DE19602505A1 - 1-(Pyrazol-4-Indol-3-yl)-Piperidine - Google Patents

1-(Pyrazol-4-Indol-3-yl)-Piperidine

Info

Publication number
DE19602505A1
DE19602505A1 DE19602505A DE19602505A DE19602505A1 DE 19602505 A1 DE19602505 A1 DE 19602505A1 DE 19602505 A DE19602505 A DE 19602505A DE 19602505 A DE19602505 A DE 19602505A DE 19602505 A1 DE19602505 A1 DE 19602505A1
Authority
DE
Germany
Prior art keywords
ethyl
methyl
indole
pyrazolyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19602505A
Other languages
German (de)
English (en)
Inventor
Henning Dr Boettcher
Joachim Dr Maerz
Gerd Bartoszyk
Hartmut Dr Greiner
Juergen Dr Harting
Christoph Dr Seyfried
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE19602505A priority Critical patent/DE19602505A1/de
Priority to PL97328228A priority patent/PL328228A1/xx
Priority to CN97191852A priority patent/CN1209807A/zh
Priority to AU14432/97A priority patent/AU715785B2/en
Priority to CA002244136A priority patent/CA2244136A1/en
Priority to EP97901049A priority patent/EP0879234A1/de
Priority to CZ982318A priority patent/CZ231898A3/cs
Priority to SK992-98A priority patent/SK99298A3/sk
Priority to PCT/EP1997/000187 priority patent/WO1997027186A1/de
Priority to HU9900980A priority patent/HUP9900980A2/hu
Priority to KR1019980705688A priority patent/KR19990081970A/ko
Priority to BR9707467A priority patent/BR9707467A/pt
Priority to JP9526493A priority patent/JP2000503972A/ja
Priority to ZA9700572A priority patent/ZA97572B/xx
Priority to ARP970100297A priority patent/AR005549A1/es
Publication of DE19602505A1 publication Critical patent/DE19602505A1/de
Priority to NO983439A priority patent/NO983439L/no
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19602505A 1996-01-25 1996-01-25 1-(Pyrazol-4-Indol-3-yl)-Piperidine Withdrawn DE19602505A1 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DE19602505A DE19602505A1 (de) 1996-01-25 1996-01-25 1-(Pyrazol-4-Indol-3-yl)-Piperidine
SK992-98A SK99298A3 (en) 1996-01-25 1997-01-17 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidine used as medicine acting on the central nervous system
KR1019980705688A KR19990081970A (ko) 1996-01-25 1997-01-17 중추신경계에 작용하는 약물로서 사용되는 1-피라졸-3-일-에틸-4-인돌-3-일-피페리딘
AU14432/97A AU715785B2 (en) 1996-01-25 1997-01-17 1-(pyrazol-3-ylethyl)-4-(indol-3-yl) piperdines as compositions affecting the central nervous system
CA002244136A CA2244136A1 (en) 1996-01-25 1997-01-17 1-pyrazol-3-yl-ethyl-4-indol-3-yl-piperidine used as medicine acting on the central nervous system
EP97901049A EP0879234A1 (de) 1996-01-25 1997-01-17 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidine als das zentralnervensystem beeinflussende mittel
CZ982318A CZ231898A3 (cs) 1996-01-25 1997-01-17 Derivát 1-(pyrazol-3-ylethyl)-4-(indol-3-yl)piperidinu, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje
PL97328228A PL328228A1 (en) 1996-01-25 1997-01-17 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidines as agents influencing the central nervous system
PCT/EP1997/000187 WO1997027186A1 (de) 1996-01-25 1997-01-17 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidine als das zentralnervensystem beeinflussende mittel
HU9900980A HUP9900980A2 (hu) 1996-01-25 1997-01-17 1-(Pirazol-3-il-etil)-4-(indol-3-il)-piperidinek mint központi idegrendszert befolyásoló szerek
CN97191852A CN1209807A (zh) 1996-01-25 1997-01-17 作为中枢神经系统药物的1－吡唑－3－基乙基－4－吲哚－3－基吡啶
BR9707467A BR9707467A (pt) 1996-01-25 1997-01-17 1-Pirazol-3-iletil-4-indol-3-ilpiperdinas
JP9526493A JP2000503972A (ja) 1996-01-25 1997-01-17 １―ピラゾール―３―イルエチル―４―インドール―３―イルピペリジン
ZA9700572A ZA97572B (en) 1996-01-25 1997-01-23 1-pyrazol-3-ylethyl-4-indol-3-ylpiperidines.
ARP970100297A AR005549A1 (es) 1996-01-25 1997-01-24 Derivados de la 1-pirazol-3-iletil-4-indol-3-ilpiperidina, un procedimiento para prepararlos, medicamentos y preparaciones farmaceuticas que los contienen,un procedimiento para preparar las preparaciones farmaceuticas y empleo de los mismos para la preparacion de medicamentos.
NO983439A NO983439L (no) 1996-01-25 1998-07-24 1-(pyrazol-3-yl-etyl)-4-(indol-3-yl)-piperidin anvendt som medisin som virker på sentralnervesystemet

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19602505A DE19602505A1 (de) 1996-01-25 1996-01-25 1-(Pyrazol-4-Indol-3-yl)-Piperidine

Publications (1)

Publication Number Publication Date
DE19602505A1 true DE19602505A1 (de) 1997-07-31

Family

ID=7783568

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19602505A Withdrawn DE19602505A1 (de) 1996-01-25 1996-01-25 1-(Pyrazol-4-Indol-3-yl)-Piperidine

Country Status (16)

Country Link
EP (1) EP0879234A1 (hu)
JP (1) JP2000503972A (hu)
KR (1) KR19990081970A (hu)
CN (1) CN1209807A (hu)
AR (1) AR005549A1 (hu)
AU (1) AU715785B2 (hu)
BR (1) BR9707467A (hu)
CA (1) CA2244136A1 (hu)
CZ (1) CZ231898A3 (hu)
DE (1) DE19602505A1 (hu)
HU (1) HUP9900980A2 (hu)
NO (1) NO983439L (hu)
PL (1) PL328228A1 (hu)
SK (1) SK99298A3 (hu)
WO (1) WO1997027186A1 (hu)
ZA (1) ZA97572B (hu)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003042208A1 (en) * 2001-11-14 2003-05-22 Merck Patent Gmbh Pyrazole derivatives as psychopharmaceuticals
EP1945213A2 (en) * 2005-10-24 2008-07-23 Janssen Pharmaceutica N.V. 3-piperidin-4-yl-indole orl-1 receptor modulators
US7507729B2 (en) 2005-10-11 2009-03-24 Hoffmann-La Roche Inc. Substituted imidazo-[1,5-a][1,2,4]triazolo[1,5-d][1,4] benzodiazepine derivatives

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1214312E (pt) * 1999-09-09 2004-08-31 Lundbeck & Co As H Indoles 5-aminoalquilo e 5-aminocarbonilo substituidos
HUP0203165A3 (en) 1999-11-10 2004-03-29 Takeda Pharmaceutical 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
US7332494B2 (en) 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
JP5140225B2 (ja) 2000-08-14 2013-02-06 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 置換ピラゾール
TWI548630B (zh) * 2011-04-06 2016-09-11 Ｌｇ生命科學有限公司 １－（３－氰基－１－異丙基－吲哚－５－基）吡唑－４－羧酸結晶型及其製造方法
TW202225158A (zh) * 2020-11-04 2022-07-01 南韓商Ｌｇ化學股份有限公司 １－（３－氰基－１－異丙基－吲哚－５－基）吡唑－４－羧酸結晶之製備方法及包含彼之醫藥組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060816C3 (de) * 1970-12-10 1980-09-04 Merck Patent Gmbh, 6100 Darmstadt 4-Phenylpiperidinderivate Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen enthaltend diese Verbindungen
DE2258033A1 (de) * 1972-11-27 1974-05-30 Merck Patent Gmbh Verfahren zur herstellung von pyrazolderivaten
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5045550A (en) * 1990-09-20 1991-09-03 Warner-Lambert Co. Substituted tetrahydropyridines as central nervous system agents
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003042208A1 (en) * 2001-11-14 2003-05-22 Merck Patent Gmbh Pyrazole derivatives as psychopharmaceuticals
US7507729B2 (en) 2005-10-11 2009-03-24 Hoffmann-La Roche Inc. Substituted imidazo-[1,5-a][1,2,4]triazolo[1,5-d][1,4] benzodiazepine derivatives
EP1945213A2 (en) * 2005-10-24 2008-07-23 Janssen Pharmaceutica N.V. 3-piperidin-4-yl-indole orl-1 receptor modulators
EP1945213A4 (en) * 2005-10-24 2009-12-02 Janssen Pharmaceutica Nv MODULATORS OF THE R3-PIPERIDINE-4-YL-INDOLE ORL-1 RECEPTOR

Also Published As

Publication number Publication date
KR19990081970A (ko) 1999-11-15
SK99298A3 (en) 1999-01-11
NO983439D0 (no) 1998-07-24
ZA97572B (en) 1997-08-04
CZ231898A3 (cs) 1998-10-14
EP0879234A1 (de) 1998-11-25
AU715785B2 (en) 2000-02-10
BR9707467A (pt) 1999-07-20
AU1443297A (en) 1997-08-20
AR005549A1 (es) 1999-06-23
NO983439L (no) 1998-09-25
WO1997027186A1 (de) 1997-07-31
CN1209807A (zh) 1999-03-03
HUP9900980A2 (hu) 1999-07-28
JP2000503972A (ja) 2000-04-04
CA2244136A1 (en) 1997-07-31
PL328228A1 (en) 1999-01-18

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee