CN120939219A - 用于在治疗癌症中增强效力的pd-1抑制剂和lag-3抑制剂的组合 - Google Patents

用于在治疗癌症中增强效力的pd-1抑制剂和lag-3抑制剂的组合

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Publication number
CN120939219A
CN120939219A CN202511166496.4A CN202511166496A CN120939219A CN 120939219 A CN120939219 A CN 120939219A CN 202511166496 A CN202511166496 A CN 202511166496A CN 120939219 A CN120939219 A CN 120939219A
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CN
China
Prior art keywords
antibody
lag
dose
cancer
patients
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202511166496.4A
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English (en)
Chinese (zh)
Inventor
G·克鲁格
T·N·西姆斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of CN120939219A publication Critical patent/CN120939219A/zh
Pending legal-status Critical Current

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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN202511166496.4A 2019-05-13 2020-05-12 用于在治疗癌症中增强效力的pd-1抑制剂和lag-3抑制剂的组合 Pending CN120939219A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962847068P 2019-05-13 2019-05-13
US62/847,068 2019-05-13
CN202080035740.2A CN113825527A (zh) 2019-05-13 2020-05-12 用于在治疗癌症中增强效力的pd-1抑制剂和lag-3抑制剂的组合
PCT/US2020/032515 WO2020232019A1 (en) 2019-05-13 2020-05-12 Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer

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CN120939219A true CN120939219A (zh) 2025-11-14

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CN202080035740.2A Pending CN113825527A (zh) 2019-05-13 2020-05-12 用于在治疗癌症中增强效力的pd-1抑制剂和lag-3抑制剂的组合

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US (1) US20220249659A1 (https=)
EP (1) EP3969040A1 (https=)
JP (2) JP2022532490A (https=)
KR (1) KR20220007593A (https=)
CN (2) CN120939219A (https=)
AU (1) AU2020276242B2 (https=)
BR (1) BR112021021713A2 (https=)
CA (1) CA3136568A1 (https=)
CL (1) CL2021002966A1 (https=)
EA (1) EA202192528A1 (https=)
IL (1) IL287728A (https=)
MA (1) MA55965A (https=)
MX (1) MX2021013815A (https=)
PH (1) PH12021552675A1 (https=)
SG (1) SG11202111262XA (https=)
WO (1) WO2020232019A1 (https=)

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