TW202140075A - 具有含肽之連接子的位置特異性抗體－藥物共軛體 - Google Patents

具有含肽之連接子的位置特異性抗體－藥物共軛體 Download PDF

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TW202140075A
TW202140075A TW110100793A TW110100793A TW202140075A TW 202140075 A TW202140075 A TW 202140075A TW 110100793 A TW110100793 A TW 110100793A TW 110100793 A TW110100793 A TW 110100793A TW 202140075 A TW202140075 A TW 202140075A
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antibody
conjugate
amino acid
drug
cancer
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TW110100793A
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Chinese (zh)
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提摩西 勞文吉爾
馬克 達姆林
多林 托德
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美商梅爾莎納醫療公司
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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TW110100793A 2020-01-09 2021-01-08 具有含肽之連接子的位置特異性抗體－藥物共軛體 TW202140075A (zh)

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US202062958916P 2020-01-09 2020-01-09
US62/958,916 2020-01-09
US202063040735P 2020-06-18 2020-06-18
US63/040,735 2020-06-18

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WO2023141856A1 (zh) * 2022-01-27 2023-08-03 岩唐生物科技(杭州)有限责任公司 靶向cd3的多特异性抗体及其应用

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IL294321B1 (en) 2020-01-09 2026-04-01 Mersana Therapeutics Inc Antibody-drug conjugates are attached at a specific site with linkers that include peptides.
JP2024501894A (ja) 2021-01-04 2024-01-16 メルサナ セラピューティクス インコーポレイテッド Ｂ７ｈ４ターゲティング抗体－薬物コンジュゲートおよびその使用方法
US20240190958A1 (en) * 2022-10-18 2024-06-13 Tubulis Gmbh Novel antibody drug conjugates with novel napi2b antibodies, therapeutic methods and uses thereof
WO2025248500A1 (en) 2024-05-31 2025-12-04 Janssen Biotech, Inc. Antibody drug conjugates that target enpp3

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