CN115956123A - 两步制备3-羟基丙酸的方法 - Google Patents
两步制备3-羟基丙酸的方法 Download PDFInfo
- Publication number
- CN115956123A CN115956123A CN202180044979.0A CN202180044979A CN115956123A CN 115956123 A CN115956123 A CN 115956123A CN 202180044979 A CN202180044979 A CN 202180044979A CN 115956123 A CN115956123 A CN 115956123A
- Authority
- CN
- China
- Prior art keywords
- hydroxypropionic acid
- culture
- concentration
- production
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/52—Propionic acid; Butyric acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01006—Glycerol dehydrogenase (1.1.1.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01001—Formaldehyde dehydrogenase (glutathione) (1.2.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/22—Klebsiella
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01003—Aldehyde dehydrogenase (NAD+) (1.2.1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01004—Aldehyde dehydrogenase (NADP+) (1.2.1.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01005—Aldehyde dehydrogenase [NAD(P)+] (1.2.1.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/0103—Glycerol dehydratase (4.2.1.30)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20200096238 | 2020-07-31 | ||
| KR10-2020-0096238 | 2020-07-31 | ||
| PCT/KR2021/009988 WO2022025710A1 (ko) | 2020-07-31 | 2021-07-30 | 3-하이드록시프로피온산의 2단계 제조 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115956123A true CN115956123A (zh) | 2023-04-11 |
Family
ID=80035923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180044979.0A Pending CN115956123A (zh) | 2020-07-31 | 2021-07-30 | 两步制备3-羟基丙酸的方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230265466A1 (https=) |
| EP (1) | EP4190907A4 (https=) |
| JP (2) | JP2023531938A (https=) |
| KR (1) | KR102639658B1 (https=) |
| CN (1) | CN115956123A (https=) |
| WO (1) | WO2022025710A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250114925A (ko) * | 2024-01-22 | 2025-07-29 | 주식회사 엘지화학 | 3-하이드록시프로피온산의 생산 방법 |
| CN121488048A (zh) * | 2024-01-31 | 2026-02-06 | 株式会社Lg化学 | 用于生产3-羟基丙酸的方法 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85102975A (zh) * | 1984-04-10 | 1986-10-15 | 麒麟麦酒株式会社 | 含乙醇饮料的制备 |
| EP1124979A1 (en) * | 1999-08-30 | 2001-08-22 | Wisconsin Alumni Research Foundation | Production of 3-hydroxypropionic acid in recombinant organisms |
| CN1416320A (zh) * | 2000-01-28 | 2003-05-07 | 奥米加技术公司 | 通过在发酵罐中高密度培养真核微生物来增加含有多烯脂肪酸的脂质的产生 |
| CN102317436A (zh) * | 2008-07-23 | 2012-01-11 | Opx生物工艺学公司 | 用于增加微生物对3-羟基丙酸(3-hp)的耐受性以及增加3-羟基丙酸产量的方法、系统和组合物 |
| CN102559790A (zh) * | 2012-02-07 | 2012-07-11 | 清华大学 | 一种提高产油微生物发酵生产微生物油脂的方法 |
| CN104774790A (zh) * | 2015-04-03 | 2015-07-15 | 江南大学 | 一种高效发酵生产l-丙氨酸的大肠杆菌 |
| WO2016189203A1 (en) * | 2015-05-25 | 2016-12-01 | Neste Corporation | Methods for continuous production of products from microorganisms |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101189187B1 (ko) * | 2009-03-12 | 2012-10-10 | 한국생명공학연구원 | 글리세롤 산화대사경로를 차단시킨 재조합 균주를 이용한 1、3―프로판디올의 제조방법 |
| KR101090362B1 (ko) * | 2009-10-29 | 2011-12-07 | 한국생명공학연구원 | 글리세롤로부터 3-하이드록시프로피온산을 생산하는 새로운 방법 |
| US9090918B2 (en) * | 2010-11-22 | 2015-07-28 | Novozymes A/A | Compositions and methods for 3-hydroxypropionic acid production |
| KR20120099315A (ko) * | 2011-01-26 | 2012-09-10 | 삼성전자주식회사 | 3-하이드록시프로피온산 및 1,3-프로판디올 동시 생산용 재조합미생물 |
| JP2013071898A (ja) * | 2011-09-27 | 2013-04-22 | Nippon Shokubai Co Ltd | 3−ヒドロキシプロピオン酸類の製造方法 |
| KR101437042B1 (ko) * | 2012-12-28 | 2014-09-02 | 삼성전자 주식회사 | 포도당 및 글리세롤을 이용한 3-히드록시프로피온산의 생산방법 |
| KR101483012B1 (ko) * | 2013-01-22 | 2015-01-19 | 서울대학교산학협력단 | 재조합 대장균을 이용하여 3-히드록시프로피온산을 고수율로 생산하는 방법 |
| KR20150011111A (ko) * | 2013-07-22 | 2015-01-30 | 삼성종합화학주식회사 | 대장균 돌연변이체 및 이를 사용한 유기산 합성방법 |
| CN103789388B (zh) * | 2014-02-19 | 2016-05-18 | 江南大学 | 一种以甘油为原料发酵-生物催化耦合合成体系生产3-羟基丙酸的方法 |
| CN108291231B (zh) * | 2015-06-11 | 2022-04-08 | 纳路Ic有限公司 | 由3-羟基丙酸诱导表达的启动子系统及用其生物生产3-羟基丙酸的方法 |
| KR101760340B1 (ko) * | 2016-01-07 | 2017-07-21 | 포항공과대학교 산학협력단 | 3-히드록시프로피온산을 생산하는 재조합 미생물 및 이를 이용한 3-히드록시프로피온산의 생산방법 |
| EP3358015A1 (en) | 2017-02-03 | 2018-08-08 | Eligo Bioscience | Optimized vector for delivery in microbial populations |
| KR102103408B1 (ko) * | 2018-01-16 | 2020-04-23 | 한국과학기술원 | 1,3-프로판디올 생성능을 가지는 변이미생물 및 이를 이용한 1,3-pdo의 제조방법 |
-
2021
- 2021-07-30 KR KR1020210100741A patent/KR102639658B1/ko active Active
- 2021-07-30 CN CN202180044979.0A patent/CN115956123A/zh active Pending
- 2021-07-30 JP JP2022579093A patent/JP2023531938A/ja active Pending
- 2021-07-30 WO PCT/KR2021/009988 patent/WO2022025710A1/ko not_active Ceased
- 2021-07-30 EP EP21848600.9A patent/EP4190907A4/en active Pending
- 2021-07-30 US US18/005,369 patent/US20230265466A1/en active Pending
-
2024
- 2024-09-09 JP JP2024155129A patent/JP7852981B2/ja active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85102975A (zh) * | 1984-04-10 | 1986-10-15 | 麒麟麦酒株式会社 | 含乙醇饮料的制备 |
| EP1124979A1 (en) * | 1999-08-30 | 2001-08-22 | Wisconsin Alumni Research Foundation | Production of 3-hydroxypropionic acid in recombinant organisms |
| CN1416320A (zh) * | 2000-01-28 | 2003-05-07 | 奥米加技术公司 | 通过在发酵罐中高密度培养真核微生物来增加含有多烯脂肪酸的脂质的产生 |
| CN102317436A (zh) * | 2008-07-23 | 2012-01-11 | Opx生物工艺学公司 | 用于增加微生物对3-羟基丙酸(3-hp)的耐受性以及增加3-羟基丙酸产量的方法、系统和组合物 |
| CN102559790A (zh) * | 2012-02-07 | 2012-07-11 | 清华大学 | 一种提高产油微生物发酵生产微生物油脂的方法 |
| CN104774790A (zh) * | 2015-04-03 | 2015-07-15 | 江南大学 | 一种高效发酵生产l-丙氨酸的大肠杆菌 |
| WO2016189203A1 (en) * | 2015-05-25 | 2016-12-01 | Neste Corporation | Methods for continuous production of products from microorganisms |
Non-Patent Citations (2)
| Title |
|---|
| LI ET AL.: "High Production of 3-Hydroxypropionic Acid in Klebsiella pneumoniae by Systematic Optimization of Glycerol Metabolism", SCIENTIFIC REPORTS, 27 May 2016 (2016-05-27) * |
| 吴豪: "重组大肠杆菌利用甘油合成3-羟基丙酸的工艺条件研究", 中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑, no. 05, 15 May 2020 (2020-05-15), pages 16 - 18 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023531938A (ja) | 2023-07-26 |
| WO2022025710A1 (ko) | 2022-02-03 |
| KR20220015996A (ko) | 2022-02-08 |
| JP7852981B2 (ja) | 2026-04-28 |
| EP4190907A1 (en) | 2023-06-07 |
| EP4190907A4 (en) | 2023-12-06 |
| KR102639658B1 (ko) | 2024-02-22 |
| US20230265466A1 (en) | 2023-08-24 |
| JP2024163267A (ja) | 2024-11-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102016006B (zh) | 具有异丙醇生产能力的棒状细菌转化体 | |
| JP5254353B2 (ja) | 2−デオキシ−シロ−イノソース(doi)生産細菌及びこれを用いた2−デオキシ−シロ−イノソース(doi)生産方法 | |
| CN105420154B (zh) | 双基因敲除重组红球菌、构建方法及其应用 | |
| JP7852981B2 (ja) | 3-ヒドロキシプロピオン酸の2段階製造方法 | |
| CN102933715B (zh) | 从甘油生产3-羟基丙酸的方法 | |
| JP5243546B2 (ja) | 植物由来原料から乳酸を生産する方法及び乳酸生産細菌 | |
| CN105051181B (zh) | 2,3-丁二醇的生成能力增加的重组微生物及利用其的2,3-丁二醇的制备方法 | |
| CN112662637A (zh) | 一种甲酸脱氢酶突变体及其制备方法和应用 | |
| US11898188B2 (en) | Mutant microorganism having ability to produce 1,3-propanediol, and method for preparing 1,3-PDO by using same | |
| JPWO2010032698A6 (ja) | 植物由来原料から乳酸を生産する方法及び乳酸生産細菌 | |
| CN117965484A (zh) | 高效合成乳酰-n-岩藻糖基五糖-ⅴ的工程大肠杆菌的构建方法及应用 | |
| WO2004081216A1 (ja) | 酢酸菌のアルコール脱水素酵素遺伝子 | |
| KR102696014B1 (ko) | 3-하이드록시프로피온산의 생산 방법 | |
| EP2348101B1 (en) | Corynebacterium genus microorganism having ability to produce n-acetyl glucosamine and method for producing n-acetyl glucosamine or glucosamine using same | |
| CN116064345A (zh) | 高效生产岩藻糖基乳糖的无抗基因工程菌及其应用 | |
| CN116004496B (zh) | 一种生产透明质酸的基因工程菌及其应用 | |
| CN116103215A (zh) | 一种高产l-2-氨基丁酸的无质粒基因工程菌及其应用 | |
| CN104830851A (zh) | 一种甲酸脱氢酶的重组菌及其应用 | |
| CN116536229B (zh) | 一种利用甘油生产乳酸单体的菌株及其应用 | |
| KR102943839B1 (ko) | 저가 기질을 이용한 3-하이드록시 프로피온산 생산 방법 | |
| CN121100189A (zh) | 用于生产3-羟基丙酸的方法 | |
| CN116875521A (zh) | 一种敲除大肠杆菌maa基因和lacA基因提高β-熊果苷产量的方法 | |
| CN119823925A (zh) | 重组大肠杆菌菌株及利用其发酵生产甘露醇的方法 | |
| CN120005792A (zh) | 一种α-酮异己酸生产菌株及其构建方法与应用 | |
| KR20250153350A (ko) | 헥산올 생산성이 향상된 형질전환 균주 및 이를 이용한 헥산올 생산 방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |