JP2000503972A - １―ピラゾール―３―イルエチル―４―インドール―３―イルピペリジン - Google Patents

１―ピラゾール―３―イルエチル―４―インドール―３―イルピペリジン

Info

Publication number
JP2000503972A
JP2000503972A JP9526493A JP52649397A JP2000503972A JP 2000503972 A JP2000503972 A JP 2000503972A JP 9526493 A JP9526493 A JP 9526493A JP 52649397 A JP52649397 A JP 52649397A JP 2000503972 A JP2000503972 A JP 2000503972A
Authority
JP
Japan
Prior art keywords
methyl
ethyl
indole
pyrazolyl
piperidyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9526493A
Other languages
English (en)
Japanese (ja)
Inventor
ベトケル，ヘンニンク
メルツ，ヨーハイム
バルトスキク，ゲルト
グレイネル，ハルトムト
ハルティンク，ユルゲン
ゼイフリート，クリストフ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of JP2000503972A publication Critical patent/JP2000503972A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP9526493A 1996-01-25 1997-01-17 １―ピラゾール―３―イルエチル―４―インドール―３―イルピペリジン Pending JP2000503972A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19602505A DE19602505A1 (de) 1996-01-25 1996-01-25 1-(Pyrazol-4-Indol-3-yl)-Piperidine
DE19602505.2 1996-01-25
PCT/EP1997/000187 WO1997027186A1 (de) 1996-01-25 1997-01-17 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidine als das zentralnervensystem beeinflussende mittel

Publications (1)

Publication Number Publication Date
JP2000503972A true JP2000503972A (ja) 2000-04-04

Family

ID=7783568

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9526493A Pending JP2000503972A (ja) 1996-01-25 1997-01-17 １―ピラゾール―３―イルエチル―４―インドール―３―イルピペリジン

Country Status (16)

Country Link
EP (1) EP0879234A1 (es)
JP (1) JP2000503972A (es)
KR (1) KR19990081970A (es)
CN (1) CN1209807A (es)
AR (1) AR005549A1 (es)
AU (1) AU715785B2 (es)
BR (1) BR9707467A (es)
CA (1) CA2244136A1 (es)
CZ (1) CZ231898A3 (es)
DE (1) DE19602505A1 (es)
HU (1) HUP9900980A2 (es)
NO (1) NO983439L (es)
PL (1) PL328228A1 (es)
SK (1) SK99298A3 (es)
WO (1) WO1997027186A1 (es)
ZA (1) ZA97572B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014510133A (ja) * 2011-04-06 2014-04-24 エルジー・ライフ・サイエンシーズ・リミテッド １−（３−シアノ−１−イソプロピル−インドール−５−イル）ピラゾール−４−カルボン酸の結晶形とその製造方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1214312E (pt) * 1999-09-09 2004-08-31 Lundbeck & Co As H Indoles 5-aminoalquilo e 5-aminocarbonilo substituidos
HUP0203165A3 (en) 1999-11-10 2004-03-29 Takeda Pharmaceutical 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
US7332494B2 (en) 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
JP5140225B2 (ja) 2000-08-14 2013-02-06 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 置換ピラゾール
KR20050036882A (ko) * 2001-11-14 2005-04-20 메르크 파텐트 게엠베하 향정신제로서의 피라졸 유도체
CA2625611A1 (en) 2005-10-11 2007-04-19 F. Hoffman-La Roche Ag Imidazo benzodiazepine derivatives
JP2009515833A (ja) * 2005-10-24 2009-04-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ３−ピペリジン−４−イル−インドールｏｒｌ−１受容体モジュレーター
TW202225158A (zh) * 2020-11-04 2022-07-01 南韓商Ｌｇ化學股份有限公司 １－（３－氰基－１－異丙基－吲哚－５－基）吡唑－４－羧酸結晶之製備方法及包含彼之醫藥組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060816C3 (de) * 1970-12-10 1980-09-04 Merck Patent Gmbh, 6100 Darmstadt 4-Phenylpiperidinderivate Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen enthaltend diese Verbindungen
DE2258033A1 (de) * 1972-11-27 1974-05-30 Merck Patent Gmbh Verfahren zur herstellung von pyrazolderivaten
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5045550A (en) * 1990-09-20 1991-09-03 Warner-Lambert Co. Substituted tetrahydropyridines as central nervous system agents
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014510133A (ja) * 2011-04-06 2014-04-24 エルジー・ライフ・サイエンシーズ・リミテッド １−（３−シアノ−１−イソプロピル−インドール−５−イル）ピラゾール−４−カルボン酸の結晶形とその製造方法

Also Published As

Publication number Publication date
KR19990081970A (ko) 1999-11-15
SK99298A3 (en) 1999-01-11
NO983439D0 (no) 1998-07-24
ZA97572B (en) 1997-08-04
CZ231898A3 (cs) 1998-10-14
EP0879234A1 (de) 1998-11-25
AU715785B2 (en) 2000-02-10
BR9707467A (pt) 1999-07-20
DE19602505A1 (de) 1997-07-31
AU1443297A (en) 1997-08-20
AR005549A1 (es) 1999-06-23
NO983439L (no) 1998-09-25
WO1997027186A1 (de) 1997-07-31
CN1209807A (zh) 1999-03-03
HUP9900980A2 (hu) 1999-07-28
CA2244136A1 (en) 1997-07-31
PL328228A1 (en) 1999-01-18

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