CN1176650C - 巴氯芬在制备治疗烟碱依赖药物中的用途 - Google Patents

巴氯芬在制备治疗烟碱依赖药物中的用途 Download PDF

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Publication number
CN1176650C
CN1176650C CNB00811031XA CN00811031A CN1176650C CN 1176650 C CN1176650 C CN 1176650C CN B00811031X A CNB00811031X A CN B00811031XA CN 00811031 A CN00811031 A CN 00811031A CN 1176650 C CN1176650 C CN 1176650C
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CN
China
Prior art keywords
nicotine
baclofen
transdermal
treatment
delivery device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB00811031XA
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English (en)
Chinese (zh)
Other versions
CN1377265A (zh
Inventor
Gl
G·L·盖萨
G·哥伦布
L·帕尼
W·弗拉塔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
L Molteni and C dei Fratelli Alitti Societa di Esercizio SpA
Original Assignee
L Molteni and C dei Fratelli Alitti Societa di Esercizio SpA
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Publication of CN1377265A publication Critical patent/CN1377265A/zh
Application granted granted Critical
Publication of CN1176650C publication Critical patent/CN1176650C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CNB00811031XA 1999-07-30 2000-06-30 巴氯芬在制备治疗烟碱依赖药物中的用途 Expired - Lifetime CN1176650C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI001715A IT1313585B1 (it) 1999-07-30 1999-07-30 Uso di agonisti dei recettori gabab per la terapia di mantenimentodell'astinenza da nicotina in soggetti nicotino-dipendenti.
ITMI99A001715 1999-07-30

Publications (2)

Publication Number Publication Date
CN1377265A CN1377265A (zh) 2002-10-30
CN1176650C true CN1176650C (zh) 2004-11-24

Family

ID=11383467

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB00811031XA Expired - Lifetime CN1176650C (zh) 1999-07-30 2000-06-30 巴氯芬在制备治疗烟碱依赖药物中的用途

Country Status (16)

Country Link
EP (1) EP1202727B1 (enExample)
CN (1) CN1176650C (enExample)
AT (1) ATE285763T1 (enExample)
AU (1) AU6153400A (enExample)
CA (1) CA2379752C (enExample)
DE (1) DE60017147T2 (enExample)
DK (1) DK1202727T3 (enExample)
ES (1) ES2235913T3 (enExample)
HK (1) HK1046849B (enExample)
IL (2) IL147876A0 (enExample)
IT (1) IT1313585B1 (enExample)
PL (1) PL196334B1 (enExample)
PT (1) PT1202727E (enExample)
RU (1) RU2262352C2 (enExample)
SI (1) SI1202727T1 (enExample)
WO (1) WO2001008675A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005019163A2 (en) * 2003-08-20 2005-03-03 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
EP2354120A1 (en) 2003-08-20 2011-08-10 XenoPort, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
WO2006050471A2 (en) 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
WO2006050472A2 (en) 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids
US7585996B2 (en) 2006-09-15 2009-09-08 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
JP4498407B2 (ja) 2006-12-22 2010-07-07 キヤノン株式会社 プロセスカートリッジ、電子写真画像形成装置、及び、電子写真感光体ドラムユニット
JP5291123B2 (ja) 2008-01-25 2013-09-18 ゼノポート，インコーポレイティド （３ｓ）−アミノメチル−５−ヘキサン酸プロドラッグの結晶形態及びその使用
WO2009094577A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
EP2250148B1 (en) 2008-01-25 2016-08-17 XenoPort, Inc. Crystalline form of calcium-salts of (3s)-aminomethyl-5-methyl-hexanoic acids and methods of use
US7989641B2 (en) 2008-08-07 2011-08-02 Xenoport, Inc. Methods of synthesizing N-hydroxysuccinimidyl carbonates
WO2010017504A1 (en) 2008-08-07 2010-02-11 Xenoport, Inc. Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
JP2012519212A (ja) 2009-03-03 2012-08-23 ゼノポート，インコーポレイティド Ｒ−バクロフェンプロドラッグの持効性放出経口投与形
US8344028B2 (en) 2009-04-17 2013-01-01 Xenoport, Inc. Gamma-amino-butyric acid derivatives as GABAB receptor ligands
WO2011081558A1 (ru) * 2009-08-21 2011-07-07 Komissarov Jury Vladimirovich Курительное устройство для отказа от табачного курения
US8580850B2 (en) 2011-08-11 2013-11-12 Xenoport, Inc. Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use
WO2019195813A1 (en) * 2018-04-06 2019-10-10 Ovid Therapeutics Inc. Use of gaboxadol in the treatment of substance use disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4126684A (en) * 1976-02-11 1978-11-21 Ciba-Geigy Corporation 4-amino-3-p-halophenylbutyric acids and their derivatives used in the control of narcotic abuse
US5073539A (en) * 1990-01-22 1991-12-17 Ciba-Geigy Corporation Transdermal administration of zwitterionic drugs
US5760049A (en) * 1997-02-21 1998-06-02 Synapse Pharmaceuticals International, Inc. Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use
US6541520B1 (en) * 1998-08-05 2003-04-01 Brookhaven Science Associates Treatment of addiction and addiction-related behavior
RU2132203C1 (ru) * 1998-09-03 1999-06-27 Шакирзянов Галимзян Закирович Способ лечения табачной зависимости и антитабачный комбинированный препарат

Also Published As

Publication number Publication date
SI1202727T1 (enExample) 2005-08-31
CA2379752C (en) 2008-05-27
DE60017147T2 (de) 2006-01-12
CN1377265A (zh) 2002-10-30
PT1202727E (pt) 2005-05-31
DK1202727T3 (da) 2005-05-09
EP1202727A1 (en) 2002-05-08
ATE285763T1 (de) 2005-01-15
ITMI991715A0 (it) 1999-07-30
HK1046849B (en) 2005-07-15
IL147876A0 (en) 2002-08-14
RU2262352C2 (ru) 2005-10-20
DE60017147D1 (de) 2005-02-03
HK1046849A1 (en) 2003-01-30
IT1313585B1 (it) 2002-09-09
EP1202727B1 (en) 2004-12-29
ITMI991715A1 (it) 2001-01-30
PL353373A1 (en) 2003-11-17
AU6153400A (en) 2001-02-19
WO2001008675A1 (en) 2001-02-08
CA2379752A1 (en) 2001-02-08
IL147876A (en) 2007-06-17
PL196334B1 (pl) 2007-12-31
ES2235913T3 (es) 2005-07-16

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Granted publication date: 20041124