439L (es)
PL (1) PL328228A1 (es)
SK (1) SK99298A3 (es)
WO (1) WO1997027186A1 (es)
ZA (1) ZA97572B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103459381A (zh) * 2011-04-06 2013-12-18 株式会社Lg生命科学 1-(3-氰基-1-异丙基-吲哚-5-基)吡唑-4-甲酸晶型及其生产方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003509509A (ja) * 1999-09-09 2003-03-11 ハー・ルンドベック・アクチエゼルスカベット ５−アミノアルキル及び５−アミノカルボニル置換されたインドール類
PL356487A1 (en) 1999-11-10 2004-06-28 Takeda Chemical Industries, Ltd. 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
US7332494B2 (en) 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
AU2001281255B2 (en) 2000-08-14 2006-07-20 Ortho-Mcneil Pharmaceutical, Inc. Substituted pyrazoles
HUP0402124A2 (hu) * 2001-11-14 2005-02-28 Merck Patent Gmbh Pszichofarmakológiában alkalmazható pirazolszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
BRPI0617204A2 (pt) 2005-10-11 2011-07-19 Hoffmann La Roche derivados de imidazo benzodiazepina
JP2009515833A (ja) * 2005-10-24 2009-04-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ３−ピペリジン−４−イル−インドールｏｒｌ−１受容体モジュレーター
TW202336015A (zh) * 2020-11-04 2023-09-16 南韓商Ｌｇ化學股份有限公司 唑－４－羧酸結晶之製備方法及包含彼之醫藥組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060816C3 (de) * 1970-12-10 1980-09-04 Merck Patent Gmbh, 6100 Darmstadt 4-Phenylpiperidinderivate Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen enthaltend diese Verbindungen
DE2258033A1 (de) * 1972-11-27 1974-05-30 Merck Patent Gmbh Verfahren zur herstellung von pyrazolderivaten
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5045550A (en) * 1990-09-20 1991-09-03 Warner-Lambert Co. Substituted tetrahydropyridines as central nervous system agents
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103459381A (zh) * 2011-04-06 2013-12-18 株式会社Lg生命科学 1-(3-氰基-1-异丙基-吲哚-5-基)吡唑-4-甲酸晶型及其生产方法
CN103459381B (zh) * 2011-04-06 2015-12-09 株式会社Lg生命科学 1-(3-氰基-1-异丙基-吲哚-5-基)吡唑-4-甲酸晶型及其生产方法

Also Published As

Publication number Publication date
CZ231898A3 (cs) 1998-10-14
WO1997027186A1 (de) 1997-07-31
CA2244136A1 (en) 1997-07-31
EP0879234A1 (de) 1998-11-25
NO983439L (no) 1998-09-25
AU1443297A (en) 1997-08-20
DE19602505A1 (de) 1997-07-31
NO983439D0 (no) 1998-07-24
BR9707467A (pt) 1999-07-20
AU715785B2 (en) 2000-02-10
ZA97572B (en) 1997-08-04
JP2000503972A (ja) 2000-04-04
HUP9900980A2 (hu) 1999-07-28
SK99298A3 (en) 1999-01-11
AR005549A1 (es) 1999-06-23
PL328228A1 (en) 1999-01-18
KR19990081970A (ko) 1999-11-15

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