CN111700853A - Cosmetic composition with anti-allergy repairing effect and application thereof - Google Patents
Cosmetic composition with anti-allergy repairing effect and application thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic composition with an anti-allergy repairing effect and application thereof. A cosmetic composition with anti-allergy repairing effect comprises, by mass, 0.1-1% of plant extract, 0.5-2% of active peptide, 30-40% of panthenol, 3-10% of saccharide isomer, 0.1-0.5% of compound containing inositol structure, 11-33% of glycerol compound, and the balance of water. The active ingredients are promoted to be absorbed through the synergistic effect of the ingredients, so that the itching and redness removing ointment has the effects of quickly relieving itching, eliminating redness, relieving inflammation, fundamentally improving the symptoms of dry skin and desquamation, regulating the ecological balance of skin and strengthening the skin barrier; the emulsion system has good stability, not only promotes the penetration and absorption of effective substances, but also solves the problem that the skin feel of the product is sticky; the long-acting repairing effect and the anti-allergy repairing effect are good, the component effects are mild, the use is safe, and the secondary damage to sensitive skin in the using process is effectively avoided.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic composition with an anti-allergy repairing effect and application thereof.
Background
Skin is a natural barrier of human body surface, but in recent years, along with the change of dietary structure, environmental pollution and the increase of working and living pressure, allergic people are increased rapidly, and particularly in developed areas along the sea, skin sensitivity has become a social problem affecting human health. Skin susceptible to skin allergy is also called sensitive skin. Various external causes cause allergic reactions of the skin, and abnormal phenomena such as red swelling, itching, desquamation, allergic dermatitis and the like can occur. The incidence of skin allergy in China is high, particularly in autumn and winter, the skin is dry, and many people can show skin allergy symptoms such as skin itch.
Sensitive skin is not actually a disease, it refers to a state of physiological hyperresponsiveness (Italy) that makes the skin to environmental or internal factors. This condition can occur when exposed to skin care products, soaps, sunscreen products, detergents, and can exacerbate common skin discomfort symptoms in dry and cold environments. There are many factors that cause skin allergy or damage: physical factors include ultraviolet rays, heat, cold, mechanical damage, etc.; chemical factors include surfactant excessive degreasing, chemical solvents, sunscreen agents and other harmful chemical substances; biological factors such as bacteria, mold, germs, etc. can cause skin allergy or damage. The skin damage caused by these factors is free radical oxidation damage, cell DNA damage, inflammation damage, ultraviolet light induced photoaging damage, skin wrinkles caused by protein decomposition and cross-linking, skin barrier damage caused by excessive washing, immune cell damage, skin dryness, etc. Scientific anti-allergy methods should have a comprehensive effect on anti-inflammation, free radical scavenging, skin moisturizing, itching relieving, etc.
However, the existing anti-allergy repair products have the following defects: 1) some anti-allergy repair products only focus on repairing the skin barrier, ignoring the influencing factors of TRPV1 receptor, immunity and inflammatory factors; 2) in targeting skin barrier repair, repair is made only to the stratum corneum, ignoring the micro-ecological barrier located above it, i.e. the microbial flora symbiotic with the skin. The skin microecology is composed of a plurality of microbial flora of different habitats of the skin, the microbial flora colonized under the normal skin state and the skin form a good symbiotic relationship, keratinocytes can specifically recognize symbiotic flora through PRR, the symbiotic flora inhibits invasion of external harmful flora through spontaneous generation of AMPs, and simultaneously can regulate and induce the keratinocytes to secrete AMPs for inhibiting and killing harmful transient flora, so that a microbial barrier at the outermost periphery of the skin is formed, and the function of an immune barrier is exerted. However, once the barrier is disturbed, the flora is disordered, the skin microbial barrier is unbalanced, and various skin problems can be induced mainly by excessive reproduction of harmful bacteria, wherein the most common phenomenon is the occurrence of sensitive skin; 3) skin sensitivity is a complex reaction involving nerve vessels in the dermis, active ingredients must penetrate the epidermal barrier to reach each target point of the dermis to play a role, and the existing repair anti-sensitivity products are usually added with penetration enhancers capable of changing the permeability of the skin, such as propylene glycol, azone, dimethyl sulfoxide, dimethyl acetamide and the like, so that although the penetration of the active ingredients is facilitated, the skin irritation is easily caused by changing the permeability of the skin, and the secondary damage of the sensitive skin is caused.
Disclosure of Invention
In order to solve the above problems, the present invention provides, in a first aspect, a cosmetic composition having anti-allergy restoration efficacy comprising, as active ingredients, 0.1 to 1% by mass of a plant extract, 0.5 to 2% by mass of an active peptide, 30 to 40% by mass of panthenol, and 3 to 10% by mass of a saccharide isomer.
As a preferable technical scheme, the plant extract contains methylglyoxal and glycolic acid.
As a preferred embodiment, said panthenol is D-panthenol and/or DL-panthenol.
As a preferred technical scheme, the saccharide isomer is selected from one or more of psicose, glucose, mannose, fructose, glucose, galactose and maltose.
As a preferable technical scheme, the cosmetic composition also comprises 0.1-0.5 percent of compound containing an inositol structure, 11-33 percent of glycerol compound and the balance of water by mass percentage.
As a preferred technical solution, the glycerol compounds include diglycerol and polyglycerin-3; the mass ratio of diglycerol to polyglycerol-3 is (5-15): 1.
as a preferred technical scheme, the active peptide is selected from one or more of dipeptide-1, dipeptide-2, dipeptide-4, dipeptide diaminobutyrylbenzylamide diacetate, tripeptide-6, trifluoroacetyl tripeptide-2, tripeptide-1 copper, tripeptide-10 citrulline, tripeptide-2, tripeptide-3, tripeptide-32, reduced glutathione, oxidized glutathione, L-carnosine, D-carnosine, oligopeptide-1, oligopeptide-2, oligopeptide-29, oligopeptide-3, oligopeptide-32, oligopeptide-4, oligopeptide-5 and oligopeptide-6.
As a preferred technical solution, the plant extract is derived from flowers of new zealand manuka tree, and is prepared by a water extraction process.
As a preferable technical scheme, the mass ratio of the plant extract to the glycerol compound is 1: (33-110).
In a second aspect, the present invention provides a use of the above cosmetic composition in cosmetics, wherein the cosmetics comprise one or more of face toilet, moisturizer, lotion, cream, foundation, mask, lotion, and essence.
Has the advantages that: the cosmetic composition with the anti-allergy repair effect provided by the invention has the advantages that the absorption of effective components is promoted through the synergistic effect of the components, the itching, redness and inflammation are quickly relieved, the dry and desquamation symptoms of the skin are fundamentally improved, the ecological balance of the skin is adjusted, and the skin barrier is strengthened; the emulsion system is good in stability, not only promotes the penetration and absorption of effective substances, but also can solve the problem that the skin of the product is sticky, has the promotion effects on the formation of protein and DNA repair, can improve the self-regulation level of the skin, improve the water activity of the skin, promote the water balance of the skin, increase the elasticity of the skin, make the skin smoother, healthier, have good long-acting repair effect and anti-allergy repair effect, and simultaneously have mild component action and safe use, and secondary damage to sensitive skin in the using process is effectively avoided.
In order to solve the above problems, the present invention provides, in a first aspect, a cosmetic composition having anti-allergy restoration efficacy comprising, as active ingredients, 0.1 to 1% by mass of a plant extract, 0.5 to 2% by mass of an active peptide, 30 to 40% by mass of panthenol, and 3 to 10% by mass of a saccharide isomer.
In one embodiment, the composition comprises 0.5% by mass of a plant extract, 1.2% by mass of an active peptide, 35% by mass of panthenol, and 6% by mass of a saccharide isomer as an active ingredient.
Plant extracts
In one embodiment, the plant extract contains methylglyoxal and glycolic acid components.
In a preferred embodiment, the plant extract contains methylglyoxal, glycolic acid, amino acids, sugars, honey ingredients.
In the invention, the methylglyoxal is an aldehyde compound, also called as pyruvaldehyde and 2-oxopropanal, CAS number: 78-98-8, is yellow or yellow brown transparent liquid, has pungent smell and hygroscopicity, is easy to polymerize into viscous semisolid, is dissolved in water to release heat, and is recovered into monomer solution. Heating at 72 deg.C to form yellow-green gas.
In the invention, the methylglyoxal is an effective antibacterial active factor and can treat acne skin.
In the invention, the glycolic acid, colorless deliquescent crystals, is soluble in water, organic solvents such as methanol, ethanol, ethyl acetate and the like, slightly soluble in ether, insoluble in hydrocarbons, has duality of alcohol and acid, is decomposed when being heated to the boiling point, and is used for organic synthesis and the like; CAS registry number 79-14-1; glycolic acid is a colorless crystal, slightly hygroscopic; low corrosivity, nonflammability, no odor, low toxicity, strong biodegradability and high water solubility.
In the invention, the glycolic acid contains a carboxyl group and a hydroxyl group, has the dual properties of carboxylic acid and alcohol, and can be esterified to generate glycolide and also can generate ether or acetal; the glycolic acid enhances epidermal metabolism and presents a young, healthy skin.
In the present invention, the amino acid helps skin cells to regenerate; the sugar is a natural humectant that can draw moisture from the environment; the sugar can tighten the skin, reduce wrinkles and reshape the young face; the honey has natural antiinflammatory components, and can be used for treating acne and smoothing skin. The ingredients such as methylglyoxal, glycolic acid, amino acid, sugar, honey and the like act together, so that the acne scar skin cream has the effects of resisting bacteria and inflammation, helping the acne scar skin to regenerate, more importantly, preventing the premature aging process and nourishing the skin and hair, is particularly suitable for daily and night nursing, and has strong anti-aging property.
In a preferred embodiment, the plant extract is manuka honey extract, available from guangzhou Yinjand trade company, Inc.
The INCI name of the manuka honey extract is: glycerin and water and honey extract.
In one embodiment, the plant extract is derived from flowers of new zealand manuka tree, prepared by an aqueous extraction process.
Active peptides
In one embodiment, the active peptide is selected from one or more of dipeptide-1, dipeptide-2, dipeptide-4, dipeptide diaminobutyrylbenzylamide diacetate, tripeptide-6, trifluoroacetyl tripeptide-2, tripeptide-1 copper, tripeptide-10 citrulline, tripeptide-2, tripeptide-3, tripeptide-32, reduced glutathione, oxidized glutathione, L-carnosine, D-carnosine, oligopeptide-1, oligopeptide-2, oligopeptide-29, oligopeptide-3, oligopeptide-32, oligopeptide-4, oligopeptide-5, oligopeptide-6.
Preferably, the active peptide is L-carnosine and/or D-carnosine.
More preferably, the active peptide is L-carnosine.
In the present invention, the L-Carnosine (L-Carnosine), known as β -alanyl-L-histidine, is a crystalline solid composed of a dipeptide consisting of two amino acids, β -alanine and L-histidine; can scavenge Reactive Oxygen Species (ROS) and alpha-beta unsaturated aldehydes formed during oxidative stress by over-oxidation of cell membrane fatty acids; the L-carnosine has the effects of resisting wrinkles and ageing, resisting oxidation, improving the quality of skin, and preventing skin aging and whitening the skin of a face, a neck and a hand care product, the carnosine can prevent the generation of free radicals generated by smoking, the free radicals can damage the skin more than sunlight, and the free radicals are atoms or atomic groups with strong activity in a human body and can oxidize other substances in the human body.
Panthenol
In one embodiment, said panthenol is D-panthenol and/or DL-panthenol.
Preferably, said panthenol is D-panthenol.
In the present invention, the D-panthenol (dexpanthenol) is also called provitamin B5, and has a chemical name: (D) -N- (2, 4-dihydroxy- β, β -dimethylbutyryl) - β -aminopropanol having CAS number 81-13-0; readily soluble in water and alcohol, and practically insoluble in fat, it is the most stable form of pantothenic acid in liquid. D-panthenol can be converted into pantothenic acid after entering human body, so as to synthesize coenzyme A, promote metabolism of protein, fat and saccharide in human body, protect skin and mucosa, improve hair luster, and prevent diseases; d-panthenol can be used for preventing and treating small wrinkles, inflammation, solarization, and erosion, preventing alopecia, promoting hair growth, keeping hair moist, reducing hair bifurcation, preventing brittleness and breakage, and protecting, repairing, and caring hair.
Saccharide isomerate
In one embodiment, the saccharide isomerate is selected from one or more of psicose, glucose, mannose, fructose, glucose, galactose, maltose.
Preferably, the saccharide isomerate comprises psicose, glucose, mannose, fructose, glucose, galactose; the saccharide isomerate was purchased from kasha, guangzhou.
In the present invention, the saccharide isomerate is similar in composition to carbohydrate complex (NMF) in human skin, derived from plant D-glucose, has a unique binding mechanism to skin, is not washed away, and binds to lysine (free-amino group) in keratinocytes; can prevent dehydration of the underlying tissue, chemical and mechanical stimulation; can up-regulate the gene expression level of filaggrin and hyaluronic acid synthetase 3, promote the synthesis of NMF and hyaluronic acid and improve the water retention capacity of skin; can improve the gene expression level of the loricrine and influence the function of cornified envelope; can improve the expression level of acid sphingomyelinase gene and stimulate the synthesis of ceramide.
In one embodiment, the cosmetic composition further comprises 0.1-0.5% of a compound containing an inositol structure, 11-33% of a glycerin compound, and the balance of water by mass percentage.
Preferably, the cosmetic composition also comprises 0.3 percent of compound containing an inositol structure, 22 percent of glycerol compound and the balance of water by mass percentage.
Compound containing inositol structure
In one embodiment, the compound comprising an inositol structure is inositol and/or glycerophosphoinositide choline salt.
Preferably, the compound containing an inositol structure is glycerophosphoinositide choline salt.
In the invention, the CAS number of the glycerophosphoinositide choline salt is 425642-32-6, and the structural formula is shown in the specification
Is a skin conditioner, is an active ingredient obtained from sunflower lecithin, is a semisynthetic derivative of glycerophosphoinositide, is a natural ingredient of cell lipid metabolism, can quickly relieve inflammation and relieve itching, and is safe and reliable for long-term use; inhibit the intracellular phospholipase A2(cPLA2), the cPLA2 is a key enzyme of inflammatory reaction and mainly triggers the release of arachidonic acid; acts on the source of inflammatory cascade reaction, and has the same action as cortisone medicament; can be used for relieving after-sun treatment; controlling the symptoms of allergic and inflamed skin; control of dermatitis and related symptoms (redness, itching); preventing photoaging (controlling skin micro-inflammation); preventing red mark after inflammation.
Glycerol compound
In one embodiment, the glycerols include diglycerol and polyglyceryl-3.
In one embodiment, the mass ratio of diglycerol to polyglycerin-3 is (5-15): 1.
preferably, the mass ratio of the diglycerol to the polyglycerol-3 is 10: 1.
in the invention, the diglycerol is DIGLYCERIN under the English name of the same name: glycerol ether, diglycerol, dicarboxydipropyl ether, 4-oxyheptan-1, 2,6, 7-tetraol, diglycerol ether, 3' -oxydi-1, 2-propanediol, CAS No.: 627-82-7; the diglycerol is mainly used as a humectant in cosmetics and skin care products, has a risk coefficient of 1, is safe, can be used at ease, has no influence on pregnant women, and has no pox-causing property. The structural formula of the diglycerol is shown in the specification
The molecule contains 4 hydroxyl groups, and is an organic synthesis intermediate with multiple reaction possibilities such as esterification and etherification.
In the invention, the polyglycerol-3 is also called triglycerol, and the CAS number is 56090-54-1; a humectant; the moisturizing and moistening performance is excellent, and the skin can be kept moist for a long time without chapping; is natural and mild, and can be used in infant products, skin care products, facial mask essence, and facial cleanserCleaning products, bath lotion and hair care products. The structural formula of the polyglycerol-3 is shown as
The applicant unexpectedly finds in the research process that the addition of diglycerol and polyglycerol-3 to the composition has high moisturizing performance, excellent skin permeability, improved skin softness and sticky skin feel. The reason the inventor believes is that the diglycerol and the polyglycerol-3 have 4 hydroxyl groups, and have strong hydrogen bonding action with the glycerol phosphoinositide choline salt and the D-panthenol, so that the bonding force of the composition and water is further improved, the percutaneous water loss is greatly reduced, and the composition is lubricated without forming sticky feeling. In the further research process, the applicant finds that when the mass ratio of the diglycerol to the polyglycerol-3 is 10: 1, wherein the mass ratio of the manuka honey extract to the glycerol compound is 1: 44, the composition has the best stability, and can change the permeability of the skin without causing skin irritation or secondary damage to sensitive skin, and the applicant guesses that the reason is probably that the structures of diglycerol and polyglycerol-3 can be embedded into polyhydroxy structures such as PEG-stearate, saccharide isomers, glycerophosphoinositide choline salt and the like, so that the surface tension of the skin surface is reduced, and active substances can enter the skin through the skin surface; meanwhile, due to the combined action of the saccharide isomerate and the glycerophosphoinositide choline salt, diglycerol is arranged on the surface of the skin in a specific form, and the hydroxyl groups of the diglycerol have the hydrogen bond function, so that the diglycerol is promoted to be orderly arranged to form a soft breathable film, the irritation to the skin is reduced, and the sensitive skin cannot be secondarily damaged; meanwhile, the acridity of the methylglyoxal is effectively reduced by the diglycerol and the polyglycerol-3, the methylglyoxal interacts with the glycerophosphoinositide choline salt, and excellent high-temperature stability, low-temperature stability and illumination stability can be kept in a PEG-stearate emulsifying system.
In one embodiment, the mass ratio of the plant extract to the glycerol compound is 1: (33-110).
Preferably, the mass ratio of the plant extract to the glycerol compound is 1: (33-44).
More preferably, the mass ratio of the plant extract to the glycerol compound is 1: 44.
water (W)
In one embodiment, the water is deionized water.
The invention has the advantages that the absorption of effective components is promoted through the synergistic effect of seven components of manuka honey extract, carnosine, glycerophosphoinositide choline salt, panthenol, saccharide isomerate, diglycerin and polyglycerol-3, and the invention has the effects of quickly relieving itching, eliminating red, relieving inflammation, fundamentally improving the symptoms of dry skin and desquamation, regulating the ecological balance of skin and strengthening the skin barrier; and the emulsion system has good stability, not only promotes the penetration and absorption of effective substances, but also can solve the problem of sticky skin feel of the product. The long-acting repairing effect and the anti-allergy repairing effect are good, the component effects are mild, the use is safe, and the secondary damage to sensitive skin in the using process is effectively avoided.
In a second aspect, the present invention provides a use of the above cosmetic composition in cosmetics, wherein the cosmetics comprise one or more of face toilet, moisturizer, lotion, cream, foundation, mask, lotion, and essence.
The third aspect of the present invention provides a method for preparing the above cosmetic composition, comprising the steps of: mixing plant extract, active peptide, panthenol, saccharide isomerate, inositol structure-containing compound, glycerol compound, and water uniformly to obtain the cosmetic composition.
The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the starting materials used are all commercially available, unless otherwise specified.
Examples
Example 1
Example 1 provides a cosmetic composition having anti-allergy restoration efficacy, comprising, by mass, 0.1% of a plant extract, 0.5% of an active peptide, 30% of panthenol, 3% of a saccharide isomer, 0.1% of a compound having an inositol structure, 11% of a glycerol compound, and the balance water;
the plant extract is Manuka honey extract, purchased from Guangzhou Yizhen and trade Co;
the active peptide is L-carnosine;
the panthenol is D-panthenol;
the saccharide isomerate was purchased from kasha, guangzhou;
the compound containing an inositol structure is glycerophosphoinositide choline salt (CAS number is 425642-32-6);
the glycerol compounds comprise diglycerol and polyglycerol-3; the mass ratio of diglycerol to polyglycerol-3 is 5: 1; the CAS number of the diglycerol is 627-82-7; the CAS number of the polyglycerol-3 is 56090-54-1;
the water is deionized water;
the preparation method of the cosmetic composition comprises the following steps: mixing plant extract, active peptide, panthenol, saccharide isomerate, inositol structure-containing compound, glycerol compound, and water uniformly to obtain the cosmetic composition.
Example 2
Example 2 provides a cosmetic composition having anti-allergy restoration efficacy comprising 1% of a plant extract, 2% of an active peptide, 40% of panthenol, 10% of a saccharide isomer, 0.5% of a compound having an inositol structure, 33% of a glycerol compound, and the balance water;
the plant extract is Manuka honey extract, purchased from Guangzhou Yizhen and trade Co;
the active peptide is L-carnosine;
the panthenol is D-panthenol;
the saccharide isomerate was purchased from kasha, guangzhou;
the compound containing an inositol structure is glycerophosphoinositide choline salt (CAS number is 425642-32-6);
the glycerol compounds comprise diglycerol and polyglycerol-3; the mass ratio of diglycerol to polyglycerol-3 is 15: 1; the CAS number of the diglycerol is 627-82-7; the CAS number of the polyglycerol-3 is 56090-54-1;
the water is deionized water;
the preparation method of the cosmetic composition comprises the following steps: mixing plant extract, active peptide, panthenol, saccharide isomerate, inositol structure-containing compound, glycerol compound, and water uniformly to obtain the cosmetic composition.
Example 3
Example 3 provides a cosmetic composition having anti-allergy restoration efficacy, comprising, by mass, 0.5% of a plant extract, 1.2% of an active peptide, 35% of panthenol, 6% of a saccharide isomer, 0.3% of a compound having an inositol structure, 22% of a glycerol compound, and the balance water;
the plant extract is Manuka honey extract, purchased from Guangzhou Yizhen and trade Co;
the active peptide is L-carnosine;
the panthenol is D-panthenol;
the saccharide isomerate was purchased from kasha, guangzhou;
the compound containing an inositol structure is glycerophosphoinositide choline salt (CAS number is 425642-32-6);
the glycerol compounds comprise diglycerol and polyglycerol-3; the mass ratio of diglycerol to polyglycerol-3 is 10: 1; the CAS number of the diglycerol is 627-82-7; the CAS number of the polyglycerol-3 is 56090-54-1;
the water is deionized water;
the preparation method of the cosmetic composition comprises the following steps: mixing plant extract, active peptide, panthenol, saccharide isomerate, inositol structure-containing compound, glycerol compound, and water uniformly to obtain the cosmetic composition.
Example 4
Example 4 provides a cosmetic composition having anti-allergy restoration efficacy, comprising, by mass, 0.5% of a plant extract, 1.2% of an active peptide, 35% of panthenol, 6% of a saccharide isomer, 0.3% of a compound having an inositol structure, 22% of a glycerol compound, and the balance water;
the plant extract is Manuka honey extract, purchased from Guangzhou Yizhen and trade Co;
the active peptide is L-carnosine;
the panthenol is D-panthenol;
the saccharide isomerate was purchased from kasha, guangzhou;
the compound containing an inositol structure is glycerophosphoinositide choline salt (CAS number is 425642-32-6);
the glycerol compound is polyglycerol-3; the CAS number of the polyglycerol-3 is 56090-54-1;
the water is deionized water;
the preparation method of the cosmetic composition comprises the following steps: mixing plant extract, active peptide, panthenol, saccharide isomerate, inositol structure-containing compound, glycerol compound, and water uniformly to obtain the cosmetic composition.
Example 5
Example 5 provides a cosmetic composition having anti-allergy restoration efficacy, comprising, by mass, 0.5% of a plant extract, 1.2% of an active peptide, 35% of panthenol, 6% of a saccharide isomer, 0.3% of a compound having an inositol structure, 22% of a glycerol compound, and the balance water;
the plant extract is Manuka honey extract, purchased from Guangzhou Yizhen and trade Co;
the active peptide is L-carnosine;
the panthenol is D-panthenol;
the saccharide isomerate was purchased from kasha, guangzhou;
the compound containing an inositol structure is glycerophosphoinositide choline salt (CAS number is 425642-32-6);
the glycerol compound is diglycerol; the CAS number of the diglycerol is 627-82-7;
the water is deionized water;
the preparation method of the cosmetic composition comprises the following steps: mixing plant extract, active peptide, panthenol, saccharide isomerate, inositol structure-containing compound, glycerol compound, and water uniformly to obtain the cosmetic composition.
Example 6
Example 6 provides a cosmetic composition having anti-allergy restoration efficacy, comprising, by mass, 0.5% of a plant extract, 1.2% of an active peptide, 35% of panthenol, 6% of a saccharide isomer, 0.3% of a compound having an inositol structure, 5% of a glycerol compound, and the balance water;
the plant extract is Manuka honey extract, purchased from Guangzhou Yizhen and trade Co;
the active peptide is L-carnosine;
the panthenol is D-panthenol;
the saccharide isomerate was purchased from kasha, guangzhou;
the compound containing an inositol structure is glycerophosphoinositide choline salt (CAS number is 425642-32-6);
the glycerol compounds comprise diglycerol and polyglycerol-3; the mass ratio of diglycerol to polyglycerol-3 is 10: 1; the CAS number of the diglycerol is 627-82-7; the CAS number of the polyglycerol-3 is 56090-54-1;
the water is deionized water;
the preparation method of the cosmetic composition comprises the following steps: mixing plant extract, active peptide, panthenol, saccharide isomerate, inositol structure-containing compound, glycerol compound, and water uniformly to obtain the cosmetic composition.
Example 7
Example 7 provides a cosmetic composition having anti-allergy restoration efficacy, comprising, by mass, 0.5% of a plant extract, 1.2% of an active peptide, 35% of panthenol, 6% of a saccharide isomer, 22% of a glycerol compound, and the balance water;
the plant extract is Manuka honey extract, purchased from Guangzhou Yizhen and trade Co;
the active peptide is L-carnosine;
the panthenol is D-panthenol;
the saccharide isomerate was purchased from kasha, guangzhou;
the glycerol compounds comprise diglycerol and polyglycerol-3; the mass ratio of diglycerol to polyglycerol-3 is 10: 1; the CAS number of the diglycerol is 627-82-7; the CAS number of the polyglycerol-3 is 56090-54-1;
the water is deionized water;
the preparation method of the cosmetic composition comprises the following steps: mixing plant extract, active peptide, panthenol, saccharide isomerate, inositol structure-containing compound, glycerol compound, and water uniformly to obtain the cosmetic composition.
Evaluation of Performance
1. Stability: the cosmetic compositions described in examples 1 to 7 were added to an emulsion system containing 3% of PEG-stearate, 10% of isononyl isononanoate, 3% of fruit fat of shea butter (butyspermumparkii), 1% of polydimethylsiloxane, 0.5% of carbomer, 0.45% of triethanolamine, and the balance of deionized water (the amount of the cosmetic composition described in examples 1 to 7 was 5 wt% of the total mass of the emulsion system), and the emulsion system was left at room temperature, 45 ℃, -10 ℃ and after 1 week, 2 weeks, and 1 month of storage under light irradiation, and visual observation was performed on the appearance change of the emulsion system, and the stability was evaluated based on the following criteria:
a: under the condition, no layering phenomenon is observed, and the paste is fine;
b: no delamination was observed under these conditions and a coarse paste was observed
C: the layering phenomenon is observed under the condition, and the paste body is coarse and goes out of water;
the test results are shown in tables 1 to 4, in which table 1 shows the storage stability at room temperature, table 2 shows the storage stability at 45 ℃, table 3 shows the storage stability at-10 ℃, and table 4 shows the storage stability under light conditions;
TABLE 1
TABLE 2
TABLE 3
TABLE 4
2. Irritation: 50 female subjects with sensitive skin aged 45-55 years were selected, and each of the subjects was fitted with an aqueous solution containing 10 wt% of sodium lauryl sulfate and 5 wt% of the cosmetic composition described in examples 1-7 on the forearm of a human body for 24 hours, and the clinical evaluation of irritation after removal of the patch was scored, and the statistical average (rounded to an integer), where 0 score indicates no irritation, 5 score indicates irritation, and a higher score indicates stronger irritation, and the statistical results of irritation are shown in Table 5.
3. Permeability: the cosmetic compositions described in examples 1 to 7 were subjected to a moisturizing efficacy test to determine their penetration, and the cosmetic compositions described in examples 1 to 7 were added to a marine energy supplement liquid of gram-free fries (the amount of the cosmetic composition described in examples 1 to 7 added was 2 wt%); the test method comprises the following steps: selecting 50 subjects of 25-35 years of age, and randomly dividing the subjects into 5 groups of 10 persons; the specific method comprises the following steps:
after cleansing the face, the subjects rested in a constant environment for 3 minutes, and then tested for stratum corneum moisture content using a stratum corneum moisture content tester (Corneometer CM825, Courage & Khazaka, germany); the average value is taken by 3 times of continuous tests, and the higher the parameter value, the higher the water content of the stratum corneum of the skin is. Then, uniformly smearing a test sample by using a latex glove, starting timing, and measuring each water content at each time according to the design of an experiment; wherein, the water content is more than 75% is marked as A, the water content is 65-75% is marked as B, the water content is 55-65% is marked as C, the water content is less than 55% is marked as D, and the test results are shown in Table 5.
TABLE 5
4. Anti-allergy repairing effect: 50 volunteers, 3 wt% aqueous solution of sodium lauryl sulfate, applied to the forearm of a human body for 24 hours, and after removing the patch, the patch was applied to the forearm of a human body with 5 wt% aqueous solution of the cosmetic composition described in examples 1 to 7, respectively, without adding the cosmetic composition, for a blank test, and applied every 6 hours. The transepidermal water loss (TEWL) and skin red pigment of the skin were measured separately using 3 times (after 24 hours). The skin transepidermal water loss rate (TEWL) was measured using a skin transepidermal water loss tester (Tewameter TM300, CK corporation, Germany), and the skin red pigment content was measured using a skin red pigment tester (Mexameter MX 18). The lower the transepidermal water loss rate (TEWL) of the skin, the better the repair effect, and the lower the skin red pigment content, the better the soothing and anti-allergy effect. The results of the transepidermal water loss (TEWL) and skin red pigment tests on the skin are shown in table 6.
TABLE 6
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (10)
1. A cosmetic composition with anti-allergy repairing effect is characterized by comprising 0.1-1% of plant extract, 0.5-2% of active peptide, 30-40% of panthenol and 3-10% of saccharide isomer by mass as effective components.
2. The cosmetic composition of claim 1, wherein said plant extract comprises methylglyoxal and glycolic acid.
3. Cosmetic composition according to claim 1, characterized in that said panthenol is D-panthenol and/or DL-panthenol.
4. Cosmetic composition according to claim 1, characterized in that said sugar isomers are selected from one or more of psicose, glucose, mannose, fructose, glucose, galactose, maltose.
5. The cosmetic composition according to any one of claims 1 to 4, wherein the cosmetic composition further comprises, in mass percent, 0.1 to 0.5% of a compound containing an inositol structure, 11 to 33% of a glycerol compound, and the balance water.
6. The cosmetic composition of claim 5, wherein the glycerols comprise diglycerol and polyglycerin-3; the mass ratio of diglycerol to polyglycerol-3 is (5-15): 1.
7. cosmetic composition according to any one of claims 1 to 4, characterized in that the active peptide is selected from one or more of dipeptide-1, dipeptide-2, dipeptide-4, dipeptide diaminobutyrylbenzylamide diacetate, tripeptide-6, trifluoroacetyl tripeptide-2, tripeptide-1 copper, tripeptide-10 citrulline, tripeptide-2, tripeptide-3, tripeptide-32, reduced glutathione, oxidised glutathione, L-carnosine, D-carnosine, oligopeptide-1, oligopeptide-2, oligopeptide-29, oligopeptide-3, oligopeptide-32, oligopeptide-4, oligopeptide-5, oligopeptide-6.
8. The cosmetic composition as claimed in claim 5, wherein the plant extract is derived from flowers of New Zealand Manuka tree, which is prepared by water extraction process.
9. The cosmetic composition as claimed in claim 8, wherein the mass ratio of the plant extract to the glycerin compound is 1: (33-110).
10. Use of a cosmetic composition according to any one of claims 1 to 9 in a cosmetic product comprising one or more of a facial cleanser, a moisturizer, an emulsion, a cream, a foundation, a mask, a lotion, a serum.
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