CN119120423A - 优化的二核酸酶融合体和方法 - Google Patents

优化的二核酸酶融合体和方法 Download PDF

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Publication number
CN119120423A
CN119120423A CN202410960265.XA CN202410960265A CN119120423A CN 119120423 A CN119120423 A CN 119120423A CN 202410960265 A CN202410960265 A CN 202410960265A CN 119120423 A CN119120423 A CN 119120423A
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domain
amino acid
linker
acid sequence
heterodimer
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CN202410960265.XA
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Chinese (zh)
Inventor
J·A·波萨达
S·帕特尔
余维红
C·加贝尔
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Resolve Therapeutics LLC
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Resolve Therapeutics LLC
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/27005—Pancreatic ribonuclease (3.1.27.5)
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Diabetes (AREA)
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  • Epidemiology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
CN202410960265.XA 2016-07-01 2017-06-30 优化的二核酸酶融合体和方法 Pending CN119120423A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662357756P 2016-07-01 2016-07-01
US62/357,756 2016-07-01
CN201780053637.9A CN109790526A (zh) 2016-07-01 2017-06-30 优化的二核酸酶融合体和方法
PCT/US2017/040267 WO2018005954A2 (en) 2016-07-01 2017-06-30 Optimized binuclease fusions and methods

Related Parent Applications (1)

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CN201780053637.9A Division CN109790526A (zh) 2016-07-01 2017-06-30 优化的二核酸酶融合体和方法

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CN119120423A true CN119120423A (zh) 2024-12-13

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CN202410960265.XA Pending CN119120423A (zh) 2016-07-01 2017-06-30 优化的二核酸酶融合体和方法
CN201780053637.9A Pending CN109790526A (zh) 2016-07-01 2017-06-30 优化的二核酸酶融合体和方法

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US (4) US20190241878A1 (https=)
EP (2) EP4410378A3 (https=)
JP (4) JP7308034B2 (https=)
CN (2) CN119120423A (https=)
AU (2) AU2017290389B2 (https=)
CA (1) CA3029627A1 (https=)
DK (1) DK3478830T3 (https=)
HR (1) HRP20240603T1 (https=)
MA (1) MA45554A (https=)
WO (1) WO2018005954A2 (https=)

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US20190241878A1 (en) 2019-08-08
AU2017290389A1 (en) 2019-02-14
JP2026063077A (ja) 2026-04-10
EP4410378A3 (en) 2024-10-09
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EP3478830B1 (en) 2024-04-10
CN109790526A (zh) 2019-05-21
US20250002884A1 (en) 2025-01-02
US20250002885A1 (en) 2025-01-02
WO2018005954A2 (en) 2018-01-04
JP7308034B2 (ja) 2023-07-13
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AU2024219520A1 (en) 2024-10-03
US12077790B2 (en) 2024-09-03
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MA45554A (fr) 2019-05-08
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HRP20240603T1 (hr) 2024-07-19
US20220112474A1 (en) 2022-04-14

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