EA202192528A1 - Комбинация ингибиторов pd-1 и ингибиторов lag-3 для повышения эффективности при лечении рака - Google Patents

Комбинация ингибиторов pd-1 и ингибиторов lag-3 для повышения эффективности при лечении рака

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Publication number
EA202192528A1
EA202192528A1 EA202192528A EA202192528A EA202192528A1 EA 202192528 A1 EA202192528 A1 EA 202192528A1 EA 202192528 A EA202192528 A EA 202192528A EA 202192528 A EA202192528 A EA 202192528A EA 202192528 A1 EA202192528 A1 EA 202192528A1
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Prior art keywords
inhibitors
lag
combination
inhibitor
cancer treatment
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EA202192528A
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English (en)
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Гленн Круг
Таша Н. Симс
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Регенерон Фармасьютикалз, Инк.
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Publication of EA202192528A1 publication Critical patent/EA202192528A1/ru

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Abstract

Изобретение предусматривает способы лечения или подавления роста рака, включающие отбор пациента с раком и введение терапевтически эффективного количества ингибитора LAG-3 в комбинации с терапевтически эффективным количеством ингибитора PD-1 (например, антитела к PD-1 или его антигенсвязывающего фрагмента). В определенных вариантах осуществления введение ингибитора PD-1 повышает эффективность ингибитора LAG-3 (например, антитела к LAG-3 или его антигенсвязывающего фрагмента) при подавлении роста рака.
EA202192528A 2019-05-13 2020-05-12 Комбинация ингибиторов pd-1 и ингибиторов lag-3 для повышения эффективности при лечении рака EA202192528A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962847068P 2019-05-13 2019-05-13
PCT/US2020/032515 WO2020232019A1 (en) 2019-05-13 2020-05-12 Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer

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US (1) US20220249659A1 (ru)
EP (1) EP3969040A1 (ru)
JP (1) JP2022532490A (ru)
KR (1) KR20220007593A (ru)
CN (1) CN113825527A (ru)
AU (1) AU2020276242A1 (ru)
BR (1) BR112021021713A2 (ru)
CA (1) CA3136568A1 (ru)
CL (1) CL2021002966A1 (ru)
EA (1) EA202192528A1 (ru)
IL (1) IL287728A (ru)
MA (1) MA55965A (ru)
MX (1) MX2021013815A (ru)
SG (1) SG11202111262XA (ru)
WO (1) WO2020232019A1 (ru)

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WO2020232019A1 (en) 2020-11-19
SG11202111262XA (en) 2021-11-29
EP3969040A1 (en) 2022-03-23
KR20220007593A (ko) 2022-01-18
BR112021021713A2 (pt) 2022-04-19
US20220249659A1 (en) 2022-08-11
CA3136568A1 (en) 2020-11-19
MA55965A (fr) 2022-03-23
JP2022532490A (ja) 2022-07-15
CN113825527A (zh) 2021-12-21
MX2021013815A (es) 2021-12-14
AU2020276242A1 (en) 2021-12-02
IL287728A (en) 2021-12-01
CL2021002966A1 (es) 2022-08-26

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