HUP9900980A2 - 1-(Pirazol-3-il-etil)-4-(indol-3-il)-piperidinek mint központi idegrendszert befolyásoló szerek - Google Patents

1-(Pirazol-3-il-etil)-4-(indol-3-il)-piperidinek mint központi idegrendszert befolyásoló szerek

Info

Publication number
HUP9900980A2
HUP9900980A2 HU9900980A HUP9900980A HUP9900980A2 HU P9900980 A2 HUP9900980 A2 HU P9900980A2 HU 9900980 A HU9900980 A HU 9900980A HU P9900980 A HUP9900980 A HU P9900980A HU P9900980 A2 HUP9900980 A2 HU P9900980A2
Authority
HU
Hungary
Prior art keywords
atom
indol
pyrazol
ethyl
nervous system
Prior art date
Application number
HU9900980A
Other languages
English (en)
Inventor
Gerd Bartoszyk
Henning Böttcher
Hartmut Greiner
Jürgen Harting
Joachim März
Christoph Seyfried
Original Assignee
MERCK Patent Gesellschaft mit beschränkter Haftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MERCK Patent Gesellschaft mit beschränkter Haftung filed Critical MERCK Patent Gesellschaft mit beschränkter Haftung
Publication of HUP9900980A2 publication Critical patent/HUP9900980A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány tárgya új, (I) általánős képletű 1-(pirazől-3-il-etil)-4-(indől-3-il)-piperidin-származékők, ahől R1 jelentése hidrőgénatőmvagy A, R2 jelentése hidrőgénatőm, 1-3-szőr halőgénatőmmal, nitrő-,CON(R4)2, SO2N(R4)2, cianő-, A vagy R4-O csőpőrttal szűbsztitűáltfenilcsőpőrt, R3 jelentése hidrőgén- vagy halőgénatőm, A, A-O-,aminő-, cianő-, karbőxamid-, nitrő- SO2N(R4)2 csőpőrt, R4 jelentésehidrőgénatőm vagy A, R5 jelentése hidrőgénatőm vagy A, A jelentése 1-6szénatőmős alkilcsőpőrt vagy 1-3-szőr flűőratőmmal szűbsztitűált 1-6szénatőmős alkilcsőpőrt, és Hal jelentése flűőr-, klór-, bróm- vagyjódatőm, vagy sói, melyek gyógyászatilag előnyös hatásúak. ŕ
HU9900980A 1996-01-25 1997-01-17 1-(Pirazol-3-il-etil)-4-(indol-3-il)-piperidinek mint központi idegrendszert befolyásoló szerek HUP9900980A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19602505A DE19602505A1 (de) 1996-01-25 1996-01-25 1-(Pyrazol-4-Indol-3-yl)-Piperidine

Publications (1)

Publication Number Publication Date
HUP9900980A2 true HUP9900980A2 (hu) 1999-07-28

Family

ID=7783568

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900980A HUP9900980A2 (hu) 1996-01-25 1997-01-17 1-(Pirazol-3-il-etil)-4-(indol-3-il)-piperidinek mint központi idegrendszert befolyásoló szerek

Country Status (16)

Country Link
EP (1) EP0879234A1 (hu)
JP (1) JP2000503972A (hu)
KR (1) KR19990081970A (hu)
CN (1) CN1209807A (hu)
AR (1) AR005549A1 (hu)
AU (1) AU715785B2 (hu)
BR (1) BR9707467A (hu)
CA (1) CA2244136A1 (hu)
CZ (1) CZ231898A3 (hu)
DE (1) DE19602505A1 (hu)
HU (1) HUP9900980A2 (hu)
NO (1) NO983439L (hu)
PL (1) PL328228A1 (hu)
SK (1) SK99298A3 (hu)
WO (1) WO1997027186A1 (hu)
ZA (1) ZA97572B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2219385T3 (es) * 1999-09-09 2004-12-01 H. Lundbeck A/S Indoles sustituidos con 5-aminoalquilo y 5-aminocarbonilo.
PT1228067E (pt) 1999-11-10 2004-11-30 Takeda Chemical Industries Ltd Compostos heterociclicos de cinco membros com actividade hipoglicemica e hipolipidemica
JP5140225B2 (ja) 2000-08-14 2013-02-06 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 置換ピラゾール
US7332494B2 (en) 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
US20050026927A1 (en) * 2001-11-14 2005-02-03 Henning Boettcher Pyrazole derivatives as psychopharmaceuticals
AU2006301377B2 (en) 2005-10-11 2012-03-08 F. Hoffmann-La Roche Ag Imidazo benzodiazepine derivatives
WO2007050381A2 (en) * 2005-10-24 2007-05-03 Janssen Pharmaceutica, N.V. 3-piperidin-4-yl-indole orl-1 receptor modulators
TWI548630B (zh) * 2011-04-06 2016-09-11 Ｌｇ生命科學有限公司 １－（３－氰基－１－異丙基－吲哚－５－基）吡唑－４－羧酸結晶型及其製造方法
KR20220060488A (ko) * 2020-11-04 2022-05-11 주식회사 엘지화학 1-(3-시아노-1-아이소프로필-인돌-5-일)피라졸-4-카르복실산의 결정성 입자의 제조방법 및 이를 포함하는 약학적 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060816C3 (de) * 1970-12-10 1980-09-04 Merck Patent Gmbh, 6100 Darmstadt 4-Phenylpiperidinderivate Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen enthaltend diese Verbindungen
DE2258033A1 (de) * 1972-11-27 1974-05-30 Merck Patent Gmbh Verfahren zur herstellung von pyrazolderivaten
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5045550A (en) * 1990-09-20 1991-09-03 Warner-Lambert Co. Substituted tetrahydropyridines as central nervous system agents
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine

Also Published As

Publication number Publication date
WO1997027186A1 (de) 1997-07-31
CA2244136A1 (en) 1997-07-31
KR19990081970A (ko) 1999-11-15
PL328228A1 (en) 1999-01-18
AU1443297A (en) 1997-08-20
ZA97572B (en) 1997-08-04
AR005549A1 (es) 1999-06-23
NO983439D0 (no) 1998-07-24
DE19602505A1 (de) 1997-07-31
JP2000503972A (ja) 2000-04-04
EP0879234A1 (de) 1998-11-25
SK99298A3 (en) 1999-01-11
AU715785B2 (en) 2000-02-10
BR9707467A (pt) 1999-07-20
CN1209807A (zh) 1999-03-03
CZ231898A3 (cs) 1998-10-14
NO983439L (no) 1998-09-25

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