CN116348498A - 多肽、多聚体、固相、受试物质的测定方法及试剂盒 - Google Patents

多肽、多聚体、固相、受试物质的测定方法及试剂盒 Download PDF

Info

Publication number
CN116348498A
CN116348498A CN202180070129.8A CN202180070129A CN116348498A CN 116348498 A CN116348498 A CN 116348498A CN 202180070129 A CN202180070129 A CN 202180070129A CN 116348498 A CN116348498 A CN 116348498A
Authority
CN
China
Prior art keywords
amino acid
biotin
polypeptide
streptavidin
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180070129.8A
Other languages
English (en)
Chinese (zh)
Inventor
菅沼政俊
西川洋一
久保卓也
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sysmex Corp
Original Assignee
Sysmex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sysmex Corp filed Critical Sysmex Corp
Publication of CN116348498A publication Critical patent/CN116348498A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/375—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Basidiomycetes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
CN202180070129.8A 2020-10-16 2021-10-15 多肽、多聚体、固相、受试物质的测定方法及试剂盒 Pending CN116348498A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020174961 2020-10-16
JP2020-174961 2020-10-16
PCT/JP2021/038254 WO2022080486A1 (ja) 2020-10-16 2021-10-15 ポリペプチド、多量体、固相、被検物質の測定方法および試薬キット

Publications (1)

Publication Number Publication Date
CN116348498A true CN116348498A (zh) 2023-06-27

Family

ID=81208108

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180070129.8A Pending CN116348498A (zh) 2020-10-16 2021-10-15 多肽、多聚体、固相、受试物质的测定方法及试剂盒

Country Status (5)

Country Link
US (1) US20230288411A1 (https=)
EP (1) EP4230643A4 (https=)
JP (1) JPWO2022080486A1 (https=)
CN (1) CN116348498A (https=)
WO (1) WO2022080486A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023132075A (ja) * 2022-03-10 2023-09-22 シスメックス株式会社 Ｌ－ビオチン測定用試薬、ｌ－ビオチンを含む試料の測定方法、ｌ－ビオチン標識された物質の標識数の決定方法、及び光学異性アビジン類が固定化された固相の製造方法
EP4522281A2 (en) * 2022-05-13 2025-03-19 University of Utah Research Foundation Biotin orthogonal streptavidin system

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103025875A (zh) * 2010-08-30 2013-04-03 霍夫曼-拉罗奇有限公司 原核表达构建体
US20160137704A1 (en) * 2013-02-20 2016-05-19 Savid Therapeutics Inc. Modified biotin, mutant streptavidin, and use thereof
CN111032850A (zh) * 2017-04-27 2020-04-17 朱诺治疗学有限公司 寡聚粒子试剂及其使用方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2606722B2 (ja) 1988-04-05 1997-05-07 栄治 石川 超高感度抗原物質の測定法
WO1995015978A1 (en) * 1993-12-07 1995-06-15 Neorx Corporation Pretargeting methods and compounds
JP3277071B2 (ja) * 1994-04-27 2002-04-22 キッコーマン株式会社 変異型ストレプトアビジン遺伝子、変異型ストレプトアビジン−ホタルルシフェラーゼ融合蛋白質遺伝子、新規な組み換え体ｄｎａ及びストレプトアビジン−ホタルルシフェラーゼ融合蛋白質の製造法
JPH1010359A (ja) * 1996-06-21 1998-01-16 Ando Electric Co Ltd 光結合器
EP0977770A4 (en) * 1997-03-14 2000-04-05 Univ Boston DIFFERENTLY FLAVORED STREPTAVIDINE
EP1369476B1 (en) 2001-03-12 2010-07-21 Japan Tobacco Inc. A novel protein, a gene encoding therefor and a method of using the same
JP4228072B2 (ja) * 2003-06-04 2009-02-25 独立行政法人農業・食品産業技術総合研究機構 アビジンをコードする人工合成遺伝子
WO2006058226A2 (en) 2004-11-24 2006-06-01 The Trustees Of Boston University Modified dimeric streptavidins and uses thereof
GB0919102D0 (en) * 2009-10-30 2009-12-16 Isis Innovation Streptavidin mutant proteins
WO2011158798A1 (ja) * 2010-06-14 2011-12-22 国立大学法人山口大学 乾癬治療効果の経過観察及び早期の予測方法並びにそれらに使用するキット
WO2013018836A1 (ja) * 2011-08-01 2013-02-07 日本たばこ産業株式会社 生物学的試料中の物質を検出する工程において、非特異的結合を抑制する方法、当該方法に使用するための剤
JP7153460B2 (ja) * 2018-03-30 2022-10-14 シスメックス株式会社 リポタンパク質の取り込み能を測定する方法及び試薬

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103025875A (zh) * 2010-08-30 2013-04-03 霍夫曼-拉罗奇有限公司 原核表达构建体
US20160137704A1 (en) * 2013-02-20 2016-05-19 Savid Therapeutics Inc. Modified biotin, mutant streptavidin, and use thereof
CN111032850A (zh) * 2017-04-27 2020-04-17 朱诺治疗学有限公司 寡聚粒子试剂及其使用方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOHN H T LUONG等: "Biotin interference in immunoassays based on biotin-strept(avidin) chemistry: An emerging threat", 《BIOTECHNOL ADV.》, vol. 37, no. 5, 11 March 2019 (2019-03-11), pages 634 - 641 *
LE ZHAO等: "Mirror image proteins", 《CURR OPIN CHEM BIOL.》, vol. 22, 1 October 2014 (2014-10-01), pages 56 - 61 *

Also Published As

Publication number Publication date
JPWO2022080486A1 (https=) 2022-04-21
WO2022080486A1 (ja) 2022-04-21
EP4230643A1 (en) 2023-08-23
US20230288411A1 (en) 2023-09-14
EP4230643A4 (en) 2025-04-02

Similar Documents

Publication Publication Date Title
CN100586959C (zh) 具有与钛、银、硅结合能力的肽
US20230251265A1 (en) Preparation method and the application of capture magnetic bead targeting weak protein-protein interactions based on the photo-affinity covalent linkage strategy
KR101104417B1 (ko) 단백질 ｇ 변형체를 이용한 항체의 특이적 공유결합 커플링방법
CN116355092B (zh) 抗人血清白蛋白的纳米抗体及其应用
US20230288411A1 (en) Polypeptide, multimer, solid phase, measurement method for test substance, and reagent kit
JPH04505857A (ja) Ｃ反応性蛋白質に対するモノクローナル抗体
AU2001275975B2 (en) Method for immuno-detection of epitopes
CA1341014C (en) Hcg peptides for use in antibody purification procedures
CN110456053A (zh) 一种二价靶向多肽探针及其制备方法
JP6818305B2 (ja) 非天然型立体構造を形成した抗体に親和性を示すポリペプチド
CN119119183A (zh) 靶向pd-l1的小分子多肽及应用
CN116284424A (zh) 抗鼠抗体可结晶段的纳米抗体及其应用
EP4242660A1 (en) Reagent for measuring l-biotin, method for measuring sample containing l-biotin, method for determining number of labels of l-biotin-labeled substance, and method for producing solid phase on which optically isomeric biotin-binding site is immobilized
JP2010122002A (ja) 抗体の検出方法及び該方法に用いられる試薬キット
WO2021256524A1 (ja) 免疫原性低減型低分子抗体とその製造法
EP3523327B1 (en) Peptides for binding epidermal growth factor
RU2062473C1 (ru) Иммунометрический способ определения хорионического гонадотропина человека
Møller et al. Peptide Tags for Site‐Selective Nonenzymatic Covalent Modification of Proteins
JP2002014102A (ja) タンパク質の検出方法、プローブペプチドおよびインシュリンの検出方法
JP2026505450A (ja) 一本鎖抗体断片の化学合成法およびそれにより得られる物
JP4618751B2 (ja) ルシフェラーゼに対して結合性を有するペプチド
CN117264076A (zh) 标记多肽、修饰多肽、这些多肽的制造方法、含这些多肽的试剂及目标物质的测定方法
Iwamoto Synthesis of Functional Characterization of Protein Domains for the Development of Mirror-Image Therapeutics
KR101809135B1 (ko) 형광면역측정용 키트 및 이를 이용하여 질병을 진단하는 방법
JP2025096496A (ja) ＩｇＧ結合ペプチドを用いたＩｇＧ抗体の部位特異的修飾体を用いた免疫測定方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination