CL2022003511A1 - Inhibidores de alk2 para el tratamiento de la anemia. - Google Patents
Inhibidores de alk2 para el tratamiento de la anemia.Info
- Publication number
- CL2022003511A1 CL2022003511A1 CL2022003511A CL2022003511A CL2022003511A1 CL 2022003511 A1 CL2022003511 A1 CL 2022003511A1 CL 2022003511 A CL2022003511 A CL 2022003511A CL 2022003511 A CL2022003511 A CL 2022003511A CL 2022003511 A1 CL2022003511 A1 CL 2022003511A1
- Authority
- CL
- Chile
- Prior art keywords
- anemia
- treatment
- alk2 inhibitors
- alk2
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
En el presente documento se proporcionan métodos para tratar la anemia en un sujeto que lo necesita, que comprenden administrar al sujeto una cantidad terapéuticamente eficaz de un inhibidor de ALK2.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063039742P | 2020-06-16 | 2020-06-16 | |
US202063056761P | 2020-07-27 | 2020-07-27 | |
US202163152516P | 2021-02-23 | 2021-02-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2022003511A1 true CL2022003511A1 (es) | 2023-06-02 |
Family
ID=76845323
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2022003511A CL2022003511A1 (es) | 2020-06-16 | 2022-12-09 | Inhibidores de alk2 para el tratamiento de la anemia. |
CL2023001952A CL2023001952A1 (es) | 2020-06-16 | 2023-06-30 | Inhibidores de alk2 para el tratamiento de la anemia (divisional). |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2023001952A CL2023001952A1 (es) | 2020-06-16 | 2023-06-30 | Inhibidores de alk2 para el tratamiento de la anemia (divisional). |
Country Status (12)
Country | Link |
---|---|
US (2) | US11723899B2 (es) |
EP (1) | EP4164641A1 (es) |
JP (1) | JP2023530316A (es) |
KR (1) | KR20230025444A (es) |
CN (1) | CN115968289A (es) |
AU (1) | AU2021292484A1 (es) |
CA (1) | CA3187767A1 (es) |
CL (2) | CL2022003511A1 (es) |
IL (1) | IL298767A (es) |
MX (1) | MX2022015900A (es) |
TW (1) | TW202214239A (es) |
WO (1) | WO2021257532A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2023502742A (ja) | 2019-11-22 | 2023-01-25 | インサイト コーポレーション | Alk2阻害剤及びjak2阻害剤を含む併用療法 |
IL298767A (en) | 2020-06-16 | 2023-02-01 | Incyte Corp | ALK2 inhibitors for the treatment of anemia |
WO2022240948A1 (en) * | 2021-05-11 | 2022-11-17 | Keros Therapeutics, Inc. | Methods of using alk2 and alk3 antibodies |
WO2023198114A1 (zh) * | 2022-04-13 | 2023-10-19 | 杭州邦顺制药有限公司 | Alk2激酶抑制剂 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
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US5077290A (en) | 1990-10-11 | 1991-12-31 | Merck & Co., Inc. | Morpholine derivatives compositions and use |
TW530054B (en) | 1997-09-24 | 2003-05-01 | Duphar Int Res | New piperazine and piperidine compounds |
SE0102439D0 (sv) | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
CA2484209C (en) | 2002-05-03 | 2013-06-11 | Exelixis, Inc. | Protein kinase modulators and methods of use |
AU2003249369A1 (en) | 2002-06-21 | 2004-01-06 | Cellular Genomics, Inc. | Certain amino-substituted monocycles as kinase modulators |
US20040067985A1 (en) | 2002-10-04 | 2004-04-08 | Fortuna Haviv | Method of inhibiting angiogenesis |
SE0203753D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
AU2004230519A1 (en) | 2003-04-11 | 2004-10-28 | Sgx Pharmaceuticals, Inc. | Compound libraries and methods for drug discovery |
CA2567935C (en) | 2004-05-27 | 2009-10-27 | Pfizer Limited | Aminopyridine derivatives as selective dopamine d3 agonists |
SA05260265A (ar) | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
EP1875912A4 (en) | 2005-04-08 | 2008-06-04 | Eisai R&D Man Co Ltd | MEANS OF TREATING UNWILLING MOVEMENTS |
WO2007011760A2 (en) | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
AR059036A1 (es) | 2006-01-17 | 2008-03-12 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
WO2008002671A2 (en) | 2006-06-29 | 2008-01-03 | Alantos Pharmaceuticals Holding, Inc. | Metalloprotease inhibitors |
AU2009271414A1 (en) | 2008-06-20 | 2010-01-21 | Metabolex, Inc. | Aryl GPR119 agonists and uses thereof |
WO2012088438A1 (en) | 2010-12-22 | 2012-06-28 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
LT2714677T (lt) | 2011-05-23 | 2018-12-10 | Merck Patent Gmbh | Piridino ir pirazino dariniai |
SG2014013767A (en) | 2011-09-09 | 2014-05-29 | Lantheus Medical Imaging Inc | Compositions, methods, and systems for the synthesis and use of imaging agents |
US9738636B2 (en) | 2012-09-28 | 2017-08-22 | Vanderbilt University | Fused heterocyclic compounds as selective BMP inhibitors |
US20160115167A1 (en) | 2013-03-04 | 2016-04-28 | The Brigham And Women's Hospital, Inc. | Bmp inhibitors and methods of use thereof |
WO2014151871A2 (en) | 2013-03-14 | 2014-09-25 | Tolero Pharmaceuticals, Inc. | Jak2 and alk2 inhibitors and methods for their use |
RS59140B1 (sr) | 2013-10-21 | 2019-09-30 | Merck Patent Gmbh | Heteroarilna jedinjenja kao inhibitori btk i njihova upotreba |
MX2017009408A (es) | 2015-01-20 | 2017-10-02 | Merial Inc | Compuestos antihelminticos, composiciones y metodo para usar los mismos. |
BR112018004065B1 (pt) | 2015-08-31 | 2023-12-12 | Dong-A Socio Holdings Co., Ltd | Compostos heterocíclicos, composições farmacêuticas compreendendo os ditos compostos e usos terapêuticos dos mesmos |
WO2018014829A1 (en) | 2016-07-20 | 2018-01-25 | Novartis Ag | Aminopyridine derivatives and their use as selective alk-2 inhibitors |
WO2018106820A1 (en) | 2016-12-07 | 2018-06-14 | Kura Oncology, Inc. | Methods of promoting beta cell proliferation |
US20220372136A1 (en) | 2019-09-27 | 2022-11-24 | Disc Medicine, Inc. | Methods for treating anemia of chronic disease |
WO2021062163A1 (en) | 2019-09-27 | 2021-04-01 | Disc Medicine, Inc. | Methods for treating myelofibrosis and related conditions |
JP2023502742A (ja) | 2019-11-22 | 2023-01-25 | インサイト コーポレーション | Alk2阻害剤及びjak2阻害剤を含む併用療法 |
IL298767A (en) | 2020-06-16 | 2023-02-01 | Incyte Corp | ALK2 inhibitors for the treatment of anemia |
-
2021
- 2021-06-15 IL IL298767A patent/IL298767A/en unknown
- 2021-06-15 JP JP2022577319A patent/JP2023530316A/ja active Pending
- 2021-06-15 TW TW110121744A patent/TW202214239A/zh unknown
- 2021-06-15 EP EP21739843.7A patent/EP4164641A1/en active Pending
- 2021-06-15 US US17/348,102 patent/US11723899B2/en active Active
- 2021-06-15 WO PCT/US2021/037377 patent/WO2021257532A1/en unknown
- 2021-06-15 CA CA3187767A patent/CA3187767A1/en active Pending
- 2021-06-15 KR KR1020237001508A patent/KR20230025444A/ko unknown
- 2021-06-15 MX MX2022015900A patent/MX2022015900A/es unknown
- 2021-06-15 CN CN202180042461.3A patent/CN115968289A/zh active Pending
- 2021-06-15 AU AU2021292484A patent/AU2021292484A1/en active Pending
-
2022
- 2022-12-09 CL CL2022003511A patent/CL2022003511A1/es unknown
-
2023
- 2023-06-28 US US18/343,267 patent/US20230338352A1/en active Pending
- 2023-06-30 CL CL2023001952A patent/CL2023001952A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
TW202214239A (zh) | 2022-04-16 |
US20230338352A1 (en) | 2023-10-26 |
WO2021257532A1 (en) | 2021-12-23 |
CL2023001952A1 (es) | 2023-12-15 |
US11723899B2 (en) | 2023-08-15 |
CA3187767A1 (en) | 2021-12-23 |
MX2022015900A (es) | 2023-01-24 |
US20210393605A1 (en) | 2021-12-23 |
AU2021292484A1 (en) | 2023-01-19 |
IL298767A (en) | 2023-02-01 |
EP4164641A1 (en) | 2023-04-19 |
KR20230025444A (ko) | 2023-02-21 |
JP2023530316A (ja) | 2023-07-14 |
CN115968289A (zh) | 2023-04-14 |
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