CN118879696A - 用于抑制载脂蛋白C-III(APOC3)的表达的RNAi试剂和组合物 - Google Patents
用于抑制载脂蛋白C-III(APOC3)的表达的RNAi试剂和组合物 Download PDFInfo
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- CN118879696A CN118879696A CN202410900721.1A CN202410900721A CN118879696A CN 118879696 A CN118879696 A CN 118879696A CN 202410900721 A CN202410900721 A CN 202410900721A CN 118879696 A CN118879696 A CN 118879696A
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- apoc3
- rnai agent
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- antisense strand
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/351—Conjugate
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
- C12N2310/3533—Halogen
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
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- Cardiology (AREA)
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- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762556818P | 2017-09-11 | 2017-09-11 | |
| US62/556818 | 2017-09-11 | ||
| US201862643927P | 2018-03-16 | 2018-03-16 | |
| US62/643927 | 2018-03-16 | ||
| US201862720434P | 2018-08-21 | 2018-08-21 | |
| US62/720434 | 2018-08-21 | ||
| CN201880059004.3A CN111107853B (zh) | 2017-09-11 | 2018-09-10 | 用于抑制载脂蛋白C-III (APOC3)的表达的RNAi试剂和组合物 |
| PCT/US2018/050248 WO2019051402A1 (en) | 2017-09-11 | 2018-09-10 | RNA INTERFERENCE AGENTS AND COMPOSITIONS FOR INHIBITING THE EXPRESSION OF APOLIPOPROTEIN C-III (APOC3) |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880059004.3A Division CN111107853B (zh) | 2017-09-11 | 2018-09-10 | 用于抑制载脂蛋白C-III (APOC3)的表达的RNAi试剂和组合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118879696A true CN118879696A (zh) | 2024-11-01 |
Family
ID=65630632
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880059004.3A Active CN111107853B (zh) | 2017-09-11 | 2018-09-10 | 用于抑制载脂蛋白C-III (APOC3)的表达的RNAi试剂和组合物 |
| CN202410900721.1A Pending CN118879696A (zh) | 2017-09-11 | 2018-09-10 | 用于抑制载脂蛋白C-III(APOC3)的表达的RNAi试剂和组合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880059004.3A Active CN111107853B (zh) | 2017-09-11 | 2018-09-10 | 用于抑制载脂蛋白C-III (APOC3)的表达的RNAi试剂和组合物 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US10597657B2 (enExample) |
| EP (1) | EP3681516A4 (enExample) |
| JP (2) | JP7438103B2 (enExample) |
| KR (2) | KR102723833B1 (enExample) |
| CN (2) | CN111107853B (enExample) |
| AU (1) | AU2018329190B2 (enExample) |
| BR (1) | BR112020002413A2 (enExample) |
| CA (1) | CA3074303A1 (enExample) |
| CL (2) | CL2020000593A1 (enExample) |
| CO (1) | CO2020002586A2 (enExample) |
| CR (1) | CR20200108A (enExample) |
| EC (1) | ECSP20017905A (enExample) |
| IL (2) | IL273172B1 (enExample) |
| JO (1) | JOP20200054A1 (enExample) |
| MX (1) | MX2020002648A (enExample) |
| MY (1) | MY202025A (enExample) |
| PE (1) | PE20201283A1 (enExample) |
| PH (1) | PH12020500332A1 (enExample) |
| SG (1) | SG11201912178VA (enExample) |
| TN (1) | TN2020000039A1 (enExample) |
| TW (2) | TW202415389A (enExample) |
| UY (1) | UY37871A (enExample) |
| WO (1) | WO2019051402A1 (enExample) |
| ZA (1) | ZA202100806B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015350120B2 (en) | 2014-11-17 | 2021-05-27 | Alnylam Pharmaceuticals, Inc. | Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof |
| KR102856522B1 (ko) * | 2016-09-02 | 2025-09-08 | 애로우헤드 파마슈티컬스 인코포레이티드 | 표적화 리간드 |
| CN110520531A (zh) | 2017-04-05 | 2019-11-29 | 赛伦斯治疗有限责任公司 | 产品和组合物 |
| US10597657B2 (en) * | 2017-09-11 | 2020-03-24 | Arrowhead Pharmaceuticals, Inc. | RNAi agents and compositions for inhibiting expression of apolipoprotein C-III (APOC3) |
| US11414661B2 (en) | 2017-12-01 | 2022-08-16 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| JP7365052B2 (ja) | 2017-12-01 | 2023-10-19 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| KR20210110839A (ko) * | 2018-12-28 | 2021-09-09 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 핵산, 핵산을 함유하는 조성물 및 접합체, 이의 제조 방법 및 용도 |
| CA3139195A1 (en) | 2019-05-22 | 2020-11-26 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| MX2022001460A (es) * | 2019-08-05 | 2022-02-22 | Arrowhead Pharmaceuticals Inc | Metodos para el tratamiento de enfermedades y trastornos relacionados con apoc3. |
| JP7735288B2 (ja) | 2020-02-18 | 2025-09-08 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | アポリポタンパク質C3(APOC3)iRNA組成物およびその使用法 |
| CN114480382A (zh) * | 2020-11-12 | 2022-05-13 | 北京大学 | 用于抑制SURF4基因表达的RNAi试剂和组合物 |
| WO2022162155A1 (en) * | 2021-01-30 | 2022-08-04 | E-Therapeutics Plc | Nucleic acids containing abasic nucleotides |
| US20230089915A1 (en) * | 2021-06-24 | 2023-03-23 | Sirnaomics, Inc. | Products and compositions |
| KR20240034787A (ko) * | 2021-07-16 | 2024-03-14 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 핵산, 이를 함유하는 조성물 및 접합체, 제조 방법 및 용도 |
| JP2024537251A (ja) * | 2021-10-08 | 2024-10-10 | イー-セラピューティクス・ピーエルシー | 脱塩基ヌクレオシドを含有する核酸 |
| EP4441218A2 (en) | 2021-12-01 | 2024-10-09 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for modulating apoc3 expression |
| JP2025504845A (ja) * | 2022-01-20 | 2025-02-19 | 上海拓界生物医薬科技有限公司 | dsRNA、その使用及び調製方法 |
| TW202345865A (zh) * | 2022-01-24 | 2023-12-01 | 大陸商上海舶望製藥有限公司 | 抑制LPA(Apo(a))蛋白表達的組合物和方法 |
| EP4471140A1 (en) | 2022-01-30 | 2024-12-04 | Rona Bioscience, Limited | Targeting ligand containing n-acetylgalactosamine |
| EP4541893A1 (en) | 2022-06-14 | 2025-04-23 | Rona Bioscience, Limited | Sirna molecule for regulating pcsk9 gene activity |
| WO2024002093A1 (zh) * | 2022-06-27 | 2024-01-04 | 大睿生物医药科技(上海)有限公司 | 抑制载脂蛋白C3表达的siRNA |
| AU2023307152A1 (en) * | 2022-07-11 | 2025-01-09 | Sanegene Bio Usa Inc. | Optimized 2'- modified ribose derivatives and methods of use |
| KR20250043473A (ko) * | 2022-07-27 | 2025-03-28 | 이-테라퓨틱스 피엘씨 | 핵산 화합물 |
| IL318229A (en) * | 2022-07-27 | 2025-03-01 | E Therapeutics Plc | Nucleic acid compounds |
| WO2024023256A1 (en) * | 2022-07-27 | 2024-02-01 | E-Therapeutics Plc | Nucleic acid compounds |
| CN116814621B (zh) * | 2022-08-05 | 2025-09-09 | 厦门甘宝利生物医药有限公司 | 一种抑制apoc3基因表达的rna抑制剂及其应用 |
| WO2024032680A1 (zh) * | 2022-08-11 | 2024-02-15 | 益杰立科(上海)生物科技有限公司 | 一种表观编辑靶点的方法及用途 |
| AU2024218976A1 (en) * | 2023-02-06 | 2025-09-11 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2024165571A2 (en) * | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2024188173A1 (zh) * | 2023-03-10 | 2024-09-19 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及其用途 |
| US20250243487A1 (en) | 2023-09-14 | 2025-07-31 | Ionis Pharmaceuticals, Inc. | Compounds and Methods for Reducing APOCIII Expression |
| CN120344664A (zh) * | 2023-10-27 | 2025-07-18 | 北京安龙生物医药有限公司 | 靶向脂蛋白a的寡核苷酸及其用途 |
| WO2025125576A2 (en) * | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025133348A1 (en) * | 2023-12-22 | 2025-06-26 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025184301A1 (en) * | 2024-02-29 | 2025-09-04 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for dual inhibition of expression of apolipoprotein c-iii (apoc3) and proprotein convertase subtilisin kexin 9 (pcsk9), compositions thereof, and methods of use |
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