CA3136568A1 - Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer - Google Patents

Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer Download PDF

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Publication number
CA3136568A1
CA3136568A1 CA3136568A CA3136568A CA3136568A1 CA 3136568 A1 CA3136568 A1 CA 3136568A1 CA 3136568 A CA3136568 A CA 3136568A CA 3136568 A CA3136568 A CA 3136568A CA 3136568 A1 CA3136568 A1 CA 3136568A1
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Prior art keywords
antibody
cancer
lag
dose
tumor
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Pending
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CA3136568A
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English (en)
French (fr)
Inventor
Glenn KROOG
Tasha N. Sims
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of CA3136568A1 publication Critical patent/CA3136568A1/en
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3136568A 2019-05-13 2020-05-12 Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer Pending CA3136568A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962847068P 2019-05-13 2019-05-13
US62/847,068 2019-05-13
PCT/US2020/032515 WO2020232019A1 (en) 2019-05-13 2020-05-12 Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer

Publications (1)

Publication Number Publication Date
CA3136568A1 true CA3136568A1 (en) 2020-11-19

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Application Number Title Priority Date Filing Date
CA3136568A Pending CA3136568A1 (en) 2019-05-13 2020-05-12 Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer

Country Status (16)

Country Link
US (1) US20220249659A1 (https=)
EP (1) EP3969040A1 (https=)
JP (2) JP2022532490A (https=)
KR (1) KR20220007593A (https=)
CN (2) CN120939219A (https=)
AU (1) AU2020276242B2 (https=)
BR (1) BR112021021713A2 (https=)
CA (1) CA3136568A1 (https=)
CL (1) CL2021002966A1 (https=)
EA (1) EA202192528A1 (https=)
IL (1) IL287728A (https=)
MA (1) MA55965A (https=)
MX (1) MX2021013815A (https=)
PH (1) PH12021552675A1 (https=)
SG (1) SG11202111262XA (https=)
WO (1) WO2020232019A1 (https=)

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CN115845052B (zh) * 2022-12-28 2023-12-29 广州誉衡生物科技有限公司 一种药物组合物和药物制剂及其在治疗结肠癌中的应用
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AU2020276242B2 (en) 2025-01-30
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JP2022532490A (ja) 2022-07-15
CN113825527A (zh) 2021-12-21
BR112021021713A2 (pt) 2022-04-19
WO2020232019A1 (en) 2020-11-19
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IL287728A (en) 2021-12-01
US20220249659A1 (en) 2022-08-11
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