TWI863945B - 2-側氧基喹唑啉衍生物作為甲硫胺酸腺苷基轉移酶２ａ抑制劑 - Google Patents

2-側氧基喹唑啉衍生物作為甲硫胺酸腺苷基轉移酶２ａ抑制劑 Download PDF

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TWI863945B
TWI863945B TW108145188A TW108145188A TWI863945B TW I863945 B TWI863945 B TW I863945B TW 108145188 A TW108145188 A TW 108145188A TW 108145188 A TW108145188 A TW 108145188A TW I863945 B TWI863945 B TW I863945B
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group
alkyl
amino
quinazolin
cycloalkyl
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TW108145188A
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TW202039487A (zh
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姆賽法 阿朗
麗 克麗瑞
瑪莉莎 佛利瑞
中華 裴
理查 史地爾
詹姆士 薩登
約翰 Ｅ 納克斯
柴查瑞 Ｅ Ｒ 紐比
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美商愛德亞生物科學公司
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW108145188A 2018-12-10 2019-12-10 2-側氧基喹唑啉衍生物作為甲硫胺酸腺苷基轉移酶２ａ抑制劑 TWI863945B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862777715P 2018-12-10 2018-12-10
US62/777,715 2018-12-10
US201962835853P 2019-04-18 2019-04-18
US62/835,853 2019-04-18
US201962883945P 2019-08-07 2019-08-07
US62/883,945 2019-08-07

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TW202039487A TW202039487A (zh) 2020-11-01
TWI863945B true TWI863945B (zh) 2024-12-01

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US (4) US12503467B2 (https=)
EP (1) EP3894396A1 (https=)
JP (2) JP7688578B2 (https=)
KR (1) KR20210103498A (https=)
CN (2) CN119528824A (https=)
AU (1) AU2019395338B2 (https=)
BR (1) BR112021010842A2 (https=)
CA (1) CA3121236A1 (https=)
CL (1) CL2021001508A1 (https=)
CO (1) CO2021008895A2 (https=)
IL (1) IL283743A (https=)
MA (1) MA54452A (https=)
MX (1) MX2021006841A (https=)
PH (1) PH12021551274A1 (https=)
SG (1) SG11202105469YA (https=)
TW (1) TWI863945B (https=)
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