DOP2020000209A - Métodos para tratar cánceres y potenciar la eficacia de agentes terapéuticos para el redireccionamiento de células t - Google Patents

Métodos para tratar cánceres y potenciar la eficacia de agentes terapéuticos para el redireccionamiento de células t

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Publication number
DOP2020000209A
DOP2020000209A DO2020000209A DO2020000209A DOP2020000209A DO P2020000209 A DOP2020000209 A DO P2020000209A DO 2020000209 A DO2020000209 A DO 2020000209A DO 2020000209 A DO2020000209 A DO 2020000209A DO P2020000209 A DOP2020000209 A DO P2020000209A
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DO
Dominican Republic
Prior art keywords
antibody
subject
provides
disclosure
cancer
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DO2020000209A
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English (en)
Inventor
Gaudet Francois
Adams Homer
Van de Donk Niels
Verleij Christie
Frerichs Kris
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Janssen Biotech Inc
Stichting Vumc
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Application filed by Janssen Biotech Inc, Stichting Vumc filed Critical Janssen Biotech Inc
Publication of DOP2020000209A publication Critical patent/DOP2020000209A/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

La descripción proporciona métodos para tratar un cáncer y/o destruir células tumorales en un sujeto, que comprende administrar una cantidad terapéuticamente eficaz de un anticuerpo anti-CD38 y un agente terapéutico para el redireccionamiento de células T al sujeto para tratar el cáncer. La presente descripción proporciona un método para potenciar la eficacia de un agente terapéutico para el redireccionamiento de células T en un sujeto que tiene un cáncer, que comprende administrar al sujeto un anticuerpo anti-CD38. La descripción también proporciona un método para tratar un mieloma múltiple en un sujeto, que comprende administrar una cantidad terapéuticamente eficaz de un anticuerpo biespecífico BCMAxCDS y un anticuerpo anti-CD38 al sujeto para tratar el mieloma múltiple. La descripción también proporciona una combinación farmacéutica que comprende un anticuerpo biespecífico GPRC5DxCD3. La descripción también proporciona un kit que comprende una composición farmacéutica que comprende un anticuerpo biespecífico BCMAxCD3 y un anticuerpo anti-CD38.
DO2020000209A 2018-05-16 2020-11-13 Métodos para tratar cánceres y potenciar la eficacia de agentes terapéuticos para el redireccionamiento de células t DOP2020000209A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862672222P 2018-05-16 2018-05-16
US201862736804P 2018-09-26 2018-09-26
US201962842080P 2019-05-02 2019-05-02
PCT/IB2019/054034 WO2019220369A2 (en) 2018-05-16 2019-05-15 Methods of treating cancers and enhancing efficacy of t cell redirecting therapeutics

Publications (1)

Publication Number Publication Date
DOP2020000209A true DOP2020000209A (es) 2021-09-30

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DO2020000209A DOP2020000209A (es) 2018-05-16 2020-11-13 Métodos para tratar cánceres y potenciar la eficacia de agentes terapéuticos para el redireccionamiento de células t

Country Status (18)

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US (3) US20190352421A1 (es)
EP (2) EP3793599A1 (es)
JP (4) JP7395508B2 (es)
KR (2) KR20220080044A (es)
CN (2) CN112368019A (es)
AU (4) AU2019270624B2 (es)
BR (2) BR112020023264A2 (es)
CA (2) CA3100118A1 (es)
CL (2) CL2020002945A1 (es)
DO (1) DOP2020000209A (es)
JO (1) JOP20200292A1 (es)
MA (2) MA52640A (es)
MX (2) MX2020012286A (es)
PH (2) PH12020551908A1 (es)
SG (2) SG11202010977QA (es)
TW (2) TW202012442A (es)
UY (2) UY38235A (es)
WO (2) WO2019220368A1 (es)

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