CN112107526A - Skin care composition for infants and children for repairing skin barrier and preparation method thereof - Google Patents

Skin care composition for infants and children for repairing skin barrier and preparation method thereof Download PDF

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CN112107526A
CN112107526A CN201910532020.6A CN201910532020A CN112107526A CN 112107526 A CN112107526 A CN 112107526A CN 201910532020 A CN201910532020 A CN 201910532020A CN 112107526 A CN112107526 A CN 112107526A
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周正
郭苗
郭阳
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Hubei Jimei Cosmetics Co ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract

The invention discloses an infant skin care product composition for repairing skin barrier and a preparation method thereof, wherein the skin care product composition comprises ceramide II, phytosterol, stearic acid, bisabolol, a white-flowered lily bulb extract, a rose extract, a vetiver iris root extract, 1, 2-pentanediol, 4-tert-butyl cyclohexanol and beta-glucan. The skin care product composition for the infants for repairing the skin barrier simultaneously has comprehensive effects of relieving itching, removing red, diminishing inflammation, resisting stabbing pain, burning, repairing the barrier and the like, particularly has the effect of deeply repairing the skin barrier for the skin of the infants, and is mild and non-irritant to the skin of the infants.

Description

Skin care composition for infants and children for repairing skin barrier and preparation method thereof
Technical Field
The invention relates to a skin care product, in particular to a skin care product composition for infants for repairing skin barriers and a preparation method thereof.
Background
The skin is the largest organ of the human body, and the barrier of the skin is the first line of defense of the human body. In the field of cosmetics, many products with whitening effect make skin tender by removing horny layer. The stratum corneum, in turn, is an important barrier of the skin and plays an important role in maintaining the health of the skin.
Skin thickness of infants is far less than that of adults, natural barriers of the skin are not completely developed, and skin cuticles of the infants are easily damaged in severe environments such as cold, dryness, sand dust and the like, so that deeper damage is caused to the skin. If there is a lack of skin barrier protection, contaminants in the air and contaminants on items that the skin contacts are prone to enter the skin, causing more serious health problems such as inflammation.
In addition, because the ability of the infants to secrete grease is not strong, and the skin barrier is damaged, the skin barrier is difficult to repair by the infants, so that the development of the skin care product which is specially used for the infants and children and used for repairing the skin barrier has important significance.
Chinese patent CN108969446A discloses an infant anti-chap skin care composition for enhancing the skin barrier function, but the action principle is that a moisturizing composite layer is formed on the surface of the skin, and the repairing effect on the deep layer of the skin is weak.
Therefore, the development of a skin care product which can really repair the deep skin barrier has urgent and important significance.
Disclosure of Invention
The invention aims to overcome the defect that skin barriers of infants and children cannot be deeply repaired in the prior art, and provides an infant skin care composition for repairing the skin barriers and a preparation method thereof.
The invention solves the technical problems through the following technical scheme:
an infant skin care composition for repairing skin barrier, wherein the active ingredients of the composition comprise the following components in percentage by weight:
0.075-0.1% of ceramide II
Phytosterol 0.5-2%
Stearic acid 0.425% -1.7%
0.15 to 0.2 percent of bisabolol
0.01 to 3 percent of lily bulb extract
0.01 to 3 percent of rose extract
0.01 to 3 percent of the extract of the iris pallida root
0.5 to 3 percent of 1, 2-pentanediol
4-tert-butylcyclohexanol 0.5-3%
0.3 to 0.5 percent of beta-glucan.
Preferably, the ceramide II is a synthetic ceramide II.
Preferably, the bisabolol is synthetic bisabolol.
Preferably, the amount of the ceramide II is 0.09-0.1%.
Preferably, the phytosterols are used in an amount of 0.5% to 1.5%, for example 1%.
Preferably, the stearic acid is used in an amount of 1.5% to 1.7%.
Preferably, the bisabolol is used in an amount of 0.35% to 0.4%.
Preferably, the 1, 2-pentanediol is used in an amount of 2% to 3%.
Preferably, the amount of the 4-tert-butylcyclohexanol is 0.5% -1%.
Preferably, the beta-glucan is used in an amount of 0.4% -0.5%. Preferably, the active ingredients of the composition comprise the following components in percentage by weight:
0.075% of ceramide II;
2% of phytosterol;
0.45 percent of stearic acid;
0.25% of bisabolol;
lilium Candidum bulb extract 2%
0.1 percent of rose extract
1% of the extract of Iris pallida
0.5 percent of 1, 2-pentanediol;
2% of 4-tert-butylcyclohexanol;
beta-glucan 0.5%;
preferably, the composition further comprises one or more of a humectant, a grease, a thickener, a preservative system, an emulsifier and deionized water.
The humectant is a hydrophilic emollient substance, and the formula of the whitening and freckle removing compound has no special limitation on the humectant and the content thereof. Theoretically, moisturizers commonly used in cosmetics, such as polyols, natural moisturizing factors, amino acids and high molecular biochemicals, can be used in the technical scheme of the invention. The preferable humectant in the technical scheme of the invention can be selected from one or more of glycerol, 1, 3-butanediol, propylene glycol, pentanediol, hexanediol, sorbitol and other polyols, amides, trehalose, glucose/glucose esters, fructose and other polysaccharides, urea, allantoin, lactic acid/sodium lactate, PCA sodium and other natural moisturizing factors, betaine, polyethylene glycols, panthenol, nicotinamide, chitosan, vitamin E acetate and triethanolamine. Furthermore, from the perspective of moisturizing effect and saving raw materials, the preferable range of the addition ratio of the moisturizing agent is 0.1-30 wt% based on the total mass of the whitening and freckle-removing compound.
The oil and fat are basic raw materials for making up cream cosmetics, and mainly play a role in protecting, smoothing and moistening skin. Glycerin fatty acid is the main component constituting animal and vegetable oil. Oil is a liquid at room temperature, and fat is a solid. And vegetable oils and fats such as coconut oil, castor oil, olive oil, almond oil, peanut oil, soybean oil, palm oil, etc. can be classified according to the source. The animal fat and oil includes beef tallow, lard, mink oil, and turtle oil, and the hydrogenated product of these animal and vegetable fats and oils is called hardened oil. Hardened oils commonly used in cosmetics are: hardened coconut oil, hardened beef tallow, hardened castor oil, hardened soybean oil, and the like. The addition ratio of the fat or oil of the present invention is preferably in the range of 2 to 10% by weight.
The thickener is a thickener system using inorganic salt sodium chloride, in the cosmetic, the thickener can be added and stirred with other raw materials, micelles can be formed in an aqueous solution, the association number of the micelles is increased due to the existence of electrolyte, the spherical micelles are converted into rod-shaped micelles, the movement resistance is increased, and the viscosity of the system is increased. The thickener preferred in the technical scheme of the invention can be selected from one or more of beeswax, xanthan gum and acryloyl dimethyl ammonium taurate/VP copolymer. The addition ratio of the thickener of the present invention is preferably in the range of 2 to 5% by weight.
The preservative system is a substance for protecting cosmetics from microbial contamination or preventing microbial growth, and can play a role in prolonging the shelf life of products. It should be noted that, in principle, the formula of the whitening and freckle-removing compound of the present invention has no special limitation on the preservative system and the content thereof (within the legal requirement), and the commonly used preservative systems in cosmetics can be used in the technical scheme of the present invention. The preservative system provided by the scheme of the invention can be one or more selected from p-hydroxyacetophenone, sorbic acid/potassium sorbate, phenoxyethanol, p-hydroxybenzoate esters, polyols, chlorphenesin, glyceryl caprylate, glyceryl caprate, diethylhexyl syringylidenemalonate, dehydroacetic acid and salts thereof, salicylic acid/sodium salicylate, benzoic acid, iodopropynyl butylcarbamate, sorbitan caprylate and anisic acid. The weight percentage of the anticorrosion system is 0.1-10%.
Emulsifiers are surfactants which stabilize emulsions. Thus, after the emulsifier is added to the oil-water system, the water and oil can be mixed with each other to form a fully dispersed emulsion. Emulsifiers not only improve the stability of the emulsion, but also determine the type of emulsion. Emulsifiers can be classified into natural emulsifiers and synthetic emulsifiers according to their origin; according to the action type, the surfactant, the viscosity enhancer and the solid adsorbent can be divided; they can be classified into oleophilic type and hydrophilic type according to their oleophilic and hydrophilic properties. The emulsifier in the scheme of the invention can be one or more selected from potassium cetyl phosphate, hydrogenated palm oil glycerides, glyceryl stearate citrate and glyceryl stearate. The weight percentage of the emulsifier is 2% -5%.
Preferably, in the composition, the sum of the mass percentages of the ceramide II, the phytosterol, the stearic acid and the bisabolol is 3-4%.
Further preferably, in said composition, use is made of
Figure BDA0002100048790000041
100 in place of said ceramide ii, said phytosterol, said stearic acid and said bisabolol.
Further preferably, the
Figure BDA0002100048790000043
100 may be used in amounts of 3%, 3.5% or 4%.
Preferably, in the composition, the sum of the mass percentages of the 1, 2-pentanediol and the 4-tert-butylcyclohexanol is 1% -3%.
Further preferably, in said composition, use is made of
Figure BDA0002100048790000042
1609 instead of said 1, 2-pentanediol and said 4-tert-butylcyclohexanol.
Further preferably, the
Figure BDA0002100048790000051
1609 can be used in an amount of 1%, 1.5%, 1.7% or 2%.
Preferably, in said composition, use is made of
Figure BDA0002100048790000052
Instead of said beta-glucan, said
Figure BDA0002100048790000053
The dosage of the composition is 6 to 10 percent.
Further preferably, the
Figure BDA0002100048790000054
Can be used in an amount of 6%, 7%, 8% or 10%.
A method for preparing a skin care composition for infants and children for repairing skin barrier comprises the following steps: according to the weight percentage of the total weight of the composition, 0.075-0.1 percent of ceramide II, 0.5-2 percent of phytosterol, 0.425-1.7 percent of stearic acid and 0.25-0.4 percent of bisabolol are heated to 80-85 ℃ to be homogenized for 3-7 minutes, cooled to 40-45 ℃, sequentially added with 0.01-3 percent of lily bulb extract, 0.01-3 percent of rose extract, 0.01-3 percent of iris tectorum root extract, 0.5-3 percent of 1, 2-pentanediol, 0.5-3 percent of 4-tert-butylcyclohexanol and 0.3-0.5 percent of beta-glucan, added with an auxiliary agent to make up to 100 percent, and the pH is adjusted to 5.5-6, the auxiliary agent comprises one or more of a humectant, grease, a thickening agent, an antiseptic system, an emulsifier and deionized water.
Preferably, 3% -4% is used
Figure BDA0002100048790000057
100 to replace 0.075 to 0.1 percent of ceramide II, 0.5 to 2 percent of phytosterol, 0.425 to 1.7 percent of stearic acid and 0.25 to 0.4 percent of bisabolol;
by 1% -2%
Figure BDA0002100048790000056
1609 to replace 0.5% -3% of 1, 2-pentanediol, 0.5% -3% of 4-tert-butylcyclohexanol;
by 6-10%
Figure BDA0002100048790000055
To replace 0.3% -0.5% of beta-glucan
On the basis of the common knowledge in the field, the above preferred conditions can be combined randomly to obtain the preferred embodiments of the invention.
The positive progress effects of the invention are as follows: the skin care product composition for the infants for repairing the skin barrier simultaneously has comprehensive effects of relieving itching, removing red, diminishing inflammation, resisting stabbing pain, burning, repairing the barrier and the like, particularly has the effect of deeply repairing the skin barrier for the skin of the infants, and is mild and non-irritant to the skin of the infants.
Detailed Description
The invention is further illustrated by the following examples, which are not intended to limit the scope of the invention.
The sources of the raw materials used in the present invention are illustrated below:
as the Ceramide II, a synthetic Ceramide II produced by Symrise corporation was used, and a commercial product thereof was Ceramide BIO391 (160106). Ceramide BIO391 is a novel synthetic Ceramide with a structure similar to that of natural Ceramide 2. The Ceramide BIO391 is synthesized by taking L-hydroxyproline, cetyl alcohol and palmitic acid as raw materials, and the cetyl alcohol and the palmitic acid are respectively grafted on the L-hydroxyproline to form a double-graft structure of C16/C16, while the naturally-occurring Ceramide 2 is a double-graft structure of C16/C18. The test parameters of the SDS model IN VIVO were TEWL and erythema, the test area was the forearm, the skin barrier was disrupted by applying 2% SDS for 24h, the residual SDS solution was removed, and the Ceramide BIO391(2 mg/cm) was applied twice a day2) Application was continued for 9 days. The efficacy of Ceramide BIO391 was demonstrated to be comparable to that of native Ceramide, with a difference of less than 8% in skin barrier integrity based on TEWL values compared to native Ceramide at day five after SDS treatment.
The phytosterol can be conventional campesterol.
The bisabolol can be synthesized from Symrise, and is available in the form of commercial product
Figure BDA0002100048790000061
100。
Symrepaire
Figure BDA0002100048790000062
Commercially available under the trade name Symrise under the trade name Symrepiar100(445662) and international cosmetic raw material names hexyldecanol, bisabolol, N-palmitoyl hydroxyproline cetyl alcohol, stearic acid, campesterol.
Symsitive
Figure BDA0002100048790000063
Is available from Symrise under the trade name of SymITIVE 1609(399944) and the international cosmetic raw material names of 1,2 pentanediol and 4-tert-butylcyclohexanol.
Figure BDA0002100048790000064
Commercially available under the trade name Symrise under the trade name SymGlucan (151719) and under the international cosmetic raw material name β -glucan. In the invention, the beta-glucan is from all natural oat, has mildness and can better ensure the repair effect.
The Lilium Candidum (Lilium Candidum) flower extract is obtained by soaking Lilium Candidum flower in water-propylene glycol mixed medium. The soaking operations and conditions are conventional in the art. The proportions of the water and the propylene glycol may be conventional in the art.
A topical composition containing extract of Lilium Multiflorum flower has effects in keeping moisture, relieving, killing bacteria and healing wound. The performance parameters of the lilium candidum extract are preferably as follows: color (Gardner index) of 8.0-12.0, specific gravity (D20/4) of 1.025-1.055 at 20 deg.C, refractive index of 1.375-1.405 at 20 deg.C, pH of 5.6-7.2, dry extract content of 0.30-2.00g/100g, total aerobic bacteria content of <100/g, heavy metal content (lead) <20ppm, arsenic content of <1 ppm. The Lilium Candidum extract is available from the product VEGETOL LILY MCF1968HYDRO of Jiafa lion (Shanghai) trade company Limited (GATTEFOSSECCHINATRADINGCO., LTD).
The rose (ROSA RUGOSA) flower extract is generally obtained by soaking light-colored rose petals in a water-propylene glycol mixing medium. The soaking operations and conditions are conventional in the art. The proportions of the water and the propylene glycol may be conventional in the art.
A topical composition containing rose extract has nourishing, astringent and soothing effects. The performance parameters of the rose extract are preferably as follows: the color Gardner index is 6.0-9.0, the specific gravity (D20/4) at 20 ℃ is 1.030-1.050, the refractive index at 20 ℃ is 1.383-1.396, the pH value is 4.5-6.0, the content of dry extract is 0.20-1.50g/100g, the content of total aerobic bacteria is less than 100/g, the content of heavy metal (lead) is less than 20ppm, and the content of arsenic is less than 1 ppm. The ROSE extract is available from VEGETOL ROSE MCF789HYDRO, a product of GATTEFOSSECCHINATRADINGCO, LTD, from Jiafa lion (Shanghai).
The extract of Iris pallida (IRIS FLORENTINA) is generally obtained by soaking Iris pallida in a water-propylene glycol-ethanol mixed medium. The soaking operations and conditions are conventional in the art. The proportions of the water, the propylene glycol and the ethanol can be conventional in the field.
A topical composition containing Iris pallida extract has moisturizing, soothing, astringent and cleansing effects. Preferably, the iris citrifolia extract further comprises 0.2-0.4% of zinc and 2UI/mL of vitamin A (retinyl palmitate). The extract of Iris pallida can be obtained from Cytobiol, a product of Kao-shi trade company, Shanghai, Inc. (GATTEFOSSECONITAXIDINDUCO., LTD)TMIris A2。
The component ratios of examples 1 to 10 and comparative examples 1 to 10 are shown in tables 1 to 4.
Table 1 components of active ingredients of examples 1-5
Figure BDA0002100048790000071
Figure BDA0002100048790000081
Table 2 composition of active ingredients of comparative examples 1 to 5
Figure BDA0002100048790000082
Figure BDA0002100048790000091
TABLE 3 Components of examples 6-10
Figure BDA0002100048790000092
Figure BDA0002100048790000101
TABLE 4 Components of comparative examples 6-10
Figure BDA0002100048790000102
The preparation method of the skin care composition for infants and children of examples 1 to 5 and comparative examples 1 to 5 for repairing skin barrier comprises the following steps: heating water solution of ceramide II, phytosterol, stearic acid and bisabolol to 80-85 deg.C, homogenizing for 3-7 min, cooling to 40-45 deg.C, sequentially adding Bulbus Lilii bulb extract, flos Rosae Rugosae extract, rhizoma Iridis Tectori extract, 1, 2-pentanediol, 4-tert-butylcyclohexanol, and beta-glucan, adding adjuvant, supplementing to 100% with deionized water, and adjusting pH to 5.5-6.
The preparation method of the skin care composition for infants and children of examples 6 to 10 and comparative examples 6 to 10 for repairing skin barrier comprises the following steps: will be provided with
Figure BDA0002100048790000112
100 heating to 80-85 deg.C, homogenizing for 3-7 min, cooling to 40-45 deg.C, sequentially adding VEGETOL LILY MCF1968HYDRO, VEGETOL ROSE MCF789HYDRO, and cytodiolTMIris A2、
Figure BDA0002100048790000113
1609 and
Figure BDA0002100048790000114
adjusting pH to 5.5-6.
Effect example 1
Safety evaluation, the compositions of examples 1-10 and comparative examples 1-10 were tested for safety using a human skin patch test. The test method was in accordance with technical Specifications for cosmetic safety (2015 edition). 50 samples of 50 volunteers with 20-40 years old healthy skin are selected to participate in the patch test by a closed patch test method, and 50mg of the test sample and a blank control (without any substance) sample are randomly added into a patch device. The patch with the tested substance is applied to the inner side of the forearm of the subject by a special adhesive tape, lightly pressed by palm to be uniformly applied to the skin, the tested substance is removed after 24 hours, the skin reaction is observed after 0.5, 12, 24 and 48 hours of the patch with the tested substance is removed, and the result is recorded according to the skin reaction grading standard in the cosmetic hygiene standard. The judgment standard is as follows:
(; only faint (unclear) erythema.
(+) -weak (bleb-free) positive reaction; erythema, infiltrates, possibly with small rashes.
(++) -strong (blister) positive reaction; erythema, infiltration, papules non-small blisters.
(+++) extremely positive reaction; red and swollen with bulla.
(-) -No reaction
The test results of examples 1-10 and comparative examples 1-10 are shown in Table 5 below:
TABLE 5 test results of human skin patches
Figure BDA0002100048790000111
Figure BDA0002100048790000121
The result of the human body skin patch test shows that: skin reactions were observed at 0.5, 12, 24, 48 hours, with all subjects of examples 1-10 having negative skin reactions. The adverse reactions do not appear in the examples 1-10, which shows that the components of the invention are safe and mild, are mild and particularly have no irritation to the skin of infants, and are suitable for infant products. Of the comparative examples, comparative example 9 is due to the lack of CytobiolTMIris A2Leading to possible adverse reactions.
Effect example 2
The hydration state of the stratum corneum of the skin was tested using a Comermeter CM 825: the 50mg samples were applied evenly to the test area and the hydration state of the skin was tested l, 3, 6h after application, the test data are shown in table 6. The larger the hydration state value, the larger the moisture content, and conversely, the smaller the moisture content. Considering the difference of the hydration state index in the individual absolute value, the change rate of the hydration state index is calculated as an evaluation parameter. The rate of change of the hydration state index was (measured value-blank value)/blank value 100%. The higher the rate of change of the indication of the hydration state, the stronger the ability to maintain the skin hydration state and the stronger the moisturizing efficacy.
TABLE 6 hydration state index change rate test results of stratum corneum
Figure BDA0002100048790000131
Figure BDA0002100048790000141
As can be seen in table 6, examples 1-10 exhibited excellent ability to maintain the skin hydration state.
Effect example 3
The skin stratum corneum percutaneous water loss (TEWL) was tested by means of a German CK company MC900 skin evaluation center instrument with different test probes under test conditions of temperature 25 + -2 ℃ and humidity 50 + -10%: the TEWL values were measured for 1,2, and 6 hours by uniformly spreading 50mg of the sample in the test area, and the change rate of the TEWL was calculated, thereby obtaining the change rate of the percutaneous water loss (TEWL), and the test results are shown in Table 7. The lower the TEWL value of the skin, the greater the rate of change of the reduction, indicating a better barrier function against the loss of water, and conversely the worse, the unit is g/(m2 h). The change rate of TEWL value is TEWL (measured value-blank value)/blank value 100%, for example, 1 hour change in water dispersion is water content after 1 hour of using the product-water content before using the product.
TABLE 7 rate of change of the transdermal water dispersion loss of the stratum corneum
Figure BDA0002100048790000142
Figure BDA0002100048790000151
The results in table 7 show: compared with a comparative example, the skin barrier repair preparation disclosed by the invention has the advantages that the skin percutaneous moisture loss value is greatly reduced, and the skin barrier repair effect is obvious, so that the skin barrier repair preparation disclosed by the invention has ideal test results on skin barrier repair, moisture retention and continuous moistening capabilities.
While specific embodiments of the invention have been described above, it will be appreciated by those skilled in the art that this is by way of example only, and that the scope of the invention is defined by the appended claims. Various changes and modifications to these embodiments may be made by those skilled in the art without departing from the spirit and scope of the invention, and these changes and modifications are within the scope of the invention.

Claims (10)

1. An infant skin care composition for repairing skin barrier, which is characterized by comprising the following components in percentage by weight:
0.075-0.1% of ceramide II
Phytosterol 0.5-2%
Stearic acid 0.425% -1.7%
0.15 to 0.2 percent of bisabolol
0.01 to 3 percent of lily bulb extract
0.01 to 3 percent of rose extract
0.01 to 3 percent of the extract of the iris pallida root
0.5 to 3 percent of 1, 2-pentanediol
4-tert-butylcyclohexanol 0.5-3%
Beta-glucan 0.3% -0.5%
The balance is made up to 100% by using water and/or alcohol solvent.
2. The skin barrier repairing infant skin care composition according to claim 1 wherein the sum of the mass percentages of said ceramide ii, said phytosterol, said stearic acid and said bisabolol in said composition is not more than 4%.
3. Skin barrier repairing baby skin care composition according to claim 2, wherein in said composition, use is made of
Figure FDA0002100048780000011
100 in place of said ceramide ii, said phytosterol, said stearic acid and said bisabolol.
4. The skin barrier repairing infant skin care composition according to claim 1 wherein the sum of the mass percentages of said 1, 2-pentanediol and said 4-tert-butylcyclohexanol in said composition is from 1% to 3%.
5. Skin barrier repairing baby skin care composition according to claim 4 wherein in said composition is used
Figure FDA0002100048780000012
1609 instead of said 1, 2-pentanediol and said 4-tert-butylcyclohexanol.
6. The skin barrier repairing infant skin care composition according to claim 1, wherein said lilium albo-marginatum bulb extract is present in an amount of 1% to 3% of said composition.
7. The skin barrier repairing infant skin care composition according to claim 1, wherein the rose extract is contained in an amount of 0.01% to 1% in the composition.
8. Skin barrier repairing baby skin care composition according to claim 1 wherein in said composition, use is made of
Figure FDA0002100048780000021
Instead of said beta-glucan, said
Figure FDA0002100048780000022
The dosage of the composition is 6 to 10 percent.
9. A method of preparing a skin care composition for infants and children to repair skin barriers, comprising the steps of: according to the weight percentage of the total weight of the composition, 0.075-0.1 percent of ceramide II, 0.5-2 percent of phytosterol, 0.425-1.7 percent of stearic acid and 0.25-0.4 percent of bisabolol are heated to 80-85 ℃ to be homogenized for 3-7 minutes, cooled to 40-45 ℃, sequentially added with 0.01-3 percent of lily bulb extract, 0.01-3 percent of rose extract, 0.01-3 percent of iris tectorum root extract, 0.5-3 percent of 1, 2-pentanediol, 0.5-3 percent of 4-tert-butylcyclohexanol and 0.3-0.5 percent of beta-glucan, added with alcohol solvent to make up to 100 percent, and the pH value is adjusted to 5.5-6.
10. A method of preparing a skin barrier rejuvenating infant skin care composition according to claim 9 wherein from 3% to 4% by weight of the total composition is used
Figure FDA0002100048780000023
100 to replace 0.075 to 0.1 percent of ceramide II, 0.5 to 2 percent of phytosterol, 0.425 to 1.7 percent of stearic acid and 0.25 to 0.4 percent of bisabolol;
by 1% -2%
Figure FDA0002100048780000024
1609 to replace 0.5% -3% of 1, 2-pentanediol, 0.5% -3% of 4-tert-butylcyclohexanol;
by 6-10%
Figure FDA0002100048780000025
To replace 0.3% -0.5% of beta-glucan.
CN201910532020.6A 2019-06-19 2019-06-19 Skin care composition for infants and children for repairing skin barrier and preparation method thereof Pending CN112107526A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023002851A1 (en) * 2021-07-21 2023-01-26 株式会社 資生堂 Obp promoter
JP2023016710A (en) * 2021-07-21 2023-02-02 株式会社 資生堂 Obp promoter

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023002851A1 (en) * 2021-07-21 2023-01-26 株式会社 資生堂 Obp promoter
JP2023016710A (en) * 2021-07-21 2023-02-02 株式会社 資生堂 Obp promoter
JP7333854B2 (en) 2021-07-21 2023-08-25 株式会社 資生堂 OBP accelerator

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