CN116096386A - 组合iPSC衍生的效应细胞类型以用于免疫疗法用途 - Google Patents

组合iPSC衍生的效应细胞类型以用于免疫疗法用途 Download PDF

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CN116096386A
CN116096386A CN202180055596.3A CN202180055596A CN116096386A CN 116096386 A CN116096386 A CN 116096386A CN 202180055596 A CN202180055596 A CN 202180055596A CN 116096386 A CN116096386 A CN 116096386A
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cells
cell
derived
car
ipsc
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B·瓦拉马尔
J·古德里奇
R·比约达尔
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Fate Therapeutics Inc
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Fate Therapeutics Inc
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CN202180055596.3A 2020-06-19 2021-06-18 组合iPSC衍生的效应细胞类型以用于免疫疗法用途 Pending CN116096386A (zh)

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US202063041672P 2020-06-19 2020-06-19
US63/041,672 2020-06-19
PCT/US2021/038134 WO2021258016A1 (en) 2020-06-19 2021-06-18 Combining ipsc-derived effector cell types for immunotherapy use

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US (2) US12275955B2 (https=)
EP (1) EP4168538A4 (https=)
JP (1) JP2023530704A (https=)
KR (1) KR20230040337A (https=)
CN (1) CN116096386A (https=)
AU (1) AU2021292695A1 (https=)
BR (1) BR112022025806A2 (https=)
CA (1) CA3182852A1 (https=)
IL (1) IL299106B1 (https=)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118389421A (zh) * 2024-04-01 2024-07-26 苏州艾凯利元生物科技有限公司 一种体外评估nk细胞群的特性的方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021392032A1 (en) 2020-12-03 2023-06-22 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AR124414A1 (es) * 2020-12-18 2023-03-22 Century Therapeutics Inc Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable
WO2023129937A1 (en) * 2021-12-29 2023-07-06 Century Therapeutics, Inc. Genetically engineered cells having anti-cd19 / anti-cd22 chimeric antigen receptors, and uses thereof
EP4508193A4 (en) * 2022-04-11 2026-04-29 In8Bio Inc Ipsc-based gamma-delta t-cells, compositions and methods of use thereof
CN116948012B (zh) * 2022-04-13 2024-07-26 星奕昂(上海)生物科技有限公司 增强细胞功能的cd16抗剪切突变体
WO2023240212A2 (en) * 2022-06-08 2023-12-14 Century Therapeutics, Inc. Genetically engineered cells having anti-cd133 / anti-egfr chimeric antigen receptors, and uses thereof
CN117305241B (zh) * 2023-11-28 2024-03-19 上海兴瑞一达生物科技有限公司 一种hiPSCs诱导分化为NK细胞的方法
WO2026073244A1 (en) * 2024-09-30 2026-04-02 Ensoma, Inc. Constructs for multi-lineage expression of therapeutic agents

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160009813A1 (en) * 2013-04-03 2016-01-14 Memorial Sloan-Kettering Cancer Center Effective generation of tumor-targeted t cells derived from pluripotent stem cells
WO2019112899A2 (en) * 2017-12-08 2019-06-13 Fate Therepeutics, Inc. IMMUNOTHERAPIES USING ENHANCED iPSC DERIVED EFFECTOR CELLS
US20200069734A1 (en) * 2017-12-22 2020-03-05 Fate Therapeutics, Inc. Enhanced immune effector cells and use thereof

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
GB9710807D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
US6140081A (en) 1998-10-16 2000-10-31 The Scripps Research Institute Zinc finger binding domains for GNN
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
JP2002060786A (ja) 2000-08-23 2002-02-26 Kao Corp 硬質表面用殺菌防汚剤
US20040224385A1 (en) 2001-08-20 2004-11-11 Barbas Carlos F Zinc finger binding domains for cnn
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US7972854B2 (en) 2004-02-05 2011-07-05 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
AU2005250408B2 (en) 2004-05-27 2010-09-23 The Trustees Of The University Of Pennsylvania Novel artificial antigen presenting cells and uses therefor
WO2007146968A2 (en) 2006-06-12 2007-12-21 Trubion Pharmaceuticals, Inc. Single-chain multivalent binding proteins with effector function
HUE041436T2 (hu) 2009-12-10 2019-05-28 Univ Minnesota Tal-effektor-közvetített DNS-módosítás
EP3399026B1 (en) 2010-06-14 2024-06-26 The Scripps Research Institute Reprogramming of cells to a new fate
EP3549611B1 (en) 2011-07-29 2021-06-30 The Trustees of the University of Pennsylvania Switch costimulatory receptors
JP6850528B2 (ja) 2012-02-13 2021-03-31 シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート 二重特異性キメラ抗原受容体およびその治療的使用
KR102437522B1 (ko) 2012-05-25 2022-08-26 셀렉티스 면역요법을 위한 동종이형 및 면역억제제 저항성인 t 세포의 조작 방법
EP4303232A3 (en) 2013-02-15 2024-04-17 The Regents of The University of California Chimeric antigen receptor and methods of use thereof
US9932607B2 (en) 2013-11-15 2018-04-03 The Board Of Trustees Of The Leland Stanford Junior University Site-specific integration of transgenes into human cells
US10934346B2 (en) 2014-02-14 2021-03-02 Bellicum Pharmaceuticals, Inc. Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12
EP3656864A1 (en) 2014-02-14 2020-05-27 Board of Regents, The University of Texas System Chimeric antigen receptors and methods of making
SG11201606934SA (en) 2014-03-04 2016-09-29 Fate Therapeutics Inc Improved reprogramming methods and cell culture platforms
CN113699159A (zh) 2014-03-28 2021-11-26 明尼苏达大学评议会 涉及经工程改造的cd16的多肽、细胞和方法
US10888608B2 (en) 2014-09-02 2021-01-12 Bellicum Pharmaceuticals, Inc. Costimulation of chimeric antigen receptors by MyD88 and CD40 polypeptides
SG10202111851YA (en) 2015-10-16 2021-12-30 Fate Therapeutics Inc Platform for the Induction & Maintenance of Ground State Pluripotency
CA3003152A1 (en) 2015-11-04 2017-05-11 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
JP6928604B2 (ja) * 2015-11-04 2021-09-01 フェイト セラピューティクス,インコーポレイテッド 万能性細胞のゲノム改変
JP2019506143A (ja) 2015-12-14 2019-03-07 ベリカム ファーマシューティカルズ, インコーポレイテッド 治療用細胞の活性化及び排除のための二重コントロール
EP3405568A4 (en) 2016-01-20 2019-12-04 Fate Therapeutics, Inc. COMPOUNDS AND METHODS FOR IMMUNOCELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES
JP7554670B2 (ja) 2017-10-11 2024-09-20 フェイト セラピューティクス,インコーポレイテッド 一時的かつ一過性プラスミドベクター発現システムを用いる細胞のリプログラミング
JP7575271B2 (ja) * 2018-03-29 2024-10-29 フェイト セラピューティクス,インコーポレイテッド 操作された免疫エフェクター細胞およびその使用
KR102943217B1 (ko) * 2018-12-02 2026-03-25 페이트 세러퓨틱스, 인코포레이티드 향상된 iPSC 유래 효과기 세포를 사용한 면역요법
AU2020271523A1 (en) 2019-04-11 2021-10-14 Fate Therapeutics, Inc. CD3 reconstitution in engineered iPSC and immune effector cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160009813A1 (en) * 2013-04-03 2016-01-14 Memorial Sloan-Kettering Cancer Center Effective generation of tumor-targeted t cells derived from pluripotent stem cells
WO2019112899A2 (en) * 2017-12-08 2019-06-13 Fate Therepeutics, Inc. IMMUNOTHERAPIES USING ENHANCED iPSC DERIVED EFFECTOR CELLS
US20200069734A1 (en) * 2017-12-22 2020-03-05 Fate Therapeutics, Inc. Enhanced immune effector cells and use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NIANIAS, A.等: "Induced Pluripotent Stem Cell (iPSC)?Derived Lymphocytes for Adoptive Cell Immunotherapy: Recent Advances and Challenges", CURRENT HEMATOLOGIC MALIGNANCY REPORTS, vol. 14, pages 261 - 268, XP036839934, DOI: 10.1007/s11899-019-00528-6 *
WANG, W.等: "CAR-NK for tumor immunotherapy: CIinical transformation and future prospects", vol. 472, pages 175 - 180 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118389421A (zh) * 2024-04-01 2024-07-26 苏州艾凯利元生物科技有限公司 一种体外评估nk细胞群的特性的方法

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