CN116236430A - Composition with skin barrier repair function and application - Google Patents

Composition with skin barrier repair function and application Download PDF

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Publication number
CN116236430A
CN116236430A CN202310320141.0A CN202310320141A CN116236430A CN 116236430 A CN116236430 A CN 116236430A CN 202310320141 A CN202310320141 A CN 202310320141A CN 116236430 A CN116236430 A CN 116236430A
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China
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composition
ceramide
microcapsule
skin
efficacy
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Inventor
刘永成
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Shanghai Rentian Biotechnology Co ltd
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Shanghai Rentian Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/738—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The application relates to the field of cosmetics, and particularly discloses a composition with a skin barrier repairing function and application thereof. The composition with the skin barrier repair function comprises the following components in parts by weight: 20-40 parts of efficacy microcapsule; 10-15 parts of woad extract; 3-5 parts of hydrolyzed coffee yellow sunflower extract; the core material of the efficacy microcapsule comprises ceramide, vegetable oil and sterol, wherein the weight ratio of the ceramide to the vegetable oil to the sterol is 1 (1.5-3) to 0.8-1.5. The composition can be used for preparing cosmetics, and has the advantages of better relieving and repairing skin.

Description

Composition with skin barrier repair function and application
Technical Field
The present application relates to the field of cosmetics, and more particularly, to a composition having a skin barrier repair function and application thereof.
Background
The skin is the largest organ of human body, is wrapped on the surface of the body, directly contacts with the external environment, and has the functions of protecting, excreting, regulating the body temperature, sensing external stimulus and the like. The skin plays a very important role in the barrier of human body, and the skin with healthy skin barrier is equal to the skin with beautiful nature. However, the skin is extremely susceptible to damage due to environmental pollution, improper diet, irregular life work and rest, improper use of cosmetics, etc., thereby affecting the barrier and protective functions of the skin, and severely causing the skin to be in a highly intolerant state, which is called sensitive skin. Sensitive skin people are easy to be stimulated by various factors to produce symptoms such as stinging, burning, tightening, itching and the like.
Along with the improvement of living standard, people pay more and more attention to health, frequent skin symptoms bring great trouble to the life of people, so that people pay more and more attention to and favor for cosmetics with relieving and repairing effects. At present, soothing or repairing effects are often imparted to cosmetic compositions by using the following methods: (1) The moisturizing agent such as hyaluronic acid, micromolecular polyalcohol, polysaccharide and the like is added, so that the effects of relieving and repairing the skin are achieved by increasing the moisture in the skin; (2) The ceramide is added to supplement the skin ceramide so as to achieve the effect of repairing the skin barrier.
Although the existing method has certain relieving and repairing effects on skin, the humectant can only supplement water for a short time, the skin repairing effect is very limited, and the ceramide can repair skin barrier, but can not effectively relieve skin anaphylactic reaction in time. Therefore, the research of a composition with better skin soothing and repairing effects is of great importance.
Disclosure of Invention
In order to improve the soothing and repairing effects on skin, the application provides a composition with a skin barrier repairing function and application thereof.
In a first aspect, the present application provides a composition with skin barrier repair function, which adopts the following technical scheme:
a composition with skin barrier repair function comprises the following components in parts by weight:
20-40 parts of efficacy microcapsule;
10-15 parts of woad extract;
3-5 parts of hydrolyzed coffee yellow sunflower extract;
the core material of the efficacy microcapsule comprises ceramide, vegetable oil and sterol, wherein the weight ratio of the ceramide to the vegetable oil to the sterol is 1 (1.5-3) to 0.8-1.5.
By adopting the technical scheme and adopting the microcapsule technology, the ceramide, the vegetable oil and the sterol are embedded, so that the stability of the core material functional substance can be improved, the sustained-release effect is achieved, and the ceramide, the vegetable oil and the sterol can be continuously released, so that the effective acting time of the functional microcapsule is prolonged.
The ceramide can help the thickening of the horny layer, promote the tolerance of skin, resist external stimulus, play a role in protecting natural skin, keep the skin barrier from being damaged, play a role in repairing sensitive skin such as redness and the like, and quickly restore the functions of skin moisturizing and barrier. The vegetable oil contains various unsaturated fatty acids and natural active substances which are indispensable to human body, is close to the structure of human sebum membrane, is easier to be absorbed by skin than water, has better permeability, and can deeply infiltrate into and nourish the skin. According to the application, the ceramide and the vegetable oil are compounded, and the sterol is added to serve as a core material component, so that the ceramide, the vegetable oil and the sterol play a good role in synergetic moisturizing and repairing sensitive skin, and the soothing and repairing effects of the composition on the skin are improved.
The Isatis tinctoria extract has antibacterial and antiinflammatory effects, can balance skin flora, enhance skin resistance, and has moisturizing effect, and is suitable for moisturizing and caring sensitive skin, and has certain effects of relieving and repairing skin. The hydrolyzed coffee-wasabi extract has the effects of moisturizing and promoting collagen production, and although the skin repairing effect is weak when being singly used, the effect of relieving and repairing the skin of the wasabi extract can be further improved when the hydrolyzed coffee-wasabi extract is compounded with the wasabi extract.
The effect microcapsule, the woad extract and the hydrolyzed coffee wasabi extract are compounded for use, so that quick water supplementing and long-acting water supplementing can be realized at the same time, and the effect of relieving and repairing skin is greatly improved.
Preferably, the weight ratio of the ceramide to the vegetable fat to the sterol is 1 (1.5-2): 1-1.2.
By adopting the technical scheme, when the weight ratio of the ceramide to the vegetable fat to the sterol is in the range, the synergistic water supplementing and sensitive skin repairing effects of the ceramide, the vegetable fat and the sterol are better.
Preferably, the ceramide comprises one or more of ceramide EOP, ceramide NS, ceramide NG and ceramide NP.
Preferably, the sterols are plant sterols including one or more of beta-sitosterol, stigmasterol, campesterol, and brassicasterol.
Preferably, the vegetable oil is selected from one or more of avocado oil, white pool seed oil, evening primrose oil, peony seed oil, camellia seed oil, jojoba seed oil, macadamia nut seed oil, dog rose fruit oil and castor seed oil.
By adopting the technical scheme, the vegetable oil component can inhibit the evaporation of skin moisture, prevent skin chapping, and fully exert the synergistic effect with ceramide and sterol, thereby improving the effects of relieving and repairing the skin of the composition.
Preferably, the vegetable oil consists of peony seed oil and macadimia nut seed oil according to the weight ratio of 1 (0.2-0.4).
By adopting the technical scheme, the peony seed oil contains carotene, natural antioxidation and other components, and after being smeared on the skin surface, the peony seed oil not only has the effect of cleaning the skin, but also is beneficial to promoting the skin repair and has the effect of nourishing and caring the skin. The fatty acid component of the macadimia nut seed oil mainly comprises oleic acid, palmitoleic acid and palmitic acid, has good stability, better skin permeability and excellent skin moisturizing effect.
In the process of realizing the technical scheme, the composition has better relieving and repairing effects when the peony seed oil and the macadimia nut seed oil are adopted simultaneously. On the basis, the use effect of the composition is further improved by optimizing the proportion of the peony seed oil and the macadamia nut seed oil.
Preferably, the wall material of the efficacy microcapsule comprises one or more of chitosan, sodium alginate, cyclodextrin, acacia and gelatin.
Preferably, the efficacy microcapsule comprises:
a core material;
the inner wall is coated on the outer side of the core material, and the base material of the inner wall is beta-cyclodextrin;
the outer wall is coated on the outer side of the inner wall, and the base material of the outer wall is acacia.
By adopting the technical scheme, the core material is embedded by adopting the multilayer coating technology and adopting the beta-cyclodextrin and the Arabic gum in sequence, so that the slow release effect of the efficacy microcapsule is further improved, the utilization rate of core material active substances is effectively improved, and the composition has better relieving and repairing effects and lasting effects by matching with the isatis indigotica extract and the hydrolysis coffee wasabi extract.
Preferably, the preparation method of the efficacy microcapsule comprises the following steps:
a, adding the core material into ethanol solution of beta-cyclodextrin, and stirring to obtain a single-layer capsule;
b, mixing the single-layer capsule, the nonionic surfactant, the polyol and the sodium alginate, adding the mixture into an aqueous solution of the Arabic gum, and stirring to obtain the efficacy microcapsule.
By adopting the technical scheme, in the preparation process of the microcapsule, the nonionic surfactant is used as an emulsifier, and sodium alginate and polyalcohol are used as an auxiliary emulsion, so that the biocompatibility of the single-layer capsule and the Arabic gum is improved, and the double-layer structure functional microcapsule with good stability is successfully prepared.
Preferably, the weight ratio of the core material to the beta-cyclodextrin is 1 (2-2.5).
Preferably, the weight ratio of the single-layer capsule to the nonionic surfactant to the polyol to the sodium alginate is 1 (0.4-0.6): 0.2-0.3): 0.1-0.2.
Preferably, the weight ratio of the single-layer capsule to the Arabic gum is 1 (1.2-1.5).
In a second aspect, the present application provides the use of the above composition having a skin barrier repair function in the preparation of an external preparation for skin.
Preferably, the external preparation for skin comprises cream, lotion, aqua, essence, facial mask and gel.
Preferably, the composition having a skin barrier repair function is contained in the skin external preparation in an amount of 0.1 to 50wt%.
In summary, the present application has at least the following beneficial effects:
1. the ceramide, the vegetable oil and the sterol are compounded, the ceramide, the vegetable oil and the sterol play a good role in synergetic moisturizing and repairing sensitive skin, the soothing and repairing effects on the skin are improved, and the ceramide, the vegetable oil and the sterol are embedded to realize the slow release effect of the functional components, so that the acting time of the functional microcapsule is prolonged;
2. the isatis tinctoria extract has certain relieving and repairing effects on the skin, and the hydrolyzed coffee-horseradish extract has certain promoting effects on the isatis tinctoria extract by adding the hydrolyzed coffee-horseradish extract, so that the relieving and repairing effects of the isatis tinctoria extract are further improved;
3. according to the method, the effect microcapsule, the woad extract and the hydrolyzed coffee wasabi extract are compounded for use, so that the effects of rapid water supplementing and long-acting water supplementing can be achieved at the same time, and the effects of relieving and repairing the skin are greatly improved;
4. the vegetable oil and fat is preferably composed of the peony seed oil and the macadimia nut seed oil, and experiments show that the composition can further improve the relieving and repairing effects of the composition through the compounding of the peony seed oil and the macadimia nut seed oil.
Detailed Description
The present application is described in further detail below with reference to examples.
The raw materials used in the examples of the present application are commercially available except for the following specific descriptions.
Preparation example of efficacy microcapsule
Preparation example 1
The wall material of the functional microcapsule is beta-cyclodextrin, the core material is ceramide, vegetable oil and sterol, and the weight ratio of the ceramide to the vegetable oil and the sterol is 1:1.5:0.8.
The preparation method of the efficacy microcapsule comprises the following steps:
dissolving 100g of cyclodextrin (beta-cyclodextrin) in 2L of ethanol solution with the mass concentration of 30% to obtain ethanol solution of beta-cyclodextrin;
mixing 100g of ceramide (ceramide NP), 150g of vegetable fat (butter fruit fat) and 80g of sterol (beta-sitosterol) thoroughly to obtain a core material mixture;
50g of core material mixture is taken and put into ethanol solution of beta-cyclodextrin, and stirred for 2 hours under the condition of 600r/min by adopting a magnetic stirrer, and spray-dried, so as to obtain the efficacy microcapsule.
Preparation example 2
The wall material of the functional microcapsule is beta-cyclodextrin, the core material is ceramide, vegetable oil and sterol, and the weight ratio of the ceramide to the vegetable oil and the sterol is 1:1.5:1.
The preparation method of the efficacy microcapsule is different from that of the preparation example 1 in that: 100g of ceramide (ceramide NP), 150g of vegetable fat (butter fruit fat) and 100g of sterol (beta-sitosterol) were thoroughly mixed to obtain a core material mixture.
Preparation example 3
The wall material of the functional microcapsule is beta-cyclodextrin, the core material is ceramide, vegetable oil and sterol, and the weight ratio of the ceramide to the vegetable oil and the sterol is 1:2:1.
The preparation method of the efficacy microcapsule is different from that of the preparation example 1 in that: 100g of ceramide (ceramide NP), 200g of vegetable fat (butter fruit fat) and 100g of sterol (beta-sitosterol) were thoroughly mixed to obtain a core material mixture.
Preparation example 4
The wall material of the functional microcapsule is beta-cyclodextrin, the core material is ceramide, vegetable oil and sterol, and the weight ratio of the ceramide to the vegetable oil and the sterol is 1:1.5:1.2.
The preparation method of the efficacy microcapsule is different from that of the preparation example 1 in that: 100g of ceramide (ceramide NP), 150g of vegetable fat (butter fruit fat) and 120g of sterol (beta-sitosterol) were thoroughly mixed to obtain a core material mixture.
Preparation example 5
The wall material of the functional microcapsule is beta-cyclodextrin, the core material is ceramide, vegetable oil and sterol, and the weight ratio of the ceramide to the vegetable oil and the sterol is 1:2:1.2.
The preparation method of the efficacy microcapsule is different from that of the preparation example 1 in that: 100g of ceramide (ceramide NP), 200g of vegetable fat (butter fruit fat) and 120g of sterol (beta-sitosterol) were thoroughly mixed to obtain a core material mixture.
Preparation example 6
The wall material of the functional microcapsule is beta-cyclodextrin, the core material is ceramide, vegetable oil and sterol, and the weight ratio of the ceramide to the vegetable oil and the sterol is 1:3:1.5.
The preparation method of the efficacy microcapsule is different from that of the preparation example 1 in that: 100g of ceramide (ceramide NP), 300g of vegetable fat (butter fruit fat) and 150g of sterol (beta-sitosterol) were thoroughly mixed to obtain a core material mixture.
Preparation example 7
The wall material of the functional microcapsule is beta-cyclodextrin, the core material is ceramide, vegetable oil and sterol, and the weight ratio of the ceramide to the vegetable oil and the sterol is 1:1.5:0.8.
The preparation method of the efficacy microcapsule is different from that of the preparation example 1 in that: 100g of ceramide (ceramide NP), 150g of vegetable fat (peony seed oil) and 80g of sterol (beta-sitosterol) were thoroughly mixed to obtain a core material mixture.
Preparation example 8
The wall material of the functional microcapsule is beta-cyclodextrin, the core material is ceramide, vegetable oil and sterol, and the weight ratio of the ceramide to the vegetable oil and the sterol is 1:1.5:0.8.
The preparation method of the efficacy microcapsule is different from that of the preparation example 1 in that: 100g of ceramide (ceramide NP), 150g of vegetable fat (macadamia nut seed oil) and 80g of sterol (beta-sitosterol) were thoroughly mixed to obtain a core material mixture.
Preparation example 9
The wall material of the functional microcapsule is beta-cyclodextrin, the core material is ceramide, vegetable oil and sterol, and the weight ratio of the ceramide to the vegetable oil and the sterol is 1:1.5:0.8.
The preparation method of the efficacy microcapsule is different from that of the preparation example 1 in that: 100g of ceramide (ceramide NP), 150g of vegetable fat (50 g of white pool seed oil, 100g of castor seed oil) and 80g of sterol (beta-sitosterol) were thoroughly mixed to obtain a core material mixture.
Preparation example 10
The wall material of the functional microcapsule is beta-cyclodextrin, the core material is ceramide, vegetable oil and sterol, and the weight ratio of the ceramide to the vegetable oil and the sterol is 1:1.5:0.8.
The preparation method of the efficacy microcapsule is different from that of the preparation example 1 in that: 100g of ceramide (ceramide NP, obtained from Shenzhen Artemisia pure organism), 150g of vegetable oil (125 g of peony seed oil, 25g of macadamia seed oil) and 80g of sterol (beta-sitosterol) were mixed well to obtain a core material mixture.
PREPARATION EXAMPLE 11
The wall material of the functional microcapsule is beta-cyclodextrin, the core material is ceramide, vegetable oil and sterol, and the weight ratio of the ceramide to the vegetable oil and the sterol is 1:1.5:0.8.
The preparation method of the efficacy microcapsule is different from that of the preparation example 1 in that: 100g of ceramide (ceramide NP), 150g of vegetable fat (115 g of peony seed oil, 35g of macadamia nut seed oil) and 80g of sterol (beta-sitosterol) were mixed thoroughly to obtain a core material mixture.
Preparation example 12
The wall material of the functional microcapsule is beta-cyclodextrin, the core material is ceramide, vegetable oil and sterol, and the weight ratio of the ceramide to the vegetable oil and the sterol is 1:1.5:0.8.
The preparation method of the efficacy microcapsule is different from that of the preparation example 1 in that: 100g of ceramide (ceramide NP), 150g of vegetable fat (107 g of peony seed oil, 43g of macadamia nut seed oil) and 80g of sterol (beta-sitosterol) were thoroughly mixed to obtain a core material mixture.
Preparation example 13
An efficacy microcapsule comprising:
the core material is ceramide, vegetable oil and sterol, and the weight ratio of the ceramide to the vegetable oil and sterol is 1:1.5:0.8;
the inner wall is coated on the outer side of the core material, and the base material of the inner wall is beta-cyclodextrin;
the outer wall is coated on the outer side of the inner wall, and the base material of the outer wall is acacia.
The preparation method of the efficacy microcapsule comprises the following steps:
dissolving 100g of cyclodextrin (beta-cyclodextrin) in 2L of ethanol solution with the mass concentration of 30% to obtain ethanol solution of beta-cyclodextrin;
100g of ceramide (ceramide NP), 150g of vegetable fat (115 g of peony seed oil, 35g of macadamia nut seed oil) and 80g of sterol (beta-sitosterol) are fully mixed to obtain a core material mixture;
taking 50g of core material mixture, adding the core material mixture into ethanol solution of beta-cyclodextrin, stirring for 2 hours under the condition of 600r/min by adopting a magnetic stirrer, and spray-drying to obtain a single-layer capsule;
mixing 100g of single-layer capsule, 40g of nonionic surfactant (Tween-20), 20g of polyalcohol (glycerol) and 10g of sodium alginate, adding into aqueous solution of acacia (obtained by mixing 120g of acacia with 2L of distilled water), stirring at 800r/min for 3h, and spray drying to obtain the functional microcapsule.
PREPARATION EXAMPLE 14
An efficacy microcapsule differs from preparation example 13 only in that 40g of core material mixture is taken and put into an ethanol solution of beta-cyclodextrin, and stirred for 2 hours under the condition of 600r/min by using a magnetic stirrer, and spray-dried to obtain a single-layer capsule.
Preparation example 15
An efficacy microcapsule is different from preparation example 13 only in that, in preparation, 100g of a single-layer capsule, 50g of nonionic surfactant (Tween-20), 25g of polyalcohol (glycerol) and 15g of sodium alginate are taken and mixed, and then added into an aqueous solution of Arabic gum (obtained by mixing 120g of Arabic gum with 2L of distilled water), stirred for 3 hours at 800r/min, and spray-dried, thus obtaining the efficacy microcapsule.
PREPARATION EXAMPLE 16
An efficacy microcapsule is different from preparation example 13 only in that, in preparation, 100g of single-layer capsule, 60g of nonionic surfactant (Tween-20), 30g of polyalcohol (glycerol) and 20g of sodium alginate are taken and mixed, and then added into an aqueous solution of Arabic gum (obtained by mixing 120g of Arabic gum with 2L of distilled water), stirred for 3 hours under the condition of 800r/min, and spray-dried, thus obtaining the efficacy microcapsule.
Preparation example 17
An efficacy microcapsule is different from preparation example 15 only in that, in the preparation, 100g of a single-layer capsule, 50g of nonionic surfactant (Tween-20), 25g of polyalcohol (glycerol) and 15g of sodium alginate are taken and mixed, and then added into an aqueous solution of Arabic gum (obtained by mixing 150g of Arabic gum with 2L of distilled water), stirred for 3 hours at 800r/min, and spray-dried, thus obtaining the efficacy microcapsule.
In addition, in preparing the functional microcapsules according to preparation example 13, the weight ratio of the core material to the β -cyclodextrin may be 1:1, 1:1.5, 1:2.2, 1:3, etc., but it is known from the performance test that the performance of the functional microcapsules obtained is best when the weight ratio of the core material to the β -cyclodextrin is in the range of 1 (2 to 2.5); the weight ratio of the single-layer capsule, the nonionic surfactant, the polyol and the sodium alginate can be 1:0.3:0.1:0.1, 1:0.4:0.1:0.05, 1:0.4:0.2:0.05, 1:0.7:0.4:0.3 and the like, but the performance of the obtained efficacy microcapsule is best when the weight ratio of the single-layer capsule, the nonionic surfactant, the polyol and the sodium alginate is in the range of 1 (0.4-0.6): (0.2-0.3): (0.1-0.2); the weight ratio of the single-layer capsules to the Arabic gum can be 1:1, 1:1.3, 1:2 and the like, but the performance test shows that the obtained efficacy microcapsule has the best performance when the weight ratio of the single-layer capsules to the Arabic gum is in the range of 1 (1.2-1.5).
Examples of compositions with skin Barrier repair function
Example 1
A composition with skin barrier repairing function is prepared by mechanically stirring the components and their corresponding weights as shown in Table 1.
Examples 2 to 5
A composition having skin barrier repair function, which is different from example 1 in that each component and its corresponding weight are shown in table 1.
Figure BDA0004151386760000081
Table 1 Components and weights (g) of examples 1 to 5
Examples 6 to 21
A composition having a skin barrier repair function, differing from example 3 only in that: the efficacy microcapsules were used differently and the specific use is shown in table 2.
Group of Efficacy microcapsule Group of Efficacy microcapsule
Example 6 Efficacy microcapsule prepared in preparation example 2 Example 14 Efficacy microcapsule prepared in preparation example 10
Example 7 Functional microcapsules prepared in preparation example 3 Example 15 Efficacy microcapsule prepared in preparation example 11
Example 8 Efficacy microcapsule prepared in preparation example 4 Example 16 Preparation example 12 preparationThe obtained functional microcapsule
Example 9 Functional microcapsules prepared in preparation example 5 Example 17 Efficacy microcapsule prepared in preparation example 13
Example 10 Functional microcapsules prepared in preparation example 6 Example 18 Efficacy microcapsule prepared in preparation example 14
Example 11 Functional microcapsules prepared in preparation example 7 Example 19 Efficacy microcapsule prepared in preparation example 15
Example 12 Functional microcapsules prepared in preparation example 8 Example 20 Efficacy microcapsule prepared in preparation example 16
Example 13 Functional microcapsules prepared in preparation example 9 Example 21 Efficacy microcapsule prepared in preparation example 17
TABLE 2 use of efficacy microcapsules in examples 6-21
Comparative example
Comparative examples 1 to 4
A composition differs from example 1 in that the components and their respective weights are shown in Table 3.
Figure BDA0004151386760000091
TABLE 3 Components of example 1 and comparative examples 1-4 and weights (g)
Comparative examples 5 to 7
A composition differing from example 1 in the components of the functional microcapsule core and their respective weights are shown in table 4.
Figure BDA0004151386760000092
Figure BDA0004151386760000101
TABLE 4 Components of functional microcapsule core materials and weights (g) of example 1 and comparative examples 1-4
Application example
Skin external preparations (emulsions) were prepared using the compositions of examples 1 to 21 and comparative examples 1 to 7, respectively:
the emulsion is obtained by mechanically stirring and mixing the components according to the proportion of 20 weight percent of the composition, 5 weight percent of glycerol, 0.1 weight percent of xanthan gum, 3 weight percent of butanediol, 0.5 weight percent of glycerol stearate, 0.5 weight percent of cetostearyl alcohol and 70.9 weight percent of deionized water.
It should be noted that, in this application example, only an emulsion is taken as an example for brief description, but in other application examples, the external preparation for skin may also be in the form of cream, aqua, essence, facial mask and gel.
Performance test
Skin barrier repair Performance test
Test material: emulsions prepared from the compositions of examples 1-21 and comparative examples 1-7 in the application examples;
test object: selecting 140 volunteers with moderately sensitive skin aged 25-30 years (questionnaire total score 24-32) according to the sensitive skin Hua Xi questionnaire;
the testing method comprises the following steps: volunteers were randomly divided into 28 groups (5 persons each) and tested using the emulsions prepared from the compositions of examples 1 to 21 and comparative examples 1 to 7 in the application examples, respectively, the same emulsions were used for volunteers in the same group, face was smeared with the emulsions 8 early and 8 late each day, and the volunteers were continuously used for 14 days, TEWL (percutaneous water loss) value, moisture content, heme and erythema value of the faces of the volunteers were tested on day 0 and day 14, respectively, and day 14 data were compared with the standard, reflecting the change condition of the data before and after use;
detection instrument: tewameter TM300 (measuring TEWL value), corneometer CM825 (measuring moisture content), mexameter MX18 (measuring heme and erythema value);
the calculation method comprises the following steps:
TEWL value change case= (day 14 TEWL value-day 0 TEWL value)/day 0 TEWL value;
moisture content change case= (day 14 moisture content-day 0 moisture content)/day 0 moisture content;
heme improvement case= (day 0 heme content-day 14 heme content)/day 0 heme content;
erythema value improvement = (day 0 erythema value-day 14 erythema value)/day 0 erythema value;
test results: average values within the same group are reported in Table 5 below.
Figure BDA0004151386760000102
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Figure BDA0004151386760000111
TABLE 5 Performance test results
As can be seen from the data in Table 5, the compositions of examples 1-21 of the present application have better skin soothing and repairing effects than those of comparative examples 1-7.
By combining example 1 and comparative examples 1-4 and combining the data of Table 5, it is clear that the Isatis tinctoria extract and the hydrolyzed coffee Abelmoschus esculentus extract used in the formulation of the composition exert better synergistic effects, and the soothing and skin repairing effects of the composition can be further improved.
By combining the example 1 and the comparative examples 5-7 and combining the data of Table 5, the application has better synergistic moisturizing and sensitive skin repairing effects by compounding the ceramide, the vegetable oil and the sterol as core material components of the functional microcapsule, and improves the soothing and repairing effects on the skin.
As can be seen from the data of Table 5, the resulting compositions perform better when the core of the performance microcapsules consists of ceramide, vegetable fat and sterols in a weight ratio of 1 (1.5-2) to 1-1.2, in combination with examples 3 and examples 6-10.
By combining the embodiment 3 with the embodiment 11-16 and combining the data of the table 5, it is known that the peony seed oil and the macadamia nut seed oil can exert better synergistic effect when being compounded for use, and can further improve the skin soothing and repairing effects of the composition.
The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.

Claims (10)

1. The composition with the skin barrier repair function is characterized by comprising the following components in parts by weight:
20-40 parts of efficacy microcapsule;
10-15 parts of woad extract;
3-5 parts of hydrolyzed coffee yellow sunflower extract;
the core material of the efficacy microcapsule comprises ceramide, vegetable oil and sterol, wherein the weight ratio of the ceramide to the vegetable oil to the sterol is 1 (1.5-3) to 0.8-1.5.
2. The composition having a skin barrier repair function according to claim 1, wherein the weight ratio of the ceramide, the vegetable fat and the sterol is 1 (1.5-2): 1-1.2.
3. The composition having a skin barrier repair function according to claim 1 or 2, wherein the vegetable oil is selected from one or more of avocado oil, white pool seed oil, evening primrose oil, peony seed oil, camellia seed oil, jojoba seed oil, macadamia nut seed oil, dog rose-hip oil and castor seed oil.
4. The composition having a skin barrier repair function according to claim 3, wherein the vegetable oil is composed of peony seed oil and macadamia nut seed oil in a weight ratio of 1 (0.2 to 0.4).
5. The composition having skin barrier repair function according to claim 1, wherein the efficacy microcapsule comprises:
a core material;
the inner wall is coated on the outer side of the core material, and the base material of the inner wall is beta-cyclodextrin;
the outer wall is coated on the outer side of the inner wall, and the base material of the outer wall is acacia.
6. The composition with skin barrier repair function according to claim 5, wherein the preparation method of the efficacy microcapsule comprises the following steps:
a, adding the core material into ethanol solution of beta-cyclodextrin, and stirring to obtain a single-layer capsule;
b, mixing the single-layer capsule, the nonionic surfactant, the polyol and the sodium alginate, adding the mixture into an aqueous solution of the Arabic gum, and stirring to obtain the efficacy microcapsule.
7. The composition having a skin barrier repair function according to claim 6, wherein the weight ratio of the core material to beta-cyclodextrin is 1 (2-2.5).
8. The composition having a skin barrier repair function according to claim 6, wherein the weight ratio of the single-layer capsule, the nonionic surfactant, the polyol and the sodium alginate is 1 (0.4 to 0.6): 0.2 to 0.3): 0.1 to 0.2.
9. The composition having a skin barrier repair function according to claim 6, wherein the weight ratio of the single-layer capsule to the gum arabic is 1 (1.2 to 1.5).
10. Use of the composition having a skin barrier repair function according to any one of claims 1 to 9 for the preparation of an external preparation for skin.
CN202310320141.0A 2023-03-29 2023-03-29 Composition with skin barrier repair function and application Pending CN116236430A (en)

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