CN115884793A - 具有含肽接头的位点特异性抗体-药物缀合物 - Google Patents

具有含肽接头的位点特异性抗体-药物缀合物 Download PDF

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CN115884793A
CN115884793A CN202180022159.1A CN202180022159A CN115884793A CN 115884793 A CN115884793 A CN 115884793A CN 202180022159 A CN202180022159 A CN 202180022159A CN 115884793 A CN115884793 A CN 115884793A
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antibody
conjugate
moiety
amino acid
drug
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CN202180022159.1A
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Chinese (zh)
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T·B·罗文格尔
M·I·达梅林
D·托亚德
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Mersana Therapeutics Inc
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Mersana Therapeutics Inc
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Immunology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202180022159.1A 2020-01-09 2021-01-08 具有含肽接头的位点特异性抗体-药物缀合物 Pending CN115884793A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062958916P 2020-01-09 2020-01-09
US62/958916 2020-01-09
US202063040735P 2020-06-18 2020-06-18
US63/040735 2020-06-18
PCT/US2021/012611 WO2021142199A1 (en) 2020-01-09 2021-01-08 Site specific antibody-drug conjugates with peptide-containing linkers

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CN115884793A true CN115884793A (zh) 2023-03-31

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US (2) US11786605B2 (https=)
EP (1) EP4087614A1 (https=)
JP (1) JP7846624B2 (https=)
KR (1) KR20220124762A (https=)
CN (1) CN115884793A (https=)
AU (1) AU2021205312A1 (https=)
BR (1) BR112022013255A2 (https=)
CA (1) CA3163833A1 (https=)
IL (1) IL294321B1 (https=)
MX (1) MX2022008437A (https=)
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WO (1) WO2021142199A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022013255A2 (pt) 2020-01-09 2022-09-06 Mersana Therapeutics Inc Conjugados anticorpo-fármaco específicos de sítio com ligantes contendo peptídeo
MX2023008000A (es) 2021-01-04 2023-07-13 Mersana Therapeutics Inc Conjugados de anticuerpo dirigido a b7-h4 y farmaco, y metodos de uso de los mismos.
CN118574857A (zh) * 2022-01-27 2024-08-30 岩唐生物科技(杭州)有限责任公司 靶向cd3的多特异性抗体及其应用
JP2025536308A (ja) * 2022-10-18 2025-11-05 テューブリス ゲーエムベーハー 新規なＮａＰｉ２ｂ抗体を有する新規な抗体－薬物コンジュゲート、治療的方法、ならびにそれらの使用
WO2025248500A1 (en) 2024-05-31 2025-12-04 Janssen Biotech, Inc. Antibody drug conjugates that target enpp3
WO2026017107A1 (en) * 2024-07-19 2026-01-22 Primelink Biotherapeutics (Shenzhen) Co., Ltd. Linker-polymer-drug conjugates

Citations (5)

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CN105142672A (zh) * 2012-10-23 2015-12-09 西纳福克斯股份有限公司 经修饰的抗体、抗体-缀合物及其制备方法
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