CN115925865A - Nkx3.2片段和包含其作为活性成分的药物组合物 - Google Patents

Nkx3.2片段和包含其作为活性成分的药物组合物 Download PDF

Info

Publication number
CN115925865A
CN115925865A CN202211029784.1A CN202211029784A CN115925865A CN 115925865 A CN115925865 A CN 115925865A CN 202211029784 A CN202211029784 A CN 202211029784A CN 115925865 A CN115925865 A CN 115925865A
Authority
CN
China
Prior art keywords
seq
amino acid
polypeptide
terminal
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202211029784.1A
Other languages
English (en)
Chinese (zh)
Inventor
金旲洹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ICM Co Ltd
Original Assignee
ICM Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICM Co Ltd filed Critical ICM Co Ltd
Publication of CN115925865A publication Critical patent/CN115925865A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202211029784.1A 2016-11-09 2017-11-09 Nkx3.2片段和包含其作为活性成分的药物组合物 Pending CN115925865A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20160149090 2016-11-09
KR10-2016-0149090 2016-11-09
CN201780069569.5A CN110036023B (zh) 2016-11-09 2017-11-09 Nkx3.2片段和包含其作为活性成分的药物组合物
PCT/KR2017/012651 WO2018088813A2 (ko) 2016-11-09 2017-11-09 Nkx3.2 단편 및 이를 유효성분으로 포함하는 약학 조성물

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201780069569.5A Division CN110036023B (zh) 2016-11-09 2017-11-09 Nkx3.2片段和包含其作为活性成分的药物组合物

Publications (1)

Publication Number Publication Date
CN115925865A true CN115925865A (zh) 2023-04-07

Family

ID=62110655

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202211029784.1A Pending CN115925865A (zh) 2016-11-09 2017-11-09 Nkx3.2片段和包含其作为活性成分的药物组合物
CN201780069569.5A Active CN110036023B (zh) 2016-11-09 2017-11-09 Nkx3.2片段和包含其作为活性成分的药物组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201780069569.5A Active CN110036023B (zh) 2016-11-09 2017-11-09 Nkx3.2片段和包含其作为活性成分的药物组合物

Country Status (9)

Country Link
US (2) US11235025B2 (enExample)
EP (2) EP3835311B1 (enExample)
JP (2) JP6991593B2 (enExample)
KR (4) KR102049978B1 (enExample)
CN (2) CN115925865A (enExample)
AU (2) AU2017358282C1 (enExample)
CA (1) CA3042186C (enExample)
ES (2) ES3009014T3 (enExample)
WO (1) WO2018088813A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3060947B1 (fr) * 2016-12-28 2025-12-26 Ynsect Procede de traitement d'insectes comprenant la separation des cuticules de la partie molle des insectes puis la separation de la partie molle en trois fractions
CA3112915A1 (en) 2018-10-19 2020-04-23 Icm Co., Ltd. Pharmaceutical composition for treating retinal diseases, comprising nkx3.2 and fragment thereof as active ingredients
KR102336515B1 (ko) * 2018-10-25 2021-12-07 애니젠 주식회사 부포린 유도체 및 이의 용도
CN112409454B (zh) * 2020-11-04 2022-07-05 青岛农业大学 一种法氏囊七肽及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011093647A2 (en) * 2010-01-26 2011-08-04 Industry-Academic Cooperation Foundation, Yonsei University Genes implicated in osteoarthritis and use thereof
US20140004047A1 (en) * 2011-01-11 2014-01-02 Tufts University Methods, compositions and kits for modulating trans-differentiation of muscle satellite cells
CN105025917A (zh) * 2013-03-08 2015-11-04 诺华股份有限公司 用于治疗关节损坏的肽和组合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
JP5996429B2 (ja) * 2009-09-03 2016-09-21 ジェネンテック， インコーポレイテッド 関節リウマチの治療、診断及びモニターするための方法
KR101150900B1 (ko) * 2010-01-26 2012-05-30 연세대학교 산학협력단 퇴행성 관절염 치료 조성물
KR101150990B1 (ko) 2010-06-19 2012-06-13 김유정 슬롯리스 고정자를 갖는 브러시리스 직류 모터
AU2014310360B2 (en) * 2013-06-11 2019-10-24 PPL (BVI) Limited Structure, manufacturing and uses of human-derived cell-permeable peptides conjugated with specific biologically active cargo peptides
KR102044530B1 (ko) * 2017-04-21 2019-11-14 아이씨엠 주식회사 Nkx3.2 및 이의 단편을 유효성분으로 포함하는 망막질환 치료용 약학적 조성물

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011093647A2 (en) * 2010-01-26 2011-08-04 Industry-Academic Cooperation Foundation, Yonsei University Genes implicated in osteoarthritis and use thereof
US20140004047A1 (en) * 2011-01-11 2014-01-02 Tufts University Methods, compositions and kits for modulating trans-differentiation of muscle satellite cells
CN105025917A (zh) * 2013-03-08 2015-11-04 诺华股份有限公司 用于治疗关节损坏的肽和组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MARJOLEIN M. J. CARON ET AL.: "BAPX-1/NKX-3.2 Acts as a Chondrocyte Hypertrophy Molecular Switch in Osteoarthritis", ARTHRITIS & RHEUMATOLOGY, vol. 67, no. 11, 30 November 2015 (2015-11-30), pages 2944 - 2956, XP055557946, DOI: 10.1002/art.39293 *

Also Published As

Publication number Publication date
EP3539978A2 (en) 2019-09-18
EP3835311B1 (en) 2024-08-28
ES3009014T3 (en) 2025-03-25
EP3539978C0 (en) 2025-02-26
AU2017358282B2 (en) 2020-07-30
WO2018088813A3 (ko) 2018-10-04
JP2019535310A (ja) 2019-12-12
US11235025B2 (en) 2022-02-01
AU2017358282C1 (en) 2020-11-26
EP3835311C0 (en) 2024-08-28
JP6991593B2 (ja) 2022-01-12
EP3835311A1 (en) 2021-06-16
EP3539978A4 (en) 2020-08-05
KR102049987B1 (ko) 2019-11-28
CN110036023B (zh) 2023-01-10
KR20190126753A (ko) 2019-11-12
KR20200129068A (ko) 2020-11-17
US20200188480A1 (en) 2020-06-18
WO2018088813A2 (ko) 2018-05-17
JP2021020962A (ja) 2021-02-18
KR20180052103A (ko) 2018-05-17
AU2020207879A1 (en) 2020-08-13
CA3042186A1 (en) 2018-05-17
CN110036023A (zh) 2019-07-19
AU2017358282A1 (en) 2019-05-23
US11154590B2 (en) 2021-10-26
CA3042186C (en) 2021-06-15
KR102342171B1 (ko) 2021-12-23
AU2020207879B2 (en) 2021-04-15
JP7055455B2 (ja) 2022-04-18
KR20180052104A (ko) 2018-05-17
ES2987020T3 (es) 2024-11-13
WO2018088813A9 (ko) 2018-11-15
KR102049978B1 (ko) 2019-11-28
EP3539978B1 (en) 2025-02-26
US20190351015A1 (en) 2019-11-21
KR102340761B1 (ko) 2021-12-21

Similar Documents

Publication Publication Date Title
US11154590B2 (en) Nkx3.2 fragment and pharmaceutical composition comprising same as active ingredient
BR112013033175B1 (pt) Peptídeo quimérico, composição farmacêutica, célula transformada e uso do peptídeo quimérico
EP3033095B1 (en) Therapeutic use of vegf-c and ccbe1
JP6928324B1 (ja) 滑膜細胞増殖抑制剤、関節腔注入剤、及び食品組成物
TWI894291B (zh) 用於治療及預防SARS-CoV-2感染的人源化ACE2-Fc融合蛋白
CA2984629A1 (en) Modified ube3a gene for a gene therapy approach for angelman syndrome
CN114366802A (zh) 用于治疗2型糖尿病的肠内递送的苦味寡肽
JP2005504010A (ja) 成長ホルモンおよびｆｏｘｍ１ｂを用いた肝臓疾患および肝臓損傷の処置方法
CN110167564A (zh) 调节tjp1表达以调节心脏细胞的再生
KR20120061070A (ko) 당뇨병 치료를 위한 ｍｇ２９를 조정하는 조성물 및 방법
JPWO2007139120A1 (ja) アミロイドβクリアランス促進剤
WO2010053199A1 (ja) 前立腺癌の治療用医薬組成物及び前立腺癌の治療方法
JP2026506963A (ja) 副腎皮質ステロイド処置を利用する改善されたアデノウイルスベースの遺伝子治療のための組成物および方法
CN117959442A (zh) 预防或治疗肺纤维化的试剂及应用
WO2007032396A1 (ja) 脊髄損傷治療剤
WO2018085645A1 (en) Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20230407