HK1046849B - Use of GABAB receptor agonist and its pharmaceutically acceptable derivatives in the treatment of nicotine dependence to maintain nicotine withdrawal - Google Patents

Use of GABAB receptor agonist and its pharmaceutically acceptable derivatives in the treatment of nicotine dependence to maintain nicotine withdrawal Download PDF

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Publication number
HK1046849B
HK1046849B HK02107911.9A HK02107911A HK1046849B HK 1046849 B HK1046849 B HK 1046849B HK 02107911 A HK02107911 A HK 02107911A HK 1046849 B HK1046849 B HK 1046849B
Authority
HK
Hong Kong
Prior art keywords
nicotine
gaba
use according
receptors
agonists
Prior art date
Application number
HK02107911.9A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1046849A1 (en
Inventor
Luigi Gessa Gian
Colombo Giancarlo
Pani Luca
Fratta Walter
Original Assignee
L‧莫尔特尼及阿利蒂兄弟联合股份公司
L‧莫爾特尼及阿利蒂兄弟聯合股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by L‧莫尔特尼及阿利蒂兄弟联合股份公司, L‧莫爾特尼及阿利蒂兄弟聯合股份公司 filed Critical L‧莫尔特尼及阿利蒂兄弟联合股份公司
Publication of HK1046849A1 publication Critical patent/HK1046849A1/en
Publication of HK1046849B publication Critical patent/HK1046849B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
HK02107911.9A 1999-07-30 2000-06-30 Use of GABAB receptor agonist and its pharmaceutically acceptable derivatives in the treatment of nicotine dependence to maintain nicotine withdrawal HK1046849B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI991715 1999-07-30
IT1999MI001715A IT1313585B1 (it) 1999-07-30 1999-07-30 Uso di agonisti dei recettori gabab per la terapia di mantenimentodell'astinenza da nicotina in soggetti nicotino-dipendenti.
PCT/EP2000/006120 WO2001008675A1 (en) 1999-07-30 2000-06-30 Use of agonists of gabab receptors and pharmaceutically acceptable derivates thereof, in the therapy of maintaining nicotine abstinence-dependent patients

Publications (2)

Publication Number Publication Date
HK1046849A1 HK1046849A1 (en) 2003-01-30
HK1046849B true HK1046849B (en) 2005-07-15

Family

ID=11383467

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02107911.9A HK1046849B (en) 1999-07-30 2000-06-30 Use of GABAB receptor agonist and its pharmaceutically acceptable derivatives in the treatment of nicotine dependence to maintain nicotine withdrawal

Country Status (16)

Country Link
EP (1) EP1202727B1 (enExample)
CN (1) CN1176650C (enExample)
AT (1) ATE285763T1 (enExample)
AU (1) AU6153400A (enExample)
CA (1) CA2379752C (enExample)
DE (1) DE60017147T2 (enExample)
DK (1) DK1202727T3 (enExample)
ES (1) ES2235913T3 (enExample)
HK (1) HK1046849B (enExample)
IL (2) IL147876A0 (enExample)
IT (1) IT1313585B1 (enExample)
PL (1) PL196334B1 (enExample)
PT (1) PT1202727E (enExample)
RU (1) RU2262352C2 (enExample)
SI (1) SI1202727T1 (enExample)
WO (1) WO2001008675A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005019163A2 (en) * 2003-08-20 2005-03-03 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
EP2354120A1 (en) 2003-08-20 2011-08-10 XenoPort, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
WO2006050471A2 (en) 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
WO2006050472A2 (en) 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids
US7585996B2 (en) 2006-09-15 2009-09-08 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
JP4498407B2 (ja) 2006-12-22 2010-07-07 キヤノン株式会社 プロセスカートリッジ、電子写真画像形成装置、及び、電子写真感光体ドラムユニット
JP5291123B2 (ja) 2008-01-25 2013-09-18 ゼノポート，インコーポレイティド （３ｓ）−アミノメチル−５−ヘキサン酸プロドラッグの結晶形態及びその使用
WO2009094577A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
EP2250148B1 (en) 2008-01-25 2016-08-17 XenoPort, Inc. Crystalline form of calcium-salts of (3s)-aminomethyl-5-methyl-hexanoic acids and methods of use
US7989641B2 (en) 2008-08-07 2011-08-02 Xenoport, Inc. Methods of synthesizing N-hydroxysuccinimidyl carbonates
WO2010017504A1 (en) 2008-08-07 2010-02-11 Xenoport, Inc. Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
JP2012519212A (ja) 2009-03-03 2012-08-23 ゼノポート，インコーポレイティド Ｒ−バクロフェンプロドラッグの持効性放出経口投与形
US8344028B2 (en) 2009-04-17 2013-01-01 Xenoport, Inc. Gamma-amino-butyric acid derivatives as GABAB receptor ligands
WO2011081558A1 (ru) * 2009-08-21 2011-07-07 Komissarov Jury Vladimirovich Курительное устройство для отказа от табачного курения
US8580850B2 (en) 2011-08-11 2013-11-12 Xenoport, Inc. Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use
WO2019195813A1 (en) * 2018-04-06 2019-10-10 Ovid Therapeutics Inc. Use of gaboxadol in the treatment of substance use disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4126684A (en) * 1976-02-11 1978-11-21 Ciba-Geigy Corporation 4-amino-3-p-halophenylbutyric acids and their derivatives used in the control of narcotic abuse
US5073539A (en) * 1990-01-22 1991-12-17 Ciba-Geigy Corporation Transdermal administration of zwitterionic drugs
US5760049A (en) * 1997-02-21 1998-06-02 Synapse Pharmaceuticals International, Inc. Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use
US6541520B1 (en) * 1998-08-05 2003-04-01 Brookhaven Science Associates Treatment of addiction and addiction-related behavior
RU2132203C1 (ru) * 1998-09-03 1999-06-27 Шакирзянов Галимзян Закирович Способ лечения табачной зависимости и антитабачный комбинированный препарат

Also Published As

Publication number Publication date
SI1202727T1 (enExample) 2005-08-31
CA2379752C (en) 2008-05-27
DE60017147T2 (de) 2006-01-12
CN1377265A (zh) 2002-10-30
PT1202727E (pt) 2005-05-31
DK1202727T3 (da) 2005-05-09
EP1202727A1 (en) 2002-05-08
ATE285763T1 (de) 2005-01-15
ITMI991715A0 (it) 1999-07-30
IL147876A0 (en) 2002-08-14
RU2262352C2 (ru) 2005-10-20
DE60017147D1 (de) 2005-02-03
CN1176650C (zh) 2004-11-24
HK1046849A1 (en) 2003-01-30
IT1313585B1 (it) 2002-09-09
EP1202727B1 (en) 2004-12-29
ITMI991715A1 (it) 2001-01-30
PL353373A1 (en) 2003-11-17
AU6153400A (en) 2001-02-19
WO2001008675A1 (en) 2001-02-08
CA2379752A1 (en) 2001-02-08
IL147876A (en) 2007-06-17
PL196334B1 (pl) 2007-12-31
ES2235913T3 (es) 2005-07-16

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150630