CN117618280B - Collagen anti-aging composition and application thereof - Google Patents
Collagen anti-aging composition and application thereof Download PDFInfo
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- CN117618280B CN117618280B CN202410108926.6A CN202410108926A CN117618280B CN 117618280 B CN117618280 B CN 117618280B CN 202410108926 A CN202410108926 A CN 202410108926A CN 117618280 B CN117618280 B CN 117618280B
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Abstract
The application relates to the field of anti-aging compositions, and particularly discloses a collagen anti-aging composition and application thereof. The collagen anti-aging composition comprises a skin conditioner, a common matrix of external preparation forms of cosmetics and/or water; the skin conditioning agent comprises the following components in percentage by mass based on the total mass of the collagen anti-aging composition: 0.01-1% of recombinant III-type humanized collagen, 0.1-5% of Abies starburst algae extract, 0-2% of celery extract and 0-2% of MPC-lactopeptide complex. The collagen anti-aging composition can be used for preparing elastic nourishing face cream, and has the advantages of effectively resisting aging and wrinkle, supplementing water deeply, repairing skin and improving skin elasticity and softness.
Description
Technical Field
The application relates to the field of anti-aging compositions, in particular to a collagen anti-aging composition and application thereof.
Background
The external anti-aging products in the beauty market at present mainly improve skin aging by adding active substances with functions of supplementing collagen, scavenging free radicals or promoting cell metabolism, however, the anti-aging effect which can be achieved by using some common anti-aging components in cosmetics alone is limited, and the effects of fully and effectively resisting aging, resisting wrinkles and repairing skin cannot be achieved.
Therefore, how to develop a safe and effective cosmetic with the functions of resisting aging and wrinkle, repairing and strengthening skin barrier and restoring skin moisture and elasticity is a problem to be solved at present.
Disclosure of Invention
The application provides a collagen anti-aging composition and application thereof, in order to improve the effects of resisting aging and wrinkling and repairing skin elasticity of cosmetics.
In a first aspect, the present application provides a collagen anti-aging composition, which adopts the following technical scheme:
a collagen anti-aging composition comprises a skin conditioner, a cosmetic topical dosage form matrix and/or water;
the skin conditioning agent comprises the following components in percentage by mass based on the total mass of the collagen anti-aging composition:
0.01-1% of recombinant III humanized collagen,
0.1-5% Of Abies starburst algae extract,
0-2% Of celery extract,
0-2% Of MPC-milk peptide complex.
By adopting the technical scheme, the recombinant III type humanized collagen has good transdermal performance, and can enter the dermis layer through the hair follicle and be diffused to the collagen fiber layer; the recombinant III type humanized collagen has the functions of bidirectional regulation, repair and regeneration, supplements III type collagen with skin deficiency, improves facial aging, achieves a better anti-wrinkle effect, has a trend guiding effect, can guide epithelial cells to quickly enter damaged parts, effectively improves the skin regeneration speed, promotes the repair of damaged aged fibroblasts, promotes the secretion of I type collagen by the fibroblasts and the recovery of skin barrier function, and further has the effects of resisting aging and resisting wrinkles;
The inventor finds that the collagen has limited improvement on the moisture retention and the elasticity of the skin and can not meet the higher skin repair requirements when researching the influence on the recombinant III type humanized collagen to improve the skin in resisting aging and resisting wrinkles, so that the skin moisture retention, the elasticity and other performances tend to be further improved. The Huperzia serrata extract is rich in sulfated polysaccharide, and can induce and activate skin multifunctional barrier, regulate skin wettability, control skin barrier permeability, reduce skin moisture loss, and play a role in deep moisture retention; the inventor finds that when the Coomassie extract is matched with the recombinant III type humanized collagen, the protection and structural support effects of the recombinant III type humanized collagen and the regenerated I type collagen on skin tissues can be improved, the recombination of a dermis bracket is promoted, the skin elasticity and stability are improved more efficiently, the skin repair process is promoted, regulated and improved, and the skin barrier is further strengthened; this is probably due to the fact that the extract of Huperzia serrata can induce recovery of collagen fiber anisotropy, and thus a more advantageous skin repair effect is achieved by mixing with the recombinant type III humanized collagen.
In addition, the inventors have found that the cress extract is added as a composition of skin conditioner to have a more favorable skin restoration effect. This is probably due to the fact that the celery extract contains the acetylated polymannan and the phenylanthraquinone, which can play an effective role in enhancing collagen, help recalibrate the balance between reconstruction and decomposition of the dermis structure, activate fibroblasts, reduce the activity of collagenolytic enzymes, promote the synthesis of high-quality type I collagen and the recovery of dermis thickness, make the skin elastic and help enhance the anti-wrinkle effect.
The lactopeptide compound contains activated TGF-beta, can promote the synthesis of type I collagen, hyaluronic acid and fibronectin by fibroblasts, ensures that skin is more compact and elastic, can reduce the decomposition speed of collagen caused by ultraviolet rays, and can delay skin aging.
The recombinant III type humanized collagen and the Huperzia serrata extract are used as main active components, and are matched, so that the III type collagen can be effectively supplemented, the regeneration of the I type collagen is promoted, the recombination of a dermis bracket is guided, and the rapid recovery of skin elasticity and stability is promoted; the auxiliary active ingredients are added into the main active ingredients, so that the fibroblast can be promoted to synthesize high-quality type I collagen, the decomposition rate of the collagen is reduced, the protection and supporting effects of the collagen on skin are further promoted, the recombination efficiency and quality of a dermis bracket are improved, and the anti-aging and anti-wrinkle effects of the collagen anti-aging composition are effectively enhanced.
Experiments of the inventor show that the recombinant III type humanized collagen and the Huperzia serrata extract are cooperated, so that the III type collagen can be better and effectively supplemented, the regeneration of the I type collagen is promoted, and the recombination of a dermis bracket and the recovery of skin elasticity and stability are promoted; the synergistic effect of the celery extract and the MPC-lactopeptide compound can further improve the functional effect of the collagen anti-aging composition, and the collagen anti-aging composition has the effects of resisting aging and wrinkling, deeply moisturizing, repairing skin and improving skin elasticity and softness.
Preferably, the molecular weight of the recombinant type III humanized collagen is 5kDa.
By adopting the technical scheme, the recombinant III type humanized collagen has smaller molecular weight and good activity, can ensure that the recombinant III type humanized collagen has higher skin permeability, promotes the skin to absorb the recombinant III type humanized collagen, and fully plays the anti-aging effect of the recombinant III type humanized collagen.
Preferably, the collagen anti-aging composition comprises the following components in percentage by mass: 0.01-0.5% of recombinant III-type humanized collagen, 0.5-3% of a Huperzia serrata extract, 0.1-2% of a celery extract and 0.1-2% of an MPC-milk peptide compound.
By adopting the technical scheme, the mass percentage of the main active ingredient recombinant III type humanized collagen and the Huperzia serrata extract is optimized, and the collagen anti-aging composition has better effects of resisting aging and wrinkling and repairing skin while controlling the material cost of the collagen anti-aging composition.
The combination of the cress extract and the MPC-milk peptide complex can be used as auxiliary active substances under any mass ratio to promote the activation of fibroblasts and the improvement of the synthesis activity, and the mass ratio of the cress extract to the MPC-milk peptide complex is (2-4): 1 is preferred.
By adopting the technical scheme, the mass ratio of the cress extract to the MPC-lactopeptide complex is further optimized, and the cress extract and the MPC-lactopeptide complex are matched to play a better role in promoting the activation of fibroblasts, promote the synthesis of the fibroblasts to high-quality type I collagen, hyaluronic acid and fibronectin, effectively reduce the activity of collagenolytic enzymes, effectively improve the recombination efficiency and quality of the dermis scaffold, and improve the skin elasticity and stability.
Preferably, the collagen anti-aging composition further comprises a penetration enhancer, which is combined with the skin conditioning agent to form a delivery/sustained release system;
The delivery/sustained release system is selected from one of liposome, mixed liposome, oleosome, ethosome, nanostructured lipid support, vesicle, micelle, mixed micelle of surfactant, lipid sphere and microcapsule.
By adopting the technical scheme, the absorption of skin conditioning agent by human skin is improved, the function of active ingredients in the collagen anti-aging composition is promoted, and the anti-aging and anti-wrinkle effects of the collagen anti-aging composition are further improved.
Preferably, the permeation enhancer comprises lecithin and the delivery/sustained release system comprises liposomes.
By adopting the technical scheme, the liposome has high similarity between the structure of the liposome and skin lipid of a human body, has high biocompatibility and good biodegradability, can promote the transdermal absorption of the skin conditioner, promote the skin conditioner to pass through the stratum corneum, form a reservoir in dermis and slowly release, prolong the action aging of the skin conditioner, and further promote the anti-aging and anti-wrinkle effects of the skin conditioner.
Preferably, the common matrix of the cosmetic external preparation is one or more selected from emulsifying agent, grease, emollient, humectant, thickener, polyalcohol, antiseptic, essence, essential oil and deionized water.
Preferably, the formulation of the collagen anti-aging composition is selected from one of cream, emulsion, gel, water aqua, essence, facial mask, gel and spray.
Preferably, the collagen anti-aging composition is in a cream form, and comprises the following components in percentage by mass:
5-20% of glycerin,
0-10% Of sea bird oil,
1-5% Of cetostearyl alcohol,
1-5% Of dioctyl carbonate,
0.1 To 5 percent of dimethyl silicone oil,
0.1-3% Dipalmitoyl hydroxyproline,
0.01-1% Of recombinant III humanized collagen,
0.1-5% Of Abies starburst algae extract,
0-2% Of celery extract,
0-2% Of MPC-milk peptide complex,
0-5% Of penetration enhancer,
0.1 To 5 percent of emulsifying agent,
0.1 To 2 percent of thickening agent,
0.1 To 3 percent of preservative,
0.1-5% Of essential oil;
The balance being water.
By adopting the technical scheme, glycerol, sea bird oil, dioctyl carbonate and dimethyl silicone oil are used as grease components, wherein the sea bird oil has good spreadability, water resistance, dispersibility and moistening property, can endow skin with moist and soft skin feel and no sticky skin feel, has mild dioctyl carbonate property and low skin irritation, and is beneficial to improving the stability of active components in the collagen anti-aging composition; dipalmitoyl hydroxyproline is used as a moisturizing emollient to help shrink collagen fibers, protect elastin and remove free radicals, and has certain quick-acting anti-aging and anti-wrinkle activities; the recombinant III type humanized collagen, the Huperzia serrata extract, the celery extract and the MPC-lactopeptide compound are matched to be used as skin conditioning agents, so that the collagen anti-aging composition can be endowed with excellent anti-aging and anti-wrinkle effects, deep water supplementing is realized, the elastic recovery of skin is promoted, the skin barrier is strengthened, and the penetration enhancer and the skin conditioning agents are matched to effectively promote the absorption of skin to the skin conditioning agents, so that the effect of the skin conditioning agents is improved.
Preferably, the collagen anti-aging composition comprises the following components in percentage by mass:
5-20% of glycerin,
0-10% Of sea bird oil,
1-5% Of cetostearyl alcohol,
1-5% Of dioctyl carbonate,
0.1 To 5 percent of dimethyl silicone oil,
0.1-3% Dipalmitoyl hydroxyproline,
0.01-0.5% Of recombinant III humanized collagen,
0.5-3% Of Abies starburst algae extract,
0.1-2% Of cress extract,
0.1-2% Of MPC-milk peptide complex,
0.1 To 3 percent of penetration enhancer,
0.1 To 5 percent of emulsifying agent,
0.1 To 2 percent of thickening agent,
0.1 To 3 percent of preservative,
0.1-5% Of essential oil;
the balance of water
By adopting the technical scheme, the collagen anti-aging composition is finer and more moist and has better use effect by optimizing the mass percentage of each raw material component.
In a second aspect, the application provides a moisturizing and nourishing face cream, which adopts the following technical scheme:
The elastic moisturizing face cream is prepared from the composition for promoting collagen synthesis and improving the structural quality of collagen.
In a third aspect, the application provides a preparation method of a moisturizing and nourishing face cream, which adopts the following technical scheme:
A preparation method of a moisturizing and nourishing face cream comprises the following steps:
uniformly mixing and dispersing recombinant III type humanized collagen, a huperzia serrata extract, a celery extract and an MPC-milk peptide compound to obtain a skin conditioner;
The skin conditioning agent is uniformly mixed with the external preparation form matrix of the cosmetic and/or water according to the proportion to obtain the elastic nourishing face cream.
Preferably, the preparation method of the elastic moisturizing facial cream comprises the following steps of:
Mixing water and glycerol, heating, and uniformly mixing to obtain a first premix;
Mixing sea bird oil, cetostearyl alcohol, dioctyl carbonate, dimethyl silicone oil, dipalmitin and emulsifying agent, heating, and uniformly mixing to obtain a second premix;
Uniformly mixing and dispersing recombinant III type humanized collagen, a huperzia serrata extract, a celery extract and an MPC-milk peptide compound to obtain a skin conditioner; then the skin conditioning agent is mixed with the penetration enhancer to prepare a delivery/slow release system;
According to the proportion, the premix I, the premix II and the thickener are mixed and uniformly dispersed, and then the delivery/slow release system, the preservative and the essential oil are added, and the elastic moisturizing face cream is obtained after uniform dispersion.
By adopting the technical scheme, the components in the face cream are matched with each other, so that the face cream has excellent effects of resisting ageing and wrinkling and supplementing water and repairing.
In summary, the application has the following beneficial effects:
1. Because the recombinant III type humanized collagen and the Huperzia serrata extract are used as main active ingredients, the recombinant III type humanized collagen is matched with the Huperzia serrata extract, so that the III type collagen can be effectively supplemented, the regeneration of the I type collagen is promoted, the recombination of a dermis bracket is guided, and the rapid recovery of skin elasticity and stability is promoted; the cress extract and the lactopeptide compound are taken as auxiliary active ingredients, so that the synthesis of high-quality type I collagen by fibroblasts is promoted, the decomposition rate of the collagen is reduced, the protection and supporting effects of the collagen on skin are further promoted, the recombination efficiency and quality of a dermis bracket are improved, and the anti-aging and anti-wrinkle effects of the collagen anti-aging composition are effectively enhanced;
2. the application optimizes the mass percentage of the main active ingredient recombinant III type humanized collagen and the Huperzia serrata extract, so that the collagen anti-aging composition has better anti-aging and anti-wrinkle effects and skin repairing effects while controlling the material cost of the collagen anti-aging composition;
3. According to the application, by optimizing the mass ratio of the cress extract to the MPC-milk peptide compound, the matching of the cress extract and the MPC-milk peptide compound can play a better role in promoting the activation of fibroblasts, promote the synthesis of high-quality type I collagen, hyaluronic acid and fibronectin by the fibroblasts, effectively reduce the activity of collagen decomposing enzyme, effectively improve the recombination efficiency and quality of a dermis bracket and improve the skin elasticity and stability.
Detailed Description
Examples
Example 1
The elastic moisturizing and nourishing face cream comprises a collagen anti-aging composition in a cream form, and specifically comprises the following raw material components in parts by mass:
72.89g of water, 8g of glycerol, 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline, 0.01g of recombinant III-type humanized collagen, 0.1g of a Huperzia serrata extract, 3g of an emulsifier, 1g of a thickener, 1g of a preservative and 2g of lavender essential oil.
In this example, recombinant humanized collagen III was purchased from Shanxi Bo biomedical Co., ltd, model H0101, molecular weight 5kDa; the extract of Abies starburst algae was purchased from Qi Hua Du Givaudan FRANCE SAS; the emulsifier is cetostearyl alcohol polyether-20; the thickener is a commercially available Lubo-Pemulen TR-1 surfactant; the preservative is p-hydroxyacetophenone.
The preparation method of the elastic nourishing face cream comprises the following steps:
72.89g of water and 8g of glycerin are mixed and heated to 80 ℃, and the mixture is stirred and mixed until the mixture is in a homogeneous phase, so as to obtain a premix I;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
uniformly mixing and dispersing 0.01g of recombinant III-type humanized collagen and 0.1g of Abies starburst algae extract to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
Example 2
The present example differs from example 1 only in that the preparation method of the moisturizing and nourishing cream in this example is as follows:
72.49g of water and 8g of glycerin are mixed and heated to 80 ℃, and the mixture is stirred and mixed until the mixture is in a homogeneous phase, so as to obtain a premix I;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
uniformly mixing and dispersing 0.01g of recombinant III-type humanized collagen and 0.5g of Abies starburst algae extract to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
Example 3
The present example differs from example 1 only in that the preparation method of the moisturizing and nourishing cream in this example is as follows:
70.8g of water and 8g of glycerin are mixed and heated to 80 ℃, and the mixture is stirred and mixed until the mixture is in a homogeneous phase, so as to obtain a premix I;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
uniformly mixing and dispersing 0.4g of recombinant III-type humanized collagen and 1.8g of Abies starburst algae extract to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
Example 4
The present example differs from example 1 only in that the preparation method of the moisturizing and nourishing cream in this example is as follows:
70g of water and 8g of glycerin are mixed and heated to 80 ℃, and the mixture is stirred and mixed until the mixture is in a homogeneous phase, so as to obtain a premix I;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
uniformly mixing and dispersing 0.5g of recombinant III-type humanized collagen and 2.5g of Abies starburst algae extract to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
Example 5
The present example differs from example 1 only in that the preparation method of the moisturizing and nourishing cream in this example is as follows:
Mixing 69.5g of water and 8g of glycerol, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a first premix;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
uniformly mixing and dispersing 0.5g of recombinant III-type humanized collagen and 3g of Abies starburst algae extract to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
Example 6
The present example differs from example 1 only in that the preparation method of the moisturizing and nourishing cream in this example is as follows:
Mixing 69.4g of water and 8g of glycerol, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a first premix;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
Uniformly mixing and dispersing 0.6g of recombinant III-type humanized collagen and 3g of Abies starburst algae extract to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
Example 7
The present example differs from example 1 only in that the preparation method of the moisturizing and nourishing cream in this example is as follows:
mixing 68.5g of water and 8g of glycerol, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a first premix;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
Uniformly mixing and dispersing 0.5g of recombinant III-type humanized collagen and 4g of Abies starburst algae extract to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
Example 8
The present example differs from example 1 only in that the preparation method of the moisturizing and nourishing cream in this example is as follows:
67g of water and 8g of glycerin are mixed and heated to 80 ℃, and the mixture is stirred and mixed until the mixture is in a homogeneous phase, so as to obtain a premix I;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
Uniformly mixing and dispersing 1g of recombinant III-type humanized collagen and 5g of a huperzia serrata extract to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
Example 9
The present example differs from example 3 only in that the preparation method of the moisturizing and nourishing cream in this example is as follows:
Mixing 68.8g of water and 8g of glycerol, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a first premix;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
uniformly mixing and dispersing 0.4g of recombinant III-type humanized collagen, 1.8g of Abies starburst algae extract and 2g of parsley extract to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
In this example, the parsley extract is LIFTONIN bar-XPERT ECO from Rahn AG.
Example 10
The present example differs from example 3 only in that the preparation method of the moisturizing and nourishing cream in this example is as follows:
Mixing 68.8g of water and 8g of glycerol, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a first premix;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
uniformly mixing and dispersing 0.4g of recombinant III-type humanized collagen, 1.8g of Abies starburst algae extract and 2g of MPC-milk peptide complex to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
In this example, the MPC-milk peptide complex is an MPC-milk peptide complex available from CLR Berlin.
Example 11
The present example differs from example 3 only in that the preparation method of the moisturizing and nourishing cream in this example is as follows:
Mixing 68.8g of water and 8g of glycerol, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a first premix;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
Uniformly mixing and dispersing 0.4g of recombinant III-type humanized collagen, 1.8g of Abies starburst algae extract, 1.7g of parsley extract and 0.3g of MPC-milk peptide complex to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
In this example, the parsley extract is LIFTONIN bar-XPERT ECO from ruangrahn AG; the MPC-milk peptide complex is an MPC-milk peptide complex available from CLR Berlin.
Example 12
The present example differs from example 11 only in that the preparation method of the moisturizing and nourishing cream in this example is as follows:
67.8g of water and 8g of glycerol are mixed and heated to 80 ℃, and the mixture is stirred and mixed until the mixture is in a homogeneous phase, so as to obtain a premix I;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
uniformly mixing and dispersing 0.4g of recombinant III-type humanized collagen, 1.8g of Abies starburst algae extract, 1.6g of parsley extract and 0.4g of MPC-milk peptide complex to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
Example 13
The present example differs from example 11 only in that the preparation method of the moisturizing and nourishing cream in this example is as follows:
Mixing 68.8g of water and 8g of glycerol, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a first premix;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
uniformly mixing and dispersing 0.4g of recombinant III-type humanized collagen, 1.8g of Abies starburst algae extract, 1.4g of parsley extract and 0.6g of MPC-milk peptide complex to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
Example 14
The present example differs from example 11 only in that the preparation method of the moisturizing and nourishing cream in this example is as follows:
Mixing 68.8g of water and 8g of glycerol, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a first premix;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
uniformly mixing and dispersing 0.4g of recombinant III-type humanized collagen, 1.8g of Abies starburst algae extract, 1g of parsley extract and 1g of MPC-lactopeptide complex to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
Example 15
The embodiment differs from embodiment 12 only in that the moisturizing and nourishing cream in the embodiment comprises the following raw material components in parts by mass:
65.8g of water, 8g of glycerol, 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline, 0.4g of recombinant III-type humanized collagen, 1.8g of a Huperzia serrata extract, 1.6g of a celery extract, 0.4g of an MPC-lactopeptide complex, 3g of a penetration enhancer, 3g of an emulsifier, 1g of a thickener, 1g of a preservative, and 2g of lavender essential oil.
In this example, the permeation enhancer is lecithin, specifically Pro-Lipo Neo available from Lucas Meyer Cosmetics.
The preparation method of the elastic nourishing face cream comprises the following steps:
51.8g of water and 8g of glycerin are mixed and heated to 80 ℃, and the mixture is stirred and mixed until the mixture is in a homogeneous phase, so as to obtain a premix I;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
uniformly mixing 0.4g of recombinant III-type humanized collagen, 1.8g of Abies starburst algae extract, 1.6g of parsley extract, 0.4g of MPC-milk peptide complex and 4g of water to obtain a skin conditioner aqueous solution;
adding 3g of penetration enhancer into 10g of water, uniformly stirring, dropwise adding an aqueous solution of skin conditioner into the mixture while stirring, and stirring to a homogeneous phase to obtain an aqueous solution of a delivery/slow release system;
mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the delivery/slow release system aqueous solution, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic nourishing face cream.
Example 16
The present example differs from example 15 only in that the preparation method of the moisturizing and nourishing cream is as follows:
51.8g of water and 11g of glycerin are mixed and heated to 80 ℃, and the mixture is stirred and mixed until the mixture is in a homogeneous phase, so as to obtain a premix I;
Mixing 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of simethicone, 1g of dipalmitin and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
uniformly mixing 0.4g of recombinant III-type humanized collagen, 1.8g of Abies starburst algae extract, 1.6g of parsley extract, 0.4g of MPC-milk peptide complex and 4g of water to obtain a skin conditioner aqueous solution;
adding 3g of penetration enhancer into 10g of water, uniformly stirring, dropwise adding an aqueous solution of skin conditioner into the mixture while stirring, and stirring to a homogeneous phase to obtain an aqueous solution of a delivery/slow release system;
mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the delivery/slow release system aqueous solution, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic nourishing face cream.
Example 17
The present example differs from example 15 only in that the preparation method of the moisturizing and nourishing cream is as follows:
Mixing 43.7g of water and 5g of glycerol, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a first premix;
Mixing 10g of sea bird oil, 5g of cetostearyl alcohol, 5g of dioctyl carbonate, 0.1g of dimethyl silicone oil, 3g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a premix II;
uniformly mixing 0.4g of recombinant III-type humanized collagen, 1.8g of Abies starburst algae extract, 1.6g of parsley extract, 0.4g of MPC-milk peptide complex and 4g of water to obtain a skin conditioner aqueous solution;
adding 3g of penetration enhancer into 10g of water, uniformly stirring, dropwise adding an aqueous solution of skin conditioner into the mixture while stirring, and stirring to a homogeneous phase to obtain an aqueous solution of a delivery/slow release system;
mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the delivery/slow release system aqueous solution, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic nourishing face cream.
Example 18
The present example differs from example 15 only in that the preparation method of the moisturizing and nourishing cream is as follows:
mixing 43.7g of water and 20g of glycerol, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a first premix;
Mixing 1g of sea bird oil, 1g of cetostearyl alcohol, 1g of dioctyl carbonate, 5g of dimethyl silicone oil, 0.1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a premix II;
uniformly mixing 0.4g of recombinant III-type humanized collagen, 1.8g of Abies starburst algae extract, 1.6g of parsley extract, 0.4g of MPC-milk peptide complex and 4g of water to obtain a skin conditioner aqueous solution;
adding 3g of penetration enhancer into 10g of water, uniformly stirring, dropwise adding an aqueous solution of skin conditioner into the mixture while stirring, and stirring to a homogeneous phase to obtain an aqueous solution of a delivery/slow release system;
mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the delivery/slow release system aqueous solution, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic nourishing face cream.
Comparative example
Comparative example 1
The present comparative example differs from example 1 only in that the preparation method of the moisturizing and nourishing cream in the present comparative example is as follows:
72.89g of water and 8g of glycerin are mixed and heated to 80 ℃, and the mixture is stirred and mixed until the mixture is in a homogeneous phase, so as to obtain a premix I;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding 1g of preservative and 2g of lavender essential oil, stirring and dispersing uniformly, and obtaining the elastic nourishing face cream.
Comparative example 2
The present comparative example differs from example 1 only in that the preparation method of the moisturizing and nourishing cream in the present comparative example is as follows:
72.89g of water and 8g of glycerin are mixed and heated to 80 ℃, and the mixture is stirred and mixed until the mixture is in a homogeneous phase, so as to obtain a premix I;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding 0.11g of recombinant III type humanized collagen, 1g of preservative and 2g of lavender essential oil, stirring and dispersing uniformly, and obtaining the elastic nourishing face cream.
Comparative example 3
The present comparative example differs from example 1 only in that the preparation method of the moisturizing and nourishing cream in the present comparative example is as follows:
72.89g of water and 8g of glycerin are mixed and heated to 80 ℃, and the mixture is stirred and mixed until the mixture is in a homogeneous phase, so as to obtain a premix I;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding 0.11g of Abies starburst algae extract, 1g of preservative and 2g of lavender essential oil, stirring and dispersing uniformly, and obtaining the elastic nourishing face cream.
Comparative example 4
The present comparative example differs from example 1 only in that the present comparative example replaces the extract of the astrospora sinensis with the extract of the coral alga. The preparation method of the elastic nourishing face cream comprises the following steps:
72.89g of water and 8g of glycerin are mixed and heated to 80 ℃, and the mixture is stirred and mixed until the mixture is in a homogeneous phase, so as to obtain a premix I;
Mixing 3g of sea bird oil, 2g of cetostearyl alcohol, 4g of dioctyl carbonate, 2g of dimethyl silicone oil, 1g of dipalmitoyl hydroxyproline and 3g of emulsifier, heating to 80 ℃, and stirring and mixing until the mixture is in a homogeneous phase to obtain a second premix;
Uniformly mixing and dispersing 0.01g of recombinant III-type humanized collagen and 0.1g of coral algae extract to obtain a skin conditioner;
Mixing the premix I and the premix II with 1g of thickener, dispersing uniformly, adding the skin conditioner, 1g of preservative and 2g of lavender essential oil, and stirring and dispersing uniformly to obtain the elastic moisturizing face cream.
In this comparative example, coral algae extract was purchased from chia Hua Du Givaudan FRANCE SAS.
Performance test
(1) Subject grouping and testing methods
69 People of sensitive skin healthy Chinese subjects were selected, wherein 28 men and 41 women with ages of 36 to 60 years and average ages of 49.25+/-6.58 meet the volunteer input and output standards of the subjects, the subjects were randomly divided into 23 groups according to the principle of consistent skin conditions, 3 replicates of each group, 1 subject was replicated, and the test was ended from the day before the use of the product to the day after the use of the product 28 days.
After each group of subjects were cleaned in the morning and evening during the test period, after the subjects were used for the toner, a proper amount of the cream product was applied to the face, the test groups 1 to 20 were respectively applied with the moisturizing and nourishing creams prepared in examples 1 to 20, and the test groups 21 to 23 were chalks were applied with the creams prepared in comparative examples 1 to 3. Other cosmetics must not be used.
(2) Test method
Prior to use of the product (D0), each group of subjects was tested as follows: skin wrinkle analysis using Primos CR; detecting skin elasticity and skin tightness by using a skin elasticity tester Cutometer cube MPA 580; detecting the moisture content of the skin cuticle by using a Corneometer CM 825; skin softness was measured using a skin softness tester Indentometer IDM 800.
Measuring and analyzing skin wrinkles, skin elasticity, skin firmness, skin cuticle moisture content and skin softness of a subject after 28 days (D28) of using the product, comparing the skin wrinkles, skin elasticity, skin cuticle moisture content and skin softness with data in the D0 period, and calculating the data change rate, wherein the skin wrinkles are improved when the analysis value is smaller when Primos CR is used for skin wrinkles analysis; detecting skin elasticity and skin tightness by using a skin elasticity tester Cutometer (MPA) 580, wherein an increase in the measured value of the elasticity indicates an improvement in the skin elasticity, and a decrease in the measured value of the tightness indicates an improvement in the skin tightness; detecting the moisture content of the skin cuticle by using a Corneometer CM825, wherein the measured value becomes larger to show that the moisture content of the skin cuticle is increased; the skin softness is measured using the skin softness tester Indentometer IDM800, and a measurement value is increased to indicate that the skin softness is improved.
The data is counted by using SPSS28.0, normal distribution inspection is carried out on the data, and if the data is normal distribution, a pairing t-inspection method is adopted for counting classification; and if the data are in non-normal distribution, adopting a rank sum test method to carry out statistical analysis. And the rank sum test method is adopted for statistical analysis of the rank data. Statistical method significance level p <0.05.
The evaluation results are summarized in Table 1.
TABLE 1
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By combining the embodiment 1 with the comparative examples 1-4 and combining the table 1, referring to the method disclosed by the application, the recombinant III type humanized collagen and the Cochinaroot greenbrier extract are matched to serve as skin conditioning agents, so that the III type collagen can be effectively supplemented, the regeneration of the I type collagen is promoted, the recombination of a dermis bracket and the recovery of skin elasticity and stability are promoted, the effects of effectively resisting aging and wrinkle, deeply moisturizing, repairing skin and improving skin elasticity and softness can be achieved for the face cream product, and compared with other red algae extracts, the effect of jointly using the Cochinaroot greenbrier extract and the recombinant III type humanized collagen is better.
By combining examples 1-8 and combining Table 1, it can be seen that the facial cream product has higher anti-aging and anti-wrinkle effects and skin repairing functional effects and can effectively save cost by controlling the addition amount of the recombinant III type humanized collagen and the Huperzia serrata extract.
By combining the embodiment 3 and the embodiment 9-14 and combining the table 1, it can be seen that the effects of anti-aging and anti-wrinkle and skin repair of the cream product can be further improved by adding the cress extract and the MPC-lactopeptide compound, and the cress extract and the lactopeptide compound can be used as auxiliary active ingredients to effectively promote fibroblasts to synthesize high-quality type I collagen, reduce the decomposition rate of the collagen, further promote the protection and supporting effects of the collagen on skin, improve the recombination efficiency and quality of the dermis bracket, and effectively enhance the effects of anti-aging and anti-wrinkle, skin elasticity and softness of the cream product.
It can be seen from the combination of examples 9 to 10 and Table 1 that the combination of the Lepidium extract and the MPC-milk peptide further enhances the functional effect of the cream product. Meanwhile, as can be seen in the combination of examples 11 to 14 and Table 1, the mass ratio of the parsley extract to the MPC-milk peptide complex was controlled to be (2-4): 1, the combination of the two can play a better role in promoting the activation of fibroblasts, and further promote the effects of resisting aging and wrinkling of the cream product and improving the skin elasticity and softness.
It can be seen from the combination of examples 12 and 15 and the combination of table 1 that the penetration enhancer can promote the absorption of skin to the effective components of the facial cream such as skin conditioner, promote the function of the facial cream product, and further improve the anti-aging and anti-wrinkle effects of the facial cream product.
It can be seen from the combination of examples 15 and 16 and the combination of table 1 that the addition of the seabird oil is beneficial to improving the moisturizing effect of the cream product, improving the moisture content of the horny layer and the softness of the skin, and further promoting the absorption of the skin to the effective components of the cream. The present embodiment is only for explanation of the present application and is not to be construed as limiting the present application, and modifications to the present embodiment, which may not creatively contribute to the present application as required by those skilled in the art after reading the present specification, are all protected by patent laws within the scope of claims of the present application.
Claims (10)
1. A collagen anti-aging composition, characterized in that the collagen anti-aging composition comprises a skin conditioner and a cosmetic external dosage form matrix;
The skin conditioning agent comprises the following components in percentage by mass based on the total mass of the collagen anti-aging composition:
0.01-1% of recombinant III humanized collagen,
0.1-5% Of Abies starburst algae extract,
0-2% Of celery extract,
0-2% Of MPC-milk peptide complex;
The celery extract is LIFTONIN-XPERT ECO purchased from Rahn AG.
2. The collagen anti-aging composition according to claim 1, wherein the skin conditioning agent consists of the following components in mass percent: 0.01-0.5% of recombinant III-type humanized collagen, 0.5-3% of a Huperzia serrata extract, 0.1-2% of a celery extract and 0.1-2% of an MPC-milk peptide compound.
3. The collagen anti-aging composition according to claim 2, wherein the mass ratio of the parsley extract to the MPC-milk peptide complex is (2-4): 1.
4. The collagen anti-aging composition according to claim 1, further comprising a penetration enhancer in combination with the skin conditioning agent to form a delivery/sustained release system;
The delivery/sustained release system is selected from one of liposome, mixed liposome, oleosome, ethosome, nanostructured lipid support, vesicle, micelle, mixed micelle of surfactant, lipid sphere and microcapsule.
5. The collagen anti-aging composition according to claim 4, wherein the permeation enhancer comprises lecithin and the delivery/sustained release system comprises liposomes.
6. The collagen anti-aging composition according to claim 1, wherein the cosmetic topical dosage form base is selected from one or more of an emulsifier, a lipid, an emollient, a humectant, a thickener, a polyol, a preservative, an essence, an essential oil, deionized water.
7. The collagen anti-aging composition according to claim 1, wherein the formulation of the collagen anti-aging composition is selected from one of cream, lotion, gel, water aqua, essence, mask, jelly, spray.
8. The collagen anti-aging composition according to claim 7, wherein the collagen anti-aging composition is in the form of a cream, and comprises the following components in percentage by mass:
5-20% of glycerin,
0-10% Of sea bird oil,
1-5% Of cetostearyl alcohol,
1-5% Of dioctyl carbonate,
0.1 To 5 percent of dimethyl silicone oil,
0.1-3% Dipalmitoyl hydroxyproline,
0.01-1% Of recombinant III humanized collagen,
0.1-5% Of Abies starburst algae extract,
0-2% Of celery extract,
0-2% Of MPC-milk peptide complex,
0-5% Of penetration enhancer,
0.1 To 5 percent of emulsifying agent,
0.1 To 2 percent of thickening agent,
0.1 To 3 percent of preservative,
0.1-5% Of essential oil;
The balance being water.
9. An elastic moisturizing cream prepared from the collagen anti-aging composition according to any one of claims 1 to 8.
10. A method of preparing the moisturizing and nourishing cream as claimed in claim 9, comprising the steps of:
uniformly mixing and dispersing recombinant III type humanized collagen, a huperzia serrata extract, a celery extract and an MPC-milk peptide compound to obtain a skin conditioner;
the skin conditioning agent and the external preparation form matrix of the cosmetics are uniformly mixed according to the proportion, and the elastic moisturizing face cream is obtained.
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| CN113786376A (en) * | 2021-09-26 | 2021-12-14 | 湖北省麦诗特生物科技有限公司 | Eye cream composition with eyeprint removing effect and preparation method thereof |
| CN116747158A (en) * | 2023-08-01 | 2023-09-15 | 广州市花木草生物科技有限公司 | Cosmetic composition capable of resisting wrinkle and compacting through mitochondria and application thereof |
| CN117017887A (en) * | 2023-07-28 | 2023-11-10 | 广州市涵美化妆品有限公司 | Composition for relieving and reducing wrinkles and application thereof |
| CN117257691A (en) * | 2023-11-10 | 2023-12-22 | 花安堂生物科技集团有限公司 | Composition for reducing neck wrinkles, neck mask patch and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113786376A (en) * | 2021-09-26 | 2021-12-14 | 湖北省麦诗特生物科技有限公司 | Eye cream composition with eyeprint removing effect and preparation method thereof |
| CN117017887A (en) * | 2023-07-28 | 2023-11-10 | 广州市涵美化妆品有限公司 | Composition for relieving and reducing wrinkles and application thereof |
| CN116747158A (en) * | 2023-08-01 | 2023-09-15 | 广州市花木草生物科技有限公司 | Cosmetic composition capable of resisting wrinkle and compacting through mitochondria and application thereof |
| CN117257691A (en) * | 2023-11-10 | 2023-12-22 | 花安堂生物科技集团有限公司 | Composition for reducing neck wrinkles, neck mask patch and preparation method thereof |
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