CN1186021C - 抗微生物组合物 - Google Patents

抗微生物组合物 Download PDF

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Publication number
CN1186021C
CN1186021C CNB981191924A CN98119192A CN1186021C CN 1186021 C CN1186021 C CN 1186021C CN B981191924 A CNB981191924 A CN B981191924A CN 98119192 A CN98119192 A CN 98119192A CN 1186021 C CN1186021 C CN 1186021C
Authority
CN
China
Prior art keywords
alkyl
substituted
phenyl
hydroxyl
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB981191924A
Other languages
English (en)
Chinese (zh)
Other versions
CN1216246A (zh
Inventor
P·安格恩
I·海茨－克劳斯
M·帕格
H·G·F·
里彻特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASLIER PHARMACEUTICAL AG
Original Assignee
Basilea Pharmaceutica AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica AG filed Critical Basilea Pharmaceutica AG
Publication of CN1216246A publication Critical patent/CN1216246A/zh
Application granted granted Critical
Publication of CN1186021C publication Critical patent/CN1186021C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79—Polymers of vinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
CNB981191924A 1997-09-15 1998-09-15 抗微生物组合物 Expired - Fee Related CN1186021C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97115997 1997-09-15
EP97115997.5 1997-09-15

Publications (2)

Publication Number Publication Date
CN1216246A CN1216246A (zh) 1999-05-12
CN1186021C true CN1186021C (zh) 2005-01-26

Family

ID=8227350

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB981191924A Expired - Fee Related CN1186021C (zh) 1997-09-15 1998-09-15 抗微生物组合物

Country Status (16)

Country Link
US (1) US6150350A (enExample)
EP (1) EP0911030B1 (enExample)
JP (1) JP4621311B2 (enExample)
KR (1) KR100630012B1 (enExample)
CN (1) CN1186021C (enExample)
AR (1) AR013490A1 (enExample)
AT (1) ATE292994T1 (enExample)
AU (1) AU747285B2 (enExample)
BR (1) BR9803443A (enExample)
CA (1) CA2247232C (enExample)
DE (1) DE69829720T2 (enExample)
DK (1) DK0911030T3 (enExample)
ES (1) ES2241084T3 (enExample)
PT (1) PT911030E (enExample)
TR (1) TR199801835A2 (enExample)
ZA (1) ZA988399B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2335288A1 (en) * 1998-06-22 1999-12-29 F. Hoffmann-La Roche Ag Propenyl cephalosporin derivatives
WO2000032605A1 (en) * 1998-12-03 2000-06-08 F. Hoffmann-La Roche Ag Bi-pyrrolidinylvinl (carba) cephalosporins
JP4583559B2 (ja) * 2000-07-24 2010-11-17 栄研化学株式会社 Ｍｒｓａスクリーニング用培地
CN100384857C (zh) * 2003-11-28 2008-04-30 浙江永宁制药厂 耐β-内酰胺酶的头孢菌素酯化合物及其盐
CN112608369A (zh) * 2020-12-30 2021-04-06 中国海洋大学 一种具有抑菌活性的细菌素及其生产方法及用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0347122A (ja) * 1989-02-21 1991-02-28 Banyu Pharmaceut Co Ltd 抗菌性組成物
EP0384410B1 (en) * 1989-02-21 1995-05-17 Banyu Pharmaceutical Co., Ltd. Antimicrobial composition
GB9019743D0 (en) * 1990-09-10 1990-10-24 Beecham Group Plc Novel compounds
KR100214288B1 (ko) * 1993-04-16 1999-08-02 성재갑 안개서림 방지용 내마모성 피복조성물 및 이를 도포한 합성수지 성형품
PT620225E (pt) * 1993-04-16 2003-03-31 Basilea Pharmaceutica Ag Derivados de cefalosporina
TW383308B (en) * 1993-08-24 2000-03-01 Hoffmann La Roche 2-beta-alkenyl penam sulfones as beta-lactamase inhibitors
US5464616A (en) * 1994-08-04 1995-11-07 Synphar Laboratories, Ind. 6β-substituted penicillanic acids as beta-lactamase inhibitors
TR199700859T1 (xx) * 1995-02-27 1998-02-21 F. Hoffmann-La Roche Ag 3-Pirolidiliden-2-on-sefalosporin t�revleri.
ATE354577T1 (de) * 1996-11-06 2007-03-15 Basilea Pharmaceutica Ag Vinylpyrrolidinon-cephalosporin-derivate

Also Published As

Publication number Publication date
EP0911030A3 (en) 1999-10-13
AU8425198A (en) 1999-04-01
ES2241084T3 (es) 2005-10-16
EP0911030A2 (en) 1999-04-28
TR199801835A3 (tr) 1999-04-21
DK0911030T3 (da) 2005-08-01
ZA988399B (en) 1999-03-15
CA2247232A1 (en) 1999-03-15
CA2247232C (en) 2007-08-28
US6150350A (en) 2000-11-21
KR100630012B1 (ko) 2006-11-30
AR013490A1 (es) 2000-12-27
KR19990029769A (ko) 1999-04-26
JPH11140087A (ja) 1999-05-25
DE69829720T2 (de) 2006-03-09
BR9803443A (pt) 2000-02-08
EP0911030B1 (en) 2005-04-13
DE69829720D1 (de) 2005-05-19
AU747285B2 (en) 2002-05-16
CN1216246A (zh) 1999-05-12
TR199801835A2 (xx) 1999-04-21
PT911030E (pt) 2005-08-31
JP4621311B2 (ja) 2011-01-26
ATE292994T1 (de) 2005-04-15

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: BASILEA PHARMACEUTICA AG

Free format text: FORMER OWNER: FUEL HA FUMAN-LALUOQI LTD.

Effective date: 20020403

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20020403

Address after: Swiss Bin Ninggen

Applicant after: Baslier Pharmaceutical AG

Address before: Basel

Applicant before: F. Hoffmann-La Roche AG

C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050126

Termination date: 20120915