MA54452A - Dérivés de 2-oxoquinazoline utilisés en tant qu'inhibiteurs de la méthionine adénosyltransférase 2a - Google Patents
Dérivés de 2-oxoquinazoline utilisés en tant qu'inhibiteurs de la méthionine adénosyltransférase 2aInfo
- Publication number
- MA54452A MA54452A MA054452A MA54452A MA54452A MA 54452 A MA54452 A MA 54452A MA 054452 A MA054452 A MA 054452A MA 54452 A MA54452 A MA 54452A MA 54452 A MA54452 A MA 54452A
- Authority
- MA
- Morocco
- Prior art keywords
- inhibitors
- derivatives used
- methionine adenosyltransferase
- oxoquinazoline derivatives
- oxoquinazoline
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862777715P | 2018-12-10 | 2018-12-10 | |
US201962835853P | 2019-04-18 | 2019-04-18 | |
US201962883945P | 2019-08-07 | 2019-08-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA54452A true MA54452A (fr) | 2022-03-16 |
Family
ID=69138003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA054452A MA54452A (fr) | 2018-12-10 | 2019-12-09 | Dérivés de 2-oxoquinazoline utilisés en tant qu'inhibiteurs de la méthionine adénosyltransférase 2a |
Country Status (17)
Country | Link |
---|---|
US (4) | US20220106276A1 (fr) |
EP (1) | EP3894396A1 (fr) |
JP (1) | JP2022512156A (fr) |
KR (1) | KR20210103498A (fr) |
CN (1) | CN113166078A (fr) |
AU (1) | AU2019395338A1 (fr) |
BR (1) | BR112021010842A2 (fr) |
CA (1) | CA3121236A1 (fr) |
CL (1) | CL2021001508A1 (fr) |
CO (1) | CO2021008895A2 (fr) |
IL (1) | IL283743A (fr) |
MA (1) | MA54452A (fr) |
MX (1) | MX2021006841A (fr) |
PH (1) | PH12021551274A1 (fr) |
SG (1) | SG11202105469YA (fr) |
TW (1) | TW202039487A (fr) |
WO (1) | WO2020123395A1 (fr) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021252678A1 (fr) * | 2020-06-10 | 2021-12-16 | Ideaya Biosciences, Inc. | Dérivés de 2-oxoquinazoline substitués par un alkylène hétéroaryle utilisés en tant qu'inhibiteurs de la méthionine adénosyltransférase 2a |
PE20230685A1 (es) * | 2020-06-22 | 2023-04-21 | Hoffmann La Roche | Derivados de amidopirimidona |
CR20220644A (es) * | 2020-06-22 | 2023-02-17 | Hoffmann La Roche | Derivados de sulfona |
WO2021254529A1 (fr) * | 2020-07-14 | 2021-12-23 | 江苏先声药业有限公司 | Composé bicyclique |
WO2022063128A1 (fr) * | 2020-09-24 | 2022-03-31 | 上海凌达生物医药有限公司 | Composé de pyridone cyclique ou arylhétérocyclique aromatique, compositions pharmaceutiques et leur utilisation |
AU2021401232A1 (en) * | 2020-12-15 | 2023-06-22 | Mirati Therapeutics, Inc. | Azaquinazoline pan-kras inhibitors |
WO2022143864A1 (fr) | 2020-12-31 | 2022-07-07 | 江苏先声药业有限公司 | Composé tricyclique et son utilisation |
WO2022206730A1 (fr) * | 2021-03-29 | 2022-10-06 | 武汉人福创新药物研发中心有限公司 | Composé de pyrimidopyrazine et son utilisation |
WO2022222911A1 (fr) * | 2021-04-19 | 2022-10-27 | 武汉人福创新药物研发中心有限公司 | Composé pyrimidone et son utilisation |
US20240228491A1 (en) * | 2021-04-30 | 2024-07-11 | Scinnohub Pharmaceutical Co., Ltd. | Methionine adenosyltransferase inhibitor, preparation method therefor and application thereof |
CN117412967A (zh) * | 2021-06-02 | 2024-01-16 | 南京正大天晴制药有限公司 | 蛋氨酸腺苷转移酶2a抑制剂 |
AU2022287057A1 (en) * | 2021-06-02 | 2023-12-14 | Ideaya Biosciences, Inc. | Combination therapy comprising a mat2a inhibitor and a type ii prmt inhibitor |
WO2022256808A1 (fr) * | 2021-06-02 | 2022-12-08 | Ideaya Biosciences Inc. | Polythérapie comprenant un inhibiteur de mat2a et un inhibiteur de prmt de type i |
MX2024003647A (es) | 2021-09-24 | 2024-05-29 | Xenon Pharmaceuticals Inc | Derivados de piridina y su uso como activadores del canal de sodio. |
WO2023066283A1 (fr) * | 2021-10-20 | 2023-04-27 | Insilico Medicine Ip Limited | Inhibiteurs de la méthionine adénosyltransférase 2a (mat2a) et leurs utilisations |
WO2023083210A1 (fr) * | 2021-11-09 | 2023-05-19 | 上海海雁医药科技有限公司 | Dérivé de naphtyridinone substitué, composition pharmaceutique de celui-ci et utilisation de celui-ci |
WO2023086934A1 (fr) * | 2021-11-12 | 2023-05-19 | Ideaya Biosciences, Inc. | Polythérapie comprenant un inhibiteur de mat2a et un taxane |
AU2022423231A1 (en) | 2021-12-21 | 2024-07-11 | Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. | Methionine adenosyltransferase 2a heterocyclic inhibitor |
CN118541371A (zh) * | 2022-01-26 | 2024-08-23 | 勤浩医药(苏州)有限公司 | 用于治疗mtap缺失型癌症的甲硫氨酸腺苷转移酶2a抑制剂 |
WO2023177894A1 (fr) | 2022-03-18 | 2023-09-21 | Ideaya Biosciences, Inc. | Polythérapie comprenant un inhibiteur de mat2a et un agent antimétabolite |
GB202204913D0 (en) | 2022-04-04 | 2022-05-18 | Cambridge Entpr Ltd | antiviral therapy |
WO2023201338A1 (fr) | 2022-04-15 | 2023-10-19 | Ideaya Biosciences, Inc. | Polythérapie comprenant un inhibiteur de mat2a et un inhibiteur de parp |
KR20240051860A (ko) | 2022-10-13 | 2024-04-22 | 한미약품 주식회사 | 신규한 트리사이클 유도체 화합물 및 이의 용도 |
WO2024118897A1 (fr) | 2022-11-30 | 2024-06-06 | Amgen Inc. | Traitements du cancer utilisant un inhibiteur de prmt5 et un inhibiteur de mat2a |
WO2024118070A1 (fr) * | 2022-11-30 | 2024-06-06 | Ideaya Biosciences, Inc. | Formes cristallines de 2-oxoquinazoline |
WO2024118943A2 (fr) * | 2022-11-30 | 2024-06-06 | Ideaya Biosciences, Inc. | Polythérapie comprenant un inhibiteur de mat2a et un inhibiteur de prmt5 |
WO2024118830A1 (fr) * | 2022-11-30 | 2024-06-06 | Ideaya Biosciences, Inc. | Atropisomères d'inhibiteurs de mat2a |
CN116425751B (zh) * | 2022-12-19 | 2024-01-23 | 艾立康药业股份有限公司 | 作为mat2a抑制剂的多环类化合物 |
CN116283800B (zh) * | 2023-05-16 | 2023-07-18 | 英矽智能科技(上海)有限公司 | 氧代喹唑啉类化合物及其应用 |
CN116478172B (zh) * | 2023-06-20 | 2023-09-05 | 英矽智能科技(上海)有限公司 | 吡咯并[3,2-d]嘧啶类化合物及其应用 |
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EP3507290A1 (fr) * | 2016-08-31 | 2019-07-10 | Agios Pharmaceuticals, Inc. | Inhibiteurs de processus métaboliques cellulaires |
RS62456B1 (sr) * | 2016-12-22 | 2021-11-30 | Amgen Inc | Derivati benzizotiazola, izotiazolo[3,4-b]piridina, hinazolina, ftalazina, pirido[2,3-d]piridazina i pirido[2,3-d]pirimidina kao kras g12c inhibitori za tretman raka pluća, pankreasa ili debelog creva |
JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
WO2018221433A1 (fr) | 2017-05-29 | 2018-12-06 | 第一三共株式会社 | Dérivé d'amine hétéroaryle |
CA3075046A1 (fr) * | 2017-09-08 | 2019-03-14 | Amgen Inc. | Inhibiteurs de kras g12c et leurs procedes d'utilisation |
MA52232A (fr) | 2018-03-30 | 2021-02-17 | Agios Pharmaceuticals Inc | Inhibiteurs hétérobicycliques de mat2a et leurs méthodes d'utilisation pour le traitement du cancer |
MA52501A (fr) * | 2018-05-04 | 2021-03-10 | Amgen Inc | Inhibiteurs de kras g12c et leurs procédés d'utilisation |
WO2020050890A2 (fr) * | 2018-06-12 | 2020-03-12 | Amgen Inc. | Inhibiteurs de kras g12c et leurs procédés d'utilisation |
US11376256B2 (en) | 2018-07-19 | 2022-07-05 | Agency For Science, Technology And Research | Method of treating a methionine-dependent cancer |
KR20210097715A (ko) * | 2018-11-29 | 2021-08-09 | 아락세스 파마 엘엘씨 | 암 치료용 화합물 및 이의 사용 방법 |
EP3902804A1 (fr) | 2018-12-27 | 2021-11-03 | Les Laboratoires Servier SAS | Inhibiteurs aza-hétérobicycliques de mat2a et procédés d'utilisation pour le traitement du cancer |
PL3902803T3 (pl) | 2018-12-27 | 2023-05-22 | Les Laboratoires Servier | Aza-heterobicykliczne inhibitory mat2a i sposoby zastosowania do leczenia nowotworu |
-
2019
- 2019-12-09 SG SG11202105469YA patent/SG11202105469YA/en unknown
- 2019-12-09 CN CN201980081299.9A patent/CN113166078A/zh active Pending
- 2019-12-09 US US17/311,873 patent/US20220106276A1/en active Pending
- 2019-12-09 MA MA054452A patent/MA54452A/fr unknown
- 2019-12-09 KR KR1020217021424A patent/KR20210103498A/ko unknown
- 2019-12-09 WO PCT/US2019/065260 patent/WO2020123395A1/fr active Application Filing
- 2019-12-09 AU AU2019395338A patent/AU2019395338A1/en active Pending
- 2019-12-09 EP EP19832505.2A patent/EP3894396A1/fr active Pending
- 2019-12-09 CA CA3121236A patent/CA3121236A1/fr active Pending
- 2019-12-09 MX MX2021006841A patent/MX2021006841A/es unknown
- 2019-12-09 BR BR112021010842-4A patent/BR112021010842A2/pt unknown
- 2019-12-09 JP JP2021532487A patent/JP2022512156A/ja active Pending
- 2019-12-10 TW TW108145188A patent/TW202039487A/zh unknown
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2021
- 2021-02-12 US US17/175,578 patent/US11046691B1/en active Active
- 2021-02-12 US US17/175,579 patent/US11084798B1/en active Active
- 2021-02-12 US US17/175,581 patent/US11130759B1/en active Active
- 2021-05-31 PH PH12021551274A patent/PH12021551274A1/en unknown
- 2021-06-06 IL IL283743A patent/IL283743A/en unknown
- 2021-06-09 CL CL2021001508A patent/CL2021001508A1/es unknown
- 2021-07-06 CO CONC2021/0008895A patent/CO2021008895A2/es unknown
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US20220106276A1 (en) | 2022-04-07 |
MX2021006841A (es) | 2021-07-02 |
TW202039487A (zh) | 2020-11-01 |
PH12021551274A1 (en) | 2021-12-06 |
CO2021008895A2 (es) | 2021-07-30 |
BR112021010842A2 (pt) | 2021-08-24 |
SG11202105469YA (en) | 2021-06-29 |
CN113166078A (zh) | 2021-07-23 |
US11130759B1 (en) | 2021-09-28 |
US11046691B1 (en) | 2021-06-29 |
WO2020123395A1 (fr) | 2020-06-18 |
JP2022512156A (ja) | 2022-02-02 |
KR20210103498A (ko) | 2021-08-23 |
US11084798B1 (en) | 2021-08-10 |
AU2019395338A1 (en) | 2021-07-29 |
CA3121236A1 (fr) | 2020-06-18 |
IL283743A (en) | 2021-07-29 |
CL2021001508A1 (es) | 2022-01-21 |
EP3894396A1 (fr) | 2021-10-20 |
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