AU2017358282C1 - Nkx3.2 fragment and pharmaceutical composition comprising same as active ingredient - Google Patents

Nkx3.2 fragment and pharmaceutical composition comprising same as active ingredient Download PDF

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Publication number
AU2017358282C1
AU2017358282C1 AU2017358282A AU2017358282A AU2017358282C1 AU 2017358282 C1 AU2017358282 C1 AU 2017358282C1 AU 2017358282 A AU2017358282 A AU 2017358282A AU 2017358282 A AU2017358282 A AU 2017358282A AU 2017358282 C1 AU2017358282 C1 AU 2017358282C1
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Australia
Prior art keywords
seq
amino acid
polypeptide
acid sequence
terminus
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AU2017358282A
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English (en)
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AU2017358282B2 (en
AU2017358282A1 (en
Inventor
Dae-Won Kim
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ICM Co Ltd
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ICM Co Ltd
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Publication of AU2017358282A1 publication Critical patent/AU2017358282A1/en
Priority to AU2020207879A priority Critical patent/AU2020207879B2/en
Publication of AU2017358282B2 publication Critical patent/AU2017358282B2/en
Application granted granted Critical
Publication of AU2017358282C1 publication Critical patent/AU2017358282C1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2017358282A 2016-11-09 2017-11-09 Nkx3.2 fragment and pharmaceutical composition comprising same as active ingredient Active AU2017358282C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020207879A AU2020207879B2 (en) 2016-11-09 2020-07-24 Nkx3.2 fragment and pharmaceutical composition comprising same as active ingredient

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20160149090 2016-11-09
KR10-2016-0149090 2016-11-09
PCT/KR2017/012651 WO2018088813A2 (ko) 2016-11-09 2017-11-09 Nkx3.2 단편 및 이를 유효성분으로 포함하는 약학 조성물

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020207879A Division AU2020207879B2 (en) 2016-11-09 2020-07-24 Nkx3.2 fragment and pharmaceutical composition comprising same as active ingredient

Publications (3)

Publication Number Publication Date
AU2017358282A1 AU2017358282A1 (en) 2019-05-23
AU2017358282B2 AU2017358282B2 (en) 2020-07-30
AU2017358282C1 true AU2017358282C1 (en) 2020-11-26

Family

ID=62110655

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2017358282A Active AU2017358282C1 (en) 2016-11-09 2017-11-09 Nkx3.2 fragment and pharmaceutical composition comprising same as active ingredient
AU2020207879A Active AU2020207879B2 (en) 2016-11-09 2020-07-24 Nkx3.2 fragment and pharmaceutical composition comprising same as active ingredient

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2020207879A Active AU2020207879B2 (en) 2016-11-09 2020-07-24 Nkx3.2 fragment and pharmaceutical composition comprising same as active ingredient

Country Status (9)

Country Link
US (2) US11235025B2 (enExample)
EP (2) EP3835311B1 (enExample)
JP (2) JP6991593B2 (enExample)
KR (4) KR102049978B1 (enExample)
CN (2) CN115925865A (enExample)
AU (2) AU2017358282C1 (enExample)
CA (1) CA3042186C (enExample)
ES (2) ES3009014T3 (enExample)
WO (1) WO2018088813A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3060947B1 (fr) * 2016-12-28 2025-12-26 Ynsect Procede de traitement d'insectes comprenant la separation des cuticules de la partie molle des insectes puis la separation de la partie molle en trois fractions
CA3112915A1 (en) 2018-10-19 2020-04-23 Icm Co., Ltd. Pharmaceutical composition for treating retinal diseases, comprising nkx3.2 and fragment thereof as active ingredients
KR102336515B1 (ko) * 2018-10-25 2021-12-07 애니젠 주식회사 부포린 유도체 및 이의 용도
CN112409454B (zh) * 2020-11-04 2022-07-05 青岛农业大学 一种法氏囊七肽及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101150900B1 (ko) * 2010-01-26 2012-05-30 연세대학교 산학협력단 퇴행성 관절염 치료 조성물

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
JP5996429B2 (ja) * 2009-09-03 2016-09-21 ジェネンテック， インコーポレイテッド 関節リウマチの治療、診断及びモニターするための方法
WO2011093647A2 (en) * 2010-01-26 2011-08-04 Industry-Academic Cooperation Foundation, Yonsei University Genes implicated in osteoarthritis and use thereof
KR101150990B1 (ko) 2010-06-19 2012-06-13 김유정 슬롯리스 고정자를 갖는 브러시리스 직류 모터
WO2012097057A2 (en) * 2011-01-11 2012-07-19 Tufts University Methods, compositions and kits for modulating trans-differentiation of muscle satellite cells
UY35368A (es) * 2013-03-08 2014-10-31 Irm Llc Péptidos y composiciones para el tratamiento de daño articular
AU2014310360B2 (en) * 2013-06-11 2019-10-24 PPL (BVI) Limited Structure, manufacturing and uses of human-derived cell-permeable peptides conjugated with specific biologically active cargo peptides
KR102044530B1 (ko) * 2017-04-21 2019-11-14 아이씨엠 주식회사 Nkx3.2 및 이의 단편을 유효성분으로 포함하는 망막질환 치료용 약학적 조성물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101150900B1 (ko) * 2010-01-26 2012-05-30 연세대학교 산학협력단 퇴행성 관절염 치료 조성물

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CARON, M. M. J. et al., "BAPX-1/NKX-3.2 Acts as a Chondrocyte Hypertrophy Molecular Switch in Osteoarthritis", Arthritis & Rheumatology, (2015), vol. 67, no. 11, pages 2944 - 2956 *
KIM, J.-A. et al., "Suppression of Nkx3.2 by Phosphatidy linositol-3-kinase Signaling Regulates Cartilage Development by Modulating Chondrocyte Hypertrophy", Cellular Signalling, (2015), vol. 27, pages 2389 - 2400 *
PARK, M. et al., "Constitutive RelA Activation Mediated by Nkx3.2 Controls Chondrocyte Viability", Nature Cell Biology, (2007), vol. 9, no. 3, pages 287 - 298 *
Protein, (2016-10-06), Database accession no. NP_001 180.1, URL: NCBI *

Also Published As

Publication number Publication date
EP3539978A2 (en) 2019-09-18
EP3835311B1 (en) 2024-08-28
ES3009014T3 (en) 2025-03-25
EP3539978C0 (en) 2025-02-26
AU2017358282B2 (en) 2020-07-30
WO2018088813A3 (ko) 2018-10-04
JP2019535310A (ja) 2019-12-12
US11235025B2 (en) 2022-02-01
EP3835311C0 (en) 2024-08-28
JP6991593B2 (ja) 2022-01-12
EP3835311A1 (en) 2021-06-16
EP3539978A4 (en) 2020-08-05
KR102049987B1 (ko) 2019-11-28
CN110036023B (zh) 2023-01-10
KR20190126753A (ko) 2019-11-12
KR20200129068A (ko) 2020-11-17
US20200188480A1 (en) 2020-06-18
WO2018088813A2 (ko) 2018-05-17
CN115925865A (zh) 2023-04-07
JP2021020962A (ja) 2021-02-18
KR20180052103A (ko) 2018-05-17
AU2020207879A1 (en) 2020-08-13
CA3042186A1 (en) 2018-05-17
CN110036023A (zh) 2019-07-19
AU2017358282A1 (en) 2019-05-23
US11154590B2 (en) 2021-10-26
CA3042186C (en) 2021-06-15
KR102342171B1 (ko) 2021-12-23
AU2020207879B2 (en) 2021-04-15
JP7055455B2 (ja) 2022-04-18
KR20180052104A (ko) 2018-05-17
ES2987020T3 (es) 2024-11-13
WO2018088813A9 (ko) 2018-11-15
KR102049978B1 (ko) 2019-11-28
EP3539978B1 (en) 2025-02-26
US20190351015A1 (en) 2019-11-21
KR102340761B1 (ko) 2021-12-21

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DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 06 AUG 2020

TH Corrigenda

Free format text: IN VOL 34 , NO 35 , PAGE(S) 4880 UNDER THE HEADING AMENDMENTS - APPLICATION FOR AMENDMENTS UNDER THE NAME ICM CO., LTD., PATENT NO. 2017358282 CORRECT THE DATE OF THE STATEMENTS FILED TO READ 23 JULY 2020 AND 6 AUGUST 2020

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENTS FILED 23 JUL 2020 AND 6 AUGUST 2020

FGA Letters patent sealed or granted (standard patent)