CN1198836C - 编码与感觉转导有关的g－蛋白偶联受体的核酸 - Google Patents

编码与感觉转导有关的g－蛋白偶联受体的核酸 Download PDF

Info

Publication number
CN1198836C
CN1198836C CNB998105252A CN99810525A CN1198836C CN 1198836 C CN1198836 C CN 1198836C CN B998105252 A CNB998105252 A CN B998105252A CN 99810525 A CN99810525 A CN 99810525A CN 1198836 C CN1198836 C CN 1198836C
Authority
CN
China
Prior art keywords
nucleic acid
seq
gpcr
sequence
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB998105252A
Other languages
English (en)
Chinese (zh)
Other versions
CN1317010A (zh
Inventor
C·S·朱克
J·E·阿德莱尔
J·林德迈耶
N·里巴
M·胡恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
US Department of Health and Human Services
Original Assignee
University of California San Diego UCSD
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD, US Department of Health and Human Services filed Critical University of California San Diego UCSD
Publication of CN1317010A publication Critical patent/CN1317010A/zh
Application granted granted Critical
Publication of CN1198836C publication Critical patent/CN1198836C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNB998105252A 1998-07-28 1999-07-27 编码与感觉转导有关的g－蛋白偶联受体的核酸 Expired - Lifetime CN1198836C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9446598P 1998-07-28 1998-07-28
US60/094,465 1998-07-28

Publications (2)

Publication Number Publication Date
CN1317010A CN1317010A (zh) 2001-10-10
CN1198836C true CN1198836C (zh) 2005-04-27

Family

ID=22245353

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998105252A Expired - Lifetime CN1198836C (zh) 1998-07-28 1999-07-27 编码与感觉转导有关的g－蛋白偶联受体的核酸

Country Status (12)

Country Link
US (3) US20030036630A1 (enExample)
EP (1) EP1100810A4 (enExample)
JP (2) JP2002521049A (enExample)
KR (1) KR100602857B1 (enExample)
CN (1) CN1198836C (enExample)
AU (1) AU753703B2 (enExample)
BR (1) BR9912545A (enExample)
CA (2) CA2335318C (enExample)
IL (2) IL140979A0 (enExample)
NO (1) NO20010363L (enExample)
WO (1) WO2000006592A1 (enExample)
ZA (1) ZA200100401B (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
AU2976000A (en) * 1999-01-27 2000-08-18 Regents Of The University Of California, The Assays for sensory modulators using a sensory cell specific g-pr otein beta subunit
US6929925B1 (en) 1999-01-27 2005-08-16 The Regents Of The University Of California Assays for sensory modulators using a sensory cell specific G-protein beta subunit
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
ATE366261T1 (de) * 2000-03-28 2007-07-15 Lexicon Genetics Inc Humane 7-transmembranproteine und dafür codierende polynukleotide
EP1301595A2 (en) * 2000-05-22 2003-04-16 Incyte Genomics, Inc. G-protein coupled receptors
AU2001266975A1 (en) * 2000-06-16 2002-01-02 Incyte Genomics, Inc. G-protein coupled receptors
CA2424821A1 (en) * 2000-10-10 2002-04-18 Pe Corporation (Ny) Gene encoding a human g-protein coupled receptor and its use
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7301009B2 (en) 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US7309577B2 (en) 2001-03-07 2007-12-18 Senomyx, Inc. Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste
US20080244761A1 (en) 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
WO2002086079A2 (en) * 2001-04-20 2002-10-31 Mount Sinai School Of Medicine T1r3 a novel taste receptor
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
EP2327985B2 (en) 2001-06-26 2019-08-21 Senomyx, Inc. T1R Hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
JP5001512B2 (ja) * 2001-06-26 2012-08-15 セノミックス インコーポレイテッド Ｔ１ｒヘテロオリゴマー味覚受容体及び前記受容体を発現する細胞系並びに味覚化合物の特定のためのその使用
WO2003025137A2 (en) * 2001-09-18 2003-03-27 Irm, Llc Sweet taste receptors
AU2004256023B2 (en) 2003-06-27 2008-03-13 Monell Chemical Senses Center Taste receptors of the T1R family from domestic cat
NZ619746A (en) 2003-08-06 2014-05-30 Senomyx Inc Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
US8796441B2 (en) 2005-04-13 2014-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human sweet and umami taste receptor variants
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US20110097741A1 (en) * 2006-04-20 2011-04-28 Jay Patrick Slack Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays
US8148536B2 (en) 2006-04-21 2012-04-03 Senomyx, Inc. Comestible compositions comprising high potency savory flavorants, and processes for producing them
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
WO2013022948A1 (en) 2011-08-08 2013-02-14 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives
WO2021150686A1 (en) 2020-01-22 2021-07-29 Firmenich Incorporated High-sensitivity detection of gpcr activity and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146501A (en) * 1975-12-12 1979-03-27 Henkin Robert I Process for isolating and purifying taste bud receptors for screening and evaluating tastants
US5688662A (en) * 1992-04-09 1997-11-18 Linguagen Corporation Gustducin polynucleotides, vectors, host cells and recombinant methods
US7368285B2 (en) * 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
KR101511394B1 (ko) * 2007-01-18 2015-04-10 지보당 에스아 키메라 우마미 미각 수용체, 이를 코딩하는 핵산 및 이의 용도

Also Published As

Publication number Publication date
CA2335318A1 (en) 2000-02-10
NO20010363D0 (no) 2001-01-22
WO2000006592A1 (en) 2000-02-10
ZA200100401B (en) 2001-10-31
CA2776054A1 (en) 2000-02-10
JP2002521049A (ja) 2002-07-16
CA2776054C (en) 2016-08-30
AU5238199A (en) 2000-02-21
WO2000006592A9 (en) 2000-11-02
BR9912545A (pt) 2001-10-30
JP2009261399A (ja) 2009-11-12
CN1317010A (zh) 2001-10-10
EP1100810A4 (en) 2002-09-18
CA2335318C (en) 2012-05-01
US20070185312A1 (en) 2007-08-09
IL140979A0 (en) 2002-02-10
EP1100810A1 (en) 2001-05-23
NO20010363L (no) 2001-03-26
US20030036630A1 (en) 2003-02-20
US20090148948A1 (en) 2009-06-11
KR20010085306A (ko) 2001-09-07
AU753703B2 (en) 2002-10-24
IL140979A (en) 2008-07-08
KR100602857B1 (ko) 2006-07-20

Similar Documents

Publication Publication Date Title
CN1198836C (zh) 编码与感觉转导有关的g－蛋白偶联受体的核酸
CN1318068A (zh) 编码与感觉转导有关的g－蛋白偶联受体的核酸
CN1387536A (zh) T2r,一类新味觉受体
CN1543474A (zh) T1r味觉受体及其编码基因
CN1317044A (zh) 编码与感觉转导有关的蛋白质的核酸
CN1525981B (zh) T1r味觉受体及其编码基因
CN1105187C (zh) 原钙粘着蛋白蛋白质及其应用
CN1434921A (zh) T2r味觉受体及其编码基因
CN101058605A (zh) T2r，一类味觉受体
CN1520516A (zh) T1r异源寡聚的味觉受体和表达所述受体的细胞系及其在鉴定味觉化合物中的用途
CN1284966A (zh) 新型g蛋白偶联受体
CN1155299A (zh) G蛋白偶联受体蛋白质及其产生方法和用途
CN1094446A (zh) Eck受体配体
CN1809587A (zh) 涉及g－蛋白偶联受体寡聚体的材料和方法
CN1842709A (zh) 使用表达人的ENaC的卵母细胞的改进的电生理测定法和用于在使用膜电位报告染料的测定中提高ENaC增强子功效的PHENAMIL的用途
CN1445236A (zh) 促进毛发生长的寡肽
CN1135771A (zh) 编码骨形态形成蛋白受体的脱氧核糖核酸序列
CN1171816A (zh) 编码骨形态形成蛋白ii型受体的互补脱氧核糖核酸
CN101046475A (zh) 激酶活性的测定方法及测定用试剂盒
CN1609616A (zh) 糖尿病的特异性标记
CN1321164A (zh) 编码与感觉转导有关的G蛋白γ亚基的核酸
JP2012502654A (ja) チャイニーズハムスター卵巣細胞系
CN101052725A (zh) T1r异寡聚味觉受体、表达所述受体的细胞系和味觉化合物
CN1277616A (zh) 能抑制早老素和β-淀粉样肽或其前体间相互作用的肽
CN1195374A (zh) 整合素调节/信号传递的细胞质调节剂

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term

Granted publication date: 20050427

CX01 Expiry of patent term