CN119528824A - 2-氧代喹唑啉衍生物作为甲硫氨酸腺苷转移酶2a抑制剂 - Google Patents

2-氧代喹唑啉衍生物作为甲硫氨酸腺苷转移酶2a抑制剂 Download PDF

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Publication number
CN119528824A
CN119528824A CN202411684986.9A CN202411684986A CN119528824A CN 119528824 A CN119528824 A CN 119528824A CN 202411684986 A CN202411684986 A CN 202411684986A CN 119528824 A CN119528824 A CN 119528824A
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heterocyclyl
cycloalkyl
alkyl
compound
heteroaryl
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Chinese (zh)
Inventor
M·阿拉姆
L·克利里
M·弗勒里
裴中华
R·斯蒂尔
J·萨顿
J·E·诺克斯
Z·E·R·纽伯
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Idia Bioscience Co ltd
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Idia Bioscience Co ltd
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN202411684986.9A 2018-12-10 2019-12-09 2-氧代喹唑啉衍生物作为甲硫氨酸腺苷转移酶2a抑制剂 Pending CN119528824A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201862777715P 2018-12-10 2018-12-10
US62/777,715 2018-12-10
US201962835853P 2019-04-18 2019-04-18
US62/835,853 2019-04-18
US201962883945P 2019-08-07 2019-08-07
US62/883,945 2019-08-07
CN201980081299.9A CN113166078B (zh) 2018-12-10 2019-12-09 2-氧代喹唑啉衍生物作为甲硫氨酸腺苷转移酶2a抑制剂
PCT/US2019/065260 WO2020123395A1 (en) 2018-12-10 2019-12-09 2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors

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CN201980081299.9A Active CN113166078B (zh) 2018-12-10 2019-12-09 2-氧代喹唑啉衍生物作为甲硫氨酸腺苷转移酶2a抑制剂

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US (4) US12503467B2 (https=)
EP (1) EP3894396A1 (https=)
JP (2) JP7688578B2 (https=)
KR (1) KR20210103498A (https=)
CN (2) CN119528824A (https=)
AU (1) AU2019395338B2 (https=)
BR (1) BR112021010842A2 (https=)
CA (1) CA3121236A1 (https=)
CL (1) CL2021001508A1 (https=)
CO (1) CO2021008895A2 (https=)
IL (1) IL283743A (https=)
MA (1) MA54452A (https=)
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PH (1) PH12021551274A1 (https=)
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