CN1170592C - 美拉加林的新用途 - Google Patents
美拉加林的新用途 Download PDFInfo
- Publication number
- CN1170592C CN1170592C CNB008027935A CN00802793A CN1170592C CN 1170592 C CN1170592 C CN 1170592C CN B008027935 A CNB008027935 A CN B008027935A CN 00802793 A CN00802793 A CN 00802793A CN 1170592 C CN1170592 C CN 1170592C
- Authority
- CN
- China
- Prior art keywords
- pab
- melagatran
- prodrug
- inflammation
- aze
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9900070A SE9900070D0 (sv) | 1999-01-13 | 1999-01-13 | New use |
| SE99000705 | 1999-01-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1341028A CN1341028A (zh) | 2002-03-20 |
| CN1170592C true CN1170592C (zh) | 2004-10-13 |
Family
ID=20414074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB008027935A Expired - Fee Related CN1170592C (zh) | 1999-01-13 | 2000-01-13 | 美拉加林的新用途 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6683054B1 (enExample) |
| EP (1) | EP1150704B1 (enExample) |
| JP (1) | JP2002534477A (enExample) |
| KR (1) | KR100701539B1 (enExample) |
| CN (1) | CN1170592C (enExample) |
| AT (1) | ATE319473T1 (enExample) |
| AU (1) | AU767077B2 (enExample) |
| BR (1) | BR0007452A (enExample) |
| CA (1) | CA2356611A1 (enExample) |
| CY (1) | CY1107465T1 (enExample) |
| DE (1) | DE60026491T2 (enExample) |
| DK (1) | DK1150704T3 (enExample) |
| ES (1) | ES2257282T3 (enExample) |
| IL (1) | IL143985A0 (enExample) |
| NO (1) | NO20013414D0 (enExample) |
| NZ (1) | NZ512713A (enExample) |
| PT (1) | PT1150704E (enExample) |
| SE (1) | SE9900070D0 (enExample) |
| WO (1) | WO2000041716A1 (enExample) |
| ZA (1) | ZA200105275B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9900070D0 (sv) * | 1999-01-13 | 1999-01-13 | Astra Ab | New use |
| US6462021B1 (en) | 2000-11-06 | 2002-10-08 | Astrazeneca Ab | Use of low molecular weight thrombin inhibitor |
| DE10064797A1 (de) * | 2000-12-22 | 2002-06-27 | Knoll Ag | Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon |
| SE0101762D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | New use |
| DE10133786A1 (de) * | 2001-07-16 | 2003-02-06 | Boehringer Ingelheim Pharma | Verwendung von Thrombin-Inhibitoren zur Behandlung von Arthritis |
| SE0103590D0 (sv) * | 2001-10-26 | 2001-10-26 | Astrazeneca Ab | New Combination |
| SE0200198D0 (sv) * | 2002-01-23 | 2002-01-23 | Astrazeneca Ab | New use |
| SE0203349D0 (sv) * | 2002-11-12 | 2002-11-12 | Astrazeneca Ab | New use |
| EP2560966B1 (en) | 2010-03-30 | 2021-01-06 | Verseon International Corporation | Multisubstituted aromatic compounds as inhibitors of thrombin |
| EP2970141B1 (en) | 2013-03-15 | 2020-02-26 | Verseon Corporation | Halogenopyrazoles as inhibitors of thrombin |
| CN110101699A (zh) | 2013-03-15 | 2019-08-09 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的多取代芳族化合物 |
| CN106687445A (zh) | 2014-09-17 | 2017-05-17 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的吡唑基取代的吡啶酮化合物 |
| KR102824411B1 (ko) | 2015-02-27 | 2025-06-23 | 베르선 코포레이션 | 세린 프로테아제 저해제로서의 치환된 피라졸 화합물 |
| SG11202100247WA (en) | 2018-07-13 | 2021-02-25 | Verseon Int Corporation | Thrombin inhibitors, formulations, and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| US6042821A (en) * | 1995-11-21 | 2000-03-28 | Smithkline Beecham Corporation | Method of treating sepsis with chemokines |
| TW541316B (en) * | 1995-12-21 | 2003-07-11 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
| SE9600216D0 (sv) * | 1996-01-18 | 1996-01-18 | Hans Arne Hansson | Styrning av läkningsprocesser |
| US5669754A (en) * | 1996-04-22 | 1997-09-23 | Advanced Dynamics Corporation Ltd. | Method and apparatus for collecting plates |
| SE9601556D0 (sv) * | 1996-04-24 | 1996-04-24 | Astra Ab | New pharmaceutical formulation of a thrombin inhibitor for parenteral use |
| SE9603724D0 (sv) * | 1996-10-11 | 1996-10-11 | Astra Ab | New pharmaceutical parenteral formulation of a thrombin inhibitor |
| SE9802974D0 (sv) | 1998-09-03 | 1998-09-03 | Astra Ab | New crystalline forms |
| JP2002525298A (ja) | 1998-09-28 | 2002-08-13 | メルク エンド カムパニー インコーポレーテッド | トロンビン阻害剤の投与による炎症疾患の処置法 |
| SE9900070D0 (sv) * | 1999-01-13 | 1999-01-13 | Astra Ab | New use |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
-
1999
- 1999-01-13 SE SE9900070A patent/SE9900070D0/xx unknown
-
2000
- 2000-01-13 US US09/508,762 patent/US6683054B1/en not_active Expired - Fee Related
- 2000-01-13 DE DE60026491T patent/DE60026491T2/de not_active Expired - Lifetime
- 2000-01-13 CN CNB008027935A patent/CN1170592C/zh not_active Expired - Fee Related
- 2000-01-13 NZ NZ512713A patent/NZ512713A/en not_active IP Right Cessation
- 2000-01-13 JP JP2000593326A patent/JP2002534477A/ja active Pending
- 2000-01-13 PT PT00902232T patent/PT1150704E/pt unknown
- 2000-01-13 DK DK00902232T patent/DK1150704T3/da active
- 2000-01-13 KR KR1020017008824A patent/KR100701539B1/ko not_active Expired - Fee Related
- 2000-01-13 AU AU23361/00A patent/AU767077B2/en not_active Ceased
- 2000-01-13 ES ES00902232T patent/ES2257282T3/es not_active Expired - Lifetime
- 2000-01-13 IL IL14398500A patent/IL143985A0/xx unknown
- 2000-01-13 WO PCT/SE2000/000051 patent/WO2000041716A1/en not_active Ceased
- 2000-01-13 CA CA002356611A patent/CA2356611A1/en not_active Abandoned
- 2000-01-13 AT AT00902232T patent/ATE319473T1/de not_active IP Right Cessation
- 2000-01-13 EP EP00902232A patent/EP1150704B1/en not_active Expired - Lifetime
- 2000-01-13 BR BR0007452-7A patent/BR0007452A/pt not_active Application Discontinuation
-
2001
- 2001-06-26 ZA ZA200105275A patent/ZA200105275B/en unknown
- 2001-07-10 NO NO20013414A patent/NO20013414D0/no not_active Application Discontinuation
-
2003
- 2003-10-15 US US10/685,003 patent/US20040082518A1/en not_active Abandoned
-
2006
- 2006-06-07 CY CY20061100757T patent/CY1107465T1/el unknown
-
2007
- 2007-08-29 US US11/896,035 patent/US20080058303A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010101492A (ko) | 2001-11-14 |
| ATE319473T1 (de) | 2006-03-15 |
| DE60026491T2 (de) | 2006-11-02 |
| CY1107465T1 (el) | 2012-12-19 |
| BR0007452A (pt) | 2001-10-16 |
| WO2000041716A1 (en) | 2000-07-20 |
| IL143985A0 (en) | 2002-04-21 |
| PT1150704E (pt) | 2006-06-30 |
| DK1150704T3 (da) | 2006-06-12 |
| US20080058303A1 (en) | 2008-03-06 |
| NZ512713A (en) | 2004-10-29 |
| US20040082518A1 (en) | 2004-04-29 |
| DE60026491D1 (de) | 2006-05-04 |
| AU2336100A (en) | 2000-08-01 |
| EP1150704B1 (en) | 2006-03-08 |
| AU767077B2 (en) | 2003-10-30 |
| EP1150704A1 (en) | 2001-11-07 |
| CA2356611A1 (en) | 2000-07-20 |
| CN1341028A (zh) | 2002-03-20 |
| NO20013414L (no) | 2001-07-10 |
| US6683054B1 (en) | 2004-01-27 |
| JP2002534477A (ja) | 2002-10-15 |
| ES2257282T3 (es) | 2006-08-01 |
| KR100701539B1 (ko) | 2007-03-30 |
| SE9900070D0 (sv) | 1999-01-13 |
| NO20013414D0 (no) | 2001-07-10 |
| ZA200105275B (en) | 2002-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20041013 Termination date: 20110113 |