CN1185217C - 丙醇胺衍生物、其制法、含有它们的药物组合物和其用途 - Google Patents
丙醇胺衍生物、其制法、含有它们的药物组合物和其用途 Download PDFInfo
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- CN1185217C CN1185217C CNB981082521A CN98108252A CN1185217C CN 1185217 C CN1185217 C CN 1185217C CN B981082521 A CNB981082521 A CN B981082521A CN 98108252 A CN98108252 A CN 98108252A CN 1185217 C CN1185217 C CN 1185217C
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- Prior art keywords
- alkyl
- formula
- compound
- fluorine
- phenyl
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- 150000003839 salts Chemical class 0.000 claims abstract description 14
- 239000002253 acid Substances 0.000 claims abstract description 11
- -1 ketone compound Chemical class 0.000 claims description 38
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- 239000011737 fluorine Substances 0.000 claims description 24
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 20
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- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 14
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 14
- 229910052794 bromium Inorganic materials 0.000 claims description 14
- 239000000460 chlorine Substances 0.000 claims description 14
- 229910052801 chlorine Inorganic materials 0.000 claims description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
- 239000001257 hydrogen Substances 0.000 claims description 13
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- VVWRJUBEIPHGQF-UHFFFAOYSA-N propan-2-yl n-propan-2-yloxycarbonyliminocarbamate Chemical compound CC(C)OC(=O)N=NC(=O)OC(C)C VVWRJUBEIPHGQF-UHFFFAOYSA-N 0.000 description 1
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- 239000011347 resin Substances 0.000 description 1
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- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19713865.9 | 1997-04-04 | ||
| DE19713865 | 1997-04-04 | ||
| DE19802530.0 | 1998-01-26 | ||
| DE1998102530 DE19802530A1 (de) | 1998-01-26 | 1998-01-26 | Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1199731A CN1199731A (zh) | 1998-11-25 |
| CN1185217C true CN1185217C (zh) | 2005-01-19 |
Family
ID=26035472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB981082521A Expired - Fee Related CN1185217C (zh) | 1997-04-04 | 1998-04-03 | 丙醇胺衍生物、其制法、含有它们的药物组合物和其用途 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5874451A (https=) |
| EP (1) | EP0869121B1 (https=) |
| JP (1) | JP4234805B2 (https=) |
| KR (1) | KR19980081055A (https=) |
| CN (1) | CN1185217C (https=) |
| AR (1) | AR011210A1 (https=) |
| AT (1) | ATE268758T1 (https=) |
| AU (1) | AU730228B2 (https=) |
| BR (1) | BR9801150A (https=) |
| CA (1) | CA2233925A1 (https=) |
| CZ (1) | CZ293758B6 (https=) |
| DE (1) | DE59811528D1 (https=) |
| DK (1) | DK0869121T3 (https=) |
| ES (1) | ES2223091T3 (https=) |
| HU (1) | HUP9800781A3 (https=) |
| ID (1) | ID20137A (https=) |
| IL (1) | IL123927A (https=) |
| MY (1) | MY114944A (https=) |
| NZ (1) | NZ330110A (https=) |
| PL (1) | PL325699A1 (https=) |
| PT (1) | PT869121E (https=) |
| RU (1) | RU2198876C2 (https=) |
| TR (1) | TR199800608A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19845402B4 (de) * | 1998-10-02 | 2005-04-07 | Aventis Pharma Deutschland Gmbh | Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| KR100581199B1 (ko) | 1998-06-19 | 2006-05-17 | 카이론 코포레이션 | 글리코겐 신타제 키나제 3의 억제제 |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| DE19845406C2 (de) * | 1998-10-02 | 2001-10-18 | Aventis Pharma Gmbh | Substituierte 1,3-Diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)- propanolderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE19845403B4 (de) * | 1998-10-02 | 2005-02-10 | Aventis Pharma Deutschland Gmbh | Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE19845405C2 (de) * | 1998-10-02 | 2000-07-13 | Aventis Pharma Gmbh | Arylsubstituierte Propanolaminderivate und deren Verwendung |
| AU2002231688A1 (en) | 2000-12-21 | 2002-07-01 | Sanofi-Aventis Deutschland Gmbh | Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use |
| PL366855A1 (en) * | 2001-08-22 | 2005-02-07 | Aventis Pharma Deutschland Gmbh | Combination preparations of aryl substituted propanolamine derivatives with other active ingredients and the use thereof |
| JP4691988B2 (ja) | 2002-10-03 | 2011-06-01 | 小野薬品工業株式会社 | Ｌｐａ受容体拮抗剤 |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| ATE528276T1 (de) * | 2003-12-19 | 2011-10-15 | Ono Pharmaceutical Co | Lysophosphatidylsäurerezeptor-antagonistische verbindungen und ihre anwendungen |
| CN1869002A (zh) * | 2005-05-27 | 2006-11-29 | 中国科学院上海药物研究所 | 一类非甾体雄激素受体调节剂、其制备方法和用途 |
| DK2848610T3 (da) * | 2006-11-15 | 2017-11-06 | Ym Biosciences Australia Pty | Hæmmere af kinaseaktivitet |
| EP2575821B1 (en) | 2010-05-26 | 2015-08-12 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| CN104023727B (zh) | 2011-10-28 | 2017-04-05 | 鲁美纳医药公司 | 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂 |
| CA2852957C (en) | 2011-10-28 | 2020-08-04 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
| CN105228615A (zh) | 2013-03-15 | 2016-01-06 | 鲁美纳医药公司 | 用于治疗巴雷特食管和胃食管返流疾病的胆汁酸再循环抑制剂 |
| US20140275090A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| CN105553262B (zh) * | 2015-08-24 | 2018-02-16 | 苏州瑞铬优电子科技有限公司 | 一种提高dc/dc升压变换器转换效率的方法 |
| PL3923943T3 (pl) | 2019-02-12 | 2024-12-09 | Mirum Pharmaceuticals, Inc. | Zależna od genotypu i dawki odpowiedź na asbti u pacjentów z niedoborem pompy eksportu soli żółciowych |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI892341A7 (fi) * | 1988-06-10 | 1989-12-11 | Hoffmann La Roche | Propanoliamiinijohdannaisia |
| NZ240846A (en) * | 1990-12-06 | 1994-04-27 | Hoechst Ag | Dimeric bile acid derivatives; preparatory processes and pharmaceutical compositions |
| DE4040026A1 (de) * | 1990-12-14 | 1992-06-17 | Bayer Ag | Substituierte pyridyl-dihydroxy-heptensaeure und deren salze |
| GB9203347D0 (en) * | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
| DK0557879T3 (da) * | 1992-02-22 | 1997-06-16 | Hoechst Ag | 4-amino-2-ureido-pyrimidin-5-carboxylsyreamider, fremgangsmåde til deres fremstilling, lægemidler med indhold af disse forbindelser og deres anvendelse |
-
1998
- 1998-03-24 DK DK98105256T patent/DK0869121T3/da active
- 1998-03-24 DE DE59811528T patent/DE59811528D1/de not_active Expired - Lifetime
- 1998-03-24 PT PT98105256T patent/PT869121E/pt unknown
- 1998-03-24 EP EP98105256A patent/EP0869121B1/de not_active Expired - Lifetime
- 1998-03-24 AT AT98105256T patent/ATE268758T1/de not_active IP Right Cessation
- 1998-03-24 ES ES98105256T patent/ES2223091T3/es not_active Expired - Lifetime
- 1998-04-02 TR TR1998/00608A patent/TR199800608A2/xx unknown
- 1998-04-02 US US09/053,513 patent/US5874451A/en not_active Expired - Lifetime
- 1998-04-02 NZ NZ330110A patent/NZ330110A/xx unknown
- 1998-04-02 IL IL12392798A patent/IL123927A/xx active IP Right Grant
- 1998-04-02 ID IDP980494A patent/ID20137A/id unknown
- 1998-04-02 AR ARP980101512A patent/AR011210A1/es unknown
- 1998-04-03 JP JP10716198A patent/JP4234805B2/ja not_active Expired - Fee Related
- 1998-04-03 HU HU9800781A patent/HUP9800781A3/hu unknown
- 1998-04-03 CZ CZ19981025A patent/CZ293758B6/cs not_active IP Right Cessation
- 1998-04-03 CA CA002233925A patent/CA2233925A1/en not_active Abandoned
- 1998-04-03 MY MYPI98001488A patent/MY114944A/en unknown
- 1998-04-03 KR KR1019980011750A patent/KR19980081055A/ko not_active Abandoned
- 1998-04-03 RU RU98106112/04A patent/RU2198876C2/ru not_active IP Right Cessation
- 1998-04-03 CN CNB981082521A patent/CN1185217C/zh not_active Expired - Fee Related
- 1998-04-03 PL PL98325699A patent/PL325699A1/xx not_active Application Discontinuation
- 1998-04-03 AU AU60624/98A patent/AU730228B2/en not_active Ceased
- 1998-04-06 BR BR9801150A patent/BR9801150A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5874451A (en) | 1999-02-23 |
| EP0869121A1 (de) | 1998-10-07 |
| DE59811528D1 (de) | 2004-07-15 |
| HK1015789A1 (en) | 1999-10-22 |
| RU2198876C2 (ru) | 2003-02-20 |
| NZ330110A (en) | 1999-03-29 |
| IL123927A (en) | 2001-01-28 |
| PL325699A1 (en) | 1998-10-12 |
| HUP9800781A3 (en) | 1999-07-28 |
| AR011210A1 (es) | 2000-08-02 |
| EP0869121B1 (de) | 2004-06-09 |
| CZ102598A3 (cs) | 1998-10-14 |
| ATE268758T1 (de) | 2004-06-15 |
| DK0869121T3 (da) | 2004-09-20 |
| AU730228B2 (en) | 2001-03-01 |
| AU6062498A (en) | 1998-10-08 |
| ES2223091T3 (es) | 2005-02-16 |
| MY114944A (en) | 2003-02-28 |
| TR199800608A3 (tr) | 1998-10-21 |
| CZ293758B6 (cs) | 2004-07-14 |
| TR199800608A2 (en) | 1998-10-21 |
| CA2233925A1 (en) | 1998-10-04 |
| HU9800781D0 (en) | 1998-05-28 |
| ID20137A (id) | 1998-10-08 |
| BR9801150A (pt) | 2000-03-21 |
| KR19980081055A (ko) | 1998-11-25 |
| CN1199731A (zh) | 1998-11-25 |
| HUP9800781A2 (hu) | 1999-06-28 |
| JP4234805B2 (ja) | 2009-03-04 |
| JPH10287651A (ja) | 1998-10-27 |
| PT869121E (pt) | 2004-10-29 |
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