CN1184220C - 制备5－羧基－2－苯并[c]呋喃酮的方法及其用于生产西酞普兰的用途 - Google Patents

制备5－羧基－2－苯并[c]呋喃酮的方法及其用于生产西酞普兰的用途 Download PDF

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Publication number
CN1184220C
CN1184220C CNB018038484A CN01803848A CN1184220C CN 1184220 C CN1184220 C CN 1184220C CN B018038484 A CNB018038484 A CN B018038484A CN 01803848 A CN01803848 A CN 01803848A CN 1184220 C CN1184220 C CN 1184220C
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CN
China
Prior art keywords
benzo
furanone
mixture
carboxyl
oleum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB018038484A
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English (en)
Chinese (zh)
Other versions
CN1406236A (zh
Inventor
L·戴尔阿斯塔
U·卡萨扎
G·克蒂塞利
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H Lundbeck AS
Original Assignee
Infosint SA
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26332721&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1184220(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
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Publication of CN1406236A publication Critical patent/CN1406236A/zh
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Publication of CN1184220C publication Critical patent/CN1184220C/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Seasonings (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNB018038484A 2000-01-18 2001-01-17 制备5－羧基－2－苯并[c]呋喃酮的方法及其用于生产西酞普兰的用途 Expired - Lifetime CN1184220C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2000MI000050A IT1317729B1 (it) 2000-01-18 2000-01-18 Procedimento per la preparazione della 5-carbossiftalide.
ITMI2000A000050 2000-01-18
US09/690,301 US6458973B1 (en) 2000-01-18 2000-10-17 Process for the preparation of 5-carboxyphthalide

Publications (2)

Publication Number Publication Date
CN1406236A CN1406236A (zh) 2003-03-26
CN1184220C true CN1184220C (zh) 2005-01-12

Family

ID=26332721

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018038484A Expired - Lifetime CN1184220C (zh) 2000-01-18 2001-01-17 制备5－羧基－2－苯并[c]呋喃酮的方法及其用于生产西酞普兰的用途

Country Status (21)

Country Link
US (4) US6458973B1 (enExample)
EP (2) EP1118614B2 (enExample)
JP (1) JP4558182B2 (enExample)
CN (1) CN1184220C (enExample)
AT (1) ATE219489T1 (enExample)
AU (1) AU779581B2 (enExample)
BG (1) BG65763B1 (enExample)
BR (1) BR0107853A (enExample)
CA (1) CA2397497C (enExample)
DE (1) DE60000226T3 (enExample)
DK (1) DK1118614T4 (enExample)
ES (1) ES2178626T5 (enExample)
HK (1) HK1042290B (enExample)
HU (1) HUP0204187A3 (enExample)
IT (1) IT1317729B1 (enExample)
MX (1) MXPA02007031A (enExample)
PL (1) PL356563A1 (enExample)
PT (1) PT1118614E (enExample)
RO (1) RO121737B1 (enExample)
WO (1) WO2001053284A1 (enExample)
ZA (1) ZA200205475B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR026063A1 (es) * 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
CZ20023100A3 (cs) * 2000-03-13 2003-02-12 H. Lundbeck A/S Způsob výroby citalopramu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CN101362743A (zh) * 2003-03-21 2009-02-11 H.隆德贝克有限公司 用于制备西酞普兰和依他普仑的中间体
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
WO2006090409A1 (en) * 2005-02-28 2006-08-31 Kekule Pharma Ltd., An improved process for the preparation of 5 - carboxyphthalide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3607884A (en) * 1969-03-11 1971-09-21 Mobil Oil Corp Preparation of 5-carboxyphthalide in liquid sodium trioxide
US3976751A (en) † 1974-10-21 1976-08-24 Allied Chemical Corporation Stabilization of liquid sulfur trioxide
DE2630927A1 (de) 1976-07-09 1978-01-19 Basf Ag Verfahren zur herstellung von phthalidcarbonsaeure-(5)
DE3605716A1 (de) 1986-02-22 1987-09-03 Henkel Kgaa Verwendung von unloeslichen schmutzsammlern zur regenerierung von wasch- und reinigungsloesungen
TR200000066T2 (tr) * 1997-07-08 2000-11-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem.
PL199423B1 (pl) * 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
AU1130901A (en) 1999-11-01 2001-05-14 H. Lundbeck A/S Method for the preparation of 5-carboxyphthalide
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram

Also Published As

Publication number Publication date
BR0107853A (pt) 2002-10-29
DE60000226T2 (de) 2003-03-06
RO121737B1 (ro) 2008-03-28
EP1118614A2 (en) 2001-07-25
DK1118614T3 (da) 2002-10-14
EP1187822A1 (en) 2002-03-20
PT1118614E (pt) 2002-11-29
HK1042290A1 (en) 2002-08-09
US20080249319A1 (en) 2008-10-09
WO2001053284A1 (en) 2001-07-26
US6703516B2 (en) 2004-03-09
DE60000226D1 (de) 2002-07-25
ES2178626T5 (es) 2011-06-02
DE60000226T3 (de) 2012-02-16
EP1118614A3 (en) 2001-10-24
CA2397497C (en) 2010-07-06
ZA200205475B (en) 2003-12-31
EP1118614B1 (en) 2002-06-19
US20030009038A1 (en) 2003-01-09
US20040171851A1 (en) 2004-09-02
AU779581B2 (en) 2005-01-27
HUP0204187A2 (hu) 2003-03-28
HK1042290B (en) 2003-07-18
BG65763B1 (bg) 2009-10-30
ITMI20000050A1 (it) 2001-07-18
JP4558182B2 (ja) 2010-10-06
AU2679801A (en) 2001-07-31
CN1406236A (zh) 2003-03-26
US6458973B1 (en) 2002-10-01
BG106925A (bg) 2004-01-30
ITMI20000050A0 (it) 2000-01-18
PL356563A1 (en) 2004-06-28
ES2178626T3 (es) 2003-01-01
HUP0204187A3 (en) 2005-05-30
ATE219489T1 (de) 2002-07-15
MXPA02007031A (es) 2004-09-06
CA2397497A1 (en) 2001-07-26
DK1118614T4 (da) 2011-06-27
IT1317729B1 (it) 2003-07-15
JP2001206881A (ja) 2001-07-31
EP1118614B2 (en) 2011-03-09

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Owner name: H. LUNDHECK A/S

Free format text: FORMER OWNER: NORPHARMA S.P.A

Effective date: 20120306

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Address after: Copenhagen

Patentee after: H. Lundheck A/S

Address before: Swiss poschiavo

Patentee before: Norpharma S.P.A

AV01 Patent right actively abandoned

Granted publication date: 20050112

Effective date of abandoning: 20120521

AV01 Patent right actively abandoned

Granted publication date: 20050112

Effective date of abandoning: 20120521

C20 Patent right or utility model deemed to be abandoned or is abandoned