CN117229370A - H5n6禽流感广谱性疫苗的开发及其应用 - Google Patents

H5n6禽流感广谱性疫苗的开发及其应用 Download PDF

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Publication number
CN117229370A
CN117229370A CN202210647453.8A CN202210647453A CN117229370A CN 117229370 A CN117229370 A CN 117229370A CN 202210647453 A CN202210647453 A CN 202210647453A CN 117229370 A CN117229370 A CN 117229370A
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China
Prior art keywords
vaccine
asn
leu
recombinant protein
ile
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Pending
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CN202210647453.8A
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English (en)
Chinese (zh)
Inventor
王桂芹
王海坤
常小艳
周保罗
刘冬平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanjing Institute Of Life And Health Sciences
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Nanjing Institute Of Life And Health Sciences
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Application filed by Nanjing Institute Of Life And Health Sciences filed Critical Nanjing Institute Of Life And Health Sciences
Priority to CN202210647453.8A priority Critical patent/CN117229370A/zh
Priority to PCT/CN2023/097257 priority patent/WO2023236822A1/fr
Publication of CN117229370A publication Critical patent/CN117229370A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08RNA viruses
    • C07K14/11Orthomyxoviridae, e.g. influenza virus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/91Cell lines ; Processes using cell lines

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CN202210647453.8A 2022-06-08 2022-06-08 H5n6禽流感广谱性疫苗的开发及其应用 Pending CN117229370A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202210647453.8A CN117229370A (zh) 2022-06-08 2022-06-08 H5n6禽流感广谱性疫苗的开发及其应用
PCT/CN2023/097257 WO2023236822A1 (fr) 2022-06-08 2023-05-30 Développement et utilisation d'un vaccin à large spectre contre la grippe aviaire de type h5n6

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210647453.8A CN117229370A (zh) 2022-06-08 2022-06-08 H5n6禽流感广谱性疫苗的开发及其应用

Publications (1)

Publication Number Publication Date
CN117229370A true CN117229370A (zh) 2023-12-15

Family

ID=89083210

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210647453.8A Pending CN117229370A (zh) 2022-06-08 2022-06-08 H5n6禽流感广谱性疫苗的开发及其应用

Country Status (2)

Country Link
CN (1) CN117229370A (fr)
WO (1) WO2023236822A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103421843A (zh) * 2013-07-29 2013-12-04 中国农业科学院哈尔滨兽医研究所 编码h5n1亚型禽流感同义血凝素(ha)蛋白以及同义神经氨酸酶(na)蛋白的基因及其应用
CN109678937A (zh) * 2017-10-18 2019-04-26 厦门大学 H3n2亚型流感病毒血凝素蛋白的突变体及其应用
CN113150083A (zh) * 2021-04-29 2021-07-23 山西高等创新研究院 重组禽流感亚单位疫苗及其制备方法
US20210260179A1 (en) * 2018-06-21 2021-08-26 Icahn School Of Medicine At Mount Sinai Mosaic influenza virus hemagglutinin polypeptides and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7871626B2 (en) * 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency
US8202967B2 (en) * 2006-10-27 2012-06-19 Boehringer Ingelheim Vetmedica, Inc. H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use
CN103200961B (zh) * 2009-03-27 2017-10-27 中央研究院 抗病毒免疫的方法和组合物
KR20120132506A (ko) * 2010-02-18 2012-12-05 마운트 시나이 스쿨 오브 메디슨 인플루엔자 바이러스 질환의 예방 및 치료에 사용되는 백신
CN101857872A (zh) * 2010-04-06 2010-10-13 浙江省医学科学院 甲型流感病毒抗原决定区更换方法
CN109289047B (zh) * 2018-12-11 2021-09-24 江苏省农业科学院 一种通用型h5亚型禽流感亚单位疫苗及其制备方法
CN113603754B (zh) * 2021-08-23 2024-05-24 福建省农业科学院畜牧兽医研究所 一种水禽h5n8亚型流感病毒ha重组蛋白及其制备方法与应用
CN113913394B (zh) * 2021-10-19 2022-06-21 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) 人工重组的h5n6流感病毒及其制备方法和应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103421843A (zh) * 2013-07-29 2013-12-04 中国农业科学院哈尔滨兽医研究所 编码h5n1亚型禽流感同义血凝素(ha)蛋白以及同义神经氨酸酶(na)蛋白的基因及其应用
CN109678937A (zh) * 2017-10-18 2019-04-26 厦门大学 H3n2亚型流感病毒血凝素蛋白的突变体及其应用
US20210260179A1 (en) * 2018-06-21 2021-08-26 Icahn School Of Medicine At Mount Sinai Mosaic influenza virus hemagglutinin polypeptides and uses thereof
CN113150083A (zh) * 2021-04-29 2021-07-23 山西高等创新研究院 重组禽流感亚单位疫苗及其制备方法

Also Published As

Publication number Publication date
WO2023236822A1 (fr) 2023-12-14

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