CN115530371A - 一种解酒护肝组合物及其应用 - Google Patents
一种解酒护肝组合物及其应用 Download PDFInfo
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- CN115530371A CN115530371A CN202211115002.6A CN202211115002A CN115530371A CN 115530371 A CN115530371 A CN 115530371A CN 202211115002 A CN202211115002 A CN 202211115002A CN 115530371 A CN115530371 A CN 115530371A
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- powder
- liver
- opuntia ficus
- indica
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- A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
- A23L11/70—Germinated pulse products, e.g. from soy bean sprouts
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Abstract
本发明公开了一种解酒护肝组合物及其应用，属于解酒产品领域，所述组合物包括综合果蔬粉和梨果仙人掌，所述综合果蔬粉和梨果仙人掌的质量比为5:1‑1:5。本发明通过将综合果蔬粉和梨果仙人掌复配，能有效加快酒精的代谢速度、对肝脏具有明显的保护作用。与单独的综合果蔬粉、梨果仙人掌相比，复配组合物，可以显著降低小鼠的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)；增加乙醇脱氢酶(ADH)和乙醛脱氢酶(ALDH)的酶活力；组分之间相互协同作用，有效的解酒，起到护肝、养胃的作用。
Description
技术领域
本发明涉及解酒产品领域，具体涉及一种解酒护肝组合物及其应用。
背景技术
现有产品主要有两种，一种是中药为原料的解酒护肝组合物，另一种是以化学药物为主的解酒护肝制剂，第一种的组方成分复杂，价格昂贵，且口感欠佳，不适宜用于日常护肝；第二种主要是针对酒精中毒引起的昏迷，对解酒、护肝的作用不大，缺乏针对性。上述两种产品的解酒作用单一，仅具有单纯的解酒功能，缺乏解酒、护肝、养胃等复合作用。
发明内容
本发明的目的在于克服现有技术的不足，提供一种解酒护肝组合物及其应用，该组合物具有解酒、护肝、养胃的功效。
为实现上述目的，本发明采取的技术方案为：一种解酒护肝组合物，所述组合物包括综合果蔬粉和梨果仙人掌，所述综合果蔬粉和梨果仙人掌的质量比为5:1-1:5。
本发明通过将综合果蔬粉和梨果仙人掌复配，能有效加快酒精的代谢速度、对肝脏具有明显的保护作用。与单独的综合果蔬粉、梨果仙人掌相比，复配组合物，可以显著降低小鼠的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)；增加乙醇脱氢酶(ADH)和乙醛脱氢酶(ALDH)的酶活力；组分之间相互协同作用，有效的解酒，抑制肝脏肿大，起到护肝、养胃的作用。发明人发现，综合果蔬粉和梨果仙人掌之间的质量比对解酒作用的影响显著，当综合果蔬粉和梨果仙人掌之间的质量比大于5:1或小于1:5时，解酒护肝组合物的解酒性能明显下降。
优选地，所述综合果蔬粉和梨果仙人掌的质量比为2:1-1:2。
优选地，所述综合果蔬粉和梨果仙人掌的质量比为1.25:1。
当综合果蔬粉和梨果仙人掌的质量比为2:1-1:2，解酒护肝组合物的作用较好，当综合果蔬粉和梨果仙人掌的质量比为1.25:1时，解酒护肝组合物的效果是最佳的。
优选地，所述综合果蔬粉为柿子、枸杞、荞麦、柑橘皮、黄豆芽中的至少两种，优选地，所述综合果蔬粉为柿子、枸杞、荞麦、柑橘皮、黄豆芽的混合物。
本发明中，所述综合果蔬粉不仅为纯天然植物，作为解酒护肝组合物的成分，不仅安全，此外，发明人在研究过程中，意外发现，综合果蔬粉为柿子、枸杞、荞麦、柑橘皮、黄豆芽中的至少两种时，能够有效提高解酒护肝组合物的解酒护肝效果。进一步的，综合果蔬粉为柿子、枸杞、荞麦、柑橘皮、黄豆芽的混合物时，解酒护肝组合物的效果最佳。
优选地，当柿子、枸杞、荞麦、柑橘皮、黄豆芽的质量比为柿子：枸杞：荞麦：柑橘皮：黄豆芽＝(5～10)：(4～6.5)：(2～4)：(0.5～3)：(3～8)时，解酒护肝组合物能够较大幅度的降低体内的乙醇含量，提高解酒护肝的效果。
优选地，所述梨果仙人掌为梨果仙人掌粉和/或梨果仙人掌果粉。
本发明中，与梨果仙人掌粉相比，梨果仙人掌果粉和综合果蔬粉复配具有更好的解酒护肝效果。
优选地，所述梨果仙人掌粉的制备方法为：将梨果仙人掌水洗后，进行粉碎、水/醇提取、浓缩、喷雾干燥后，即得梨果仙人掌粉。
优选地，所述梨果仙人掌果粉的制备方法为：将梨果仙人掌果水洗后，进行粉碎、水/醇提取、浓缩、喷雾干燥后，即得梨果仙人掌果粉。
优选地，所述组合物还包括以下重量份的组分：猴头菇浓缩粉1-10份、葛根粉0.1-10份、玉米低聚肽0.5-10份、姜黄粉1-10份、枳椇子粉0.1-10份、针叶樱桃粉0.5-5份、维生素0-0.0015份。
本发明的发明经过研究发现，将上述组分、综合果蔬粉和梨果仙人掌组合，可以进一步提高解酒护肝组合物的解酒、护肝、养胃的效果。
所述猴头菇浓缩粉、葛根粉、姜黄粉、枳椇子粉、针叶樱桃粉可以是将原料烘干后直接粉碎制得，也可以是原料经水提或醇提后，所得提取物干燥制得。水提或醇提的方法为本领域常规的方法。
优选地，所述维生素为维生素B1和维生素B6的混合物。
本发明选用维生素B1和维生素B6的混合物，可以进一步促进酒精的分解，从而提高解酒效果。
第二方面，提供一种解酒护肝食品，所述解酒护肝食品含有所述解酒护肝组合物。
优选地，所述解酒护肝食品含有将其制成各种剂型的辅料；
优选地，所述辅料在所述解酒护肝食品中的质量百分比为1％-99％，优选为5％-90％。
作为用于口服的固体组合物，解酒护肝组合物可以配置成粉末、颗粒剂、压片剂、丸剂、胶囊剂、口香糖、干胶片、棒或类似形式。这种固体组合物通常将含有一种或多种惰性稀释剂或可食用载体。另外，可以存在以下一种或多种以下物质：粘合剂，例如羧甲基纤维素、乙基纤维素、环糊精、微晶纤维素；赋形剂，如淀粉、乳糖或糊精；崩解剂，如海藻酸、海藻酸钠、玉米淀粉等；甜味剂，如蔗糖或糖精；调味剂，如薄荷或橙味调味剂；和着色剂。
作为用于口服的液体组合物，解酒护肝组合物可以配置成口服液或饮品。所述口服液或饮品的辅料包括以下物质：水、啤酒花、蜂蜜、茶、咖啡、牛磺酸、糖(包括果聚糖、蔗糖、麦芽糖、麦芽糖醇、乳糖、海藻糖、木糖、木糖醇中的任一种或多种)、二氧化碳、果汁、油脂、甘油、大豆油、茶油、橄榄油、电解质。
与现有技术相比，本发明的有益效果为：本发明通过将综合果蔬粉和梨果仙人掌复配，能有效加快酒精的代谢速度、对肝脏具有明显的保护作用。与单独的综合果蔬粉、梨果仙人掌相比，复配组合物，可以显著降低小鼠的丙氨酸氨基转移酶、谷草转氨酶的活力，增加乙醇脱氢酶和乙醛脱氢酶的酶活力；组分之间相互协同作用，有效的解酒，起到护肝、养胃的作用。
具体实施方式
为更好的说明本发明的目的、技术方案和优点，下面将结合具体实施例对本发明作进一步的说明。
下述实施例和对比例中，所述组成组分的信息如下所示：
综合果蔬粉：市售，所述综合果蔬粉为柿子、枸杞、荞麦、柑橘皮、黄豆芽的混合物，其中柿子、枸杞、荞麦、柑橘皮、黄豆芽的质量比为柿子：枸杞：荞麦：柑橘皮：黄豆芽＝9：5：3：2：5；
梨果仙人掌粉：市售；
梨果仙人掌果粉：市售；
猴头菇浓缩粉：市售；
葛根粉：市售；
玉米低聚肽：市售；
姜黄粉：市售；
枳椇子粉：市售；
针叶樱桃粉：市售；
维生素：维生素B1和维生素B6的混合物，所述维生素B1和维生素B6的质量比为1:1，所述维生素B1和维生素B6均为市售产品。
实施例1-8和对比例1
本发明实施例1-8和对比例1解酒护肝组合物的组成组分如下表1所示。
本发明实施例1-8和对比例1解酒护肝组合物的制备方法，包括以下步骤：
按比例将综合果蔬粉、梨果仙人掌、猴头菇浓缩粉、葛根粉、玉米低聚肽、姜黄粉、枳椇子粉、针叶樱桃粉和维生素混合均匀，即得解酒护肝组合物。
表1
实施例9
为检测实施例解酒护肝组合物的效果，分别对实施例3～4和对比例1解酒护肝组合物进行动物实验，检测解酒护肝组合物对小鼠的体重、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、乙醇脱氢酶(ADH)和乙醛脱氢酶(ALDH)的酶活力进行了检测，以正常组作为空白对照组，以海王金樽牌牡蛎大豆肽肉碱口服液(采购自南宁海王健康生物科技有限公司，每100mL含多肽900mg、牛磺酸50mg、左旋肉碱60mg)作为阳性对照组，以实施例3～4和对比例1解酒护肝组合物作为对比，具体方法如下：
实验材料：实验动物为广东省医学实验动物中心的SPF级KM小鼠，雄性，18～22g。56度红星二锅头，氯化钠注射液，乙醇脱氢酶(ADH)试剂盒，丙氨酸氨基转移酶(ALT)试剂盒，天冬氨酸氨基转移酶(AST)试剂盒，乙醛脱氢酶(ALDH)试剂盒等。
实验组别：
试验方法：取体重均匀的72只小鼠，按体重随机分为正常对照组、模型对照组、阳性对照组、实施例3低剂量组、实施例3高剂量组、实施例4低剂量组、实施例4高剂量组、对比例1低剂量组、对比例1高剂量组，8只/组，共9组。其中，实施例3低剂量组、实施例4低剂量组和对比例1低剂量组的浓度均为16.7mg/mL，实施例3高剂量组、实施例4高剂量组和对比例1高剂量组的浓度均为50mg/mL。
实验前动物禁食不禁水12小时。动物分组后按20mL/kg体重灌胃给予受试物，实施例3低剂量组、实施例3高剂量组、实施例4低剂量组、实施例4高剂量组、对比例1低剂量组、对比例1高剂量组分别灌胃相对应浓度的受试物溶液，1次/日；模型对照组灌胃去离子水，1次/日；阳性对照组灌胃给予海王金樽牌牡蛎大豆肽肉碱口服液，2次/日；正常对照组不做处理，连续30天。
末次给予受试物30min后，除正常对照组按15mL/kg体重灌胃给予生理盐水外，其余组按15mL/kg体重灌胃给予56度红星二锅头，制备小鼠醉酒模型。
体重：每周称重1次；试验结束，称量动物体重1次。
醉酒时间及酒醒时间：记录各组小鼠醉酒时间(从灌完酒到翻正反射消失时间)及酒醒时间(从翻正反射消失到恢复所需的时间)。
乙醇浓度检测：各组小鼠造模后1小时，眼眶采血约0.3mL(醉酒动物不进行麻醉，未醉酒动物采用异氟烷按4％吸入诱导麻醉)，分离血清，检测乙醇浓度。
ALT、AST检测：各组小鼠造模后，禁食不禁水约12h，采用异氟烷按4％吸入诱导麻醉后眼眶采血，分离血清，检测ALT、AST。
肝组织ADH、ALDH检测：小鼠采血结束后放血处死，解剖取肝组织，取适量肝脏以氯化钠注射液匀浆，离心取上清液，按检测试剂盒说明书检测肝组织ADH、ALDH。
上述检测结果如表2-4所示。
表2受试样品对小鼠体重的影响(
n＝8，
)
表3受试样品对小鼠各项指标的影响(
n＝8，
)
| 组别 | 醉酒时间(min) | 醒酒时间(min) | 乙醇含量(g/L) |
| 正常对照组 | 0±0 | 0±0 | 0±0 |
| 模型对照组 | 41±9** | 458±43** | 5.13±0.04** |
| 阳性对照组 | 66±18<sup>▲▲</sup> | 354±57<sup>▲▲</sup> | 4.37±0.83<sup>▲</sup> |
| 对比例1低剂量组 | 47±23 | 405±61 | 5.12±0.03 |
| 对比例1高剂量组 | 63±19<sup>▲</sup> | 334±77<sup>▲▲</sup> | 4.44±0.86 |
| 实施例3低剂量组 | 57±20 | 380±84<sup>▲</sup> | 4.51±0.74 |
| 实施例3高剂量组 | 72±18<sup>▲▲</sup> | 342±59<sup>▲▲</sup> | 4.26±0.88<sup>▲</sup> |
| 实施例4低剂量组 | 59±20 | 379±74<sup>▲</sup> | 4.84±0.35 |
| 实施例4高剂量组 | 69±18<sup>▲▲</sup> | 336±73<sup>▲▲</sup> | 4.46±0.88 |
注：与正常对照组相比，**P<0.01；与模型对照组比较，▲P<0.05，▲▲P<0.01。
表4受试样品对小鼠各项指标的影响(
n＝8，
)
注：与正常对照组相比，**P<0.01；与模型对照组比较，▲P<0.05，▲▲P<0.01。
从表1可知，与正常对照组比较，模型对照组小鼠体重在各时间点均无统计学差异(P>0.05)；与模型对照组比较，各受试物组小鼠体重在各时间点均无统计学差异(P>0.05)。
从表3可知，与正常对照组比较，模型对照组小鼠醉酒及醒酒时间均偏高，具有统计学差异(P<0.01)；与模型对照组比较，阳性对照组、对比例1高剂量组、实施例3高剂量组、实施例4高剂量组小鼠醉酒时间延长，具有统计学差异(P<0.01或0.05)；阳性对照组、对比例1高剂量组、实施例3低剂量组、实施例3高剂量组、实施例4低剂量组、实施例4高剂量组小鼠醒酒时间缩短，具有统计学差异(P<0.01或0.05)。
从表3可知，与正常对照组比较，模型对照组小鼠造模后1h乙醇含量升高，具有统计学差异(P<0.01)；与模型对照组比较，阳性对照组、实施例3高剂量组小鼠造模后1h乙醇含量降低，具有统计学差异(P<0.05)。
从表4可知，与正常对照组比较，模型对照组小鼠ALT、AST升高，具有统计学差异(P<0.01)；与模型对照组比较，阳性对照组、对比例1高剂量组、实施例3低剂量组、实施例3高剂量组、实施例4低剂量组、实施例4高剂量组小鼠ALT、AST降低，具有统计学差异(P<0.01)。与正常对照组比较，模型对照组小鼠肝组织ADH、ALDH降低，具有统计学差异(P<0.01)；与模型对照组比较，阳性对照组、实施例3高剂量组、实施例4高剂量组小鼠肝组织ADH升高，阳性对照组、对比例1低剂量组、对比例1高剂量组、实施例3低剂量组、实施例3高剂量组、实施例4低剂量组、实施例4高剂量组小鼠肝组织ALDH升高，具有统计学差异(P<0.01或0.05)，其余组别无统计学差异(P>0.05)。
最后所应当说明的是，以上实施例用以说明本发明的技术方案而非对本发明保护范围的限制，尽管参照较佳实施例对本发明作了详细说明，本领域的普通技术人员应当理解，可以对本发明的技术方案进行修改或者同等替换，而不脱离本发明技术方案的实质和范围。
Claims (8)
1.一种解酒护肝组合物，其特征在于，所述组合物包括综合果蔬粉和梨果仙人掌，所述综合果蔬粉和梨果仙人掌的质量比为5:1-1:5。
2.如权利要求1所述的解酒护肝组合物，其特征在于，所述综合果蔬粉和梨果仙人掌的质量比为2:1-1:2。
3.如权利要求2所述的解酒护肝组合物，其特征在于，所述综合果蔬粉和梨果仙人掌的质量比为1.25:1。
4.如权利要求1-3任一项所述的解酒护肝组合物，其特征在于，所述综合果蔬粉为柿子、枸杞、荞麦、柑橘皮、黄豆芽中的至少两种，优选地，所述综合果蔬粉为柿子、枸杞、荞麦、柑橘皮、黄豆芽的混合物。
5.如权利要求1-3任一项所述的解酒护肝组合物，其特征在于，所述梨果仙人掌为梨果仙人掌粉和/或梨果仙人掌果汁粉。
6.如权利要求1所述的解酒护肝组合物，其特征在于，所述组合物还包括以下重量份的组分：猴头菇浓缩粉1-10份、葛根粉0.1-10份、玉米低聚肽0.5-10份、姜黄粉1-10份、枳椇子粉0.1-10份、针叶樱桃粉0.5-5份、维生素0-0.0015份。
7.如权利要求6所述解酒护肝组合物，其特征在于，所述维生素为维生素B1和维生素B6的混合物。
8.一种解酒护肝食品，其特征在于，含有权利要求1-7任一项所述解酒护肝组合物。
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