CN116828999A - 含有蓝藻的片剂 - Google Patents
含有蓝藻的片剂 Download PDFInfo
- Publication number
- CN116828999A CN116828999A CN202280012262.2A CN202280012262A CN116828999A CN 116828999 A CN116828999 A CN 116828999A CN 202280012262 A CN202280012262 A CN 202280012262A CN 116828999 A CN116828999 A CN 116828999A
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- CN
- China
- Prior art keywords
- blue algae
- powder
- present
- food
- linolenic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 241000195493 Cryptophyta Species 0.000 title claims abstract description 40
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims abstract description 44
- 239000000843 powder Substances 0.000 claims abstract description 30
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims abstract description 22
- 229960004488 linolenic acid Drugs 0.000 claims abstract description 22
- 241000192700 Cyanobacteria Species 0.000 claims abstract description 10
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
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Abstract
蓝藻粉末单独压片时，存在发生破裂、缺口等压片收率差的问题、另外由于吸湿等而崩解的问题。因此，在进行片剂化时，需要添加蔗糖脂肪酸酯、糊精等赋形剂、粘结剂，无法应对近年的忌讳这些添加剂的消费者偏好。本发明人为了解决上述课题进行了深入研究，结果发现通过含有蓝藻粉末及α亚麻酸的配方可提高含有蓝藻的片剂的压片收率，从而完成了本发明。
Description
技术领域
本发明涉及压片收率提高的含有蓝藻的片剂。
背景技术
蓝藻类、特别是螺旋藻属的蓝藻类，已知含有可发挥各种生理活性的藻蓝蛋白，一直以来进行了各种制剂化。
作为这些含有蓝藻的制剂，报道了特征在于将螺旋藻和各种有机酸组合的含有藻类的食品(专利文献1)、含有螺旋藻干燥粉末和发芽花生的健康食品(专利文献2)等。
现有技术文献
专利文献
专利文献1:日本特开2007-82444号公报
专利文献2:日本特开2009-60865号公报
发明内容
发明要解决的问题
但是，蓝藻粉末单独压片时，存在不能压片的问题、另外由于吸湿等而崩解的问题。因此，在进行片剂化时，需要添加蔗糖脂肪酸酯、糊精等赋形剂、粘结剂，存在无法应对近年的忌讳这些添加剂的消费者偏好的课题。
本发明的目的在于，提供压片收率提高的蓝藻片剂。
用于解决问题的方案
本发明人为了解决上述课题反复进行了深入研究，结果发现，通过含有蓝藻粉末及α亚麻酸的配方可提高含有蓝藻的片剂的压片性、压片收率，从而完成了本发明。
即，本发明包括以下方式。
[1]一种压片饮食品，其特征在于，其相对于蓝藻粉末100重量份含有0.0035重量份以上的α亚麻酸。
[2]根据[1]所述的饮食品，其特征在于，前述α亚麻酸来自植物。
[3]根据[1]或[2]所述的饮食品，其特征在于，前述植物为选自大豆、芝麻中的任意1种以上植物。
[4]根据[1]～[3]中任一项所述的饮食品，其特征在于，仅包含蓝藻粉末及α亚麻酸。
发明的效果
根据本发明，可以提供用于提高蓝藻片剂的压片收率性的配方。
具体实施方式
以下对本发明的饮食品进行详细说明，但是以下记载的构成要件是作为本发明的一实施方式的一例，并不受这些内容限定。
(饮食品)
本发明的饮食品以蓝藻粉末及α亚麻酸为必需成分。
本发明中的蓝藻是指螺旋藻(Spirulina)属、节旋藻(Arthrospira)属、束丝藻(Aphanizomenon)属、侧生藻(Fisherella)属、鱼腥藻(Anabaena)属、念珠藻(Nostoc)属、集胞藻(Synechocystis)属、聚球藻(Synechococcus)属、单歧藻(Tolypothrix)属、隐杆藻(Aphanothece)属、鞭枝藻(Mastigoclaus)属、宽球藻(Pleurocapsa)属等的蓝藻类。这些中，优选以工业规模生产且确认了其安全性的螺旋藻属和节旋藻属的蓝藻类，更优选使用螺旋藻属的蓝藻类。
另外，蓝藻粉末可以为将未加工的蓝藻类干燥而得的蓝藻类，可以为将未加工的蓝藻类按照常规方法制成干燥品而得者，还可以为将进行了干燥的蓝藻类粉碎成期望的粒度而得者。作为这些蓝藻粉末，也可以使用市售品。
本发明的蓝藻粉末制造时的干燥方法只要在可得到本发明的效果的范围内则没有特别限定，可以使用常规方法。作为这些干燥方法，可以使用对未加工的蓝藻类进行加热干燥、温风干燥、冷冻干燥等干燥的方法等，其中，从蓝藻类的水分充分除去、另外使风味、有效成分保持稳定方面出发，优选加热干燥或冷冻干燥，其中最优选冷冻干燥。
本发明的蓝藻粉末制造时，可以在得到本发明的效果的范围内进行粉碎处理，可以通过常规方法对蓝藻类进行粉碎。作为这些粉碎方法，可使用例如磨碎型冲击式粉碎机、销棒粉碎机、冲击磨、剪切式粉碎机、Masscolloder、研磨机、石臼、低温冷冻粉碎机之类的粉碎机等其它公知粉碎机。
本发明的蓝藻粉末在得到本发明的效果的范围内没有特别限定，可以直接使用将蓝藻类干燥而得者，可以使用将这些蓝藻类以不同顺序进行干燥、粉碎而得者。另外，还可以同时进行干燥和粉碎。
本发明的蓝藻粉末的平均粒径在得到本发明的效果的范围内没有特别限定，优选为10μm以上且500μm以下的范围，为了容易处理而更优选30μm以上且125μm以下的范围，从压片性更加良好方面出发，特别优选40μm以上且95μm以下的范围。需要说明的是，本发明中的平均粒径采用使用粒径分布测定装置的激光分析·散射法测得的平均粒径。
本发明的α亚麻酸只要是通常得到的α亚麻酸，则其起源没有特别限定，优选来自大豆、芝麻、紫苏、苏子、亚麻籽等植物的α亚麻酸，特别优选来自大豆、芝麻的α亚麻酸。另外，作为本发明的α亚麻酸，可以使用从原料中提取·分离而得的α亚麻酸，也可以不经分离而直接使用作为成分包含在各种食品原料中的α亚麻酸。
本发明中，α亚麻酸相对于蓝藻粉末100重量份以α亚麻酸计优选含有0.0035重量份以上，从提高压片饮食品的稳定性方面出发，更优选以0.0039重量份以上且0.02重量份以下的范围包含，进而从风味也良好方面出发，特别优选以0.007重量份以上且0.016重量份以下的范围包含。
关于本发明的压片饮食品中的蓝藻粉末及α亚麻酸的合计配合量，在得到本发明的压片性提高效果的范围内没有特别限定，相对于压片饮食品总量，优选含有合计50重量％以上的蓝藻粉末及α亚麻酸，从提高压片收率方面出发，更优选含有80重量％以上，从得到压片收率的显著的提高效果方面出发，特别优选含有90重量％以上，从不考虑其它原料的影响、得到合适的压片性方面出发，最优选为100重量％。
作为本发明的压片饮食品，只要是经压片成型的饮食品就没有特别限制，可以为例如健康食品、功能性标示食品、特定保健用食品、营养辅助食品或补充剂等。
本发明的压片饮食品可以在得到本发明的效果的范围内添加通常配合于饮食品的成分，例如可以将赋形剂、结合剂、崩解剂、润滑剂、保存剂、抗氧化剂、等渗剂、缓冲剂、包衣剂、矫味剂、溶解助剂、基剂、分散剂、稳定剂、着色剂等添加剂适宜组合并按照常规方法进行制备。
作为赋形剂，可列举淀粉及其衍生物(糊精、羧甲基淀粉等)、纤维素及其衍生物(甲基纤维素、羟丙甲基纤维素等)、糖类(乳糖、白糖、葡萄糖、海藻糖等)等、柠檬酸或其盐类、苹果酸或其盐类、乙二胺四乙酸或其盐类。
作为结合剂，可使用淀粉及其衍生物(α化淀粉、糊精等)、纤维素及其衍生物(乙基纤维素、羧甲基纤维素钠、羟丙甲基纤维素等)、阿拉伯胶、黄芪胶、明胶、糖类(葡萄糖、白糖等)、乙醇等。
作为崩解剂，可使用淀粉及其衍生物(羧甲基淀粉、羟丙基淀粉等)、纤维素及其衍生物(羧甲基纤维素钠、结晶纤维素、羟丙甲基纤维素等)、碳酸盐(碳酸钙、碳酸氢钙等)、黄芪胶、明胶、琼脂等。
作为润滑剂，可列举使用硬脂酸、硬脂酸钙、硬脂酸镁、滑石、氧化钛、磷酸氢钙、干燥氢氧化铝凝胶、蔗糖脂肪酸酯、食用油脂等。
作为保存剂，可列举对羟基苯甲酸酯类、亚硫酸盐类(亚硫酸钠、焦亚硫酸钠等)、磷酸盐类(磷酸钠、聚磷酸钙、多聚磷酸钠、偏磷酸钠等)、脱氢乙酸、脱氢乙酸钠、山梨酸甘油酯、糖类等。
作为抗氧化剂，可列举亚硫酸盐类(亚硫酸钠、亚硫酸氢钠等)、异抗坏血酸、L-抗坏血酸、半胱氨酸、硫代甘油、丁基羟基茴香醚、二丁基羟基甲苯、没食子酸丙酯、抗坏血酸棕榈酸酯、dl-α-生育酚等。
作为等渗剂，可列举氯化钠、硝酸钠、硝酸钾、糊精、甘油、葡萄糖等。
作为缓冲剂，可列举碳酸钠、盐酸、硼酸、磷酸盐(磷酸氢钠等)等。
作为包衣剂，可列举纤维素衍生物(羟丙基纤维素、乙酸邻苯二甲酸纤维素、羟丙甲基纤维素邻苯二甲酸酯等)、虫胶、聚乙烯基吡咯烷酮、聚乙烯基吡啶类(聚-2-乙烯基吡啶、聚-2-乙烯基-5-乙基吡啶等)、聚乙烯基乙酰基二乙基氨基乙酸酯、聚乙烯醇邻苯二甲酸酯、甲基丙烯酸酯-甲基丙烯酸共聚物等。
作为矫味剂，可列举糖类(葡萄糖、白糖、乳糖等)、糖精钠、糖醇类等。
作为溶解助剂，可列举乙二胺、烟酰胺、糖精钠、柠檬酸、柠檬酸盐类、苯甲酸钠、聚乙烯基吡咯烷酮、聚山梨酯类、失水山梨醇脂肪酸酯类、甘油、聚丙二醇、苯甲醇等。
作为基剂，可列举脂肪类(猪脂等)、植物油(橄榄油、芝麻油等)、动物油、羊毛脂酸、凡士林、石蜡、树脂、膨润土、甘油、二醇油等。
作为分散剂，可列举阿拉伯胶、黄芪胶、纤维素衍生物(甲基纤维素等)、藻酸钠、聚山梨酯类、失水山梨醇脂肪酸酯类等。
作为稳定剂，可列举亚硫酸盐类(亚硫酸氢钠等)、氮气、二氧化碳等。
进而，本发明的压片饮食品可以在不妨碍本发明的效果的范围内与任意的食品材料或其它有效成分、或食品中允许的添加物(例如溶剂、软化剂、油、乳化剂、防腐剂、酸味剂、甜味剂、苦味剂、香味剂、pH调节剂、表面活性剂、稳定剂、着色剂、紫外线吸收剂、抗氧化剂、保湿剂、增稠剂、固着剂、分散剂、流动性改善剂、发泡剂、润湿剂、香科、调味剂、风味调整剂等)等适宜组合并按照常规方法制备。
作为上述其它有效成分(生物活性成分)等，没有特别限制，可以根据目的适宜选择，可以为例如氨基酸、糖、甘油、维生素A、B、C(抗坏血酸)、D、E等维生素类、胶原蛋白、胶原肽、透明质酸、透明质酸盐、神经酰胺等成分。
本发明的压片饮食品的制造方法在得到本发明的效果的范围内没有特别限定，由具有将各种原料混合的混合工序、压片工序的工序来制造。
作为前述混合工序，可以采用使用V型混合机、W型混合机、Bohle containermixer的混合，特别优选使用V型混合机的混合。
作为前述压片工序，可以采用使用旋转型压片机、单冲压片机、双冲压片机的压片，特别优选使用旋转型压片机的压片。
实施例
以下列举实施例详细说明本发明，但是本发明的范围不受这些实施例限定。
(蓝藻粉末)
以下的实施例及比较例中，使用DIC LIFETEC CORPORATION制螺旋藻粉末(在室外培养槽中生产的螺旋藻干燥藻体(喷雾干燥品))。该螺旋藻粉末的平均粒径为90μm。
(片剂的制造)
(实施例1～5、比较例1～4)
按照表1所示的配方将原料粉末混合，制备混合粉末约3kg。具体制造方法如以下所示。各成分的混合中，将原料粉末混合，得到的混合粉末使用压片机(HT-AP24SS-U株式会社畑铁工所)，设为转速25rpm而供于压片成型，由此制造蓝藻片剂(φ8mm、200mg)。
对于实施例1～5中得到的压片品，按照下述方法对压片性、片厚度、硬度、磨损度进行评价、测定。
(压片性的评价)
作为压片加工的评价，按照以下的基准进行目视评价(n＝10)。
〇：能压片，所有压片品的外观均良好
△：能压片，但是混有压片障碍、破裂、缺口等外观不良品
×：不能压片。
(片厚度的测定)
(片厚度·硬度的测定)
使用硬度试验器(PTB311E Pharma Test Apparatebau)测定片剂的硬度。将片剂固定于装置内的样品架，1粒1粒地进行测定。合计测定10粒，计算平均值。
(磨损度试验)
使用片剂磨损度试验器(TFT-120、富山产业株式会社)，对于片剂进行针对冲击的磨损性试验、脆碎度试验。每个转鼓使用20粒试样，在试验前后测定重量。设定为转速250次、旋转时间10分钟，对于2个转鼓盒，各放入20粒，使其旋转。旋转结束后，通过吹送空气而去除附着于片剂的粉末，确认无破裂、无缺口。磨损度(％)通过((试验前片剂重量)-(试验后片剂重量))/(试验前片剂重量)×100来计算。
(结果)
将得到的结果示于表1。
[表1]
相对于蓝藻粉末100重量份含有0.0035重量份以上α亚麻酸的实施例1-5中，流动性、向压片机的臼的填充均良好，顺利地进行了压片加工。不含α亚麻酸的比较例1、比较例2中，由于压片障碍而不能进行压片加工。另外，使用相对于蓝藻粉末100重量份而言α亚麻酸含量少的混合粉末的比较例3-4中，也发生了压片障碍。
如实施例所示，确认通过本发明的配方可提高蓝藻粉末的压片收率。
Claims (4)
1.一种压片饮食品，其特征在于，其相对于蓝藻粉末100重量份含有0.0035重量份以上的α亚麻酸。
2.根据权利要求1所述的饮食品，其特征在于，所述α亚麻酸来自植物。
3.根据权利要求2所述的饮食品，其特征在于，所述植物为选自大豆、芝麻中的任意1种以上植物。
4.根据权利要求1～3中任一项所述的饮食品，其特征在于，仅包含蓝藻粉末及α亚麻酸。
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| CN103211927A (zh) * | 2013-04-26 | 2013-07-24 | 甘肃凯源生物技术开发中心 | 一种抗衰老复合片剂及其制备方法 |
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| JP2004123578A (ja) * | 2002-09-30 | 2004-04-22 | Dainippon Ink & Chem Inc | 糖衣錠およびその製造方法 |
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| JP2014156436A (ja) * | 2013-02-18 | 2014-08-28 | Spirulina Biological Lab Ltd | 崩壊剤及びこの崩壊剤を含有する錠剤 |
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| CN103211927A (zh) * | 2013-04-26 | 2013-07-24 | 甘肃凯源生物技术开发中心 | 一种抗衰老复合片剂及其制备方法 |
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