CN115804798A - 含微生物的组合物增加丁酸、叶酸或烟酸的肠道生产和/或降低琥珀酸的肠道生产的应用 - Google Patents
含微生物的组合物增加丁酸、叶酸或烟酸的肠道生产和/或降低琥珀酸的肠道生产的应用 Download PDFInfo
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| CN110358712B (zh) * | 2019-07-26 | 2021-11-09 | 浙江一鸣食品股份有限公司 | 一种乳酸菌组合物及其应用 |
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| CN101240315A (zh) | 2008-02-21 | 2008-08-13 | 上海交通大学 | 检测药物防癌效果的非损伤性分子方法 |
| CA2721981A1 (en) | 2008-05-01 | 2009-11-05 | The Procter & Gamble Company | Methods and kits for the treatment of inflammatory bowel disorder conditions |
| WO2010008272A1 (en) | 2008-07-15 | 2010-01-21 | N.V. Nutricia | Treatment of gut motility disorders |
| JP2010161944A (ja) | 2009-01-13 | 2010-07-29 | Syngen Biotech Co Ltd | 新型カゼイ菌の亜種（ｓｇ９６）及びこれを含有する菌抑制組成物及びその用途 |
| WO2010099824A1 (en) | 2009-03-05 | 2010-09-10 | Probiotical S.P.A. | Bacteria strains having a high anti-inflammatory activity |
| WO2010103132A1 (es) | 2009-03-10 | 2010-09-16 | Hero España, S.A. | Aislamiento, identificación y caracterización de cepas con actividad probiótica a partir de heces de lactantes alimentados exclusivamente con leche materna |
| JP2013505289A (ja) | 2009-09-23 | 2013-02-14 | トーマス・ジュリアス・ボロディ | 腸管感染症の治療法 |
| CN104206946A (zh) * | 2009-11-12 | 2014-12-17 | 雀巢产品技术援助有限公司 | 用于促进肠微生物群平衡和健康的营养组合物 |
| AU2010334993B2 (en) | 2009-12-22 | 2015-07-09 | Probi Ab | Non-fermented compositions comprising a cereal based fraction and a probiotic and uses thereof |
| US8575130B2 (en) | 2010-01-04 | 2013-11-05 | Holy Stone Healthcare Co., Ltd. | Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease |
| ITUD20100112A1 (it) | 2010-06-09 | 2011-12-10 | Farma Derma S R L | Preparazione per uso vaginale e rettale e relativo procedimento di produzione |
| US11235008B2 (en) | 2011-03-31 | 2022-02-01 | Ganeden Biotech, Inc. | Probiotic sports nutrition compositions |
| WO2012154738A1 (en) | 2011-05-09 | 2012-11-15 | The Cleveland Clinic Foundation | Composition and method to improve intestinal health |
| ES3005933T3 (en) | 2011-06-20 | 2025-03-17 | Heinz Co Brands H J Llc | Probiotic compositions and methods |
| GB201219873D0 (en) | 2012-11-05 | 2012-12-19 | Multigerm Uk Entpr Ltd | Diverticulitis treatment |
| CN102919922A (zh) | 2012-11-08 | 2013-02-13 | 黑龙江省轻工科学研究院 | 一种复合益生菌发酵蓝莓果汁粉的制备方法 |
| US20160000838A1 (en) * | 2013-03-05 | 2016-01-07 | Rijksuniversiteit Groningen | Use of Faecalibacterium Prausnitzii Htf-f (DSM 26943) to Suppress Inflammation |
| BR112015032918B1 (pt) * | 2013-07-02 | 2021-09-28 | Austrianova Singapore Pte Ltd | Métodos para preparação de células encapsuladas para liofilização, composição e seus usos |
| ITMI20131473A1 (it) | 2013-09-06 | 2015-03-07 | Sofar Spa | Metodo per valutare gli effetti di una composizione comprendente microrganismi sul microbiota intestinale |
| ITMI20131467A1 (it) | 2013-09-06 | 2015-03-07 | Sofar Spa | Uso di una composizione comprendente microrganismi per aumentare la produzione intestinale di acido butirrico, di acido folico o di niacina e/o per diminuire la produzione intestinale di acido succinico |
| MA39710A (fr) | 2014-04-23 | 2015-10-29 | Sofar Spa | Composition topique destinée à être utilisée dans le traitement d'une maladie inflammatoire de l'intestin |
| WO2015172191A1 (en) | 2014-05-12 | 2015-11-19 | Medlab Ip Pty Ltd | Probiotic compositions and uses thereof for treatment of obesity-related disorders |
| ES2610994T3 (es) | 2014-08-26 | 2017-05-04 | Chr. Hansen A/S | Bifidobacterium animalis subsp. lactis para el uso en la reducción del dolor abdominal en una mujer postmenopáusica |
| MA45327A (fr) | 2016-05-13 | 2019-03-20 | Sofar Spa | Utilisation de probiotiques pour améliorer l'absorption des protéines |
| WO2017195182A1 (en) | 2016-05-13 | 2017-11-16 | Sofar S.P.A. | Use of probiotics for improving protein absorption |
| MA45288A (fr) | 2016-06-08 | 2019-04-17 | Sofar Spa | Nouvelle utilisation médicale de probiotiques |
| IT201600122724A1 (it) | 2016-12-02 | 2018-06-02 | Sofar Spa | Exopolysaccharides and uses thereof |
| IT201600127498A1 (it) | 2016-12-16 | 2018-06-16 | Sofar Spa | Probiotici per uso nella diverticolosi e malattia diverticolare |
| EP3554517B1 (en) | 2016-12-16 | 2023-09-13 | Compagnie Gervais Danone | Probiotic composition comprising lactobacillus rhamnosus and lactobacillus paracasei strains |
| WO2019019961A1 (zh) | 2017-07-26 | 2019-01-31 | 海思科医药集团股份有限公司 | 防治消化道和/或皮肤反应的菌群及其应用 |
| IT201700101704A1 (it) | 2017-09-12 | 2019-03-12 | Sofar Spa | Nuovo uso per trattamento delle infezioni da clostridium difficile |
| EP3720457B1 (en) | 2017-12-06 | 2025-07-23 | Lac2Biome S.R.L. | Composition based on probiotics and uses thereof |
| CN108743851A (zh) | 2018-08-09 | 2018-11-06 | 深圳市博奥生物科技有限公司 | 一种复合益生菌粉的制备方法及复合益生菌粉 |
| IT201900016805A1 (it) | 2019-09-20 | 2021-03-20 | Sofar Spa | Ceppi batterici, loro composizioni e loro uso per il trattamento di disturbi gastrointestinali |
| IT201900016811A1 (it) | 2019-09-20 | 2021-03-20 | Sofar Spa | Ceppi batterici, loro composizioni e loro uso per il trattamento di disturbi gastrointestinali |
| IT201900016865A1 (it) | 2019-09-20 | 2021-03-20 | Sofar Spa | Composizioni a base di ceppi batterici e loro uso come antinfiammatori |
| IT201900016850A1 (it) | 2019-09-20 | 2021-03-20 | Sofar Spa | Composizioni a base di ceppi batterici e estratti di bacche e loro uso come antinfiammatori |
| IT201900020422A1 (it) | 2019-11-05 | 2021-05-05 | Sofar Spa | Composizioni comprendenti ceppi di batteri per uso per aumentare la biodisponibilità degli amminoacidi derivanti da proteine |
| US11751597B2 (en) | 2019-11-05 | 2023-09-12 | Alfasigma S.P.A. | Compositions comprising bacterial strains for use in increasing the bioavailability of amino acids derived from proteins, and related food product methods and systems |
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