CN116617145A - Rapid anti-aging repair composition and application thereof - Google Patents
Rapid anti-aging repair composition and application thereof Download PDFInfo
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- CN116617145A CN116617145A CN202310383638.7A CN202310383638A CN116617145A CN 116617145 A CN116617145 A CN 116617145A CN 202310383638 A CN202310383638 A CN 202310383638A CN 116617145 A CN116617145 A CN 116617145A
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- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9733—Lichens
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/49—Solubiliser, Solubilising system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to the field of A61K8/00, in particular to a rapid anti-aging repair composition and application thereof, which consists of a composite plant extract and a composite peptide; the compound plant extract is at least two of Carnean leaf extract, spilanthum extract, honey extract, olive leaf extract, radix puerariae extract, snow tea extract and grape seed extract; the compound peptide is at least two selected from palmitoyl tetrapeptide-7, tripeptide-1, hexapeptide-9, palmitoyl pentapeptide-4, acetyl tetrapeptide-9, acetyl hexapeptide-8, optical glutathione, palmitoyl tripeptide-5 and acetyl hexapeptide-3. The composition has excellent anti-aging repairing effect and wide formula matching compatibility, can be added to the preparation of skin care products with different dosage forms, ensures the stability and skin feel of the products by optimizing a product formula system, and meets the use requirements of consumers.
Description
Technical Field
The invention relates to the field of A61K8/00, in particular to a rapid anti-aging repair composition and application thereof.
Background
At present, the anti-aging products on the market mainly comprise skin care products, the knowledge of consumers on skin care and beauty treatment is gradually increased, and time and money are also willing to be input into some effective and reliable skin care products to obtain corresponding effects, but the consumption not only pursues instant effects, but also has long-term effects on the anti-aging skin care products, and achieves the real anti-aging and repairing effects.
With the increasing demands of consumers for safety and effectiveness of anti-aging products, the development of anti-aging cosmetics has been focused on the naturalness and comprehensive application of added active ingredients. For example, chinese patent application CN 113712833a discloses an anti-aging composition and a preparation method thereof, specifically, a polygonum multiflorum extract, VC, lycopene, vitamin E, a chenopodium album extract, a juniper berry procyanidine, ethyl hexyl glycerol, an olive leaf extract, adenosine, a dipeptide and ursolic acid are adopted, and although a good anti-aging effect is expected to be achieved through the cooperation of various effective active ingredients, various easily-oxidized active ingredients exist, the subsequent application and subsequent product development difficulty are greatly limited, the cost of raw materials is high, consumers cannot bear the raw materials, and the product selling popularization is not facilitated. Chinese patent application CN111603419A discloses a preparation method and a use method of an anti-aging reverse-age essence containing biological polypeptide components, which mainly comprises the steps of preparing active component parts containing biological polypeptides including oligopeptide-1, oligopeptide-3, oligopeptide-5, ceramide and amino acid into freeze-dried powder, mixing the rest active components with plant extracts to prepare a solvent, mixing the freeze-dried powder with solvent liquid in equal proportion and smearing the mixture for use, so that the problem that the active components cannot be preserved for a long time is solved, but only the preservation time of part of the active components in the freeze-dried powder can be prolonged, and the use is inconvenient. .
Disclosure of Invention
In order to solve the problems, the invention provides a rapid anti-aging repair composition which has excellent anti-aging repair effect and wide formula matching compatibility, can be added to the preparation of skin care products with different dosage forms, ensures the stability and skin feel of the products by optimizing a product formula system, ensures the long-term anti-aging repair effect of the products while realizing the anti-aging repair effect in a short period, and meets the use demands of consumers.
In one aspect, the invention provides a rapid anti-aging repair composition comprising a complex plant extract and a complex peptide.
As a preferable technical scheme, the compound plant extract is at least two of Carnean leaf extract, spilanthum extract, honey extract, olive leaf extract, kudzuvine root extract, snow tea extract and grape seed extract.
Preferably, the compound plant extract is a combination of a Carnean leaf extract and a spilanthum flower extract, and the mass ratio of the Carnean leaf extract (Kunzea Ericoides Leaf Extract) to the spilanthum flower extract (Acmella Oleracea extract) is (0.1-60): 1, a step of;
as a preferable technical scheme, the compound peptide is at least two selected from palmitoyl tetrapeptide-7, tripeptide-1, hexapeptide-9, palmitoyl pentapeptide-4, acetyl tetrapeptide-9, acetyl hexapeptide-8, glutathione, palmitoyl tripeptide-5, acetyl hexapeptide-3.
Preferably, the compound peptide comprises palmitoyl tetrapeptide-7, tripeptide-1, hexapeptide-9, palmitoyl pentapeptide-4, acetyl tetrapeptide-9 and acetyl hexapeptide-8, wherein the mass ratio of palmitoyl tetrapeptide-7, tripeptide-1, hexapeptide-9, palmitoyl pentapeptide-4, acetyl tetrapeptide-9 and acetyl hexapeptide-8 is 0.005: (0.1-0.15): 0.02:0.01:0.02:0.005.
The composition provided by the invention adopts the combined action of the specific composite plant extract and the composite peptide to realize the omnibearing anti-aging repair effect, so that the skin can be repaired in time, and the long-term anti-aging effect can be realized. Based on the cost of raw materials and actual action effect, a composite plant extract of the combination of the Carnean leaf extract and the spilanthus altissima extract is selected to act together with a composite peptide consisting of palmitoyl tetrapeptide-7, tripeptide-1, hexapeptide-9, palmitoyl pentapeptide-4, acetyl tetrapeptide-9 and acetyl hexapeptide-8, so that muscles are quickly relaxed, expression lines are smoothed, the skin is prevented from being damaged and aged, the problem skin is efficiently repaired, the damage of various inflammations to skin tissues is reduced, the skin cell renewal and collagen regeneration are promoted, and obvious and effective effects of stabilizing the skin and resisting aging are shown. In particular, the mass ratio of the invention is 0.005: (0.1-0.15): 0.02:0.01:0.02:0.005 of palmitoyl tetrapeptide-7, tripeptide-1, hexapeptide-9, palmitoyl pentapeptide-4, acetyl tetrapeptide-9, acetyl hexapeptide-8 to be combined with the Carnean leaf extract and the spilanthol extract, help to maintain the balance of inflammatory factors in the skin, revive the activity of epidermis and dermis cells, promote the synthesis of collagen, laminin-5, fibronectin and basil-membrane glycans, repair epidermis-dermis connective tissue, coagulate collagen fibers, tighten the skin, and have remarkable short-term and long-term effects.
The invention further provides application of the rapid anti-aging repair composition to preparation of aqueous products, emulsifier products or emulsifier-free opalescent products, wherein the addition amount of the composite plant extract in the aqueous products, the emulsifier products or the emulsifier-free opalescent products is 0.001-20wt% and the addition amount of the composite peptide is 0.001-10wt%.
In the development process of the products of different dosage forms containing the rapid anti-aging repair composition, the addition amount of the composite plant extract and the composite peptide in the rapid anti-aging repair composition can be freely adjusted according to the requirements of target clients and target consumers, and the problem of influence on the stability of a subsequent product system caused by the change of the proportion of the composite plant extract and the composite peptide is avoided, so that the composition can be widely added into skin care products of various dosage forms to realize stable and effective efficacy and effect, and has high relative performance price, thus having high market value.
As a preferable technical scheme, the preparation raw materials of the aqueous solution product at least comprise, by mass: 0.01-20% of composite plant extract, 0.01-10% of composite peptide, 1-10% of humectant, 0-0.2% of chelating agent, 0-1% of thickening agent, 0-0.2% of essence, 0-3% of solubilizer, 0.05-5% of preservative, 0-0.2% of pH regulator and the balance of deionized water.
Preferably, the humectant is at least one of glycerin and 1, 3-butanediol; preferably, the humectant is glycerin.
Preferably, the chelating agent is disodium EDTA.
Preferably, the thickener is a Carbomer thickener, preferably Carbomer 980.
Preferably, the preservative is at least one of phenoxyethanol, 1, 2-hexanediol and ethylhexyl glycerol; preferably, the preservative is a combination of phenoxyethanol, 1, 2-hexanediol and ethylhexyl glycerol, and the mass ratio of phenoxyethanol, 1, 2-hexanediol and ethylhexyl glycerol is (3-5): 3: (0.1-1).
Preferably, the pH adjustor is AMP-ULTRA PC 2000.
Preferably, the essence is an essential oil, and the essential oil is at least one selected from lemon oil, cinnamon oil, peppermint oil, jasmine oil, rose oil, rock rose oil, sandalwood oil, ylang-ylang oil, tea oil, lavender oil, violet oil and red chrysanthemum oil.
Preferably, the solubilizer is an alcohol ether solubilizer; preferably, the alcohol ether solubilizer is at least one of PPG-13-decyl tetradecyl polyether-24, PPG-30-butyl alcohol polyether-30 and PPG-20-decyl tetradecyl polyether-10; preferably, the alcohol ether solubilizer is PPG-13-decyl tetradecyl polyether-24 (SOLUBULE) TM GS-01)。
Preferably, the preparation process of the water aqua product comprises the following steps:
(1) Adding deionized water, chelating agent, humectant and thickener in the formula amount into a sterilized and cleaned stirring pot in sequence, heating to 80-90 ℃, and preserving heat and stirring for 30-40min;
(2) Cooling to 45-50deg.C, adding antiseptic and pH regulator, regulating pH to 5.0-7.0, stirring, mixing, and cooling;
(3) Cooling to 40-45deg.C, mixing solubilizer and essence, adding into the stirring pot, adding the anti-aging composition into the stirring pot, stirring, and cooling;
(4) And (5) reducing the temperature of the stirring pot to 35-40 ℃, stopping reducing the temperature, and filtering and discharging by using a 200-mesh screen after the temperature is checked to be qualified to obtain the water aqua product.
Preferably, the addition amount of the essence is 0.001-0.1wt%, and the addition amount of the solubilizer is 0.5-3wt%.
In the development of cosmetics, although the addition amount is small, the skin feel and stability of the aqueous agent product are affected to a certain extent, and the inventor unexpectedly discovers that based on the essential oil raw materials and the composite plant extract introduced into the system, 0.5-3wt% of PPG-13-decyl tetradecyl polyether-24 can be effectively solubilized by controlling the preparation process conditions, so that the problem that the aqueous agent product is turbid at low temperature is effectively solved, and foaming, irritation and sticky feel caused by mismatching of the solubilizing agent or excessively high addition amount of the aqueous agent product in use are avoided. The inventors analyzed the cause may be: the aqueous system containing the anti-aging repairing composition has the advantages that due to the fact that essential oil is introduced into the aqueous system, compatibility among raw materials in the aqueous system is poor, the aqueous product is turbid at low temperature, the problems cannot be effectively solved under the condition of low addition amount of the conventional solubilizing agent PEG-60 hydrogenated castor oil, the sticky feel of the prepared product is increased, the skin feel is poor, even the penetration and absorption of skin to functional components are affected, the anti-aging repairing effect of the aqueous product is affected, the PPG-13-decyl tetradecyl polyether-24 has a longer carbon chain structure, the essential oil can be effectively solubilized, and meanwhile, the sticky feel of the product caused by a Carbomer 980 high-molecular thickening rheological agent is effectively reduced.
As a preferred technical scheme, the preparation raw materials of the emulsifier product at least comprise the following components in percentage by mass: 0.01-20% of composite plant extract, 0.01-10% of composite peptide, 1-20% of alcohol humectant, 0-0.2% of EDTA disodium, 0-1% of thickener, 1-40% of emollient, 0.1-5% of antiseptic composition, 0.1-5% of emulsifier, 0-1% of neutralizer, 0-0.2% of essence and the balance of deionized water.
Preferably, the neutralizing agent is aminomethylpropanol, and the aminomethylpropanol is an aqueous aminomethylpropanol solution with a concentration of 89-95 wt%.
Preferably, the alcohol humectant is a composition of glycerin and 1, 3-butanediol, and the mass ratio of the glycerin to the 1, 3-butanediol is (1-2): (5-6).
Preferably, the Carbomer is Carbomer 980.
Preferably, the preservative composition is a combination of 1, 2-pentanediol, 1, 2-hexanediol and p-hydroxyacetophenone, and the mass ratio of the 1, 2-pentanediol, 1, 2-hexanediol and p-hydroxyacetophenone is 3: (0.3-0.4):0.3.
Preferably, the emollient is a combination of polydimethylsiloxane, shea butter, squalane, caprylic-capric triglyceride; preferably, the mass ratio of the polydimethylsiloxane, the shea butter, the squalane and the caprylic-capric triglyceride is 0.5: (0.8-1.2): 0.5: (2-4).
Preferably, the emulsifier is a combination of polyglycerol-10 myristate and sodium stearyl glutamate; preferably, the mass ratio of the polyglycerol-10 myristate to the sodium stearoyl glutamate is (0.8-1.5): 0.1.
based on the emulsifier product system provided by the invention, the composition of the polydimethylsiloxane, the shea butter, the squalane and the caprylic-capric triglyceride is simultaneously introduced as an emollient, and the mass ratio is especially controlled to be 0.5: (0.8-1.2): 0.5: (2-4) to make the provided emulsifier product have better skin feel, no stickiness and stable system. The inventors analyzed the cause may be: the system is simultaneously introduced with the polydimethylsiloxane and the caprylic-capric triglyceride, the repulsive force between the two types of grease is larger, the system compatibility is reduced, the emulsification process of the product is influenced, the stability of the product is influenced, the prepared product has a sticky feel which can be directly felt when in use, and by simultaneously introducing the combination of the polydimethylsiloxane, the butter tree fruit fat, the squalane and the caprylic-capric triglyceride, the good compatibility between the polydimethylsiloxane and the caprylic-capric triglyceride can be realized through the bridging effect between the polydimethylsiloxane and the caprylic-capric triglyceride, the system stability is improved, and further, the full play of the functional components in the product is ensured. Based on this, the inventors found that, under specific emulsification process conditions, a combination of polyglycerol-10 myristate and sodium stearoyl glutamate is used as an emulsifier, and in particular, the mass ratio of polyglycerol-10 myristate to sodium stearoyl glutamate is controlled to be (0.8-1.5): and 0.1, under the action of a thickener, obtaining a high-stability emulsifier product with proper viscosity and uniform emulsification. The inventors analyzed the cause may be: the small amount of sodium stearyl glutamate is introduced by compounding, ionization occurs in the system, active groups reduce surface tension to form an emulsion, sodium ions are adsorbed on the surface of liquid drops, and the stability of the emulsion system is enhanced by an electrostatic effect.
Preferably, the preparation process of the emulsifier product comprises the following steps:
s1, sequentially adding deionized water, EDTA disodium, an alcohol humectant and carbomer components in a formula amount into a sterilized and cleaned water pot, heating to 80-85 ℃, and carrying out heat preservation and stirring for 30-40min to obtain a water pot raw material;
s2, sequentially adding the components of the formula amount of the emollient and the emulsifier into the sterilized and cleaned oil pan, heating to 75-85 ℃, and carrying out heat preservation and stirring for 5-15min to obtain an oil pan raw material;
s3, pumping the raw materials of the water pot and the oil pot into an emulsifying pot, homogenizing for 8-12min in a phase-combining way, and emulsifying uniformly;
s4, cooling the temperature of the emulsifying pot to 50-60 ℃, adding the antiseptic composition and the neutralizer, adjusting the PH to 5.0-7.0, continuously stirring and mixing, and cooling;
s5, the temperature of the stirring pot is reduced to 40-45 ℃, and the composite plant extract, the composite peptide and the essence are added into the emulsifying pot, and stirring and cooling are maintained;
s6, cooling the temperature of the stirring pot to 35-40 ℃, stopping cooling, and filtering and discharging by using a 200-mesh screen after the temperature is checked to be qualified, thus obtaining the emulsifier product.
As a preferable technical scheme, the preparation raw materials of the emulsifier-free milky white product at least comprise the following components in percentage by mass: 0.001-20% of compound plant extract, 0.001-10% of compound peptide, 2-4% of glycerin, 3-5% of 1, 3-butanediol, 0.01-0.07% of EDTA disodium, 0.1-5% of compound thickener, 0.1-10% of compound grease, 0.1-5% of compound preservative, 0.01-0.5% of aminomethylpropanol, 0-0.2% of essence and the balance of deionized water.
Preferably, the composite thickener is a combination of carbomer 980 and hydroxyethyl acrylate-sodium acryloyldimethyl taurate copolymer; the mass ratio of carbomer 980 to hydroxyethyl acrylate-sodium acryloyldimethyl taurate copolymer is (0.1-0.5): 1.
preferably, the compound grease is a combination of isononyl isononanoate, polydimethylsiloxane and squalane; preferably, the mass ratio of isononyl isononanoate, polydimethylsiloxane and squalane is (1.5-3): 1:1.
Preferably, the compound preservative is a combination of phenoxyethanol, 1, 2-hexanediol and ethylhexyl glycerol, and the mass ratio of the phenoxyethanol to the 1, 2-hexanediol to the ethylhexyl glycerol is (3-5): 3: (0.1-1).
In the actual development process of the emulsifier-free milky white product prepared by adding the composition, the combination of isononyl isononanoate, polydimethylsiloxane and squalane with the mass ratio of (1.5-3) being 1:1 is adopted as the composite grease to be added into the emulsifier-free milky white product so as to improve the skin feel of the product, but the product has the oil-out phenomenon in the use process, and the mass ratio of (0.1-0.5) is introduced into the system: 1 and hydroxyethyl acrylate-sodium acryloyldimethyl taurate copolymer together as a thickening agent can effectively solve the problems, and the analysis reason of the inventor is that the carbomer 980 and the hydroxyethyl acrylate-sodium acryloyldimethyl taurate copolymer together act in the proportion, so that the oil production phenomenon caused by the movement collision of grease is limited, and the system stability is ensured.
The preparation method of the emulsifier-free milky white product comprises the following steps: adding deionized water, EDTA disodium, glycerol, 1, 3-butanediol and a composite thickener according to the formula amount into a sterilized and cleaned water pot in sequence, heating to 80-85 ℃, and preserving heat and stirring for 30-40min; adding the compound grease with the formula amount into the sterilized and cleaned oil pan in sequence, heating to 70-80 ℃, preserving heat and stirring for 10-20min; pumping the raw materials of the water pot and the oil pot into an emulsifying pot, homogenizing for 10min, and emulsifying uniformly; cooling the emulsifying pot to 50-55deg.C, adding compound antiseptic and aminomethylpropanol, adjusting pH to 5.0-7.0, stirring, mixing, and cooling; the temperature of the stirring pot is reduced to 40-45 ℃, and the composite plant extract, the composite peptide and the essence are added into the emulsifying pot, and stirring and cooling are maintained; and (5) reducing the temperature of the stirring pot to 30-35 ℃, stopping reducing the temperature, and filtering and discharging by using a 200-mesh screen after the temperature is checked to be qualified to obtain the emulsified cosmetic.
The beneficial effects are that:
1. the invention provides a rapid anti-aging repair composition, which has excellent anti-aging repair effect and wide formula matching compatibility, can be added to the preparation of skin care products with different dosage forms, ensures the stability and skin feel of the products by optimizing a product formula system, ensures the long-term anti-aging repair effect of the products while realizing the anti-aging repair effect in a short period, and meets the use requirements of consumers.
2. The addition amount of the composite plant extract and the composite peptide in the rapid anti-aging repair composition provided by the invention can be freely adjusted according to the requirements of target clients and target consumers, and the problem of influence on the stability of a subsequent product system caused by the change of the ratio of the composite plant extract to the composite peptide is avoided, so that the composition can be widely added into skin care products in various dosage forms to realize stable and effective efficacy effect, and has high relative performance price, thus having high market value.
3. According to the aqueous solution product provided by the invention, based on essential oil raw materials and composite plant extracts introduced into the system, 0.5-3wt% of PPG-13-decyl tetradecyl polyether-24 is introduced by controlling the preparation process conditions, so that the aqueous solution product can be effectively solubilized, the problem that the aqueous solution product is turbid at low temperature is effectively solved, and foaming, irritation and sticky feel caused by mismatching of the solubilizing agent or excessively high addition amount of the aqueous solution product in use are avoided.
4. Based on the emulsifier product system provided by the invention, the composition of the polydimethylsiloxane, the shea butter, the squalane and the caprylic-capric triglyceride is simultaneously introduced as an emollient, and the mass ratio is especially controlled to be 0.5: (0.8-1.2): 0.5: (2-4) to make the provided emulsifier product have better skin feel, no stickiness and stable system.
5. The emulsifier-free milky white product prepared by adding the composition is prepared by introducing the mass ratio of (0.1-0.5) into a system: 1 and hydroxyethyl acrylate-sodium acryloyldimethyl taurate copolymer together as a thickening agent can effectively solve the problems, and the analysis reason of the inventor is that the carbomer 980 and the hydroxyethyl acrylate-sodium acryloyldimethyl taurate copolymer together act in the proportion, so that the oil production phenomenon caused by the movement collision of grease is limited, and the system stability is ensured.
Drawings
Fig. 1-3 show the results of efficacy testing of the aqueous product provided in example 1.
Fig. 4 and 5 are results of efficacy testing of the emulsifier product provided in example 2.
Fig. 6 and 7 show the results of efficacy tests of the emulsifier-free opalescent product provided in example 3.
Detailed Description
Example 1
In one aspect, embodiment 1 of the present invention provides a rapid anti-aging repair composition consisting of a complex plant extract and a complex peptide.
The composite plant extract is a combination of a card leaf extract and a spilanthus altissima extract, and the mass ratio of the card leaf extract to the spilanthus altissima extract is 1:3; the Carnean leaf extract is from Tekenobao, inc., and flos Chrysanthemi extractExpression AF) was derived from the carnallia lion.
The compound peptide comprises 0.005% of palmitoyl tetrapeptide-7, 0.12% of tripeptide-1, 0.02% of hexapeptide-9, 0.01% of palmitoyl pentapeptide-4, 0.02% of acetyl tetrapeptide-9, 0.005% of acetyl hexapeptide-8, 1.2-hexanediol 1%, 1% of stearyl alcohol crisp-20, 1.2-pentanediol 2%, glycerol 30% and the balance of deionized water.
The embodiment 1 of the invention provides an application of a rapid anti-aging repair composition, which is applied to the additive preparation of an aqueous product, wherein the preparation raw materials of the aqueous product comprise, by mass: 2% of composite plant extract, 2% of composite peptide, 6% of humectant, 0.05% of chelating agent, 0.5% of thickening agent, 0.005% of essence, 2% of solubilizer, 0.75% of preservative, 0.005% of pH regulator and the balance of deionized water.
The humectant is glycerin.
The chelating agent is disodium EDTA.
The thickener is Carbomer 980, a Carbomer thickener.
The preservative is a combination of phenoxyethanol, 1, 2-hexanediol and ethylhexyl glycerol, and the mass ratio of the phenoxyethanol to the 1, 2-hexanediol to the ethylhexyl glycerol is 4:3:0.5.
the pH regulator is AMP-ULTRA PC 2000.
The essence is essential oil, and the essential oil is rose oil.
The solubilizer is alcohol ether solubilizer; the alcohol ether solubilizer is PPG-13-decyl tetradecyl polyether-24 (SOLUBULE) TM GS-01)。
The preparation process of the water aqua product comprises the following steps:
(1) Adding deionized water, chelating agent, humectant and thickener in the formula amount into a sterilized and cleaned stirring pot in sequence, heating to 85 ℃, and preserving heat and stirring for 30min;
(2) Cooling to 45deg.C, adding antiseptic and pH regulator, adjusting pH to 6.0, stirring, mixing, and cooling;
(3) The temperature of the stirring pot is reduced to 40 ℃, the solubilizer and the essence are mixed and then added into the stirring pot, and the anti-aging repair composition is added into the stirring pot, and stirring and cooling are maintained;
(4) And (3) reducing the temperature of the stirring pot to 38 ℃, stopping reducing the temperature, and filtering and discharging by using a 200-mesh screen after the temperature is checked to be qualified (meeting the standard QB/T2660), thereby obtaining the water aqua product.
Example 2
In one aspect, embodiment 2 of the present invention provides a rapid anti-aging repair composition consisting of a complex plant extract and a complex peptide.
The composite plant extract is a combination of a card leaf extract and a spilanthus altissima extract, and the mass ratio of the card leaf extract to the spilanthus altissima extract is 1:3, a step of; the Carnean leaf extract is from Tekenobao, inc., and flos Chrysanthemi extractExpression AF) was derived from the carnallia lion.
The compound peptide comprises 0.005% of palmitoyl tetrapeptide-7, 0.12% of tripeptide-1, 0.02% of hexapeptide-9, 0.01% of palmitoyl pentapeptide-4, 0.02% of acetyl tetrapeptide-9, 0.005% of acetyl hexapeptide-8, 1.2-hexanediol 1%, 1% of stearyl alcohol crisp-20, 1.2-pentanediol 2%, glycerol 30% and the balance of deionized water.
In another aspect, the embodiment 2 of the present invention provides an application of a rapid anti-aging repair composition, which is applied to additive preparation of an emulsifier product, wherein the preparation raw materials of the emulsifier product include, by mass: 3% of compound plant extract, 2% of compound peptide, 7% of alcohol humectant, 0.05% of EDTA disodium, 0.3% of carbomer, 4.5% of emollient, 3.65% of preservative composition, 1.1% of emulsifier, 0.15% of neutralizer, 0.005% of essence and the balance of deionized water.
The neutralizing agent is aminomethylpropanol which is an aqueous aminomethylpropanol solution with a concentration of 95 wt%.
The alcohol humectant is a composition of glycerin and 1, 3-butanediol, and the mass ratio of the glycerin to the 1, 3-butanediol is 2:5.
the Carbomer is Carbomer 980.
The preservative composition is a combination of 1, 2-pentanediol, 1, 2-hexanediol and p-hydroxyacetophenone, and the mass ratio of the 1, 2-pentanediol, the 1, 2-hexanediol and the p-hydroxyacetophenone is 3:0.35:0.3.
The emollient is a composition of polydimethylsiloxane, butter tree fruit fat, squalane, caprylic acid-capric acid triglyceride; the mass ratio of the polydimethylsiloxane to the shea butter to the squalane to the caprylic-capric triglyceride is 0.5:1:0.5:3. the polydimethylsiloxane (PMX-200Silicone Fluid100cSt) is derived from Dow (Zhang Jiang Kong) investment Limited; the Shea butter was Lipex Shea, available from A Hu Sika Ers fat (Zhangjinggang) Inc.
The emulsifier is a combination of polyglycerol-10 myristate and sodium stearyl glutamate; the mass ratio of the polyglycerol-10 myristate to the sodium stearoyl glutamate is 1:0.1.
the essence is essential oil, and the essential oil is rose oil.
The preparation process of the emulsifier product comprises the following steps:
s1, sequentially adding deionized water, EDTA disodium, an alcohol humectant and carbomer components in a formula amount into a sterilized and cleaned water pot, heating to 85 ℃, and carrying out heat preservation and stirring for 30min to obtain a water pot raw material;
s2, sequentially adding the components of the formula amount of the emollient and the emulsifier into the sterilized and cleaned oil pan, heating to 80 ℃, and preserving heat and stirring for 10min to obtain an oil pan raw material;
s3, pumping the raw materials of the water pot and the oil pot into an emulsifying pot, homogenizing for 10min in a phase-combining way, and emulsifying uniformly;
s4, cooling the temperature of the emulsifying pot to 55 ℃, adding the anti-corrosion composition and the neutralizer, adjusting the PH to 6.0, continuously stirring and mixing, and cooling;
s5, the temperature of the stirring pot is reduced to 40 ℃, and the composite plant extract, the composite peptide and the essence are added into the emulsifying pot, and stirring and cooling are maintained;
s6, cooling the temperature of the stirring pot to 35 ℃, stopping cooling, and filtering and discharging by using a 200-mesh screen after the temperature is checked to be qualified (meeting national standard GB/T29665-2013), thereby obtaining the emulsifier product.
Example 3
In one aspect, embodiment 3 of the present invention provides a rapid anti-aging repair composition consisting of a complex plant extract and a complex peptide.
The composite plant extract is a combination of a card leaf extract and a spilanthus altissima extract, and the mass ratio of the card leaf extract to the spilanthus altissima extract is 1:3, a step of; the Carnean leaf extract is from Tekenobao, inc., and flos Chrysanthemi extractExpression AF) was derived from the carnallia lion.
The compound peptide comprises 0.005% of palmitoyl tetrapeptide-7, 0.12% of tripeptide-1, 0.02% of hexapeptide-9, 0.01% of palmitoyl pentapeptide-4, 0.02% of acetyl tetrapeptide-9, 0.005% of acetyl hexapeptide-8, 1.2-hexanediol 1%, 1% of stearyl alcohol crisp-20, 1.2-pentanediol 2%, glycerol 30% and the balance of deionized water.
The embodiment 3 of the invention provides an application of a rapid anti-aging repair composition in the preparation of an emulsifier-free opalescent product, wherein the emulsifier-free opalescent product comprises the following preparation raw materials in percentage by mass: 4% of composite plant extract, 2% of composite peptide, 3% of glycerin, 4% of 1, 3-butanediol, 0.05% of EDTA disodium, 1.3% of composite thickener, 4% of composite grease, 0.75% of composite preservative, 0.15% of aminomethylpropanol, 0.005% of essence and the balance of deionized water.
The composite thickener is a combination of carbomer 980 and hydroxyethyl acrylate-sodium acryloyldimethyl taurate copolymer; the mass ratio of carbomer 980 to hydroxyethyl acrylate-sodium acryloyldimethyl taurate copolymer (SEPINOV WEO) is 0.3:1.
the compound grease is a combination of isononyl isononanoate, polydimethylsiloxane and squalane; the mass ratio of isononyl isononanoate, polydimethylsiloxane (type of polydimethylsiloxane is PMX-200Silicone Fluid100cSt, from Dow (Zhangjiu Kong) investment Co., ltd.) and squalane was 2:1:1.
The compound preservative is a combination of phenoxyethanol, 1, 2-hexanediol and ethylhexyl glycerol, and the mass ratio of phenoxyethanol to 1, 2-hexanediol to ethylhexyl glycerol is 4:3:0.5.
the essence is essential oil, and the essential oil is rose oil.
The preparation method of the emulsifier-free milky white product comprises the following steps: adding deionized water, EDTA disodium, glycerol, 1, 3-butanediol and a composite thickener according to the formula amount into a sterilized and cleaned water pot in sequence, heating to 85 ℃, and preserving heat and stirring for 35min; adding the compound grease with the formula amount into the sterilized and cleaned oil pan in sequence, heating to 80 ℃, preserving heat and stirring for 10min; pumping the raw materials of the water pot and the oil pot into an emulsifying pot, homogenizing for 10min, and emulsifying uniformly; cooling the temperature of the emulsifying pot to 55 ℃, adding a compound preservative and aminomethylpropanol, adjusting the PH to 6.0, continuously stirring, mixing and cooling; the temperature of the stirring pot is reduced to 40 ℃, and the composite plant extract, the composite peptide and the essence are added into the emulsifying pot, and stirring and cooling are maintained; and (3) reducing the temperature of the stirring pot to 35 ℃, stopping reducing the temperature, and filtering and discharging by using a 200-mesh screen after the temperature is checked to be qualified (meeting the standard GB/T29665-2013), thereby obtaining the emulsified cosmetic.
Comparative example 1
The invention provides a rapid anti-aging repair composition and application thereof, and a specific implementation mode of the rapid anti-aging repair composition is the same as that of the embodiment 1, wherein the composite plant extract is replaced by a spilanthum extract, and the preparation raw materials of the water aqua product comprise, by mass: 1.5% of spilanthum extract, 2% of compound peptide, 6% of humectant, 0.05% of chelating agent, 0.5% of thickening agent, 0.005% of essence, 2% of solubilizer, 0.75% of preservative, 0.005% of pH regulator and the balance of deionized water.
Comparative example 2
The invention provides a rapid anti-aging repair composition and application thereof, and a specific embodiment of the rapid anti-aging repair composition is the same as that of the embodiment 1, wherein the composite plant extract is replaced by a Carneata leaf extract, and the preparation raw materials of the water aqua product comprise, by mass: 0.5% of Carneau leaf extract, 6% of humectant, 0.05% of chelating agent, 0.5% of thickening agent, 0.005% of essence, 2% of solubilizer, 0.75% of preservative, 0.005% of pH regulator and the balance of deionized water.
Comparative example 3
Comparative example 3 of the present invention provides a rapid anti-aging repair composition and its use, which is different from example 1 in that the solubilizing agent is PEG-60 hydrogenated castor oil.
Comparative example 4
Comparative example 4 of the present invention provides a rapid anti-aging repair composition and its use, the specific embodiment of which is the same as example 2, except that the emollient is a composition of polydimethylsiloxane, shea butter, squalane, caprylic-capric triglyceride; the mass ratio of the polydimethylsiloxane to the shea butter to the squalane to the caprylic-capric triglyceride is 1:0.1:0.5:3.
comparative example 5
Comparative example 5 of the present invention provides a rapid anti-aging repair composition and its use, the specific embodiment of which is the same as example 2, except that the emulsifier is a combination of polyglycerin-10 myristate and sodium stearyl glutamate; the mass ratio of the polyglycerol-10 myristate to the sodium stearoyl glutamate is 1:2.
comparative example 6
Comparative example 6 of the present invention provides a rapid anti-aging repair composition and its use, which is different from example 3 in that the complex thickener is replaced with carbomer 980.
Performance test method
1. Stability: the products prepared in examples and comparative examples were subjected to conditions of-8 ℃, 5 ℃, 25 ℃, 40 ℃ and 45 ℃ for three months, and then the appearance of the products was observed and the pH was measured, and the results are recorded in table 1.
TABLE 1,
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3. Efficacy testing
(1) The aqueous product provided in example 1 was used for efficacy testing, and as a result of the testing, referring to fig. 1-3, the following efficacy was found from the results by using the aqueous product provided in example 1 for 28 consecutive days for 31 subjects:
a, instrument detection results show that:
1) Compared with the water aqua product provided in the example 1 before use, the water content of the skin cuticle is obviously improved (P < 0.001) after 28 days, the improvement rate is 24.29%, and the sample has the moisturizing effect under the test condition;
2) Compared with the prior use, the water aqua product provided in the example 1 has obviously improved skin glossiness (P < 0.001) after 28 days, and the improvement rate is 9.39%; the skin elasticity R2 value is obviously improved (P < 0.001), and the improvement rate is 8.16%; the value of the skin roughness parameter SEr is obviously improved (P is less than 0.001), and the improvement rate is 22.12%; the SEsm value of the skin smoothness parameter was significantly reduced (P < 0.001), the improvement rate was 15.98%, and the sample had nourishing efficacy under the test conditions.
b subjective evaluation results of the subjects show that:
after the water aqua product provided in example 1 was continuously used by subjects for 28 days, 100.00% of the subjects had moisturizing effect after the samples were used, 90.32% of the subjects had good fragrance, 100.00% of the subjects had good ductility, 100.00% had good absorbability, 96.77% had no stickiness, 93.55% had a firmer skin after the samples were used, 96.77% had a shinier skin after the samples were used, 93.55% had a soothing effect after the samples were used, 93.55% had a dry skin after the samples were used, 93.55% had improved skin roughness after the samples were used, 100.00% had accepted the samples, and 100.00% had a mild and non-irritating effect.
c, displaying a safety evaluation result: 31 subjects did not develop adverse effects on the skin using the aqueous product provided in example 1 for 28 days.
(2) The emulsifier product provided in example 2 was used for efficacy testing, see fig. 4-5, and the following efficacy was found from the results by using the emulsifier product provided in example 2 for this test sample for 28 consecutive days in 31 subjects:
a, instrument detection results show that:
1) The skin gloss was significantly improved (P < 0.001) after 28 days using the emulsifier product provided in example 2 compared to before use, with an improvement of 14.10%; the SEsm value of the skin smoothness parameter is obviously reduced (P < 0.001), and the improvement rate is 13.97%; the value of the skin roughness parameter SEr is obviously improved (P < 0.001), and the improvement rate is 44.19%; the skin elasticity R2 value is obviously improved (P < 0.001), the improvement rate is 12.68%, and the sample has nourishing effect under the test condition.
b subjective evaluation results of the subjects show that: after the subjects continuously used the emulsifier product provided in example 2 for 28 days, 100.00% of the subjects had moisturizing effect after the samples were used, 90.32% of the subjects had good fragrance of the samples, 100.00% of the subjects had good ductility of the samples, 100.00% of the subjects had easy absorption of the samples, 96.77% of the subjects had no stickiness of the samples, 100.00% of the subjects had more elastic skin after the samples were used, 100.00% of the subjects had more glossy skin after the samples were used, 100.00% of the subjects had soothing effect after the samples were used, 100.00% of the subjects had reduced dryness of the skin after the samples were used, 96.77% of the subjects had improved roughness of the skin after the samples were used, 100.00% of the subjects had accepted the samples, and 100.00% of the subjects had considered the samples mild and no irritation.
c, displaying a safety evaluation result: none of the 31 subjects had adverse effects on the skin for 28 days using the emulsifier product provided in example 2.
(3) The emulsifier-free opalescent product provided in example 3 was used for efficacy testing, and the following efficacy was found from the results by using the emulsifier-free opalescent product of the present test sample for 28 consecutive days in 30 subjects, see fig. 6-7:
a, instrument detection results show that:
1) Compared with the prior use, the skin glossiness is obviously improved (P < 0.001) after 28 days of using the emulsifier-free milky white product, and the improvement rate is 14.02%; the SEsm value of the skin smoothness parameter is obviously reduced (P < 0.001), and the improvement rate is 12.45%; the value of the skin roughness parameter SEr is obviously improved (P < 0.001), and the improvement rate is 38.78%; the skin elasticity R2 value is obviously improved (P < 0.001), the improvement rate is 10.83%, and the sample has nourishing effect under the test condition.
b subjective evaluation results of the subjects show that:
after the subjects continuously use the emulsifier-free opalescent product for 28 days, 96.67% of the subjects have moisturizing effect after the samples are used, 90.00% of the subjects feel that the samples are good in fragrance, 93.33% of the subjects feel that the samples are good in ductility, 96.67% of the subjects feel that the samples are easy to absorb, 93.33% of the subjects feel that the samples are not sticky, 96.67% of the subjects feel that the skin is more compact and elastic after the samples are used, 96.67% of the subjects feel that the skin is more glossy after the samples are used, 96.67% of the subjects feel that the skin is comfortable after the samples are used, 96.67% of the subjects feel that the skin is dry after the samples are used, 93.33% of the subjects feel that the skin is rough after the samples are used, 96.67% of the subjects agree with the samples, and 100.00% of the subjects feel that the samples are mild and are not stimulated.
c, displaying a safety evaluation result: 30 subjects used the sample of the emulsifier-free opalescent product for 28 days, and the skin did not have adverse reaction.
(4) The aqueous product provided in comparative example 1 was used for efficacy testing, and the following efficacy was found from the results by using the aqueous product provided in comparative example 1 for 28 consecutive days for 31 subjects, see table 2: compared with the aqueous product provided in comparative example 1 before use, the skin smoothness parameter SEsm value is significantly reduced (P < 0.001) after 28 days, the improvement rate is 12.56%, and under the test condition, the sample has a nourishing effect, but the nourishing effect is lower than that of the aqueous product provided in example 1.
TABLE 2,
(5) The aqueous product provided in comparative example 1 was used for efficacy testing, and the following efficacy was found from the results by using the aqueous product provided in comparative example 2 for 28 consecutive days for 31 subjects, see table 3: compared with the aqueous product provided in the prior art, the aqueous product provided in the comparative example 2 has no significance (p=0.085) of the skin smoothness parameter SEsm value and the improvement rate is 6.66%, and under the test condition, the sample does not have nourishing effect, so that the synergistic effect of the kunzea leaf extract and the spilanthum flower extract and the compound peptide in the aqueous product provided in the example 1 is proved.
TABLE 3,
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Claims (10)
1. A rapid anti-aging repair composition is characterized by comprising a compound plant extract and a compound peptide; the compound plant extract is at least two of Carnean leaf extract, spilanthum extract, honey extract, olive leaf extract, radix puerariae extract, snow tea extract and grape seed extract; the compound peptide is at least two selected from palmitoyl tetrapeptide-7, tripeptide-1, hexapeptide-9, palmitoyl pentapeptide-4, acetyl tetrapeptide-9, acetyl hexapeptide-8, optical glutathione, palmitoyl tripeptide-5 and acetyl hexapeptide-3.
2. The rapid anti-aging repair composition of claim 1, wherein the complex plant extract is a combination of kunzea ericoides leaf extract and spilanthus spicatus extract, the mass ratio of kunzea spicata leaf extract and spilanthus spicatus extract being (0.1-60): 1.
3. the rapid anti-aging repair composition of claim 1, wherein the complex peptide comprises palmitoyl tetrapeptide-7, tripeptide-1, hexapeptide-9, palmitoyl pentapeptide-4, acetyl tetrapeptide-9, acetyl hexapeptide-8, and the mass ratio of palmitoyl tetrapeptide-7, tripeptide-1, hexapeptide-9, palmitoyl pentapeptide-4, acetyl tetrapeptide-9, acetyl hexapeptide-8 is 0.005: (0.1-0.15): 0.02:0.01:0.02:0.005.
4. Use of a rapid anti-ageing repair composition according to any of claims 1-3, characterized in that it is applied to the additive preparation of aqueous products, emulsifier products or emulsifier-free opalescent products, wherein the amount of the compound plant extract added in the aqueous products, emulsifier products or emulsifier-free opalescent products is 0.001-20wt% and the amount of the compound peptide added is 0.001-10wt%.
5. The use of a rapid anti-aging repair composition according to claim 4, wherein the aqueous product is prepared from the following raw materials in percentage by mass: 0.01-20% of composite plant extract, 0.01-10% of composite peptide, 1-10% of humectant, 0-0.2% of chelating agent, 0-1% of thickening agent, 0-0.2% of essence, 0-3% of solubilizer, 0.05-5% of preservative, 0-0.2% of pH regulator and the balance of deionized water.
6. The use of a rapid anti-aging repair composition according to claim 5 wherein the solubilising agent is an alcohol ether solubilising agent.
7. The use of a rapid anti-aging repair composition according to claim 4, wherein the emulsifier product is prepared from at least the following raw materials in mass percent: 0.01-20% of composite plant extract, 0.01-10% of composite peptide, 1-20% of alcohol humectant, 0-0.2% of EDTA disodium, 0-1% of thickener, 1-40% of emollient, 0.1-5% of antiseptic composition, 0.1-5% of emulsifier, 0-1% of neutralizer, 0-0.2% of essence and the balance of deionized water.
8. The use of a rapid anti-aging repair composition according to claim 7 wherein the emollient is a composition of polydimethylsiloxane, shea butter, squalane, caprylic-capric triglyceride; the emulsifier is a combination of polyglycerol-10 myristate and sodium stearyl glutamate.
9. The use of a rapid anti-aging repair composition according to claim 4, wherein the emulsifier-free milky white product is prepared from the following raw materials in percentage by mass: 0.001-20% of compound plant extract, 0.001-10% of compound peptide, 2-4% of glycerin, 3-5% of 1, 3-butanediol, 0.01-0.07% of EDTA disodium, 0.1-5% of compound thickener, 0.1-10% of compound grease, 0.1-5% of compound preservative, 0.01-0.5% of aminomethylpropanol, 0-0.2% of essence and the balance of deionized water.
10. The use of a rapid anti-aging repair composition according to claim 9 wherein the composite thickener is a combination of carbomer 980 and hydroxyethyl acrylate-sodium acryloyldimethyl taurate copolymer; the compound grease is a combination of isononyl isononanoate, polydimethylsiloxane and squalane.
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|---|---|---|---|---|
| CN117017833A (en) * | 2023-09-08 | 2023-11-10 | 广州暨科医药有限公司 | Compound with multiple-effect repairing and anti-aging effects and preparation method thereof |
| CN117017833B (en) * | 2023-09-08 | 2024-01-23 | 广州暨科医药有限公司 | Compound with multiple-effect repairing and anti-aging effects and preparation method thereof |
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