CN1199968C - 新的地洛他定盐、其合成方法及其药物组合物 - Google Patents

新的地洛他定盐、其合成方法及其药物组合物 Download PDF

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Publication number
CN1199968C
CN1199968C CNB018193382A CN01819338A CN1199968C CN 1199968 C CN1199968 C CN 1199968C CN B018193382 A CNB018193382 A CN B018193382A CN 01819338 A CN01819338 A CN 01819338A CN 1199968 C CN1199968 C CN 1199968C
Authority
CN
China
Prior art keywords
formula
desloratadine
acid
loratadine
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB018193382A
Other languages
English (en)
Chinese (zh)
Other versions
CN1476443A (zh
Inventor
J·菲舍尔
T·福多尔
F·特里施勒
S·莱瓦伊
E·派泰尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HUANGARY GIRUI GYOGYSZERGYAR
Original Assignee
HUANGARY GIRUI GYOGYSZERGYAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HUANGARY GIRUI GYOGYSZERGYAR filed Critical HUANGARY GIRUI GYOGYSZERGYAR
Publication of CN1476443A publication Critical patent/CN1476443A/zh
Application granted granted Critical
Publication of CN1199968C publication Critical patent/CN1199968C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB018193382A 2000-11-23 2001-11-14 新的地洛他定盐、其合成方法及其药物组合物 Expired - Lifetime CN1199968C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP0004701 2000-11-23
HU0004701A HU226998B1 (en) 2000-11-23 2000-11-23 Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same

Publications (2)

Publication Number Publication Date
CN1476443A CN1476443A (zh) 2004-02-18
CN1199968C true CN1199968C (zh) 2005-05-04

Family

ID=89978790

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018193382A Expired - Lifetime CN1199968C (zh) 2000-11-23 2001-11-14 新的地洛他定盐、其合成方法及其药物组合物

Country Status (19)

Country Link
US (1) US7196195B2 (cg-RX-API-DMAC7.html)
EP (1) EP1347965B1 (cg-RX-API-DMAC7.html)
JP (1) JP4427249B2 (cg-RX-API-DMAC7.html)
CN (1) CN1199968C (cg-RX-API-DMAC7.html)
AT (1) ATE316525T1 (cg-RX-API-DMAC7.html)
AU (1) AU2002218422A1 (cg-RX-API-DMAC7.html)
CA (1) CA2425422C (cg-RX-API-DMAC7.html)
CY (1) CY1105595T1 (cg-RX-API-DMAC7.html)
CZ (1) CZ304694B6 (cg-RX-API-DMAC7.html)
DE (1) DE60116902T2 (cg-RX-API-DMAC7.html)
DK (1) DK1347965T3 (cg-RX-API-DMAC7.html)
ES (1) ES2257467T3 (cg-RX-API-DMAC7.html)
HU (1) HU226998B1 (cg-RX-API-DMAC7.html)
NO (1) NO325155B1 (cg-RX-API-DMAC7.html)
PL (1) PL206973B1 (cg-RX-API-DMAC7.html)
RU (1) RU2285001C2 (cg-RX-API-DMAC7.html)
SK (1) SK285715B6 (cg-RX-API-DMAC7.html)
UA (1) UA74858C2 (cg-RX-API-DMAC7.html)
WO (1) WO2002042290A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003086275A2 (en) * 2002-04-15 2003-10-23 Sun Pharmaceutical Industries Limited Preperation of desloratatine
MXPA05001470A (es) * 2002-08-05 2005-09-30 Sandoz Ag Sal novedosa y polimorfos de hemifumarato de desloratadina.
JP4501015B2 (ja) 2004-03-17 2010-07-14 味の素株式会社 アミノピリミジン化合物の製造方法
CZ200798A3 (cs) * 2004-07-07 2007-06-20 Egis Gyogyszergyár Nyrt. Nový pseudopolymorf desloratadinu vytvorený s oxidem uhlicitým
CA2541045A1 (en) * 2006-03-24 2007-09-24 Pharmascience Inc. A descarbonylethoxyloratadine containing pharmaceutical composition
EP2837631A1 (en) 2013-08-14 2015-02-18 Merck & Cie New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid
MX2022005102A (es) * 2019-10-31 2022-05-30 Jd Bioscience Inc Compuesto triciclico y uso farmaceutico del mismo.
CN115785065A (zh) * 2022-12-02 2023-03-14 山东达因海洋生物制药股份有限公司 一种地氯雷他定共晶及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
JPS61501205A (ja) * 1984-02-15 1986-06-19 シェリング・コ−ポレ−ション ８↓−クロル↓−６，１１↓−ジヒドロ↓−１１↓−（４↓−ピペリジリデン）↓−５Ｈ↓−ベンゾ〔５，６〕シクロヘプタ〔１，２−ｂ〕ピリジンおよびその塩、これらの化合物の製造方法、ならびにこれらの化合物を含有する医薬組成物
DE3677842D1 (de) * 1985-05-13 1991-04-11 Schering Corp Verfahren zur herstellung von piperidyliden-dihydrodibenzo(a,d)zykloheptenen und deren azoderivate, so hergestellte verbindungen und ihre anwendung zur vorbereitung von heilmitteln.
DE59409322D1 (de) * 1993-12-03 2000-06-08 Hoffmann La Roche Essigsäurederivate als Arzneimittel
GB9709945D0 (en) * 1997-05-17 1997-07-09 Glaxo Group Ltd A novel salt
AU2276801A (en) * 1999-12-20 2001-07-03 Schering Corporation Extended release oral dosage composition
RU2164796C1 (ru) * 2000-05-25 2001-04-10 Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" Противогистаминное средство и способ его получения

Also Published As

Publication number Publication date
EP1347965B1 (en) 2006-01-25
CA2425422A1 (en) 2002-05-30
NO20032314D0 (no) 2003-05-22
SK285715B6 (sk) 2007-06-07
CN1476443A (zh) 2004-02-18
JP2004514675A (ja) 2004-05-20
NO20032314L (no) 2003-07-18
PL362126A1 (en) 2004-10-18
DE60116902T2 (de) 2006-08-24
CZ304694B6 (cs) 2014-09-03
PL206973B1 (pl) 2010-10-29
EP1347965A1 (en) 2003-10-01
AU2002218422A1 (en) 2002-06-03
DE60116902D1 (de) 2006-04-13
US7196195B2 (en) 2007-03-27
CZ20031321A3 (cs) 2003-08-13
CY1105595T1 (el) 2010-07-28
ATE316525T1 (de) 2006-02-15
DK1347965T3 (da) 2006-06-06
HU0004701D0 (cg-RX-API-DMAC7.html) 2001-02-28
UA74858C2 (en) 2006-02-15
JP4427249B2 (ja) 2010-03-03
NO325155B1 (no) 2008-02-11
WO2002042290A1 (en) 2002-05-30
HUP0004701A2 (hu) 2002-11-28
ES2257467T3 (es) 2006-08-01
HU226998B1 (en) 2010-04-28
RU2285001C2 (ru) 2006-10-10
US20050203116A1 (en) 2005-09-15
SK5662003A3 (en) 2003-10-07
CA2425422C (en) 2009-11-10

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GR01 Patent grant
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CX01 Expiry of patent term

Granted publication date: 20050504