CN1188418C - 用作抗生素的具有环状氨基胍取代基的头孢菌素 - Google Patents

用作抗生素的具有环状氨基胍取代基的头孢菌素 Download PDF

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Publication number
CN1188418C
CN1188418C CNB998043192A CN99804319A CN1188418C CN 1188418 C CN1188418 C CN 1188418C CN B998043192 A CNB998043192 A CN B998043192A CN 99804319 A CN99804319 A CN 99804319A CN 1188418 C CN1188418 C CN 1188418C
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CN
China
Prior art keywords
alkyl
lactam
group
formula
amino
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB998043192A
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English (en)
Chinese (zh)
Other versions
CN1294593A (zh
Inventor
G·阿舍
W·海尔梅耶
J·路德谢尔
J·希尔德布兰特
M·施兰兹
J·威泽
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Sandoz AG
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Biochemie GmbH
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Publication date
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Publication of CN1294593A publication Critical patent/CN1294593A/zh
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Publication of CN1188418C publication Critical patent/CN1188418C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB998043192A 1998-03-23 1999-03-19 用作抗生素的具有环状氨基胍取代基的头孢菌素 Expired - Fee Related CN1188418C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0051598A AT406772B (de) 1998-03-23 1998-03-23 Antibakterielle 7-acylamino-3-iminomethyl- cephalosporine und verfahren zu deren herstellung
ATA515/1998 1998-03-23

Publications (2)

Publication Number Publication Date
CN1294593A CN1294593A (zh) 2001-05-09
CN1188418C true CN1188418C (zh) 2005-02-09

Family

ID=3492649

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998043192A Expired - Fee Related CN1188418C (zh) 1998-03-23 1999-03-19 用作抗生素的具有环状氨基胍取代基的头孢菌素

Country Status (25)

Country Link
US (1) US6440957B1 (enExample)
EP (2) EP1930335A1 (enExample)
JP (1) JP2002507616A (enExample)
KR (1) KR100696422B1 (enExample)
CN (1) CN1188418C (enExample)
AR (1) AR015248A1 (enExample)
AT (1) AT406772B (enExample)
AU (1) AU749735B2 (enExample)
BR (1) BR9908960A (enExample)
CA (1) CA2324953C (enExample)
CO (1) CO5080739A1 (enExample)
HU (1) HUP0101603A3 (enExample)
ID (1) ID26567A (enExample)
IL (2) IL138477A0 (enExample)
MY (1) MY119841A (enExample)
NO (1) NO20004760L (enExample)
NZ (1) NZ506908A (enExample)
PE (1) PE20000360A1 (enExample)
PL (1) PL343094A1 (enExample)
RU (1) RU2245884C2 (enExample)
SK (1) SK14152000A3 (enExample)
TR (1) TR200002749T2 (enExample)
TW (1) TWI250983B (enExample)
WO (1) WO1999048896A1 (enExample)
ZA (1) ZA200004850B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6693095B2 (en) * 1997-04-01 2004-02-17 Biochemie Gesellschaft M.B.H. Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
DE102007052891A1 (de) 2007-11-02 2009-05-07 Evonik Degussa Gmbh Verfahren zur Stabilisierung von olefinisch ungesättigten Monomeren
DE102013204950A1 (de) 2013-03-20 2014-09-25 Evonik Industries Ag Verfahren und Zusammensetzung zur Inhibierung der Polymerisation von Cyclopentadienverbindungen
ES2624415T3 (es) 2014-09-08 2017-07-14 Evonik Degussa Gmbh (Tio)acetales fenólicos como agentes inhibidores de la polimerización de monómeros olefínicamente insaturados
TWI669317B (zh) 2014-09-22 2019-08-21 德商贏創德固賽有限責任公司 反應性單體的改良製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE943408C (de) * 1953-03-31 1956-05-17 Bayer Ag Verfahren zur Darstellung von Bisguanylhydrazonen
FI851934A7 (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporiinijohdannaisia.
GB8721568D0 (en) * 1987-09-14 1987-10-21 Fujisawa Pharmaceutical Co Cephem compounds
NZ308518A (en) * 1995-05-11 2000-01-28 Biochemie Gmbh Antibacterial cephalosporins
NZ337732A (en) * 1997-04-01 2001-09-28 Biochemie Gmbh Antibacterial substituted 7-acylamino -3-(methylhydrazono) methyl-cephalosporins and intermediates

Also Published As

Publication number Publication date
EP1082326A1 (en) 2001-03-14
ZA200004850B (en) 2002-02-27
JP2002507616A (ja) 2002-03-12
ID26567A (id) 2001-01-18
KR100696422B1 (ko) 2007-03-20
WO1999048896A1 (en) 1999-09-30
AR015248A1 (es) 2001-04-18
TR200002749T2 (tr) 2000-12-21
PE20000360A1 (es) 2000-05-17
CO5080739A1 (es) 2001-09-25
SK14152000A3 (sk) 2001-05-10
CA2324953C (en) 2008-05-13
AU749735B2 (en) 2002-07-04
AT406772B (de) 2000-08-25
CN1294593A (zh) 2001-05-09
NO20004760L (no) 2000-11-21
KR20010074666A (ko) 2001-08-08
IL138477A (en) 2007-06-17
NZ506908A (en) 2003-04-29
RU2245884C2 (ru) 2005-02-10
PL343094A1 (en) 2001-07-30
MY119841A (en) 2005-07-29
ATA51598A (de) 2000-01-15
US6440957B1 (en) 2002-08-27
AU3518899A (en) 1999-10-18
HUP0101603A2 (hu) 2001-12-28
IL138477A0 (en) 2001-10-31
HUP0101603A3 (en) 2002-10-28
NO20004760D0 (no) 2000-09-22
TWI250983B (en) 2006-03-11
CA2324953A1 (en) 1999-09-30
EP1930335A1 (en) 2008-06-11
BR9908960A (pt) 2000-12-05

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Granted publication date: 20050209