CN116120460A - 双特异性抗体-喜树碱类药物偶联物及其医药用途 - Google Patents
双特异性抗体-喜树碱类药物偶联物及其医药用途 Download PDFInfo
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- CN116120460A CN116120460A CN202211425572.5A CN202211425572A CN116120460A CN 116120460 A CN116120460 A CN 116120460A CN 202211425572 A CN202211425572 A CN 202211425572A CN 116120460 A CN116120460 A CN 116120460A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- Immunology (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW112128599A TW202434301A (zh) | 2021-11-15 | 2023-07-31 | 雙特異性抗體-喜樹鹼類藥物偶聯物及其醫藥用途 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111351599X | 2021-11-15 | ||
| CN202111351599 | 2021-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116120460A true CN116120460A (zh) | 2023-05-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211425572.5A Pending CN116120460A (zh) | 2021-11-15 | 2022-11-15 | 双特异性抗体-喜树碱类药物偶联物及其医药用途 |
Country Status (14)
| Country | Link |
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| US (2) | US20250059296A1 (enExample) |
| EP (1) | EP4434548A1 (enExample) |
| JP (2) | JP7767613B2 (enExample) |
| KR (1) | KR20240101682A9 (enExample) |
| CN (1) | CN116120460A (enExample) |
| AU (1) | AU2022386505A1 (enExample) |
| CA (1) | CA3237844A1 (enExample) |
| CL (2) | CL2024001450A1 (enExample) |
| CO (1) | CO2024006160A2 (enExample) |
| IL (1) | IL312694A (enExample) |
| MX (1) | MX2024005831A (enExample) |
| PE (1) | PE20250759A1 (enExample) |
| TW (1) | TW202434301A (enExample) |
| WO (1) | WO2023083381A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025016453A1 (zh) * | 2023-07-19 | 2025-01-23 | 映恩生物制药(苏州)有限公司 | 一种双特异性抗体、其药物偶联物及其用途 |
| WO2025131054A1 (en) * | 2023-12-22 | 2025-06-26 | Innovent Biologics (Suzhou) Co., Ltd. | Antibody drug conjugates targeting to b7-h3 and egfr and the use thereof |
| WO2025131063A1 (en) * | 2023-12-22 | 2025-06-26 | Fortvita Biologics Inc. | Antibody drug conjugates targeting b7-h3 and trop2 and the use thereof |
| WO2025140662A1 (en) * | 2023-12-29 | 2025-07-03 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-egfr/her3 antibodies and uses thereof |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2021344531A1 (en) * | 2020-09-21 | 2023-05-18 | Systimmune, Inc. | Egfr binding complex and method of making and using thereof |
| CN119504932A (zh) * | 2023-08-23 | 2025-02-25 | 成都精西药业有限责任公司 | 一种连接子-药物的制备方法 |
| WO2025085303A1 (en) * | 2023-10-18 | 2025-04-24 | Systimmune, Inc. | Methods and compositions for treating tumors using antibody camptothecin drug conjugates |
| WO2025128837A1 (en) * | 2023-12-13 | 2025-06-19 | Systimmune, Inc. | Anti-claudin18.2 antibody-camptothecin drug conjugate and pharmaceutical use thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023088382A1 (zh) | 2021-11-17 | 2023-05-25 | 石药集团巨石生物制药有限公司 | 抗体-药物偶联物及其用途 |
| AU2022402061A1 (en) | 2021-12-03 | 2024-07-11 | Systimmune, Inc. | Anti-human trop2 antibody-camptothecin drug conjugate and medical use thereof |
| KR20240120744A (ko) | 2021-12-16 | 2024-08-07 | 맵웰 (상하이) 바이오사이언스 컴퍼니, 리미티드 | 캄프토테신 화합물 및 이의 접합체 |
| KR20240125927A (ko) | 2021-12-28 | 2024-08-20 | 베이진 스위찰랜드 게엠베하 | 항체 약물 접합체 |
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2022
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- 2022-11-15 JP JP2024529137A patent/JP7767613B2/ja active Active
- 2022-11-15 WO PCT/CN2022/132027 patent/WO2023083381A1/zh not_active Ceased
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- 2022-11-15 AU AU2022386505A patent/AU2022386505A1/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20170035906A1 (en) * | 2014-04-10 | 2017-02-09 | Daiichi Sankyo Company, Limited | (anti-her2 antibody)-drug conjugate |
| WO2016106157A1 (en) * | 2014-12-22 | 2016-06-30 | Systimmune, Inc. | Bispecific tetravalent antibodies and methods of makiing and using thereof |
| CN112125915A (zh) * | 2019-09-18 | 2020-12-25 | 四川百利药业有限责任公司 | 一种喜树碱衍生物及其偶联物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025016453A1 (zh) * | 2023-07-19 | 2025-01-23 | 映恩生物制药(苏州)有限公司 | 一种双特异性抗体、其药物偶联物及其用途 |
| WO2025131054A1 (en) * | 2023-12-22 | 2025-06-26 | Innovent Biologics (Suzhou) Co., Ltd. | Antibody drug conjugates targeting to b7-h3 and egfr and the use thereof |
| WO2025131063A1 (en) * | 2023-12-22 | 2025-06-26 | Fortvita Biologics Inc. | Antibody drug conjugates targeting b7-h3 and trop2 and the use thereof |
| WO2025140662A1 (en) * | 2023-12-29 | 2025-07-03 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-egfr/her3 antibodies and uses thereof |
Also Published As
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| EP4434548A1 (en) | 2024-09-25 |
| JP7767613B2 (ja) | 2025-11-11 |
| KR20240101682A9 (ko) | 2025-12-10 |
| CO2024006160A2 (es) | 2024-08-08 |
| US20250059296A1 (en) | 2025-02-20 |
| AU2022386505A1 (en) | 2024-05-23 |
| CL2024001450A1 (es) | 2024-08-30 |
| KR20240101682A (ko) | 2024-07-02 |
| PE20250759A1 (es) | 2025-03-13 |
| TW202434301A (zh) | 2024-09-01 |
| CL2026000307A1 (es) | 2026-03-20 |
| CA3237844A1 (en) | 2023-05-19 |
| JP2024543508A (ja) | 2024-11-21 |
| US12577325B2 (en) | 2026-03-17 |
| WO2023083381A1 (zh) | 2023-05-19 |
| US20250115679A1 (en) | 2025-04-10 |
| IL312694A (en) | 2024-07-01 |
| MX2024005831A (es) | 2024-07-09 |
| JP2026035591A (ja) | 2026-03-04 |
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